Biomarkers In Toxicology

Biomarkers In Toxicology Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Biomarkers In Toxicology book. This book definitely worth reading, it is an incredibly well-written.

Biomarkers in Toxicology

Ramesh C. Gupta
Biomarkers in Toxicology Book PDF

Author : Ramesh C. Gupta
Publisher : Academic Press
Page : 1246 pages
File Size : 43,6 Mb
Release : 2019-02-13
Category : Medical
ISBN : 9780128146569

Get Book

Biomarkers in Toxicology by Ramesh C. Gupta Pdf

Biomarkers in Toxicology, Second Edition, is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This revised and completely updated edition includes both vertebrate and non-vertebrate species models for toxicological testing and the development of biomarkers. Divided into several key sections, this reference volume contains new chapters devoted to topics in microplastics, neuroimmunotoxicity and nutraceuticals, along with a look at the latest cutting-edge technologies used to detect biomarkers. Each chapter contains several references to current literature and important resources for further reading. Given this comprehensive treatment, this book is an essential reference for anyone interested in biomarkers across the scientific and biomedical fields. Evaluates the expansive literature, providing one resource covering all aspects of toxicology biomarkers Includes completely revised chapters, along with additional chapters on the newest developments in the field Identifies and discusses the most sensitive, accurate, unique and validated biomarkers used as indicators of exposure Covers special topics and applications of biomarkers, including chapters on molecular toxicology biomarkers, biomarker analysis for nanotoxicology, development of biomarkers for drug efficacy evaluation, and much more

Drug Discovery Toxicology

Yvonne Will,J. Eric McDuffie,Andrew J. Olaharski,Brandon D. Jeffy
Drug Discovery Toxicology Book PDF

Author : Yvonne Will,J. Eric McDuffie,Andrew J. Olaharski,Brandon D. Jeffy
Publisher : John Wiley & Sons
Page : 584 pages
File Size : 40,7 Mb
Release : 2016-03-22
Category : Medical
ISBN : 9781119053392

Get Book

Drug Discovery Toxicology by Yvonne Will,J. Eric McDuffie,Andrew J. Olaharski,Brandon D. Jeffy Pdf

As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researchers as to what drug safety experiments are both practical and useful • Covers a variety of key topics – safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and –omics tools • Describes what experiments are possible and useful and offers a view into the future, indicating key areas to watch for new predictive methods • Features contributions from firsthand industry experience, giving readers insight into the strategy and execution of predictive toxicology practices

Molecular Biological Markers for Toxicology and Risk Assessment

Bruce A. Fowler
Molecular Biological Markers for Toxicology and Risk Assessment Book PDF

Author : Bruce A. Fowler
Publisher : Academic Press
Page : 164 pages
File Size : 50,7 Mb
Release : 2016-06-10
Category : Medical
ISBN : 9780128019016

Get Book

Molecular Biological Markers for Toxicology and Risk Assessment by Bruce A. Fowler Pdf

Molecular Biological Markers for Toxicology and Risk Assessment provides an introduction to the exciting field of biomarkers and their use in toxicology and risk assessment. In recent years, new classes of molecular biomarkers capable of detecting early manifestations of ongoing chemical-induced cell injury and cell death have been developed as a result of advances in analytical chemistry, molecular biology, and computational modeling. The interplay between these emergent tools of science has resulted in new insights into initial mechanisms of chemical-induced toxicity and carcinogenicity. Molecular Biological Markers for Toxicology and Risk Assessment guides the reader through a broad range of molecular biological markers, including the "omic" biomarkers, and provides an examination of the various elements in the evolution of these modern tools. It then explores possible ways in which these markers may be applied to advance the field of chemical risk assessment. Since molecular biomarkers and related technologies are inherently complex, the book concludes with a section on risk communication in order that readers may appreciate both the strengths and limitations of molecular biological marker approaches to risk assessment practice. Introduces the use of molecular biomarkers to detect toxic effects of chemicals as early as possible Provides an accessible overview of this emerging, interdisciplinary field, to best inform decision making in chemical and pharmaceutical safety Includes a section on risk communication of these complex concepts, essential for effective risk assessment Provides new insights into the initial mechanisms of chemical-induced toxicity and carcinogenicity

