Senescence

Author : Andrea Charise
Publisher : SUNY Press
Page : 242 pages
File Size : 53,7 Mb
Release : 2020-01-01
Category : Literary Criticism
ISBN : 9781438477459

Get Book

The Aesthetics of Senescence by Andrea Charise Pdf

Investigates how nineteenth-century British literature grappled with a new understanding of aging as both an individual and collective experience. The Aesthetics of Senescence investigates how chronological age has come to possess far-reaching ideological, ethical, and aesthetic implications, both in the past and present. Andrea Charise argues that authors of the nineteenth century used the imaginative resources of literature to engage with an unprecedented climate of crisis associated with growing old. Marshalling a great variety of canonical authors including William Godwin, Mary Shelley, George Eliot, Anthony Trollope, and George Gissing, as well as less familiar writings by George Henry Lewes, Christoph Wilhelm Hufeland, Agnes Strickland, and Max Nordau, Charise demonstrates why the imaginative capacity of writing became an interdisciplinary crucible for testing what it meant to grow old at a time of profound cultural upheaval. Charise’s grounding in medicine, political history, literature, and genre offers a fresh, original, thoroughly interdisciplinary analysis of nineteenth-century aging and age theory, as well as new insights into the rise of the novel—a genre usually thought of as affiliated almost entirely with the young or middle-aged. “Charise’s brilliantly argued, clearly written book is an important intervention in nineteenth-century British literature, age studies, and medical humanities. It brings these areas of inquiry together in what seems a seamless way—as if they have always traveled together or ought to have. Through an investigation of what she calls the ‘aesthetics of embodiment that shaped nineteenth-century visions of aging,’ Charise has given us an original and groundbreaking study of literary, historical, anthropological, and philosophical texts.” — Devoney Looser, author of The Making of Jane Austen

Author : Marco Demaria
Publisher : Humana Press
Page : 253 pages
File Size : 41,7 Mb
Release : 2018-11-24
Category : Science
ISBN : 1493989308

Get Book

Cellular Senescence by Marco Demaria Pdf

This book describes current methods for the identification and characterization of the major hallmarks of senescent cells. Chapters focus on the high heterogeneity of the senescence phenotypes, and techniques to induce and identify specific senescence programs. Additional chapters describe cellular and mouse models in which is possible to study the complex cell and non-cell autonomous functions of senescent cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Cellular Senescence: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Author : Richard P. Shefferson,Owen R. Jones,Roberto Salguero-Gómez
Publisher : Cambridge University Press
Page : 445 pages
File Size : 55,7 Mb
Release : 2017-02-23
Category : Science
ISBN : 9781107078505

Get Book

The Evolution of Senescence in the Tree of Life by Richard P. Shefferson,Owen R. Jones,Roberto Salguero-Gómez Pdf

Top researchers in the field introduce interdisciplinary perspectives on senescence, presenting new insights and cutting-edge research.

Author : Suresh I.S. Rattan,Leonard Hayflick
Publisher : Springer
Page : 364 pages
File Size : 47,9 Mb
Release : 2016-05-09
Category : Medical
ISBN : 9783319262390

Get Book

Cellular Ageing and Replicative Senescence by Suresh I.S. Rattan,Leonard Hayflick Pdf

This book covers the origins and subsequent history of research results in which attempts have been made to clarify issues related to cellular ageing, senescence, and age-related pathologies including cancer. Cellular Ageing and Replicative Senescence revisits more than fifty-five years of research based on the discovery that cultured normal cells are mortal and the interpretation that this phenomenon is associated with the origins of ageing. The mortality of normal cells and the immortality of cancer cells were also reported to have in vivo counterparts. Thus began the field of cytogerontology. Cellular Ageing and Replicative Senescence is organized into five sections: history and origins; serial passaging and progressive ageing; cell cycle arrest and senescence; system modulation; and recapitulation and future expectations. These issues are discussed by leading thinkers and researchers in biogerontology and cytogerontology. This collection of articles provides state-of-the-art information, and will encourage students, teachers, health care professionals and others interested in the biology of ageing to explore the fascinating and challenging question of why and how our cells age, and what can and cannot be done about it.

Author : Caleb E. Finch
Publisher : University of Chicago Press
Page : 948 pages
File Size : 53,6 Mb
Release : 1994-05-16
Category : Health & Fitness
ISBN : 0226248895

Get Book

Longevity, Senescence, and the Genome by Caleb E. Finch Pdf

Featuring extensive references, updated for this paperback edition, Longevity, Senescence, and the Genome constitutes a landmark contribution to biomedicine and the evolutionary biology of aging. To enhance gerontology's focus on human age-related dysfunctions, Caleb E. Finch provides a comparative review of all the phyla of organisms, broadening gerontology to intersect with behavioral, developmental, evolutionary, and molecular biology. By comparing species that have different developmental and life spans, Finch proposes an original typology of senescence from rapid to gradual to negligible, and he provides the first multiphyletic calculations of mortality rate constants.

