Analysis Of Complex Disease Association Studies

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Analysis of Complex Disease Association Studies

Eleftheria Zeggini,Andrew Morris
Analysis of Complex Disease Association Studies Book PDF

Author : Eleftheria Zeggini,Andrew Morris
Publisher : Academic Press
Page : 340 pages
File Size : 40,5 Mb
Release : 2010-11-17
Category : Science
ISBN : 0123751438

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Analysis of Complex Disease Association Studies by Eleftheria Zeggini,Andrew Morris Pdf

According to the National Institute of Health, a genome-wide association study is defined as any study of genetic variation across the entire human genome that is designed to identify genetic associations with observable traits (such as blood pressure or weight), or the presence or absence of a disease or condition. Whole genome information, when combined with clinical and other phenotype data, offers the potential for increased understanding of basic biological processes affecting human health, improvement in the prediction of disease and patient care, and ultimately the realization of the promise of personalized medicine. In addition, rapid advances in understanding the patterns of human genetic variation and maturing high-throughput, cost-effective methods for genotyping are providing powerful research tools for identifying genetic variants that contribute to health and disease. This burgeoning science merges the principles of statistics and genetics studies to make sense of the vast amounts of information available with the mapping of genomes. In order to make the most of the information available, statistical tools must be tailored and translated for the analytical issues which are original to large-scale association studies. Analysis of Complex Disease Association Studies will provide researchers with advanced biological knowledge who are entering the field of genome-wide association studies with the groundwork to apply statistical analysis tools appropriately and effectively. With the use of consistent examples throughout the work, chapters will provide readers with best practice for getting started (design), analyzing, and interpreting data according to their research interests. Frequently used tests will be highlighted and a critical analysis of the advantages and disadvantage complimented by case studies for each will provide readers with the information they need to make the right choice for their research. Additional tools including links to analysis tools, tutorials, and references will be available electronically to ensure the latest information is available. Easy access to key information including advantages and disadvantage of tests for particular applications, identification of databases, languages and their capabilities, data management risks, frequently used tests Extensive list of references including links to tutorial websites Case studies and Tips and Tricks

Genetic Analysis of Complex Disease

William K. Scott,Marylyn D. Ritchie
Genetic Analysis of Complex Disease Book PDF

Author : William K. Scott,Marylyn D. Ritchie
Publisher : John Wiley & Sons
Page : 340 pages
File Size : 53,5 Mb
Release : 2021-12-06
Category : Science
ISBN : 9781118123911

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Genetic Analysis of Complex Disease by William K. Scott,Marylyn D. Ritchie Pdf

Genetic Analysis of Complex Diseases An up-to-date and complete treatment of the strategies, designs and analysis methods for studying complex genetic disease in human beings In the newly revised Third Edition of Genetic Analysis of Complex Diseases, a team of distinguished geneticists delivers a comprehensive introduction to the most relevant strategies, designs and methods of analysis for the study of complex genetic disease in humans. The book focuses on concepts and designs, thereby offering readers a broad understanding of common problems and solutions in the field based on successful applications in the design and execution of genetic studies. This edited volume contains contributions from some of the leading voices in the area and presents new chapters on high-throughput genomic sequencing, copy-number variant analysis and epigenetic studies. Providing clear and easily referenced overviews of the considerations involved in genetic analysis of complex human genetic disease, including sampling, design, data collection, linkage and association studies and social, legal and ethical issues. Genetic Analysis of Complex Diseases also provides: A thorough introduction to study design for the identification of genes in complex traits Comprehensive explorations of basic concepts in genetics, disease phenotype definition and the determination of the genetic components of disease Practical discussions of modern bioinformatics tools for analysis of genetic data Reflecting on responsible conduct of research in genetic studies, as well as linkage analysis and data management New expanded chapter on complex genetic interactions This latest edition of Genetic Analysis of Complex Diseases is a must-read resource for molecular biologists, human geneticists, genetic epidemiologists and pharmaceutical researchers. It is also invaluable for graduate students taking courses in statistical genetics or genetic epidemiology.