Toxicologic Biomarkers

Anthony P. DeCaprio
Toxicologic Biomarkers Book PDF

Author : Anthony P. DeCaprio
Publisher : CRC Press
Page : 312 pages
File Size : 45,8 Mb
Release : 2006-04-18
Category : Medical
ISBN : 9780824723514

Get Book

Toxicologic Biomarkers by Anthony P. DeCaprio Pdf

Responding to the explosion of advances in the use of biomarkers to efficiently, rapidly, and economically evaluate the health effects of chemical entities, this authoritative reference provides a detailed overview of the theory, development, and practical application of biomarkers in the toxicological, environmental, forensic, and pharmaceutical sciences. Compiling the most recent studies on the generation and utilization of biomarkers for toxicant exposure, environmental and human health risk assessment, occupational safety, drug development, and the detection of biological and chemical warfare agents, this guide supplies numerous examples, figures, tables, and comprehensive reference listings within each chapter to provide the reader with an in-depth understanding of the subject.

Genomic and Epigenomic Biomarkers of Toxicology and Disease

Saura C. Sahu
Genomic and Epigenomic Biomarkers of Toxicology and Disease Book PDF

Author : Saura C. Sahu
Publisher : John Wiley & Sons
Page : 516 pages
File Size : 49,5 Mb
Release : 2022-05-02
Category : Science
ISBN : 9781119807674

Get Book

Genomic and Epigenomic Biomarkers of Toxicology and Disease by Saura C. Sahu Pdf

Genomic and Epigenomic Biomarkers of Toxicology and Disease The latest developments in biomarker research applicable to toxicology and medicine Research on genomic and epigenomic biomarkers is developing rapidly with cutting-edge studies scattered throughout the academic literature, making the status of ongoing scientific activity in this area difficult to ascertain. Genomic and Epigenomic Biomarkers of Toxicology and Disease: Clinical and Therapeutic Actions delivers a comprehensive and authoritative compilation of up-to-date developments in the application of genomic and epigenomic biomarkers to toxicology, disease prevention, cancer detection, therapeutics, gene therapy, and other areas. With contributions from a collection of internationally recognized investigators, this edited volume offers unique insights into current trends and future directions of research in the discussed areas. Combining state-of-the-art information on genomic and epigenomic biomarkers from a range of specialists from around the world, this monograph includes: A thorough introduction to microRNAs as non-invasive biomarkers of toxicity and chemical hazard Comprehensive explorations of extracellular vesicle-associated miRNAs as toxic biomarkers, as well as transcriptomic applications in toxicology and medicine Practical discussions of circulating miRNAs as biomarkers of metal exposure, as well as microRNAs biomarkers of malignant mesothelioma In-depth examinations of the role of noncoding RNAs in innate immune responses perturbed by environmental arsenic with a focus on microRNAs Perfect for researchers, toxicologists, risk assessors, and regulators, Genomic and Epigenomic Biomarkers of Toxicology and Disease: Clinical and Therapeutic Actions will also earn a place in the libraries of graduate students with an interest in biomarkers, toxicology, agriculture, or the environment.

How Tobacco Smoke Causes Disease

Anonim
How Tobacco Smoke Causes Disease Book PDF

Author : Anonim
Publisher : Unknown
Page : 728 pages
File Size : 40,5 Mb
Release : 2010
Category : Government publications
ISBN : UCSD:31822037817723

Get Book

How Tobacco Smoke Causes Disease by Anonim Pdf

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Toxicological Risk Assessment and Multi-System Health Impacts from Exposure

Aristidis M. Tsatsakis
Toxicological Risk Assessment and Multi System Health Impacts from Exposure Book PDF

Author : Aristidis M. Tsatsakis
Publisher : Elsevier
Page : 684 pages
File Size : 47,6 Mb
Release : 2021-08-01
Category : Medical
ISBN : 9780323853583

Get Book

Toxicological Risk Assessment and Multi-System Health Impacts from Exposure by Aristidis M. Tsatsakis Pdf