Author : Bernard Swynghedauw
Publisher : Springer
Page : 0 pages
File Size : 47,7 Mb
Release : 2020-08-15
Category : Medical
ISBN : 3030151131

Get Book

The Biology of Senescence by Bernard Swynghedauw Pdf

This book describes the fundamental process of senescence, and reviews a new concept developed by a number of research groups that is based on cellular senescence and its secretome. This concept provides a basic explanation of the main physiological and pathological features of senescence, and delineates possibilities for “treating” it. Following an introduction to the emerging medical landscape, the increasing incidence of a new epidemiological group (age-related “chronic non-transmissible diseases”), and the multiple origins of aging, the book explores and characterizes the senescent cell, which is linked to benign and pathological age-related manifestations. In turn, the closing chapters discuss how to “treat” or “prevent” the aging process, underscoring the central role of physical exercise and caloric reduction as compared to new senolytic approaches. Appendices are also provided, and address circadian rhythms, telomere shortening, diabetic cardiomyopathy, and senescence in plants and bacteria. Given its scope, the book will primarily be of interest to geriatricians, but will also appeal to a wider range of clinicians.

Author : Lorenzo Galluzzi,Ilio Vitale,Oliver Kepp,Guido Kroemer
Publisher : Humana Press
Page : 0 pages
File Size : 46,9 Mb
Release : 2013-01-08
Category : Science
ISBN : 162703238X

Get Book

Cell Senescence by Lorenzo Galluzzi,Ilio Vitale,Oliver Kepp,Guido Kroemer Pdf

Cell senescence is the process whereby cells permanently lose the possibility to proliferate without undergoing cell death, and occurs in a plethora of distinct model organisms. In Cell Senescence: Methods and Protocols, expert researchers in the field detail the methods that are now commonly used to study cell senescence, in model organisms encompassing bacteria, fungi, worms, flies, zebrafish, and mammalian cells. These techniques cover the study of all the morphological, biochemical and functional manifestations of senescence at the cellular level and include protocols for population analyses and high-throughput approaches in suitable model organisms. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.

Author : Alex 1920- Comfort
Publisher : Hassell Street Press
Page : 282 pages
File Size : 43,8 Mb
Release : 2021-09-09
Category : Electronic
ISBN : 1014542405

Get Book

The Biology of Senescence by Alex 1920- Comfort Pdf

This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.

Author : Peter D. Adams,John M. Sedivy
Publisher : Springer Science & Business Media
Page : 272 pages
File Size : 48,7 Mb
Release : 2010-01-23
Category : Medical
ISBN : 9781441910752

Get Book

Cellular Senescence and Tumor Suppression by Peter D. Adams,John M. Sedivy Pdf

As cells mature they naturally stop dividing and enter a period called senescence. But cellular senescence can also be induced prematurely by certain oncogenes involved in cancer development. Cellular senescence, a growth-arrest program that limits the lifespan of mammalian cells and prevents unlimited cell proliferation, is attracting considerable interest because of its links to tumor suppression.

Author : Yuelin Zhang,Songyan Liao,Qingling Fu,Mark Hamrick
Publisher : Frontiers Media SA
Page : 154 pages
File Size : 53,8 Mb
Release : 2022-01-18
Category : Science
ISBN : 9782889740635

Get Book

Mesenchymal Stem Cell Senescence and Rejuvenation by Yuelin Zhang,Songyan Liao,Qingling Fu,Mark Hamrick Pdf

Author : G. Stanley Hall
Publisher : BoD – Books on Demand
Page : 750 pages
File Size : 54,8 Mb
Release : 2023-10-13
Category : Fiction
ISBN : 9783387301007

Get Book

Senescence, The Last Half of Life by G. Stanley Hall Pdf

Reproduction of the original. The publishing house Megali specialises in reproducing historical works in large print to make reading easier for people with impaired vision.

Author : M.A. Hayat
Publisher : Springer Science & Business Media
Page : 336 pages
File Size : 48,5 Mb
Release : 2013-11-29
Category : Science
ISBN : 9789400777262

