Senescence

Author : Kazuwa Nakao,Nagahiro Minato,Shinji Uemoto
Publisher : Springer
Page : 330 pages
File Size : 44,9 Mb
Release : 2015-10-13
Category : Science
ISBN : 9784431556510

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Innovative Medicine by Kazuwa Nakao,Nagahiro Minato,Shinji Uemoto Pdf

This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

Author : Richard P. Shefferson,Owen R. Jones,Roberto Salguero-Gómez
Publisher : Cambridge University Press
Page : 445 pages
File Size : 53,8 Mb
Release : 2017-02-23
Category : Science
ISBN : 9781107078505

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The Evolution of Senescence in the Tree of Life by Richard P. Shefferson,Owen R. Jones,Roberto Salguero-Gómez Pdf

Top researchers in the field introduce interdisciplinary perspectives on senescence, presenting new insights and cutting-edge research.

Author : Marco Demaria
Publisher : Humana Press
Page : 253 pages
File Size : 48,6 Mb
Release : 2018-11-24
Category : Science
ISBN : 1493989308

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Cellular Senescence by Marco Demaria Pdf

This book describes current methods for the identification and characterization of the major hallmarks of senescent cells. Chapters focus on the high heterogeneity of the senescence phenotypes, and techniques to induce and identify specific senescence programs. Additional chapters describe cellular and mouse models in which is possible to study the complex cell and non-cell autonomous functions of senescent cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Cellular Senescence: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Author : L.D. Nooden
Publisher : Elsevier
Page : 555 pages
File Size : 46,5 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323145954

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Senescence and Aging in Plants by L.D. Nooden Pdf

Senescence and Aging in Plants reviews the state of knowledge in the processes involved in plant senescence and aging. The book begins by discussing the emergence of senescence as a concept; experimental analysis of senescence; and patterns of senescence. It then examines membrane deterioration during senescence; photosynthesis in relation to leaf senescence; senescence of detached plant organs; changing patterns of nucleic acid and protein synthesis during senescence; and degradative and associated assimilatory aspects of nitrogen removal. This is followed by chapters on aspects of ethylene that may impinge upon its role in promoting senescence of higher plants; the role of cytokinins in plant senescence; the promoters and retardants of senescence; and the role of calcium in plant senescence. The concept of whole plant senescence is discussed, which can be subdivided into patterns, correlative controls, cessation of vegetative growth, declining assimilatory processes, assimilate partitioning, and hormonal controls. The final chapters cover the deterioration of cellular membranes during the plant aging process and seed aging.

Author : Andrea Charise
Publisher : SUNY Press
Page : 242 pages
File Size : 41,6 Mb
Release : 2020-01-01
Category : Literary Criticism
ISBN : 9781438477459

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The Aesthetics of Senescence by Andrea Charise Pdf

Investigates how nineteenth-century British literature grappled with a new understanding of aging as both an individual and collective experience. The Aesthetics of Senescence investigates how chronological age has come to possess far-reaching ideological, ethical, and aesthetic implications, both in the past and present. Andrea Charise argues that authors of the nineteenth century used the imaginative resources of literature to engage with an unprecedented climate of crisis associated with growing old. Marshalling a great variety of canonical authors including William Godwin, Mary Shelley, George Eliot, Anthony Trollope, and George Gissing, as well as less familiar writings by George Henry Lewes, Christoph Wilhelm Hufeland, Agnes Strickland, and Max Nordau, Charise demonstrates why the imaginative capacity of writing became an interdisciplinary crucible for testing what it meant to grow old at a time of profound cultural upheaval. Charise’s grounding in medicine, political history, literature, and genre offers a fresh, original, thoroughly interdisciplinary analysis of nineteenth-century aging and age theory, as well as new insights into the rise of the novel—a genre usually thought of as affiliated almost entirely with the young or middle-aged. “Charise’s brilliantly argued, clearly written book is an important intervention in nineteenth-century British literature, age studies, and medical humanities. It brings these areas of inquiry together in what seems a seamless way—as if they have always traveled together or ought to have. Through an investigation of what she calls the ‘aesthetics of embodiment that shaped nineteenth-century visions of aging,’ Charise has given us an original and groundbreaking study of literary, historical, anthropological, and philosophical texts.” — Devoney Looser, author of The Making of Jane Austen

Author : Suresh I.S. Rattan,Leonard Hayflick
Publisher : Springer
Page : 364 pages
File Size : 43,5 Mb
Release : 2016-05-09
Category : Medical
ISBN : 9783319262390