Toxicological Risk Assessment and Multisystem Health Impacts From Exposure highlights the emerging problems of human and environmental health attributable to cumulative and multiple sources of long-term exposure to environmental toxicants. The book describes the cellular, biological, immunological, endocrinologic, genetic, and epigenetic effects of long-term exposure. It examines how the combined exposure to nanomaterials, metals, pharmaceuticals, multifrequency radiation, dietary mycotoxins, and pesticides accelerates ecotoxicity in humans, animals, plants, and the larger environment. The book goes on to also offer insights into mixture risk assessments, protocols for evaluating the risks, and how this information can serve the regulatory agencies in setting safer exposure limits. The book is a go-to resource for scientists and professionals in the field tackling the current and emerging trends in modern toxicology and risk assessment. • Bridges basic research with clinical, epidemiological, regulatory, and translational research, conveying both an introductory understanding and the latest developments in the field • Evaluates real-life human health risk assessment for long-term exposures to xenobiotic mixtures and the role they play in contributing to chronic disease • Discusses advances in predictive (in silico) toxicology tools and the benefits of using omics technologies in toxicology research

Environmental Toxicology and Risk Assessment

Diane S. Henshel
Environmental Toxicology and Risk Assessment Book PDF

Author : Diane S. Henshel
Publisher : ASTM International
Page : 485 pages
File Size : 41,5 Mb
Release : 1996
Category : Biochemical markers
ISBN : 9780803120310

Get Book

Environmental Toxicology and Risk Assessment by Diane S. Henshel Pdf

Papers presented at symposium as in title, held 3-5 April 1995, Denver, Colo.

Toxicogenomics

Hisham K. Hamadeh,Cynthia A. Afshari
Toxicogenomics Book PDF

Author : Hisham K. Hamadeh,Cynthia A. Afshari
Publisher : John Wiley & Sons
Page : 386 pages
File Size : 40,9 Mb
Release : 2004-09-06
Category : Science
ISBN : 0471434175

Get Book

Toxicogenomics by Hisham K. Hamadeh,Cynthia A. Afshari Pdf

Toxicogenomics: Principles and Applications fills the need for a single, thorough text on the key breakthrough technologies in genomics, proteomics, metabolomics, and bioinformatics, and their applications to toxicology research. The first section following a general introduction is on genomics and toxicogenomics, and qPCR. The next sections are toxicoproteomics and metabolomics. The final section covers bioinformatics aspects, from databases to data integration strategies. A practical resource for specialists and non-specialists alike, this book includes numerous illustrations that support the textual explanations. It offers practical guidance to investigators wishing to pursue this line of research, and lists key relevant software and Internet resources.

Human Biomonitoring for Environmental Chemicals

National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Human Biomonitoring for Environmental Toxicants
Human Biomonitoring for Environmental Chemicals Book PDF

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Human Biomonitoring for Environmental Toxicants
Publisher : National Academies Press
Page : 316 pages
File Size : 46,8 Mb
Release : 2006-10-30
Category : Science
ISBN : 9780309133906

Get Book

Human Biomonitoring for Environmental Chemicals by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Human Biomonitoring for Environmental Toxicants Pdf

Biomonitoring—a method for measuring amounts of toxic chemicals in human tissues—is a valuable tool for studying potentially harmful environmental chemicals. Biomonitoring data have been used to confirm exposures to chemicals and validate public health policies. For example, population biomonitoring data showing high blood lead concentrations resulted in the U.S. Environmental Protection Agency's (EPA's) regulatory reduction of lead in gasoline; biomonitoring data confirmed a resultant drop in blood lead concentrations. Despite recent advances, the science needed to understand the implications of the biomonitoring data for human health is still in its nascent stages. Use of the data also raises communication and ethical challenges. In response to a congressional request, EPA asked the National Research Council to address those challenges in an independent study. Human Biomonitoring for Environmental Chemicals provides a framework for improving the use of biomonitoring data including developing and using biomarkers (measures of exposure), research to improve the interpretation of data, ways to communicate findings to the public, and a review of ethical issues.