Genetic Analysis of Complex Disease

William K. Scott,Marylyn D. Ritchie
Genetic Analysis of Complex Disease Book PDF

Author : William K. Scott,Marylyn D. Ritchie
Publisher : John Wiley & Sons
Page : 340 pages
File Size : 47,7 Mb
Release : 2021-11-11
Category : Science
ISBN : 9781119104070

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Genetic Analysis of Complex Disease by William K. Scott,Marylyn D. Ritchie Pdf

Genetic Analysis of Complex Diseases An up-to-date and complete treatment of the strategies, designs and analysis methods for studying complex genetic disease in human beings In the newly revised Third Edition of Genetic Analysis of Complex Diseases, a team of distinguished geneticists delivers a comprehensive introduction to the most relevant strategies, designs and methods of analysis for the study of complex genetic disease in humans. The book focuses on concepts and designs, thereby offering readers a broad understanding of common problems and solutions in the field based on successful applications in the design and execution of genetic studies. This edited volume contains contributions from some of the leading voices in the area and presents new chapters on high-throughput genomic sequencing, copy-number variant analysis and epigenetic studies. Providing clear and easily referenced overviews of the considerations involved in genetic analysis of complex human genetic disease, including sampling, design, data collection, linkage and association studies and social, legal and ethical issues. Genetic Analysis of Complex Diseases also provides: A thorough introduction to study design for the identification of genes in complex traits Comprehensive explorations of basic concepts in genetics, disease phenotype definition and the determination of the genetic components of disease Practical discussions of modern bioinformatics tools for analysis of genetic data Reflecting on responsible conduct of research in genetic studies, as well as linkage analysis and data management New expanded chapter on complex genetic interactions This latest edition of Genetic Analysis of Complex Diseases is a must-read resource for molecular biologists, human geneticists, genetic epidemiologists and pharmaceutical researchers. It is also invaluable for graduate students taking courses in statistical genetics or genetic epidemiology.

Linkage Disequilibrium and Association Mapping

Andrew R. Collins
Linkage Disequilibrium and Association Mapping Book PDF

Author : Andrew R. Collins
Publisher : Springer Science & Business Media
Page : 529 pages
File Size : 42,6 Mb
Release : 2008-02-05
Category : Medical
ISBN : 9781597453899

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Linkage Disequilibrium and Association Mapping by Andrew R. Collins Pdf

As researchers continue to make enormous progress in mapping disease genes, exciting, novel, and complex analyses have emerged. In this book, scientists from around the world, who are leaders in this field, contribute their vast experience and expertise to produce a comprehensive and fascinating text for researchers and clinicians alike. They provide cutting-edge analysis of the most up-to-date and preeminent information available.

Genetic Association Studies: Background, Conduct, Analysis, Interpretation

Mehmet Tevfik Dorak
Genetic Association Studies Background Conduct Analysis Interpretation Book PDF

Author : Mehmet Tevfik Dorak
Publisher : Garland Science
Page : 240 pages
File Size : 53,6 Mb
Release : 2016-09-28
Category : Science
ISBN : 9781351806435

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Genetic Association Studies: Background, Conduct, Analysis, Interpretation by Mehmet Tevfik Dorak Pdf

Genetic Association Studies is designed for students of public health, epidemiology, and the health sciecnes, covering the main principles of molecular genetics, population genetics, medical genetics, epidemiology and statistics. It presents a balanced view of genetic associations with coverage of candidate gene studies as well as genome-wide association studies. All aspects of a genetic association study are included, from the lab to analysis and interpretation of results, but also bioinformatics approaches to causality assessment. The role of the environment in genetic disease is also highlighted. Genetic Association Studies will enable readers to understand and critique genetic association studies and set them on the way to designing, executing, analyzing, interpreting, and reporting their own.

Genetics of Complex Disease

Peter Donaldson,Ann Daly,Luca Ermini,Debra Bevitt
Genetics of Complex Disease Book PDF

Author : Peter Donaldson,Ann Daly,Luca Ermini,Debra Bevitt
Publisher : Garland Science
Page : 450 pages
File Size : 48,9 Mb
Release : 2015-08-25
Category : Medical
ISBN : 9781317334255

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Genetics of Complex Disease by Peter Donaldson,Ann Daly,Luca Ermini,Debra Bevitt Pdf

Genetics of Complex Disease examines how the identification of genetic variations that increase or reduce the risk of common, genetically complex, diseases can be used to improve our understanding of the pathology of many common diseases; enable better patient management and care; and help with differential diagnosis. It starts with the quest

Applied Statistical Genetics with R

Andrea S. Foulkes
Applied Statistical Genetics with R Book PDF

Author : Andrea S. Foulkes
Publisher : Springer Science & Business Media
Page : 264 pages
File Size : 52,8 Mb
Release : 2009-04-28
Category : Science
ISBN : 9780387895543

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Applied Statistical Genetics with R by Andrea S. Foulkes Pdf

Statistical genetics has become a core course in many graduate programs in public health and medicine. This book presents fundamental concepts and principles in this emerging field at a level that is accessible to students and researchers with a first course in biostatistics. Extensive examples are provided using publicly available data and the open source, statistical computing environment, R.

