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Author : J. C. Kile
Publisher : Unknown
Page : 16 pages
File Size : 54,6 Mb
Release : 1950
Category : Mice
ISBN : UOM:39015086450551
Author : Henry L. Foster,J. David Small,James G. Fox
Publisher : Academic Press
Page : 464 pages
File Size : 44,6 Mb
Release : 2014-05-10
Category : Health & Fitness
ISBN : 9781483262765
The Mouse in Biomedical Research, Volume III: Normative Biology, Immunology, and Husbandry focuses on the normative biology, immunology, and husbandry of laboratory mice. Topics covered range from gnotobiotics and gastrointestinal microflora to animal health surveillance and health delivery systems, along with environmental monitoring. The management and design of breeding and research facilities are also discussed. Comprised of 18 chapters, this volume begins with an overview of studies involving gnotobiotic mice, the induction of gnotobiosis, and microbiological testing of gnotobiotic animals. Maintenance of breeding colonies of gnotobiotic animals is also considered, together with the shipment of gnotobiotes and laboratory facilities for using gnotobiotes. The reader is then introduced to management and design of breeding and research facilities for gnotobiotic mice; practical factors associated with providing adequate nutrition for laboratory mice; and environmental and equipment monitoring. Subsequent chapters deal with the basic biology of the mouse, including anatomy, embryology, reproductive physiology, physiology, endocrinology, hematology, clinical biochemistry, and gastrointestinal microflora. The book also examines immunoglobulins and immunoglobulin genes; lymphocyte immunogenetics; immune response disorders; and biomethodology and surgical techniques. This monograph will be useful to biologists, immunologists, researchers, and others those who use mice in the laboratory or are concerned with the production and maintenance of colonies of mice.
Author : Marten H. Hofker,Jan van Deursen
Publisher : Springer Science & Business Media
Page : 382 pages
File Size : 55,6 Mb
Release : 2008-02-04
Category : Science
ISBN : 9781592593408
Marten Hofker and Jan van Deursen have assembled a multidisciplinary collection of readily reproducible methods for working with mice, and particularlyfor generating mouse models that will enable us to better understand gene function. Described in step-by-step detail by highly experienced investigators, these proven techniques include new methods for conditional, induced knockout, and transgenic mice, as well as for working with mice in such important research areas as immunology, cancer, and atherosclerosis. Such alternative strategies as random mutagenesis and viral gene transduction for studying gene function in the mouse are also presented.
Author : Jean Louis Guénet,Fernando Benavides,Jean-Jacques Panthier,Xavier Montagutelli
Publisher : Springer
Page : 408 pages
File Size : 50,7 Mb
Release : 2014-11-29
Category : Science
ISBN : 9783662442876
This book, written by experienced geneticists, covers topics ranging from the natural history of the mouse species, its handling and reproduction in the laboratory, and its classical genetics and cytogenetics, to modern issues including the analysis of the transcriptome, the parental imprinting and X-chromosome inactivation. The strategies for creating all sorts of mutations, either by genetic engineering or by using mutagens, are also reviewed and discussed in detail. Finally, a last chapter outlines the methodology used for the analysis of complex or quantitative traits. The authors also discuss the importance of accurate phenotyping, which is now performed in the mouse clinics established worldwide and identify the limits of the mouse model, which under certain circumstances can fail to present the phenotype expected from the cognate condition in the human model. For each chapter an up-to-date list of pertinent references is provided. In short, this book offers an essential resource for all scientists who use or plan to use mice in their research.
Author : Katherine Elliott,Maeve O'Connor
Publisher : John Wiley & Sons
Page : 192 pages
File Size : 45,9 Mb
Release : 2009-09-16
Category : Science
ISBN : 9780470717905
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
Author : Anonim
Publisher : Unknown
Page : 946 pages
File Size : 47,6 Mb
Release : 1950-07
Category : Nuclear energy
ISBN : MINN:31951T00248815O
Author : David T. Curiel,Joanne T. Douglas
Publisher : Springer Science & Business Media
Page : 490 pages
File Size : 49,6 Mb
Release : 2007-11-03
Category : Medical
ISBN : 9781592597857
A complete introduction and guide to the latest developments in cancer gene therapy-from bench to bedside. The authors comprehensively review the anticancer genes and gene delivery methods currently available for cancer gene therapy, including the transfer of genetic material into the cancer cells, stimulation of the immune system to recognize and eliminate cancer cells, and the targeting of the nonmalignant stromal cells that support their growth. They also thoroughly examine the advantages and limitations of the different therapies and detail strategies to overcome obstacles to their clinical implementation. Topics of special interest include vector-targeting techniques, the lessons learned to date from clinical trials of cancer gene therapy, and the regulatory guidelines for future trials. Noninvasive techniques to monitor the extent of gene transfer and disease regression during the course of treatment are also discussed.
