Alzheimer S Disease The 21st Century Challenge

Author : Jolanta Dorszewska,Wojciech Kozubski
Publisher : BoD – Books on Demand
Page : 164 pages
File Size : 41,8 Mb
Release : 2018-07-18
Category : Medical
ISBN : 9781789234626

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Alzheimer's Disease by Jolanta Dorszewska,Wojciech Kozubski Pdf

Alzheimer's disease was discovered over 100 years ago and still belongs to incurable neurological diseases; its pharmacotherapy is considered to be ineffective. This book presents contemporary views on the genetic, biochemical, and immunological determinants of this disease. This book also concerns the issue of Alzheimer's disease prevention through lifestyle and physical activity. Moreover, it describes the therapies used in Alzheimer's disease to slow the progression of the disease and delay its onset. Subsequently, the authors discuss experimental and clinical trials used now and in the near future. We hope that this book will help the readers to understand the complex mechanism leading to the development of Alzheimer's disease and indicate effective ways to prevent this disorder.

Author : Jolanta Dorszewska,Wojciech Kozubski
Publisher : Unknown
Page : 162 pages
File Size : 50,9 Mb
Release : 2018
Category : Neurosciences. Biological psychiatry. Neuropsychiatry
ISBN : 1789234638

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Alzheimer's Disease - The 21st Century Challenge by Jolanta Dorszewska,Wojciech Kozubski Pdf

Alzheimer's disease was discovered over 100 years ago and still belongs to incurable neurological diseases; its pharmacotherapy is considered to be ineffective. This book presents contemporary views on the genetic, biochemical, and immunological determinants of this disease. This book also concerns the issue of Alzheimer's disease prevention through lifestyle and physical activity. Moreover, it describes the therapies used in Alzheimer's disease to slow the progression of the disease and delay its onset. Subsequently, the authors discuss experimental and clinical trials used now and in the near future. We hope that this book will help the readers to understand the complex mechanism leading to the development of Alzheimer's disease and indicate effective ways to prevent this disorder.

Author : Athanasios Alexiou,Mohammad A. Kamal,Ghulam Md Ashraf
Publisher : Frontiers Media SA
Page : 501 pages
File Size : 45,6 Mb
Release : 2019-12-04
Category : Electronic
ISBN : 9782889631285

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The Alzheimer's Disease Challenge by Athanasios Alexiou,Mohammad A. Kamal,Ghulam Md Ashraf Pdf

Alzheimer’s disease is undoubtedly the major health challenge of our Century with significant social and economic consequences. This Frontiers eBook offers a contribution of 39 innovative papers on the multidimensional and crucial problem of Alzheimer’s disease management and treatment. Several perspectives, research updates, and trials describing methods on potential diagnosis and treatment are presented including biological mechanisms, biomarkers and risk factors for an early and efficient prognosis, diagnosis and prevention. Additionally, while the rapidly increasing Alzheimer’s disease population demands holistic solutions and clinical studies with new therapeutic target approaches, several of the contributive papers present promising drugs targeting Alzheimer’s disease treatment. We give our deepest acknowledgment to all the authors for their important and innovative contributions, to the reviewers for their valuable recommendations on improving the submitting studies and all the Frontiers Editorial team for continuous support.

Author : United States. Congress. Senate. Committee on Labor and Human Resources. Subcommittee on Aging
Publisher : Unknown
Page : 84 pages
File Size : 41,7 Mb
Release : 1997
Category : Medical
ISBN : STANFORD:36105045504441

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Meeting the Challenges of Alzheimer's Disease by United States. Congress. Senate. Committee on Labor and Human Resources. Subcommittee on Aging Pdf

Author : Menghis Bairu,Michael Weiner
Publisher : Academic Press
Page : 432 pages
File Size : 44,7 Mb
Release : 2013-08-28
Category : Medical
ISBN : 9780124115309

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Global Clinical Trials for Alzheimer's Disease by Menghis Bairu,Michael Weiner Pdf

