Antibody Fusion Proteins

Author : Steven M. Chamow,Avi Ashkenazi
Publisher : Wiley-Liss
Page : 312 pages
File Size : 52,9 Mb
Release : 1999-04-13
Category : Science
ISBN : 047118358X

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Antibody Fusion Proteins by Steven M. Chamow,Avi Ashkenazi Pdf

Thoroughly detailed and illustrated, this book examines the construction, properties, applications, and problems associated with specific types of fusion molecules used in clinical and research medicine. The editors present an overview of the field, followed by nine chapters divided into two general sections based on the two primary parts of the antibody molecule: Fab fusion proteins and Fc fusion proteins. In addition, numerous renowned scientists in the field have contributed outlines demonstrating man-made molecules that will be required not only to overcome the limitations of monoclonal antibodies, but also to extend the principle of selective targeting. Divided into specific, accessible sections, Antibody Fusion Proteins includes: * Chapters describing Fc fusion proteins, as well as several classes of antigen-binding proteins * Complete details on the design and molecular construction of genetically engineered fusion molecules * Useful information on molecular purification, large-scale production, practical applications, and their therapeutic potential * The latest data on forming fusion proteins with toxins, cytokines, or enzymes that can activate a prodrug

Author : Steven M. Chamow,Thomas Ryll,Henry B. Lowman,Deborah Farson
Publisher : John Wiley & Sons
Page : 345 pages
File Size : 43,9 Mb
Release : 2013-12-18
Category : Science
ISBN : 9783527675289

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Therapeutic Fc-Fusion Proteins by Steven M. Chamow,Thomas Ryll,Henry B. Lowman,Deborah Farson Pdf

Edited by three pioneers in the field, each with longstanding experience in the biotech industry, and a skilled scientific writer, this is the first book to cover every step in the development and production of immunoglobulin Fc-fusion proteins as therapeutics for human disease: from choosing the right molecular design, to pre-clinical characterization of the purified product, through to batch optimization and quality control for large-scale cGMP production. The whole of the second part is devoted to case studies of Fc-fusion proteins that are now commercially successful products. In this section, the authors, several of whom were personally involved in clinical development of the products themselves, detail the product?s background and give insight into issues that were faced and how these issues were overcome during clinical development. This section also includes a chapter on promising new developments for the future. An invaluable resource for professionals already working on Fc-fusion proteins and an excellent and thorough introduction for physicians, researchers, and students entering the field.

Author : Uwe Gottschalk
Publisher : John Wiley & Sons
Page : 752 pages
File Size : 51,8 Mb
Release : 2017-03-07
Category : Medical
ISBN : 9781119126935

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Process Scale Purification of Antibodies by Uwe Gottschalk Pdf

Promoting a continued and much-needed renaissance in biopharmaceutical manufacturing, this book covers the different strategies and assembles top-tier technology experts to address the challenges of antibody purification. • Updates existing topics and adds new ones that include purification of antibodies produced in novel production systems, novel separation technologies, novel antibody formats and alternative scaffolds, and strategies for ton-scale manufacturing • Presents new and updated discussions of different purification technologies, focusing on how they can address the capacity crunch in antibody purification • Emphasizes antibodies and innovative chromatography methods for processing

Author : Stefan R. Schmidt
Publisher : John Wiley & Sons
Page : 995 pages
File Size : 42,9 Mb
Release : 2013-01-28
Category : Medical
ISBN : 9781118354582

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Fusion Protein Technologies for Biopharmaceuticals by Stefan R. Schmidt Pdf

