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Author : Stanley Dagley,Donald Elliot Nicholson
Publisher : Unknown
Page : 343 pages
File Size : 40,6 Mb
Release : 1970-01-01
Category : Biochemistry
ISBN : 0471637068
Author : Dagley
Publisher : Unknown
Page : 343 pages
File Size : 41,6 Mb
Release : 1970-01-01
Category : Electronic
ISBN : 0471190608
Author : S. Dagley,Donald E. Nicholson
Publisher : Unknown
Page : 343 pages
File Size : 43,7 Mb
Release : 1972
Category : Electronic
ISBN : OCLC:818506393
Author : Christina Smolke
Publisher : CRC Press
Page : 680 pages
File Size : 52,8 Mb
Release : 2009-07-28
Category : Medical
ISBN : 9781439802977
This first volume of the Metabolic Pathway Engineering Handbook provides an overview of metabolic pathway engineering with a look towards the future. It discusses cellular metabolism, including transport processes inside the cell and energy generating reactions, as well as rare metabolic conversions. This volume also explores balances and reaction
Author : Cortassa Sonia Del Carmen,Aon Miguel Antonio,Aon Juan Carlos,Iglesias Alberto Alvaro,Lloyd David
Publisher : World Scientific
Page : 448 pages
File Size : 53,7 Mb
Release : 2011-12-28
Category : Technology & Engineering
ISBN : 9789814405171
Metabolic and Cellular Engineering (MCE) is more than an exciting scientific enterprise. It has become the cornerstone for coping with the challenges ahead of mankind. Continuous developments, new concepts, and technological innovations will enable us to deal with emerging challenges, and solve problems once thought impossible ten years ago. Challenges in MCE are broad- from unraveling fundamental aspects of cellular function to meeting unsatiated energy and food demands that are rising in parallel with population growth.In charting the progress of MCE during the last decade, we could not help but feel in awe of the enormous strides of progress made from the nascent Metabolic Engineering to the Systems Bioengineering of today. The burgeoning availability of genomic sequences from diverse species has been spectacular. It has become the engine that drives the genetic means for the modification of existing organisms and the generation of synthetic, man-made ones. From the initial attempts at purposeful genetic modification of a cell for the production of valuable compounds, we have now moved on to changing microbes genetically or metabolically.The arsenal of experimental and theoretical tools available for Metabolic and Cellular Engineering has expanded enormously, driven by the re-emergence of Physiology as Systems Biology. The revival of the concept of networks fueled by new developments has become central to Systems Biology. Networks represent an integrative vision of how processes of disparate nature relate to each other, and as such is becoming a key analytical and conceptual tool for MCE. This book reflects and addresses all these ongoing changes while providing the essential conceptual and analytical tools needed to understand and work in the MCE research field.
Author : Pablo Carbonell
Publisher : Springer Nature
Page : 168 pages
File Size : 41,5 Mb
Release : 2019-11-05
Category : Medical
ISBN : 9783030298654
This textbook presents solid tools for in silico engineering biology, offering students a step-by-step guide to mastering the smart design of metabolic pathways. The first part explains the Design-Build-Test-Learn-cycle engineering approach to biology, discussing the basic tools to model biological and chemistry-based systems. Using these basic tools, the second part focuses on various computational protocols for metabolic pathway design, from enzyme selection to pathway discovery and enumeration. In the context of industrial biotechnology, the final part helps readers understand the challenges of scaling up and optimisation. By working with the free programming language Scientific Python, this book provides easily accessible tools for studying and learning the principles of modern in silico metabolic pathway design. Intended for advanced undergraduates and master’s students in biotechnology, biomedical engineering, bioinformatics and systems biology students, the introductory sections make it also useful for beginners wanting to learn the basics of scientific coding and find real-world, hands-on examples.
Author : Christina Smolke
Publisher : CRC Press
Page : 581 pages
File Size : 42,9 Mb
Release : 2009-07-28
Category : Science
ISBN : 142007766X
This second volume of the Metabolic Pathway Engineering Handbook delves into evolutionary tools and gene expression tools for metabolic pathway engineering. It covers applications of emerging technologies including recent research genome-wide technologies, DNA and phenotypic microarrays, and proteomics tools for experimentally determining flux through pathways. This volume also looks at emerging applications for producing fine chemicals, drugs, and alternative fuels. Christine Smolke, who recently developed a novel way to churn out large quantities of drugs from genetically modified brewer’s yeast, is regarded as one of the most brilliant new minds in biomedical engineering. In this handbook, she brings together pioneering scientists from dozens of disciplines to provide a complete record of accomplishment in metabolic pathway engineering. With a wealth of cutting edge research and analysis, this work also serves as an invaluable resource for those seeking to add their own contributions. Organized by topic, this 3000 page reference is available as two volumes that can be purchased individually or as a set.