Global Clinical Trials for Alzheimer’s Disease is a handy one-stop reference for researchers and physicians planning and conducting global clinical trials in this area. This book addresses important considerations that may arise during the successful design and execution of these trials, including site selection, local regulatory issues, pharmacogenomics, ethical matters and much more. Given the saturation of traditional clinical trial markets and the worldwide progression of Alzheimer’s disease, there is a need to focus on clinical trials in emerging markets and developing countries. This book provides you with a practical approach to recognizing the opportunities and tackling the challenges that are present during the planning and execution of global clinical trials for Alzheimer’s disease. Written by leading experts with hands-on experience in designing and running global Alzheimer’s disease and other neurodegenerative diseases clinical trials A step-by-step guide that provides critical information on the design, conduct and standardization necessary to effectively execute clinical trials and accelerate drug development in this area Includes practical examples, ethical considerations, lessons learned and other valuable tools to aid the planning and implementation of Alzheimer’s disease global clinical trials in emerging markets and developing countries

Author : Magisetty Obulesu
Publisher : Academic Press
Page : 80 pages
File Size : 44,6 Mb
Release : 2019-01-20
Category : Medical
ISBN : 9780128167397

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Alzheimer’s Disease Theranostics by Magisetty Obulesu Pdf

Alzheimer’s Disease Theranostics discusses the latest information on recent theranostic avenues for both the diagnosis and treatment of Alzheimer’s patients. It presents the pros and cons of the probable mechanistic role of nanoparticles in crossing the blood-brain barrier and improving disease symptoms. Finally, it highlights the merits of existing maneuvers and suggests perspectives to aid in future developments. Despite the difficulty of drug delivery to the brain, there are some nanoparticulate platforms demonstrating promise in treating neurodegenerative disorders such as Alzheimer’s disease. Manifold theranostic maneuvers include antioxidants, natural bioactive compounds, gene therapy, and nanotechnological approaches, all of which are discussed in this important work. Examines various theranostic applications for the diagnosis and treatment of Alzheimer’s disease Features a comprehensive overview of nanoparticle therapeutics in the area and use of antioxidants Assesses the common challenges and lessons learned from blood-brain barrier challenges, viral vector approaches and mitochondria-targeted therapeutics

Author : Stephen G. Post
Publisher : JHU Press
Page : 176 pages
File Size : 44,6 Mb
Release : 2002-11-04
Category : Medical
ISBN : 9780801870156

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The Moral Challenge of Alzheimer Disease by Stephen G. Post Pdf

Society today, writes Stephen Post, is "hypercognitive": it places inordinate emphasis on people's powers of rational thinking and memory. Thus, Alzheimer disease and other dementias, which over an extended period incrementally rob patients of exactly those functions, raise many dilemmas. How are we to view—and value—persons deprived of what some consider the most important human capacities? In the second edition of The Moral Challenge of Alzheimer Disease, Post updates his highly praised account of the major ethical issues relating to dementia care. With chapters organized to follow the progression from mild to severe and then terminal stages of dementia, Post discusses topics including the experience of dementia, family caregiving, genetic testing for Alzheimer disease, quality of life, and assisted suicide and euthanasia. New to this edition are sections dealing with end-of-life issues (especially artificial nutrition and hydration), the emerging cognitive-enhancing drugs, distributive justice, spirituality, and hospice, as well as a critique of rationalistic definitions of personhood. The last chapter is a new summary of practical solutions useful to family members and professionals.

Author : Jason Karlawish
Publisher : St. Martin's Press
Page : 269 pages
File Size : 42,7 Mb
Release : 2021-02-23
Category : Health & Fitness
ISBN : 9781250218742

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The Problem of Alzheimer's by Jason Karlawish Pdf

A definitive and compelling book on one of today's most prevalent illnesses. In 2020, an estimated 5.8 million Americans had Alzheimer’s, and more than half a million died because of the disease and its devastating complications. 16 million caregivers are responsible for paying as much as half of the $226 billion annual costs of their care. As more people live beyond their seventies and eighties, the number of patients will rise to an estimated 13.8 million by 2050. Part case studies, part meditation on the past, present and future of the disease, The Problem of Alzheimer's traces Alzheimer’s from its beginnings to its recognition as a crisis. While it is an unambiguous account of decades of missed opportunities and our health care systems’ failures to take action, it tells the story of the biomedical breakthroughs that may allow Alzheimer’s to finally be prevented and treated by medicine and also presents an argument for how we can live with dementia: the ways patients can reclaim their autonomy and redefine their sense of self, how families can support their loved ones, and the innovative reforms we can make as a society that would give caregivers and patients better quality of life. Rich in science, history, and characters, The Problem of Alzheimer's takes us inside laboratories, patients' homes, caregivers’ support groups, progressive care communities, and Jason Karlawish's own practice at the Penn Memory Center.