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Cellular Ageing and Replicative Senescence by Suresh I.S. Rattan,Leonard Hayflick Pdf

This book covers the origins and subsequent history of research results in which attempts have been made to clarify issues related to cellular ageing, senescence, and age-related pathologies including cancer. Cellular Ageing and Replicative Senescence revisits more than fifty-five years of research based on the discovery that cultured normal cells are mortal and the interpretation that this phenomenon is associated with the origins of ageing. The mortality of normal cells and the immortality of cancer cells were also reported to have in vivo counterparts. Thus began the field of cytogerontology. Cellular Ageing and Replicative Senescence is organized into five sections: history and origins; serial passaging and progressive ageing; cell cycle arrest and senescence; system modulation; and recapitulation and future expectations. These issues are discussed by leading thinkers and researchers in biogerontology and cytogerontology. This collection of articles provides state-of-the-art information, and will encourage students, teachers, health care professionals and others interested in the biology of ageing to explore the fascinating and challenging question of why and how our cells age, and what can and cannot be done about it.

Author : Bernard Swynghedauw
Publisher : Springer
Page : 0 pages
File Size : 53,9 Mb
Release : 2020-08-15
Category : Medical
ISBN : 3030151131

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The Biology of Senescence by Bernard Swynghedauw Pdf

This book describes the fundamental process of senescence, and reviews a new concept developed by a number of research groups that is based on cellular senescence and its secretome. This concept provides a basic explanation of the main physiological and pathological features of senescence, and delineates possibilities for “treating” it. Following an introduction to the emerging medical landscape, the increasing incidence of a new epidemiological group (age-related “chronic non-transmissible diseases”), and the multiple origins of aging, the book explores and characterizes the senescent cell, which is linked to benign and pathological age-related manifestations. In turn, the closing chapters discuss how to “treat” or “prevent” the aging process, underscoring the central role of physical exercise and caloric reduction as compared to new senolytic approaches. Appendices are also provided, and address circadian rhythms, telomere shortening, diabetic cardiomyopathy, and senescence in plants and bacteria. Given its scope, the book will primarily be of interest to geriatricians, but will also appeal to a wider range of clinicians.

Author : Maryam Sarwat,Narendra Tuteja
Publisher : Academic Press
Page : 0 pages
File Size : 50,8 Mb
Release : 2018-12-05
Category : Science
ISBN : 012813187X

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Senescence Signalling and Control in Plants by Maryam Sarwat,Narendra Tuteja Pdf

Senescence Signalling and Control in Plants discusses the studies showing the importance of hormone action on developmental senescence. It shows the involvement of various signaling components (such as EIN2, LOX2) and transcription factors (such as oresara1 or ORE1) in controlling hormonal activity during senescence. Further, the involvement of various micro RNAs (miR164, miR319) in regulating leaf senescence are discussed. Through this book, the authors throw light on all the reverse and forward genetic approaches to reveal the role of various other phytohormones regulating plant senescence and the molecular mechanisms involved. Chapters on relevant topics are contributed by experts working in the area, making this a comprehensive treatise designed to provide an in-depth analysis on the subject matter.

Author : Lorenzo Galluzzi,Ilio Vitale,Oliver Kepp,Guido Kroemer
Publisher : Humana Press
Page : 0 pages
File Size : 41,9 Mb
Release : 2013-01-08
Category : Science
ISBN : 162703238X

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Cell Senescence by Lorenzo Galluzzi,Ilio Vitale,Oliver Kepp,Guido Kroemer Pdf

Cell senescence is the process whereby cells permanently lose the possibility to proliferate without undergoing cell death, and occurs in a plethora of distinct model organisms. In Cell Senescence: Methods and Protocols, expert researchers in the field detail the methods that are now commonly used to study cell senescence, in model organisms encompassing bacteria, fungi, worms, flies, zebrafish, and mammalian cells. These techniques cover the study of all the morphological, biochemical and functional manifestations of senescence at the cellular level and include protocols for population analyses and high-throughput approaches in suitable model organisms. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.

Author : G. Stanley Hall
Publisher : BoD – Books on Demand
Page : 750 pages
File Size : 47,8 Mb
Release : 2023-10-13
Category : Fiction
ISBN : 9783387301007

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Senescence, The Last Half of Life by G. Stanley Hall Pdf

Reproduction of the original. The publishing house Megali specialises in reproducing historical works in large print to make reading easier for people with impaired vision.