Author : David M. Greenberg
Publisher : Academic Press
Page : 477 pages
File Size : 47,6 Mb
Release : 2014-05-10
Category : Science
ISBN : 9781483273532
Metabolic Pathways, Third Edition, Volume I: Energetics, Tricarboxyl Acid Cycle, and Carbohydrates provides information pertinent to the determination of the sequential steps of the different metabolic pathways and the isolation and characterization of the enzymes catalyzing the several steps. This book discusses the chemical steps in the metabolism of the constituents of major significance in living organisms. Organized into seven chapters, this edition begins with an overview of the concept of free energy and the various methods of obtaining free energy data. This text then examines the relations between free energy and other quantities of direct interest, such as equilibrium constants, electromotive forces, and heats of reactions. Other chapters consider the transformation of energy from one form to another that is accomplished in living systems by specialized structures. The final chapter deals with the importance of L-ascorbic acid in the prevention of scurvy and its mode of action at the molecular level. This book is a valuable resource for biochemists.
Author : Lisa Bartee,Walter Shiner,Catherine Creech
Publisher : Unknown
Page : 128 pages
File Size : 44,7 Mb
Release : 2017
Category : Electronic
ISBN : 1636350410
The Principles of Biology sequence (BI 211, 212 and 213) introduces biology as a scientific discipline for students planning to major in biology and other science disciplines. Laboratories and classroom activities introduce techniques used to study biological processes and provide opportunities for students to develop their ability to conduct research.
Author : Nicholas J. Kruger,Steven A. Hill,R. George Ratcliffe
Publisher : Springer Science & Business Media
Page : 316 pages
File Size : 54,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789401148184
Over the past decade, advances in molecular biology have provided the impetus for a resurgence of interest in plant metabolism. At a general level, the potential for modifying the quantity or quality of harvestable crop products through genetic manipulation has provided an agronomic rationale for seeking a greater understanding of primary plant metabolism and its regulation. Moreover, the now facile techniques for transformation of many plant species and the consequential capacity to manipulate the amounts of specific individual enzymes within specific cell types provides an exciting direct approach for studying metabolic problems. Such transgenic plants are also becoming invaluable tools in studies at the interface between metabolism and other sub-disciplines such as physiology and ecology. The interest generated in plant metabolism by these developments has also encouraged the re-introduction of more conventional biochemical techniques for metabolic analysis. Finally, in common with other areas of cell biology, the wealth of information that can be obtained at the nucleic acid level has provided the stimulus for identification and characterisation of metabolic processes in far greater detail than previously envisaged. The result of these advances it that researchers now have the confidence to address problems in plant metabolism at levels not previously attempted. This book presents the proceedings of an international conference held on 9-11 January 1997 at St Hugh's College, Oxford under the auspices of the Phytochemical Society of Europe.
