Antimalarial Chemotherapy

Author : Philip J. Rosenthal
Publisher : Springer Science & Business Media
Page : 393 pages
File Size : 48,6 Mb
Release : 2001-04-01
Category : Medical
ISBN : 9781592591114

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Antimalarial Chemotherapy by Philip J. Rosenthal Pdf

Philip Rosenthal, MD, and a panel of leading malaria experts drawn from academia, the military, and international health organizations survey the latest scientific understanding of antimalarial chemotherapy, emphasizing the molecular mechanisms of resistance and the description of important new targets. Their survey covers the current status of malarial and antimalarial chemotherapy, the relevant biology and biochemistry of malaria parasites, the antimalarial drugs currently available, new chemical approaches to chemotherapy, and possible new targets for chemotherapy. Comprehensive and cutting-edge, Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery clearly delineates all the basic and clinical research now addressing one of the world's major unresolved disease problems, work that is now powerfully driving the rapid pace of antimalarial drug discovery today.

Author : Wallace Peters
Publisher : Unknown
Page : 822 pages
File Size : 40,7 Mb
Release : 1987
Category : Electronic
ISBN : NWU:35558001314034

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Chemotherapy and Drug Resistance in Malaria by Wallace Peters Pdf

Author : George Robert Coatney
Publisher : Unknown
Page : 344 pages
File Size : 50,7 Mb
Release : 1953
Category : Antimalarials
ISBN : UCBK:C029406997

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Survey of Antimalarial Drugs by George Robert Coatney Pdf

Author : Philip J. Rosenthal
Publisher : Unknown
Page : 412 pages
File Size : 48,6 Mb
Release : 2014-09-01
Category : Electronic
ISBN : 1468496492

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Antimalarial Chemotherapy by Philip J. Rosenthal Pdf

Author : Henry M. Staines,Sanjeev Krishna
Publisher : Springer Science & Business Media
Page : 318 pages
File Size : 41,5 Mb
Release : 2012-01-06
Category : Medical
ISBN : 9783034604796

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Treatment and Prevention of Malaria by Henry M. Staines,Sanjeev Krishna Pdf

Malaria has defeated previous efforts at eradication and remains a massive global public health problem despite being readily preventable and treatable. It is a devastating disease that also extracts huge economic costs from the poorest countries in endemic regions. Starting with an overview of the disease and its current political, financial and technical context, this Milestones in Drug Therapy volume describes the history, chemistry, mechanisms of action and resistance, preclinical and clinical use, pharmacokinetics and safety and tolerability of the current range of antimalarial drugs. There is particular emphasis on artemisinins and related peroxides, as these drugs have now become the frontline treatment for malaria. Next generation antimalarials, molecular markers for detecting resistance, the importance of diagnostics and disease prevention are also covered in detail.

Author : Leonard Jan Bruce-Chwatt,Robert H. Black
Publisher : Unknown
Page : 261 pages
File Size : 40,6 Mb
Release : 1986
Category : Antimalarials
ISBN : 9241401273

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Chemotherapy of Malaria by Leonard Jan Bruce-Chwatt,Robert H. Black Pdf

Author : Pravin Kendrekar
Publisher : John Wiley & Sons
Page : 404 pages
File Size : 52,8 Mb
Release : 2022-08-09
Category : Medical
ISBN : 9783527830596

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Drug Development for Malaria by Pravin Kendrekar Pdf

Drug Development for Malaria Provides readers with first-hand advice for the development of novel antimalarial drugs This book provides a systematic overview of antimalarial drug development and presents a wealth of data and insight from drug developers across three continents, including many from countries where the disease is endemic. Throughout, the contributions have been written with the drug developer in mind, highlighting challenges but also opportunities for the successful development of effective antimalarial drugs. Case studies and method-oriented chapters provide an abundance of practical first-hand advice on how to successfully develop an antimalarial drug. Key topics covered in the book include: The performance of current drugs and therapies, the influence of formulation and targeted delivery, and strategies to overcome drug resistance. Technologies and approaches for development of novel drugs, such as assays, computer-aided drug design, known and potential drug targets, and natural sources for novel antimalarial compounds Vaccination as an alternative to drug therapy For chemists and other professionals working in industries related to medicine and pharmaceuticals, this book provides a completely comprehensive overview of the current state of novel antimalarial drugs and how they can be developed in an efficient and cost-effective manner.