Genetic Analysis of Complex Disease

Jonathan L. Haines,Margaret A. Pericak-Vance
Genetic Analysis of Complex Disease Book PDF

Author : Jonathan L. Haines,Margaret A. Pericak-Vance
Publisher : Wiley-Liss
Page : 516 pages
File Size : 41,8 Mb
Release : 2006-05-05
Category : Medical
ISBN : UOM:39015064096780

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Genetic Analysis of Complex Disease by Jonathan L. Haines,Margaret A. Pericak-Vance Pdf

Provides a comprehensive introduction to the various strategies, designs, and methods of analysis for the study of human genetic disease. It offers a broad-based understanding of the problems and solutions based on successful applications in the design and execution of gene mapping projects. Chapters present clear and easily referenced overviews of the broad range of considerations involved in genetic analysis of human genetic disease, including design, sampling, data collection, linkage and association studies, and social, legal, and ethical issues. Incorporating all new discussion questions and practical examples within each chapter, the book significantly updates treatment of bioinformatics, multiple comparisons, sample size requirements, parametric linkage analysis, case-control and family based approaches, and genomic screening. It covers new methods for analysis of gene-gene and gene-environmental interactions, and features a complete rewrite of the chapter on determining genetic components of disease.

Genetic Dissection of Complex Traits

D.C. Rao,C. Charles Gu
Genetic Dissection of Complex Traits Book PDF

Author : D.C. Rao,C. Charles Gu
Publisher : Academic Press
Page : 300 pages
File Size : 42,9 Mb
Release : 2008-04-23
Category : Science
ISBN : 0080569110

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Genetic Dissection of Complex Traits by D.C. Rao,C. Charles Gu Pdf

The field of genetics is rapidly evolving and new medical breakthroughs are occuring as a result of advances in knowledge of genetics. This series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. * Five sections on the latest advances in complex traits * Methods for testing with ethical, legal, and social implications * Hot topics include discussions on systems biology approach to drug discovery; using comparative genomics for detecting human disease genes; computationally intensive challenges, and more

Genome-Wide Association Studies

Krishnarao Appasani
Genome Wide Association Studies Book PDF

Author : Krishnarao Appasani
Publisher : Cambridge University Press
Page : 449 pages
File Size : 51,9 Mb
Release : 2016-01-14
Category : Medical
ISBN : 9781107042766

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Genome-Wide Association Studies by Krishnarao Appasani Pdf

Experts from academia and industry highlight the potential of genome-wide association studies from basic science to clinical and biotechnological/pharmaceutical applications.

DNA Methylation and Complex Human Disease

Michel Neidhart
DNA Methylation and Complex Human Disease Book PDF

Author : Michel Neidhart
Publisher : Academic Press
Page : 552 pages
File Size : 54,7 Mb
Release : 2015-08-11
Category : Science
ISBN : 9780127999203

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DNA Methylation and Complex Human Disease by Michel Neidhart Pdf

DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as a potential tool for determining cancer risk, and diagnosis between benign and malignant disease. Therapies are at the heart of this volume and the possibilities of DNA demethylation. In cancer, unlike genetic mutations, DNA methylation and histone modifications are reversible and thus have shown great potential in the race for effective treatments. In addition, the authors present the importance of high-throughput methylome analysis, not only in cancer, but also in non-neoplastic diseases such as rheumatoid arthritis. Discusses breaking biomarker research in major disease families of current health concern and research interest, including obesity, type II diabetes, schizophrenia, and autoimmunity Summarizes advances not only relevant to cancer, but also in non-neoplastic disease, currently an emerging field Describes wholly new concepts, including the linking of metabolic pathways with epigenetics Provides translational researchers with the knowledge of both basic research and clinic applications of DNA methylation in human diseases