Author : Caleb E. Finch
Publisher : University of Chicago Press
Page : 948 pages
File Size : 53,6 Mb
Release : 1994-05-16
Category : Health & Fitness
ISBN : 0226248895

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Longevity, Senescence, and the Genome by Caleb E. Finch Pdf

Featuring extensive references, updated for this paperback edition, Longevity, Senescence, and the Genome constitutes a landmark contribution to biomedicine and the evolutionary biology of aging. To enhance gerontology's focus on human age-related dysfunctions, Caleb E. Finch provides a comparative review of all the phyla of organisms, broadening gerontology to intersect with behavioral, developmental, evolutionary, and molecular biology. By comparing species that have different developmental and life spans, Finch proposes an original typology of senescence from rapid to gradual to negligible, and he provides the first multiphyletic calculations of mortality rate constants.

Author : Alex 1920- Comfort
Publisher : Hassell Street Press
Page : 282 pages
File Size : 47,7 Mb
Release : 2021-09-09
Category : Electronic
ISBN : 1014542405

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The Biology of Senescence by Alex 1920- Comfort Pdf

This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.

Author : Peter D. Adams,John M. Sedivy
Publisher : Springer Science & Business Media
Page : 272 pages
File Size : 40,9 Mb
Release : 2010-01-23
Category : Medical
ISBN : 9781441910752

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Cellular Senescence and Tumor Suppression by Peter D. Adams,John M. Sedivy Pdf

As cells mature they naturally stop dividing and enter a period called senescence. But cellular senescence can also be induced prematurely by certain oncogenes involved in cancer development. Cellular senescence, a growth-arrest program that limits the lifespan of mammalian cells and prevents unlimited cell proliferation, is attracting considerable interest because of its links to tumor suppression.

Author : Yuelin Zhang,Songyan Liao,Qingling Fu,Mark Hamrick
Publisher : Frontiers Media SA
Page : 154 pages
File Size : 55,7 Mb
Release : 2022-01-18
Category : Science
ISBN : 9782889740635

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Mesenchymal Stem Cell Senescence and Rejuvenation by Yuelin Zhang,Songyan Liao,Qingling Fu,Mark Hamrick Pdf

Author : M.A. Hayat
Publisher : Springer Science & Business Media
Page : 320 pages
File Size : 40,5 Mb
Release : 2013-11-29
Category : Science
ISBN : 9789400777262

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Tumor Dormancy, Quiescence, and Senescence, Volume 2 by M.A. Hayat Pdf

In this second volume in the series exploring Tumor Dormancy, Quiescence, and Cellular Senescence, discussion is focused on the role of tumor dormancy in diseases such as breast cancer, melanoma, prostate cancer, liver cancer and lung cancer. M. A. Hayat, the series editor, writes in the preface that little is known of factors regulating the transition of residual cancer into a dormant state or the subsequent reinitiation of growth. A majority of us, he says, have in situ tumors that may remain dormant or may progress into a lethal form of cancer; the former are prevented from recruiting their own blood supply. Section I covers Molecular Mechanisms, with chapters on the role of NAE inhibitor MLN4924; oncogene-induced senescence; the role played by mitogen-activated protein kinase in the induction of cellular senescence; mechanisms of premature cell senescence and other topics. Section II examines Tumor and Cancer, discussing defects in chromatin structure and diseases; the role of fibrosis in tumor progression and the dormant to proliferative switch; the function of ING proteins in cancer and senescence and more. The final section is devoted to Stem Cells and Cancer Stem Cells, featuring chapters showing that senescent-derived pluripotent stem cells are able to redifferentiate into fully rejuvenated cells; that the transcription factor Gata2 regulates quiescence in haematopoietic stem and progenitor cells; and discussing dormancy and recurrence of cancer stem cells in bone. The contributors point out that the quiescent state regulates hematopoietic stem cells and muscle stem cells, and detail the role of kinase in the mediation of reversible quiescent state in a subset of ovarian, pancreatic, and colon cancers. Molecular mechanisms underlying stress-induced cellular senescence and accumulation of reactive oxygen species and induction of premature senescence are also presented. Discussion includes the important role of microRNAs in oxidative stress-induced apoptosis and senescence and the effect of microRNA as a modulator of cell proliferation in lung cancer. The book includes an explanation of the suppression of cellular senescence in glioblastoma brain tumor. Taking a broad and varied perspective, this volume was written by 70 contributors representing 11 countries.