The state of the art in biopharmaceutical FUSION PROTEIN DESIGN Fusion proteins belong to the most lucrative biotech drugs—with Enbrel® being one of the best-selling biologics worldwide. Enbrel® represents a milestone of modern therapies just as Humulin®, the first therapeutic recombinant protein for human use, approved by the FDA in 1982 and Orthoclone® the first monoclonal antibody reaching the market in 1986. These first generation molecules were soon followed by a plethora of recombinant copies of natural human proteins, and in 1998, the first de novo designed fusion protein was launched. Fusion Protein Technologies for Biopharmaceuticals examines the state of the art in developing fusion proteins for biopharmaceuticals, shedding light on the immense potential inherent in fusion protein design and functionality. A wide pantheon of international scientists and researchers deliver a comprehensive and complete overview of therapeutic fusion proteins, combining the success stories of marketed drugs with the dynamic preclinical and clinical research into novel drugs designed for as yet unmet medical needs. The book covers the major types of fusion proteins—receptor-traps, immunotoxins, Fc-fusions and peptibodies—while also detailing the approaches for developing, delivering, and improving the stability of fusion proteins. The main body of the book contains three large sections that address issues key to this specialty: strategies for extending the plasma half life, the design of toxic proteins, and utilizing fusion proteins for ultra specific targeting. The book concludes with novel concepts in this field, including examples of highly relevant multifunctional antibodies. Detailing the innovative science, commercial realities, and brilliant potential of fusion protein therapeutics, Fusion Protein Technologies for Biopharmaceuticals is a must for pharmaceutical scientists, biochemists, medicinal chemists, molecular biologists, pharmacologists, and genetic engineers interested in determining the shape of innovation in the world of biopharmaceuticals.

Author : Roland E. Kontermann,Stefan Dübel
Publisher : Springer Science & Business Media
Page : 770 pages
File Size : 43,5 Mb
Release : 2010-03-10
Category : Medical
ISBN : 9783642011443

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Antibody Engineering Volume 1 by Roland E. Kontermann,Stefan Dübel Pdf

Antibodies are indispensable tools for research, diagnosis, and therapy. Recombinant approaches allow the modification and improvement of nearly all antibody properties, such as affinity, valency, specificity, stability, serum half-life, effector functions, and immunogenicity. "Antibody Engineering" provides a comprehensive toolbox covering the well-established basics but also many exciting new techniques. The protocols reflect the latest "hands on" knowledge of key laboratories in this still fast-moving field. Newcomers will benefit from the proven step-by-step protocols, which include helpful practical advice; experienced antibody engineers will appreciate the new ideas and approaches. The book is an invaluable resource for all those engaged in antibody research and development.

Author : Maher Albitar
Publisher : Springer Science & Business Media
Page : 472 pages
File Size : 52,5 Mb
Release : 2008-02-02
Category : Medical
ISBN : 9781597453233

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Monoclonal Antibodies by Maher Albitar Pdf

This book examines a collection of state-of-the-art methods that employ monoclonal antibodies in a clinical setting. The chapters offer in-depth description for generating mouse and recombinant humanized antibodies, and a comprehensive review of how antibodies are being used in bead-based methods for measuring proteins. This field will continue to expand and provide new and innovative techniques in the laboratory and as a basis that complements targeted therapy.

Author : Allan Matte
Publisher : Elsevier
Page : 222 pages
File Size : 47,5 Mb
Release : 2020-09-07
Category : Business & Economics
ISBN : 9780081030196

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Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics by Allan Matte Pdf

Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics provides the interested and informed reader with an overview of current approaches, strategies and considerations relating to the purification, analytics and characterization of therapeutic antibodies and related molecules. While there are obviously other books published in and around this subject area, they seem to be either older (c.a. year 2000 publication date) or are more limited in scope. The book will include an extensive bibliography of the published literature in the respective areas covered. It is not, however, intended to be a how-to methods book. Covers the vital new area of R&D on therapeutic antibodies Written by leading scientists and researchers Up-to-date coverage and includes a detailed bibliography

Author : Roland E. Kontermann,Stefan Dübel
Publisher : Springer Science & Business Media
Page : 778 pages
File Size : 44,6 Mb
Release : 2013-06-29
Category : Science
ISBN : 9783662046050

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Antibody Engineering by Roland E. Kontermann,Stefan Dübel Pdf

Interest in recombinant antibody technologies has rapidly increased because of its wide range of possible applications in therapy, diagnosis, and especially, cancer treatment. The possibility of generating human antibodies that are not accessible by conventional polyclonal or monoclonal approaches has facilitated the development of antibody engineering technologies. This manual presents a comprehensive collection of detailed step-by-step protocols, provided by experts. The text covers all basic methods needed in antibody engineering as well as recently developed and emerging technologies.

