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Author : Peter S. Roland,John A. Rutka
Publisher : PMPH-USA
Page : 236 pages
File Size : 46,6 Mb
Release : 2004
Category : Aminoglycosides
ISBN : 1550092634
CD-ROM features complete text and full-color illustrations in searchable PDF files.
Author : Stephen A. Lerner,Gregory J. Matz,Joseph E. Hawkins
Publisher : Little, Brown Medical Division
Page : 488 pages
File Size : 40,9 Mb
Release : 1981
Category : Medical
ISBN : UOM:39015000886310
Author : Peter S. Steyger,Lisa Cunningham,Carlos Esquivel,Kelly Watts,Jian Zuo
Publisher : Frontiers Media SA
Page : 292 pages
File Size : 48,9 Mb
Release : 2018-06-12
Category : Electronic
ISBN : 9782889454839
The auditory perception of sounds (environmental, vocal or music) is one of the 5 principal senses consciously monitored by our brains, and is crucial for many human endeavors as well as quality of life. Loss of optimal performance in this principal sensory system leads to loss of effective communication and intimacy, as well as increased risk of isolation, depression, cognitive decline, and greater vulnerability to predators. The vestibular system ensures that individuals remain upright and effectively monitor their posture within their spatial surroundings, move effectively, and remain focused on visual targets during motion. The loss of vestibular sensitivity results in postural instability, falls, inability to observe the environment during motion, and a debilitating incapacity to function effectively. The sensory cells for both auditory and vestibular systems are located within the inner ear of the temporal bulla. There are many causes of auditory and vestibular deficits, including congenital (or genetic) events, trauma, aging and loud sound exposures. Ototoxicity refers to damage of the auditory or vestibular structures or functions, as the result of exposure to certain pharmaceuticals, chemicals, and/or ionizing radiation exposure that damage the inner ear. Ototoxicity is a major contributor to acquired hearing loss and vestibular deficits, and is entirely preventable. In 2009, the United States Department of Defense initiated the Hearing Center of Excellence (HCE), headquartered in San Antonio, Texas, in response to the prevalence of acquired auditory and vestibular deficits in military and veteran populations. The knowledge shared in this eBook supports the HCE’s mandate to improve aural protection of military and civilian populations worldwide. The last few years have seen significant advances in understanding the cellular mechanisms underlying ototoxic drug-induced hearing loss and vestibular deficits. In this eBook, we present some of these advances and highlight gaps where further research is needed. Selected articles discuss candidate otoprotective agents that can ameliorate the effects of ototoxicity in the context of how they illustrate cellular mechanisms of ototoxicity. Our goal in illustrating these advances in mechanisms of ototoxicity is to accelerate the development of clinical therapies that prevent or reverse this debilitating disorder.
Author : Gregg Colon
Publisher : Unknown
Page : 171 pages
File Size : 53,5 Mb
Release : 2019-08-30
Category : Electronic
ISBN : 1536163961
This compilation focuses on Ototoxicity, the adverse pharmacological reaction affecting the inner ear or auditory nerve, characterised by cochlear or vestibular dysfunction. Although ototoxic medications play an essential role in modern medicine, they can cause harm and lead to significant morbidity. The authors discuss aminoglycoside antibiotics, loop diuretics, platinum-based chemotherapeutic agents, macrolide antibiotics and antimalarial medications which are among the 600 frequently used ototoxic drugs. Next, an overview of cisplatin-associated ototoxicity, namely its clinical features, incidence rates, molecular and cellular mechanisms and risk factors is provided for health care practitioners managing patients with cancer. Ototoxicity and neurotoxicity are defined from the perspective of chemical agents, nicotine and cotinine, that individuals experience through cigarette smoking and environmental tobacco smoke exposure. Mechanisms for toxicity are described by review of animal and human studies revealing changes in peripheral and central auditory structures after exposure to nicotine. The mechanisms of ototoxicity induced by aminoglycoside are also discussed, as well as the usage of these drugs for treatment of several disorders such as Meniere disease, and possible protective agents. In closing, the authors highlight the serious issue of aminoglycoside mediated hearing loss in cystic fibrosis patients, and also discuss alternative approaches for avoiding aminoglycoside-induced cochleotoxicity.
Author : Christopher S. Wilcox
Publisher : Elsevier Health Sciences
Page : 1161 pages
File Size : 47,9 Mb
Release : 2008-08-22
Category : Medical
ISBN : 9781437711240
Thoroughly revised, the new edition of this companion to Brenner & Rector’s The Kidney equips you with today’s guidance to effectively manage renal and hypertension patients. International authorities emphasize the specifics of treatment while presenting field-tested advice on the best therapeutic strategies available. New chapters reflect the latest evidence impacting current clinical issues, while a new design helps you reference the information more easily. Presents the most comprehensive text available on nephrology and hypertension treatment for a convenient single source that is easy to consult. Features the evidence-based guidance of leading authorities for making more informed clinical decisions. Offers in-depth discussions and referenced coverage of key trials to help you analyze the results and the evidence provided. Provides treatment algorithms and tables of commonly used drugs in each chapter for quick-access expert advice on arriving at the best and most appropriate treatment regimen. Offers new chapters on erectile and sexual dysfunction, transplant immunology and immunosuppression, dietary salt restriction, and systematic vasculitis and pauci-immune glomerulonephritis that reflect new evidence impacting current clinical issues. Presents the contributions of newly assigned section editors—authorities in their subspecialty fields—who offer you the benefit of their practice-proven expertise. Provides rationales for the therapies presented to help you choose the most effective treatment for each patient.
Author : Robert Vink,Mihai Nechifor
Publisher : University of Adelaide Press
Page : 354 pages
File Size : 45,6 Mb
Release : 2011
Category : Medical
ISBN : 9780987073051
The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.