Author : Hiroshi Sakagami
Publisher : BoD – Books on Demand
Page : 176 pages
File Size : 41,9 Mb
Release : 2017-05-03
Category : Medical
ISBN : 9789535131199
Licorice extracts are used as additive to many Kampo medicines to alleviate pain and inflammation. With rapid progress of analytical methodology, its action mechanism is being elucidated. This book is composed of three sections. Section 1 introduces licorice as alternative medicine, its application in the industry, and the trading/market prospects between Japan and China. Section 2 summarizes the purification/identification steps of licorice ingredients and their antioxidant, antimicrobial, PPAR-? ligand-binding, antitumor, antiviral, and in vitro fertilization activities. Section 3 proposes the possible molecular mechanism by which licorice ingredients induce anti-inflammatory, antifibrosis, antihepatitis, and antileishmanial activity. All chapters are written by experts of natural sciences and economics and will surely give new insights into alternative medicines to students, clinicians, teachers, and researchers.
Author : Henry L. Foster,J. David Small,James G. Fox
Publisher : Unknown
Page : 474 pages
File Size : 43,5 Mb
Release : 1981
Category : Medical
ISBN : UOM:39015003223545
Author : Anonim
Publisher : Unknown
Page : 116 pages
File Size : 49,7 Mb
Release : 1979
Category : Birth control
ISBN : MINN:30000010713596
Author : Andras Nagy
Publisher : Cold Spring Harbor, N.Y. : Cold Spring Harbor Laboratory Press
Page : 784 pages
File Size : 43,5 Mb
Release : 2003
Category : Science
ISBN : UOM:39015056178109
Provides background information and detailed protocols for developing a mouse colony and using the animals in transgenic and gene-targeting experiments. The protocols list the animals, equipment, and reagents required and step-by-step procedures. Topics include in vitro culture of preimplantation embryos, surgical procedures, the production of chimeras, and the analysis of genome alterations. The third edition adds protocols for cloning mice, modifying embryonic stem cells, intracytoplasmic sperm injection, and cryopreservation of embryos.
Author : William G. Eberhard
Publisher : Princeton University Press
Page : 532 pages
File Size : 40,6 Mb
Release : 1996
Category : Family & Relationships
ISBN : 0691010854
Evidence from various fields indicates that such selectivity by females may be the norm rather than the exception. Because most postcopulatory competition among males for paternity is played out within the bodies of females, female behavior, morphology, and physiology probably often influence male success in these contests, Eberhard draws examples from a diversity of organisms, ranging from ctenophores to scorpions, nematodes to frogs, and crickets to humans.
Author : Anonim
Publisher : Unknown
Page : 2036 pages
File Size : 45,7 Mb
Release : 1997
Category : Medicine
ISBN : MINN:31951D01567140X
Author : Anonim
Publisher : Unknown
Page : 420 pages
File Size : 55,8 Mb
Release : 1987
Category : Fertilization (Biology)
ISBN : UCAL:B5031058
Author : Anonim
Publisher : Elsevier
Page : 352 pages
File Size : 53,9 Mb
Release : 2006-12-04
Category : Science
ISBN : 008046906X
History, Wild Mice, and Genetics, the first volume in the four volume set, The Mouse in Biomedical Research, provides information about the history, biology and genomics of the laboratory mouse (Mus musculus), as well as basic information on maintenance and use of mouse stocks. Mouse origins and relationships are covered in chapters on history, evolutionary taxonomy and wild mice. Genetics and genomics of the mouse are covered in chapters on genetic nomenclature, gene mapping, cytogenetics and the molecular organization of the mouse genome. Maintenance of laboratory mice is described in chapters on breeding systems for various types of strains and stocks and genetic monitoring. Use of the mouse as a model system for basic biomedical research is described in chapters on chemical mutagenesis, gene trapping, pharmacogenetics and embryo manipulation. The information in Volume 1 serves as a primer for scientists new to the field of mouse research.