Author : Gerhard Michal,Dietmar Schomburg
Publisher : John Wiley & Sons
Page : 420 pages
File Size : 51,5 Mb
Release : 2013-03-06
Category : Science
ISBN : 9781118656884
The pathways and networks underlying biological function Now in its second edition, Biochemical Pathways continues to garner praise from students, instructors, and researchers for its clear, full-color illustrations of the pathways and networks that determine biological function. Biochemical Pathways examines the biochemistry of bacteria, plants, and animals. It offers a quick overview of the metabolic sequences in biochemical pathways, the chemistry and enzymology of conversions, the regulation of turnover, the expression of genes, the immunological interactions, and the metabolic background of health disorders. A standard set of conventions is used in all illustrations, enabling readers to easily gather information and compare the key elements of different biochemical pathways. For both quick and in-depth understanding, the book uses a combination of: Illustrations integrating many different features of the reactions and their interrelationships Tables listing the important system components and their function Text supplementing and expanding on the illustrated facts In the second edition, the volume has been expanded by 50 percent. Text and figures have undergone a thorough revision and update, reflecting the tremendous progress in biochemical knowledge in recent years. A guide to the relevant biochemical databases facilitates access to the extensive documentation of scientific knowledge. Biochemical Pathways, Second Edition is recommended for all students and researchers in such fields as biochemistry, molecular biology, medicine, organic chemistry, and pharmacology. The book's illustrated pathways aids the reader in understanding the complex set of biochemical reactions that occur in biological systems. From the reviews: “... highly recommended for every scientist and student working in biochemistry.” –Umwelt & Gesundheit 4/2012 (review in German language)
Author : Michael Krogh Jensen,Jay D. Keasling
Publisher : Humana Press
Page : 354 pages
File Size : 55,7 Mb
Release : 2017-11-24
Category : Medical
ISBN : 1493972944
This volume outlines key steps associated with the design, building, and testing of synthetic metabolic pathways for optimal cell factory performance and robustness, and illustrates how data-driven learning from these steps can be used for rational cost-effective engineering of cell factories with improved performance. Chapters are divided into four sections focusing on the four steps of the iterative design-build-test-learn cycle related to modern cell factory engineering. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Synthetic Metabolic Pathways: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Author : Sang Yup Lee,Jens Nielsen,Gregory Stephanopoulos
Publisher : John Wiley & Sons
Page : 1075 pages
File Size : 44,8 Mb
Release : 2021-06-02
Category : Science
ISBN : 9783527823451
Learn more about foundational and advanced topics in metabolic engineering in this comprehensive resource edited by leaders in the field Metabolic Engineering: Concepts and Applications delivers a one-stop resource for readers seeking a complete description of the concepts, models, and applications of metabolic engineering. This guide offers practical insights into the metabolic engineering of major cell lines, including E. Coli, Bacillus and Yarrowia Lipolytica, and organisms, including human, animal, and plant). The distinguished editors also offer readers resources on microbiome engineering and the use of metabolic engineering in bioremediation. Written in two parts, Metabolic Engineering begins with the essential models and strategies of the field, like Flux Balance Analysis, Quantitative Flux Analysis, and Proteome Constrained Models. It also provides an overview of topics like Pathway Design, Metabolomics, and Genome Editing of Bacteria and Eukarya. The second part contains insightful descriptions of the practical applications of metabolic engineering, including specific examples that shed light on the topics within. In addition to subjects like the metabolic engineering of animals, humans, and plants, you’ll learn more about: Metabolic engineering concepts and a historical perspective on their development The different modes of analysis, including flux balance analysis and quantitative flux analysis An illuminating and complete discussion of the thermodynamics of metabolic pathways The Genome architecture of E. coli, as well as genome editing of both bacteria and eukarya An in-depth treatment of the application of metabolic engineering techniques to organisms including corynebacterial, bacillus, and pseudomonas, and more Perfect for students of biotechnology, bioengineers, and biotechnologists, Metabolic Engineering: Concepts and Applications also has a place on the bookshelves of research institutes, biotechnological institutes and industry labs, and university libraries. It's comprehensive treatment of all relevant metabolic engineering concepts, models, and applications will be of use to practicing biotechnologists and bioengineers who wish to solidify their understanding of the field.
Author : Samantha Fowler,Rebecca Roush,James Wise
Publisher : Unknown
Page : 618 pages
File Size : 44,9 Mb
Release : 2018-01-07
Category : Science
ISBN : 9888407457
Concepts of Biology is designed for the single-semester introduction to biology course for non-science majors, which for many students is their only college-level science course. As such, this course represents an important opportunity for students to develop the necessary knowledge, tools, and skills to make informed decisions as they continue with their lives. Rather than being mired down with facts and vocabulary, the typical non-science major student needs information presented in a way that is easy to read and understand. Even more importantly, the content should be meaningful. Students do much better when they understand why biology is relevant to their everyday lives. For these reasons, Concepts of Biology is grounded on an evolutionary basis and includes exciting features that highlight careers in the biological sciences and everyday applications of the concepts at hand.We also strive to show the interconnectedness of topics within this extremely broad discipline. In order to meet the needs of today's instructors and students, we maintain the overall organization and coverage found in most syllabi for this course. A strength of Concepts of Biology is that instructors can customize the book, adapting it to the approach that works best in their classroom. Concepts of Biology also includes an innovative art program that incorporates critical thinking and clicker questions to help students understand--and apply--key concepts.
Author : Institute of Medicine,Board on Global Health,Forum on Microbial Threats
Publisher : National Academies Press
Page : 570 pages
File Size : 47,9 Mb
Release : 2011-12-30
Category : Science
ISBN : 9780309219396
Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.