Author : Donald Henderson
Publisher : Unknown
Page : 464 pages
File Size : 49,9 Mb
Release : 1999
Category : Medical
ISBN : UVA:X004383949
This work presents an integrated look at research suggesting that many ototoxic and ototraumatic reactions in the inner ear from drugs and trauma (noise) can be prevented or reduced with pharmacological interventions. The papers, by international authorities, address both the basic science background and the clinical applications of new therapies involving neurotrophins, free-radical scavengers, and other compounds that reduce the risk of hearing loss. A contextual framework is provided by three tutorial papers on free-radical scavengers, neurotrophins, and the role of the kidney in ototoxic reactions.
Author : Saumil N. Merchant
Publisher : PMPH-USA
Page : 970 pages
File Size : 49,5 Mb
Release : 2010
Category : Ear
ISBN : 1607950308
This book is a dedicated text to learn pathologic images seen during EUS. The digital anatomy correlation used in this work is the natural continuation of efforts to apply the University of Colorado Visible Human data set to gastroenterology. The Visible Human data set was created by Dr. Vic Spitzer and colleagues at the University of Colorado and is currently housed at the universitys Center for Human Simulation. The data set consists of high resolution transaxial digital images captured as cadavers were abraded away at 1 mm or less depths. These images are compiled into blocks of data and each structure is identified. This information can be used to pull out and manipulate 3-D structures as well as allowing one to review planar anatomy in any orientation. Using the Visible Human dataset, one should be able to find a normal anatomy correlate to any image found during a EUS examination. However, as important as normal anatomy is, it is the abnormal features which are the crux of an EUS examination. Endosonographers are asked to define lumps, bumps, cysts to find correlates for symptoms and abnormal laboratory findings. Accuracy requires a tremendous amount of skill and experience. To help in this task, we have assembled chapters from a world-wide group of expert endosonographers. These authors have shared their insight and images to help the readers of this work better see and understand some of the complexities uncovered during a EUS evaluation. DVD showing techniques for removal of human temporal bones.
Author : William G. Barnes,Glenn R. Hodges
Publisher : CRC Press
Page : 246 pages
File Size : 47,7 Mb
Release : 2019-06-04
Category : Medical
ISBN : 9781000006407
First Published in 1984, this book offers a full, comprehensive guide into the applications of Aminoglycoside Antibiotics in therapy. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for Students of Medicine, and other practitioners in their respective fields.
Author : Byron J. Bailey,Jonas T. Johnson,Shawn D. Newlands
Publisher : Lippincott Williams & Wilkins
Page : 1496 pages
File Size : 42,9 Mb
Release : 2006
Category : Medical
ISBN : 9780781755610
Newly revised and updated, this comprehensive, easy-to-use two-volume otolaryngology text is now in its Fourth Edition. More than 30 new chapters are included that reflect advances in the field, such as outcomes and evidence-based medicine, surgical management of nasal valve collapse and choanal atresia, immunology and allergy, allergic and non-allergic rhinitis, complications of rhinosinusitis, management of dysphagia, radiographic examination of the upper aerodigestive tract, endoscopic evaluation of the upper aerodigestive tract, cosmetic uses of Botox, and more. Coverage includes both adult and pediatric otolaryngology. All chapters are written by distinguished world-renowned authorities and contain summary highlights boxes, summary tables, and end-of-chapter reviews. More than 2,500 illustrations complement the text.
Author : Ramesh C. Gupta
Publisher : Academic Press
Page : 1246 pages
File Size : 53,9 Mb
Release : 2019-02-13
Category : Medical
ISBN : 9780128146569
Biomarkers in Toxicology, Second Edition, is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This revised and completely updated edition includes both vertebrate and non-vertebrate species models for toxicological testing and the development of biomarkers. Divided into several key sections, this reference volume contains new chapters devoted to topics in microplastics, neuroimmunotoxicity and nutraceuticals, along with a look at the latest cutting-edge technologies used to detect biomarkers. Each chapter contains several references to current literature and important resources for further reading. Given this comprehensive treatment, this book is an essential reference for anyone interested in biomarkers across the scientific and biomedical fields. Evaluates the expansive literature, providing one resource covering all aspects of toxicology biomarkers Includes completely revised chapters, along with additional chapters on the newest developments in the field Identifies and discusses the most sensitive, accurate, unique and validated biomarkers used as indicators of exposure Covers special topics and applications of biomarkers, including chapters on molecular toxicology biomarkers, biomarker analysis for nanotoxicology, development of biomarkers for drug efficacy evaluation, and much more
Author : Julian J. Miller
Publisher : CRC Press
Page : 330 pages
File Size : 45,9 Mb
Release : 2019
Category : Medical
ISBN : 9780429556401
Published in 1985: This publication will serve as a useful guide to all those involved in Otology either in a clinical or research environment.
Author : Andrew Whelton,Harold C. Neu
Publisher : Unknown
Page : 664 pages
File Size : 52,5 Mb
Release : 1982
Category : Science
ISBN : UOM:39015000259450
Author : Patricia L. Chambers
Publisher : Unknown
Page : 258 pages
File Size : 40,5 Mb
Release : 1991
Category : Aminoglycosides
ISBN : UCAL:X58582
Author : Patrick J. Willems
Publisher : CRC Press
Page : 532 pages
File Size : 45,5 Mb
Release : 2003-10-17
Category : Medical
ISBN : 9781135525507
Heredity, either alone or in combination with environmental factors, is the most prominent underlying cause of hearing impairment. Thanks in large part to positional cloning techniques, scientists have identified nearly 100 gene loci implicated in hearing loss since 1995-an extraordinarily rapid rate of gene identification. Genetic Hearing Loss