Author : Stefan Dübel,Janice M. Reichert
Publisher : John Wiley & Sons
Page : 2538 pages
File Size : 45,7 Mb
Release : 2014-12-03
Category : Science
ISBN : 9783527329373

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Handbook of Therapeutic Antibodies by Stefan Dübel,Janice M. Reichert Pdf

Still the most comprehensive reference source on the development, production and therapeutic application of antibodies, this second edition is thoroughly updated and now has 30% more content. Volume 1 covers selection and engineering strategies for new antibodies, while the second volume presents novel therapeutic concepts and antibodies in clinical study, as well as their potential. Volumes 3 and 4 feature detailed and specific information about each antibody approved for therapeutic purposes, including clinical data. This unique handbook concludes with a compendium of marketed monoclonal antibodies and an extensive index. Beyond providing current knowledge, the authors discuss emerging technologies, future developments, and intellectual property issues, such that this handbook meets the needs of academic researchers, decision makers in industry and healthcare professionals in the clinic.

Author : Tianlei Ying,Rui Gong
Publisher : Frontiers Media SA
Page : 118 pages
File Size : 48,6 Mb
Release : 2018-12-21
Category : Electronic
ISBN : 9782889456789

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Antibody Fc Engineering: Towards Better Therapeutics by Tianlei Ying,Rui Gong Pdf

Author : William R Strohl,Lila M Strohl
Publisher : Elsevier
Page : 697 pages
File Size : 46,9 Mb
Release : 2012-10-16
Category : Medical
ISBN : 9781908818096

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Therapeutic Antibody Engineering by William R Strohl,Lila M Strohl Pdf

The field of antibody engineering has become a vital and integral part of making new, improved next generation therapeutic monoclonal antibodies, of which there are currently more than 300 in clinical trials across several therapeutic areas. Therapeutic antibody engineering examines all aspects of engineering monoclonal antibodies and analyses the effect that various genetic engineering approaches will have on future candidates. Chapters in the first part of the book provide an introduction to monoclonal antibodies, their discovery and development and the fundamental technologies used in their production. Following chapters cover a number of specific issues relating to different aspects of antibody engineering, including variable chain engineering, targets and mechanisms of action, classes of antibody and the use of antibody fragments, among many other topics. The last part of the book examines development issues, the interaction of human IgGs with non-human systems, and cell line development, before a conclusion looking at future issues affecting the field of therapeutic antibody engineering. Goes beyond the standard engineering issues covered by most books and delves into structure-function relationships Integration of knowledge across all areas of antibody engineering, development, and marketing Discusses how current and future genetic engineering of cell lines will pave the way for much higher productivity

Author : Melvyn Little
Publisher : Cambridge University Press
Page : 445 pages
File Size : 54,6 Mb
Release : 2009-07-27
Category : Medical
ISBN : 9780521887328

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Recombinant Antibodies for Immunotherapy by Melvyn Little Pdf

This book provides a comprehensive overview of the field of monoclonal antibodies through twenty-five articles by recognized experts in the field.

Author : Zhiqiang An
Publisher : John Wiley & Sons
Page : 932 pages
File Size : 45,8 Mb
Release : 2011-09-20
Category : Science
ISBN : 9781118210260

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Therapeutic Monoclonal Antibodies by Zhiqiang An Pdf

70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies. First book to address the discovery and development of antibody therapeutics in their entirety. Most chapters contain experimental data to illustrate the principles described in them. Authors provide detailed methodologies that readers can take away with them and use in their own laboratories.

Author : Alexandros Poulopoulos
Publisher : Humana
Page : 0 pages
File Size : 55,8 Mb
Release : 2016-12-10
Category : Medical
ISBN : 1493966863

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Synapse Development by Alexandros Poulopoulos Pdf

This detailed volume collects protocols for experimentation into how neurons connect to produce the extraordinary functionalities of the nervous system. Contributed by experts and pioneers in their respective techniques, the book covers synapses in the brain and in culture, their constituents, their structures, their dynamics, and the assemblies they form, all in the structure of a laboratory guide. Written for the highly successful Methods in Molecular Biology series, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Synapse Development: Methods and Protocols serves as an ideal guide to minimizing the barrier to entry for the integration of new approaches with existing expertise, producing syntheses that will foster novel perspectives on the many ways in which synapses form, transform, and transmit.

Author : Anonim
Publisher : Academic Press
Page : 288 pages
File Size : 43,8 Mb
Release : 2019-07-13
Category : Medical
ISBN : 9780128173176

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Drug-Induced Liver Injury by Anonim Pdf

Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series