Author : Tarun Belwal,Seyed Mohammad Nabavi,Seyed Fazel Nabavi,Ahmad Reza Dehpour,Samira Shirooie
Publisher : Academic Press
Page : 534 pages
File Size : 44,5 Mb
Release : 2020-11-19
Category : Medical
ISBN : 9780128192139

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Naturally Occurring Chemicals against Alzheimer’s Disease by Tarun Belwal,Seyed Mohammad Nabavi,Seyed Fazel Nabavi,Ahmad Reza Dehpour,Samira Shirooie Pdf

Naturally Occurring Chemicals against Alzheimer’s Disease offers a detailed discussion on the roles, molecular mechanisms, structural activity relationships, toxicology and clinical data on phytochemicals in relation to Alzheimer’s disease. The book examines the available phytochemicals and plants that are potentially effective, also determining the role and molecular targets of these phytochemicals in combating AD. This comprehensive resource will be helpful to researchers who are working on herbal drugs on AD, phytochemistry, pharmacology, toxicology, clinical trials, neuroscience and advancement in formulations. Provides information on phytochemistry, pharmacology, toxicology, clinical trials, and advancement in formulations specific to Alzheimer’s Disease in a single source Explores natural compounds, which can be more affordable to the majority of Alzheimer’s Disease patients, who will increasingly be in developing countries Covers a wide array of specific chemical compounds

Author : D. Michael P. Mingos,Paul R. Raithby
Publisher : Springer Nature
Page : 285 pages
File Size : 44,8 Mb
Release : 2021-01-20
Category : Science
ISBN : 9783030647438

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21st Century Challenges in Chemical Crystallography I by D. Michael P. Mingos,Paul R. Raithby Pdf

This volume summarises recent developments and possible future directions for small molecule X-ray crystallography. It reviews specific areas of crystallography which are rapidly developing and places them in a historical context. The interdisciplinary nature of the technique is emphasised throughout. It introduces and describes the chemical crystallographic and synchrotron facilities which have been at the cutting edge of the subject in recent decades. The introduction of new computer-based algorithms has proved to be very influential and stimulated and accelerated the growth of new areas of science. The challenges which will arise from the acquisition of ever larger databases are considered and the potential impact of artificial intelligence techniques stressed. Recent advances in the refinement and analysis of X-ray crystal structures are highlighted. In addition the recent developments in time resolved single crystal X-ray crystallography are discussed. Recent years have demonstrated how this technique has provided important mechanistic information on solid-state reactions and complements information from traditional spectroscopic measurements. The volume highlights how the prospect of being able to routinely “watch” chemical processes as they occur provides an exciting possibility for the future. Recent advances in X-ray sources and detectors that have also contributed to the possibility of dynamic single-crystal X-ray diffraction methods are presented. The coupling of crystallography and quantum chemical calculations provides detailed information about electron distributions in crystals and has resulted in a more detailed understanding of chemical bonding. The volume will be of interest to chemists and crystallographers with an interest in the synthesis, characterisation and physical and catalytic properties of solid-state materials. Postgraduate students entering the field will benefit from a historical introduction to the subject and a description of those techniques which are currently used. Since X-ray crystallography is used so widely in modern chemistry it will serve to alert senior chemists to those developments which will become routine in coming decades. It will also be of interest to the broad community of computational chemists who study chemical systems.