Biologic Markers in Urinary Toxicology

National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Subcommittee on Biologic Markers in Urinary Toxicology
Biologic Markers in Urinary Toxicology Book PDF

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Subcommittee on Biologic Markers in Urinary Toxicology
Publisher : National Academies Press
Page : 322 pages
File Size : 43,5 Mb
Release : 1995-08-28
Category : Science
ISBN : 9780309052283

Get Book

Biologic Markers in Urinary Toxicology by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Subcommittee on Biologic Markers in Urinary Toxicology Pdf

Diseases of the kidney, bladder, and prostate exact an enormous human and economic toll on the population of the United States. This book examines prevention of these diseases through the development of reliable markers of susceptibility, exposure, and effect and the promise that new technologies in molecular biology and sophisticated understanding of metabolic pathways, along with classical approaches to the study of nephrotoxicants and carcinogens, can be developed and prevention of the diseases achieved. The specific recommendations included in this book complement those made in the previous three volumes on biomarkers, Biologic Markers in Reproductive Toxicology (1989), Biologic Markers in Pulmonary Toxicology (1989), and Biologic Markers in Immunotoxicology (1991).

Stress-Inducible Cellular Responses

U. Feige,R.I. Morimoto,Barbara Polla
Stress Inducible Cellular Responses Book PDF

Author : U. Feige,R.I. Morimoto,Barbara Polla
Publisher : Birkhäuser
Page : 487 pages
File Size : 46,7 Mb
Release : 2013-03-11
Category : Science
ISBN : 9783034890885

Get Book

Stress-Inducible Cellular Responses by U. Feige,R.I. Morimoto,Barbara Polla Pdf

This book will deal with heat shock proteins and more generally with stress-related inducible gene expression as a pleiotropic adaptive response to stress. It presents a textbook-like overview of the field not only to heat shock experts, but to physiologists, pharmacologists, physicians, neuropsychologists and others as well. It is intended to be a state-of-the-art and perspective book rather than an up-to-date presentation of recent data. It should provide a basis for new experimetal approaches to fields at the edge of the classical heat shock field. Drugs, UV irradiation and environmental toxics will be considered as important modulators of the stress response. Radical scavengers such as superoxide dismutases and inducible regulatory proteins of metallic ion status such as ferritin as well as immunophilins and protein disulfide isomerases will be considered within the frame of stress proteins. The potential practical applications of heat shock proteins in toxicology and medicine for the diagnosis, prognosis and eventually therapy of clinical conditions associated with an increased oxidative burden will be outlined. The role of heat shock proteins in the modulation of immune responses will also be included. The book considers heat shock from a broad perspective including fields for which heat-shock may become of importance in the very near future such as cellular responses to environmental stresses and complex stress responses under specific conditions. It was also felt timely to incorporate a whole section on medical and technological applications of stress proteins. The book will be invaluable for all those working on stress and is intended for every "stress laboratory" as a source of knowledge and perspectives.

Toxicological Effects of Methylmercury

National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on the Toxicological Effects of Methylmercury
Toxicological Effects of Methylmercury Book PDF

Author : National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on the Toxicological Effects of Methylmercury
Publisher : National Academies Press
Page : 364 pages
File Size : 54,7 Mb
Release : 2000-09-27
Category : Nature
ISBN : 9780309171717

Get Book

Toxicological Effects of Methylmercury by National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on the Toxicological Effects of Methylmercury Pdf

Mercury is widespread in our environment. Methylmercury, one organic form of mercury, can accumulate up the aquatic food chain and lead to high concentrations in predatory fish. When consumed by humans, contaminated fish represent a public health risk. Combustion processes, especially coal-fired power plants, are major sources of mercury contamination in the environment. The U.S. Environmental Protection Agency (EPA) is considering regulating mercury emissions from those plants. Toxicological Effects of Methylmercury reviews the health effects of methylmercury and discusses the estimation of mercury exposure from measured biomarkers, how differences between individuals affect mercury toxicity, and appropriate statistical methods for analysis of the data and thoroughly compares the epidemiological studies available on methylmercury. Included are discussions of current mercury levels on public health and a delineation of the scientific aspects and policy decisions involved in the regulation of mercury. This report is a valuable resource for individuals interested in the public health effects and regulation of mercury. The report also provides an excellent example of the implications of decisions in the risk assessment process for a larger audience.

