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An Optical Study Of K Channel Inactivation Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of An Optical Study Of K Channel Inactivation book. This book definitely worth reading, it is an incredibly well-written.
Author : Kimberly Sue Best
Publisher : Unknown
Page : 576 pages
File Size : 41,9 Mb
Release : 2003
Category : Electronic
ISBN : UCAL:C3486992
Author : Stephen G. Waxman,Jeffery D. Kocsis,Peter K. Stys
Publisher : Unknown
Page : 710 pages
File Size : 49,6 Mb
Release : 1995
Category : Axons
ISBN : 9780195082937
The axon, interposed between the cell body and the synaptic terminals in most neurons, plays a crucial role in connecting neurons and acting as a conduit for the transmission of information between them. This book provides a comprehensive and up-to-date compendium that brings together chapterson the structure, function, and pathophysiology of axons in both the PNS and CNS. Carefully written, well-illustrated with superb illustrations, and generously referenced, the 33 chapters and introduction have been authored by 49 world-renowned authorities. Recent advances in the molecularneurobiology of axons are carefully reviewed, and new areas, such as the molecular biology of ion channels and myelination, the role of calcium in pathophysiology and regeneration, cell adhesion molecules and their roles in axo-glial interactions and axonal guidance, and optical recording methods,are highlighted. This book will provide an essential reference for neuroscientists as well as clinicians such as neurologists, neurosurgeons, and clinical electrophysiologists interested in axons.
Author : Albert Cha
Publisher : Unknown
Page : 252 pages
File Size : 48,8 Mb
Release : 1999
Category : Electronic
ISBN : UCLA:L0078710324
Author : Anonim
Publisher : ScholarlyEditions
Page : 903 pages
File Size : 48,9 Mb
Release : 2013-06-21
Category : Technology & Engineering
ISBN : 9781481683289
Advances in Molecular Nanotechnology Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Molecular Motors. The editors have built Advances in Molecular Nanotechnology Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Molecular Motors in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Molecular Nanotechnology Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author : Anonim
Publisher : Unknown
Page : 840 pages
File Size : 45,6 Mb
Release : 2009
Category : Dissertations, Academic
ISBN : STANFORD:36105132702593
Author : Anonim
Publisher : Academic Press
Page : 591 pages
File Size : 53,8 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323138901
This handbook provides a thorough account of recent directions in membrane channel research. Each subject is covered in terms of channel biophysics, pharmacology, and molecular biology. The introductory chapter reviews methodologies of molecular biology currently used for studying molecular structure and function of membrane channels and specific domains in channel proteins.
Author : Anonim
Publisher : Unknown
Page : 654 pages
File Size : 43,5 Mb
Release : 1993
Category : Power resources
ISBN : MSU:31293011519018
Author : David J. Triggle,Murali Gopalakrishnan,David Rampe,Wei Zheng
Publisher : John Wiley & Sons
Page : 492 pages
File Size : 51,7 Mb
Release : 2006-08-21
Category : Science
ISBN : 9783527607747
Edited by the most prominent person in the field and top researchers at US pharmaceutical companies, this is a unique resource for drug developers and physiologists seeking a molecular-level understanding of ion channel pharmacology. After an introduction to the topic, the authors evaluate the structure and function of ion channels, as well as related drug interaction. A section on assay technologies is followed by a section each on calcium, sodium and potassium channels. Further chapters cover genetic and acquired channelopathies, before the book closes with a look at safety issues in ion channel drug development. For medicinal and pharmaceutical chemists, biochemists, molecular biologists and those working in the pharmaceutical industry.