Author : Stephen G. Post
Publisher : JHU Press
Page : 289 pages
File Size : 53,6 Mb
Release : 2022-05-31
Category : Health & Fitness
ISBN : 9781421442495

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Dignity for Deeply Forgetful People by Stephen G. Post Pdf

"A new ethics guideline for caregivers of "deeply forgetful people" and a program on how to communicate and connect based on 30 years of community dialogues through Alzheimer's organizations across the globe"--

Author : Ronald Sahyouni,Nolan J Brown,Jefferson William Chen
Publisher : World Scientific
Page : 426 pages
File Size : 40,7 Mb
Release : 2021-12-23
Category : Medical
ISBN : 9789811235122

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Alzheimer's Disease Decoded: The History, Present, And Future Of Alzheimer's Disease And Dementia (Second Edition) by Ronald Sahyouni,Nolan J Brown,Jefferson William Chen Pdf

This book aims to present, educate and inform individuals about Alzheimer's disease in a comprehensive manner. Its scope ranges from the discovery of the disease, epidemiology and basic biological principles underlying it, to advanced stem cell therapies used in the treatment of Alzheimer's. It adopts a 'global' perspective on Alzheimer's disease, and include epidemiological data and science from countries around the world.Alzheimer's disease is a rapidly growing problem seen in every country around the world. This is the first and only comprehensive book to cover Alzheimer's disease, and includes the most updated literature and scientific progress in the field of dementia and Alzheimer's disease research.Most books on the market that focus on Alzheimer's disease are targeted at caregivers as practical advice on how to deal with loved ones with the disease. This book instead is a comprehensive and popular science book that can be read by anyone with an interest in learning more about the disease.Dr Jefferson Chen MD, PhD, co-author, participated in the world's first surgical clinical trial using shunts to treat Alzheimer's disease. His first-hand involvement in a clinical trial for patients with Alzheimer's disease and experience treating Normal Pressure Hydrocephalus (NPH) which is commonly misdiagnosed as Alzheimer's disease lends a unique perspective.This book with appeal to a wide audience, regardless of their scientific or educational background.

Author : Jolanta Dorszewska,Wojciech Kozubski
Publisher : BoD – Books on Demand
Page : 167 pages
File Size : 48,8 Mb
Release : 2017-08-30
Category : Medical
ISBN : 9789535134619

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Senescence by Jolanta Dorszewska,Wojciech Kozubski Pdf

In the second half of the twentieth century, life expectancy was prolonged, and the number of elderly people increased. The effect of population aging increases in the frequency of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, epilepsy, and stroke. Also, a higher incidence of infections, autoimmune diseases, and malignant cancers is observed in elderly people. The aging process is difficult to define. Are physiological changes in elderly people controlled by specific genes? Is aging process a pathophysiology affecting different organs with different severity? Finding answers to these questions may help prevent age-related diseases and improve the quality of life of old people. This book was made as a compendium on contemporary challenges in senescence.

Author : National Academies of Sciences, Engineering, and Medicine,Division of Behavioral and Social Sciences and Education,Committee on Population
Publisher : National Academies Press
Page : 409 pages
File Size : 52,6 Mb
Release : 2018-07-21
Category : Social Science
ISBN : 9780309474108

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Future Directions for the Demography of Aging by National Academies of Sciences, Engineering, and Medicine,Division of Behavioral and Social Sciences and Education,Committee on Population Pdf

Almost 25 years have passed since the Demography of Aging (1994) was published by the National Research Council. Future Directions for the Demography of Aging is, in many ways, the successor to that original volume. The Division of Behavioral and Social Research at the National Institute on Aging (NIA) asked the National Academies of Sciences, Engineering, and Medicine to produce an authoritative guide to new directions in demography of aging. The papers published in this report were originally presented and discussed at a public workshop held in Washington, D.C., August 17-18, 2017. The workshop discussion made evident that major new advances had been made in the last two decades, but also that new trends and research directions have emerged that call for innovative conceptual, design, and measurement approaches. The report reviews these recent trends and also discusses future directions for research on a range of topics that are central to current research in the demography of aging. Looking back over the past two decades of demography of aging research shows remarkable advances in our understanding of the health and well-being of the older population. Equally exciting is that this report sets the stage for the next two decades of innovative researchâ€"a period of rapid growth in the older American population.

Author : United States. Congress. Senate. Committee on Labor and Human Resources. Subcommittee on Aging
Publisher : Unknown
Page : 80 pages
File Size : 48,8 Mb
Release : 1997
Category : Medical
ISBN : PSU:000031688536

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Meeting the Challenges of Alzheimer's Disease by United States. Congress. Senate. Committee on Labor and Human Resources. Subcommittee on Aging Pdf