Toxicity Biomarkers

Anonim
Toxicity Biomarkers Book PDF

Author : Anonim
Publisher : IOS Press
Page : 126 pages
File Size : 42,7 Mb
Release : 2005
Category : Medical
ISBN : 1586035258

Get Book

Toxicity Biomarkers by Anonim Pdf

Since the dawn of civilization, humans have feared the unknown risks associated with the use of new natural herbs or other natural medications to cure their pain, aches and illnesses. In the ancient Indian Ayurvedic Medicine which is over 4000 years old, the Visha (poison) Tantra (wisdom) was developed as a discipline of medicine encompassing Toxicology and Preventive Medicines. Visha Tantra included the study of various toxic herbs and animals and their antidotes as well as the biomarkers of toxic effects. In the Visha Tantra and the practice of Ayurvedic medicine, there have been objective descriptions of the changes in colour and amount of urine, changes in the colour of nails, skin and eyes, breathing patterns, gastrointestinal disturbances, and precautionary measures to prevent adverse effects as biomarkers of toxicity associated with the use of herbal medicines and certain foods. The adverse effects are an inevitable outcome of the environmental and industrial chemicals and pharmaceuticals; however, efforts are ongoing to prevent unexpected life-threatening toxicities and/or irreversible organ damage.The search for non-invasive biomarkers that can be objectively linked to adverse effects associated with manmade synthetic chemicals, including pharmaceuticals and environmental pollutants, is becoming an important priority for academicians, federal agencies, pharmaceutical and industrial companies. This publication is devoted to toxicity biomarkers of target organs of toxicity and molecular epidemiology. It provides a comprehensive review of a wide spectrum of biomarkers, including molecular epidemiology biomarkers of aflatoxin and hepatitis B virus induced hepatocarcinogenesis, cytokines as the biomarkers of hepatocellular injury, drug-induced vascular injury, nephrotoxicity and reproductive toxicity biomarkers.

Ecological Biomarkers

Claude Amiard-Triquet,Jean-Claude Amiard,Philip S. Rainbow
Ecological Biomarkers Book PDF

Author : Claude Amiard-Triquet,Jean-Claude Amiard,Philip S. Rainbow
Publisher : CRC Press
Page : 464 pages
File Size : 54,9 Mb
Release : 2016-04-19
Category : Science
ISBN : 9781439880531

Get Book

Ecological Biomarkers by Claude Amiard-Triquet,Jean-Claude Amiard,Philip S. Rainbow Pdf

Does a change, which affects a few biological macro-molecules, some cells, or a few individuals within a population, have any ecological significance that would allow the prediction of deleterious effects at higher levels of biological organization, namely the population, community, and ultimately the ecosystem? With contributions from experts in the field, Ecological Biomarkers: Indicators of Ecotoxicological Effects explores how biomarkers can be used to predict effects farther down the chain. It presents a synthesis of the state of the art in the methodology of biomarkers and its contribution to ecological risk assessment. This book describes the core biomarkers currently used in environmental research concerned with biological monitoring, biomarkers which correspond to the defences developed by living organisms in response to contaminants in their environment, and biomarkers that reveal biological damage resulting from contaminant stressors. It examines the efficacy of lysosomal biomarkers, immunotoxicity effects, behavioral disturbances, energy metabolism impairments, endocrine disruption measures, and genotoxicity as all indicative of probable toxic effects at higher biological levels. It is time to revisit the biological responses most ecologically relevant in the diagnosis of the health status of an aquatic environment well before it becomes unmanageable. Biomarkers provide a real possibility of delivering an easily measured marker at a simple level of biological organization that is predictably linked to a potentially ecologically significant effect at higher levels of biological organization. The text explores the latest knowledge and thinking on how to use biomarkers as tools for the assessment of environmental health and management.