Analysis of Multifactorial Diseases

Timothy Bishop,P. Sham
Analysis of Multifactorial Diseases Book PDF

Author : Timothy Bishop,P. Sham
Publisher : Academic Press
Page : 376 pages
File Size : 51,7 Mb
Release : 2000-11-29
Category : Science
ISBN : UOM:39015049678652

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Analysis of Multifactorial Diseases by Timothy Bishop,P. Sham Pdf

Multifactorial diseases are genetic diseases influenced by more than one gene. As such, they are either inherited from parents or caused by mutation. Examples include common cancers, Alzeimer's, epilepsy, diabetes, multiple sclerosis, asthma, schizophrenia, manic depression, and rheumatoid arthritis. This title focuses on the studies used to analyze these diseases.

Human Genome Epidemiology, 2nd Edition

Muin Khoury,Sara Bedrosian,Marta Gwinn,Julian Higgins,John Ioannidis
Human Genome Epidemiology 2nd Edition Book PDF

Author : Muin Khoury,Sara Bedrosian,Marta Gwinn,Julian Higgins,John Ioannidis
Publisher : Oxford University Press
Page : 701 pages
File Size : 41,8 Mb
Release : 2010-01-20
Category : Medical
ISBN : 9780195398441

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Human Genome Epidemiology, 2nd Edition by Muin Khoury,Sara Bedrosian,Marta Gwinn,Julian Higgins,John Ioannidis Pdf

This text describes the role that epidemiologic methods play in the continuum from gene discovery to the development and application of genetic tests. It provides a foundation that should help researchers, policy makers and practitioners integrate genomics into medical and public health practice.

An Introduction to Genetic Epidemiology

Palmer, Lyle J.,Burton, Paul R.,George Davey Smith
An Introduction to Genetic Epidemiology Book PDF

Author : Palmer, Lyle J.,Burton, Paul R.,George Davey Smith
Publisher : Policy Press
Page : 240 pages
File Size : 44,8 Mb
Release : 2011-05-31
Category : Medical
ISBN : 9781861348975

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An Introduction to Genetic Epidemiology by Palmer, Lyle J.,Burton, Paul R.,George Davey Smith Pdf

This book brings together leading experts to provide an introduction to genetic epidemiology that begins with a primer in human molecular genetics through all the standard methods in population genetics and genetic epidemiology required for an adequate grounding in the field.

Handbook of Statistical Genomics

David J. Balding,Ida Moltke,John Marioni
Handbook of Statistical Genomics Book PDF

Author : David J. Balding,Ida Moltke,John Marioni
Publisher : John Wiley & Sons
Page : 1828 pages
File Size : 51,9 Mb
Release : 2019-07-09
Category : Science
ISBN : 9781119429258

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Handbook of Statistical Genomics by David J. Balding,Ida Moltke,John Marioni Pdf

A timely update of a highly popular handbook on statistical genomics This new, two-volume edition of a classic text provides a thorough introduction to statistical genomics, a vital resource for advanced graduate students, early-career researchers and new entrants to the field. It introduces new and updated information on developments that have occurred since the 3rd edition. Widely regarded as the reference work in the field, it features new chapters focusing on statistical aspects of data generated by new sequencing technologies, including sequence-based functional assays. It expands on previous coverage of the many processes between genotype and phenotype, including gene expression and epigenetics, as well as metabolomics. It also examines population genetics and evolutionary models and inference, with new chapters on the multi-species coalescent, admixture and ancient DNA, as well as genetic association studies including causal analyses and variant interpretation. The Handbook of Statistical Genomics focuses on explaining the main ideas, analysis methods and algorithms, citing key recent and historic literature for further details and references. It also includes a glossary of terms, acronyms and abbreviations, and features extensive cross-referencing between chapters, tying the different areas together. With heavy use of up-to-date examples and references to web-based resources, this continues to be a must-have reference in a vital area of research. Provides much-needed, timely coverage of new developments in this expanding area of study Numerous, brand new chapters, for example covering bacterial genomics, microbiome and metagenomics Detailed coverage of application areas, with chapters on plant breeding, conservation and forensic genetics Extensive coverage of human genetic epidemiology, including ethical aspects Edited by one of the leading experts in the field along with rising stars as his co-editors Chapter authors are world-renowned experts in the field, and newly emerging leaders. The Handbook of Statistical Genomics is an excellent introductory text for advanced graduate students and early-career researchers involved in statistical genetics.