Author : Anonim
Publisher : Unknown
Page : 1104 pages
File Size : 47,8 Mb
Release : 1991
Category : Medicine
ISBN : UOM:39015020571777
Author : Christopher Ahern,Stephan Pless
Publisher : Springer
Page : 154 pages
File Size : 46,8 Mb
Release : 2015-09-17
Category : Medical
ISBN : 9781493928453
This volume describes chemical approaches to assess ion channel structure, function and pharmacology. Topics discussed include the use of engineered ionizable side chains to obtain information on permeation pathways and the local environment; the modification of engineered cysteine side chains, including cysteine scanning mutagenesis and the attachment of fluorescent probes and bio-reactive tethers; and the nascent use of genetic code expansion, evaluating its applications to ion channel and membrane proteins. This comprehensive text provides multifaceted perspectives on the great diversity of state-of-the-art methods which take advantage of the ever-expanding chemical toolbox to study ion channel biology. Capturing the contributions and innovations of renowned laboratory researchers in transmembrane protein study for the first time, this book is comprehensive in scope. It covers a wide array of experimental approaches: photochemistry, novel biological tools, and innovative spectroscopy, all combined with traditional techniques of electrophysiology and molecular biology. Novel Chemical Tools to Study Ion Channel Biology, part of the bestselling Advances in Experimental Medicine and Biology series is ideal for researchers and advanced students interested in biochemistry, biophysics, fluorometry, electrophysiology, and chemical biology. .
Author : Anonim
Publisher : ScholarlyEditions
Page : 354 pages
File Size : 55,9 Mb
Release : 2013-06-21
Category : Science
ISBN : 9781481689120
Ion Channels—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Potassium Channels. The editors have built Ion Channels—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Potassium Channels in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Ion Channels—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author : James N. C. Kew,Ceri H. Davies
Publisher : Unknown
Page : 586 pages
File Size : 49,5 Mb
Release : 2010
Category : Medical
ISBN : 9780199296750
Ion channels are intimately involved in the everyday physiological functions that enable us to live a full and varied life. When disease strikes, malfunction of ion channels or their dependent is often involved, either as the cause or the effect of the illness. Thus, billions of dollars have been, and still are being, invested in research to understand the physiological and pathophysiological functions of ion channels in an attempt to develop novel therapeutic treatments for a wide range of diseases. This book provides a comprehensive overview of ion channel structure and function. It comprises two major parts. Part one is an introductory overview of the ion channel superfamily and the generic aspects of ion channel function. This part also reviews the methodologies by which ion channel function can be studied from the perspective of performing detailed biophysical characterization through to the deployment of high throughput approaches for identifying novel ion channel ligands. Part two of the book provides an in-depth review of the individual ion channel subfamilies and, as such, is subdivided into four broad sections: Voltage-Gated Ion Channels, Extracellular Ligand-Gated Ion Channels, Intracellular Ligand-Gated Ion Channels, and Polymodal-Gated Ion Channels, with each chapter focused on specific family members. These chapters have been written by world leading experts and provide a detailed overview of the structure, biophysics, localization, pharmacology, physiology, and disease relevance of each particular ion channel subfamily. Reviewing both the basic principles of ion channel function and providing a detailed up-to-date review of the phsyiological and pharmacological aspects of individual ion channel sub-families, this book constitutes both an excellent introduction to the field for non-specialists, as well as a highly valuable reference text for experienced researchers already working in the ion channel area.
Author : Frances M. Ashcroft
Publisher : Academic Press
Page : 505 pages
File Size : 45,7 Mb
Release : 1999-10-20
Category : Science
ISBN : 9780080535210
Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. Introduces the relevant aspects of molecular biology and biophysics Describes the principal methods used to study channelopathies Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype
Author : Osei Kwame Asamoah
Publisher : Unknown
Page : 350 pages
File Size : 48,6 Mb
Release : 2004
Category : Electronic
ISBN : UCLA:L0089499123
Author : Ramakrishna Seethala,Prabhavathi Fernandes
Publisher : CRC Press
Page : 619 pages
File Size : 51,6 Mb
Release : 2001-07-24
Category : Medical
ISBN : 9780824741440
A presentation of screening techniques, modern technologies, and high-capacity instrumentation for increased productivity in the development and discovery of new drugs, chemical compounds, and targeted delivery of pharmaceuticals. It contains practical applications and examples of strategies in cell-based and cell-free screens as well as homogeneous, fluorescence, chemiluminescence, and radioactive-based technologies.