Get Book

Tumor Dormancy, Quiescence, and Senescence, Volume 2 by M.A. Hayat Pdf

In this second volume in the series exploring Tumor Dormancy, Quiescence, and Cellular Senescence, discussion is focused on the role of tumor dormancy in diseases such as breast cancer, melanoma, prostate cancer, liver cancer and lung cancer. M. A. Hayat, the series editor, writes in the preface that little is known of factors regulating the transition of residual cancer into a dormant state or the subsequent reinitiation of growth. A majority of us, he says, have in situ tumors that may remain dormant or may progress into a lethal form of cancer; the former are prevented from recruiting their own blood supply. Section I covers Molecular Mechanisms, with chapters on the role of NAE inhibitor MLN4924; oncogene-induced senescence; the role played by mitogen-activated protein kinase in the induction of cellular senescence; mechanisms of premature cell senescence and other topics. Section II examines Tumor and Cancer, discussing defects in chromatin structure and diseases; the role of fibrosis in tumor progression and the dormant to proliferative switch; the function of ING proteins in cancer and senescence and more. The final section is devoted to Stem Cells and Cancer Stem Cells, featuring chapters showing that senescent-derived pluripotent stem cells are able to redifferentiate into fully rejuvenated cells; that the transcription factor Gata2 regulates quiescence in haematopoietic stem and progenitor cells; and discussing dormancy and recurrence of cancer stem cells in bone. The contributors point out that the quiescent state regulates hematopoietic stem cells and muscle stem cells, and detail the role of kinase in the mediation of reversible quiescent state in a subset of ovarian, pancreatic, and colon cancers. Molecular mechanisms underlying stress-induced cellular senescence and accumulation of reactive oxygen species and induction of premature senescence are also presented. Discussion includes the important role of microRNAs in oxidative stress-induced apoptosis and senescence and the effect of microRNA as a modulator of cell proliferation in lung cancer. The book includes an explanation of the suppression of cellular senescence in glioblastoma brain tumor. Taking a broad and varied perspective, this volume was written by 70 contributors representing 11 countries.

Author : M.A. Hayat
Publisher : Springer Science & Business Media
Page : 324 pages
File Size : 44,6 Mb
Release : 2013-03-14
Category : Medical
ISBN : 9789400759589

Get Book

Tumor Dormancy, Quiescence, and Senescence, Volume 1 by M.A. Hayat Pdf

With a particular emphasis on tumor dormancy in breast, lung, prostate, and liver cancers, as well as in melanoma, this first volume of a new Springer series focuses on the interrelationship between biological processes of aging and tumors—both dormant and quiescent. With detail supplied by numerous international researchers at the forefront of cancer research, the book examines a host of differing aspects of the topic. Featured contributions analyze the role of the quiescent state in regulating hematopoietic and muscle stem cells. They also explore the mediation, by the kinase, in the reversible quiescent state of a subset of ovarian, pancreatic, and colon cancers. The book includes key research on the molecular mechanisms underlying stress-induced cellular senescence, in addition to those governing the accumulation of reactive oxygen species, and the induction of premature senescence. It also provides information on suppressing cellular senescence in the most common, and most aggressive malignant primary brain tumor in humans, glioblastoma multiforme. With comprehensive and cutting-edge information on therapeutic interventions and on the correct diagnosis of relevant neoplasms, and with numerous color illustrations, this is the most up-to-date assessment of current medical knowledge in this crucial area of medical research.

Author : Susheng Gan
Publisher : John Wiley & Sons
Page : 352 pages
File Size : 41,9 Mb
Release : 2008-04-15
Category : Science
ISBN : 9780470994269

Get Book

Annual Plant Reviews, Senescence Processes in Plants by Susheng Gan Pdf

The scientific and economic significance of plant senescence means that much effort has been made to understand the processes involved and to devise means of manipulating them agriculturally. During the past few years there has been considerable progress in this regard, especially in the molecular, genetic and genomic aspects. Senescence has a tremendous impact on agriculture. For example, leaf senescence limits crop yield and biomass production, and contributes substantially to postharvest loss in vegetable and ornamental crops during transportation, storage and on shelves. In addition, proteins, antioxidants and other nutritional compounds are degraded during senescence. Senescing tissues also become more susceptible to pathogen infection, and some of the pathogens may produce toxins, rendering food unsafe. Mitotic senescence may also determine sizes of leaves, fruits and whole plants. This volume summarizes recent progresses in the physiology, biochemistry, cell biology, molecular biology, genomics, proteomics, and biotechnology of plant senescence. Beginning with a chapter on senescence-related terminology and our current knowledge of mitotic senescence in plants (a less well-studied area), the book focuses on post-mitotic senescence, and includes chapters addressing the senescence of leaves, flowers and fruits. Later chapters examine the development of various new biotechnologies for manipulating the senescence processes of fruit and leaves, some of which are approaching commercialization. The book is directed at researchers and professionals in plant molecular genetics, physiology and biochemistry.

Author : Anonim
Publisher : Academic Press
Page : 384 pages
File Size : 46,6 Mb
Release : 2021-04-13
Category : Medical
ISBN : 9780128241592

Get Book

Autophagy and Senescence in Cancer Therapy by Anonim Pdf

Advances in Cancer Research, Volume 150, the latest release in this ongoing series, covers the relationship(s) between autophagy and senescence, how they are defined, and the influence of these cellular responses on tumor dormancy and disease recurrence. Specific sections in this new release include Autophagy and senescence, converging roles in pathophysiology, Cellular senescence and tumor promotion: role of the unfolded protein response, autophagy and senescence in cancer stem cells, Targeting the stress support network regulated by autophagy and senescence for cancer treatment, Autophagy and PTEN in DNA damage-induced senescence, mTOR as a senescence manipulation target: A forked road, and more. Addresses the relationship between autophagy and senescence in cancer therapy Covers autophagy and senescence in tumor dormancy Explores autophagy and senescence in disease recurrence