Author : United States. Federal Supply Service
Publisher : Unknown
Page : 24 pages
File Size : 55,8 Mb
Release : 1973
Category : Moving, Household
ISBN : MINN:30000009126818

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Shipping Your Household Goods by United States. Federal Supply Service Pdf

Author : Poul Thompson
Publisher : Elsevier
Page : 409 pages
File Size : 48,6 Mb
Release : 2012-12-02
Category : Medical
ISBN : 9780323151689

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Antimalarial Agents by Poul Thompson Pdf

Medicinal Chemistry, Volume 12: Antimalarial Agents: Chemistry and Pharmacology presents the essentials of both biology and chemistry pertinent to the chemotherapy of malaria. This book discusses the nature of the disease, the physiology and biochemistry of the plasmodia, and the mode of action of drugs. Organized into 19 chapters, this volume begins with an overview of the most intensive efforts to develop synthetic antimalarial drugs. This text then examines how drugs are evaluated as well as the specific chemotherapy in malaria. Other chapters consider the diversity of chemical structures exhibiting antimalarial activity with emphasis on structure–activity relationships and methods of synthesis. This book discusses as well the plasmodial effects by quinine in vivo. The final chapter deals with the miscellaneous structures known to have activity against some types of plasmodial infection in animals. This book is a valuable resource for chemists and biologists involved in the development of antimalarial drugs.

Author : World Health Organization
Publisher : World Health Organization
Page : 208 pages
File Size : 42,7 Mb
Release : 2010
Category : Medical
ISBN : 9789241547925

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Guidelines for the Treatment of Malaria by World Health Organization Pdf

"The purpose of this document is to provide comprehensible, global, evidence-based guidelines to help formulate policies and protocols for the treatment of malaria. Information is presented on the treatment of uncomplicated malaria, including disease in special groups (young children, pregnant women, people who are HIV positive, travellers from non-malaria endemic regions) and in complex emergency situations and severe malaria."--Publisher's description.

Author : Institute of Medicine,Board on Global Health,Committee on the Economics of Antimalarial Drugs
Publisher : National Academies Press
Page : 384 pages
File Size : 41,6 Mb
Release : 2004-09-09
Category : Medical
ISBN : 9780309165938

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Saving Lives, Buying Time by Institute of Medicine,Board on Global Health,Committee on the Economics of Antimalarial Drugs Pdf

For more than 50 years, low-cost antimalarial drugs silently saved millions of lives and cured billions of debilitating infections. Today, however, these drugs no longer work against the deadliest form of malaria that exists throughout the world. Malaria deaths in sub-Saharan Africaâ€"currently just over one million per yearâ€"are rising because of increased resistance to the old, inexpensive drugs. Although effective new drugs called "artemisinins" are available, they are unaffordable for the majority of the affected population, even at a cost of one dollar per course. Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance examines the history of malaria treatments, provides an overview of the current drug crisis, and offers recommendations on maximizing access to and effectiveness of antimalarial drugs. The book finds that most people in endemic countries will not have access to currently effective combination treatments, which should include an artemisinin, without financing from the global community. Without funding for effective treatment, malaria mortality could double over the next 10 to 20 years and transmission will intensify.

Author : WHO Scientific Group on the Chemotherapy of Malaria and Resistance to Antimalarials
Publisher : Unknown
Page : 121 pages
File Size : 46,5 Mb
Release : 1973
Category : Antimalarials
ISBN : 0119505940

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Chemotherapy of Malaria and Resistance to Antimalarials by WHO Scientific Group on the Chemotherapy of Malaria and Resistance to Antimalarials Pdf

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice
Publisher : National Academies Press
Page : 427 pages
File Size : 49,5 Mb
Release : 2020-04-24
Category : Medical
ISBN : 9780309672108

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Assessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice Pdf

Among the many who serve in the United States Armed Forces and who are deployed to distant locations around the world, myriad health threats are encountered. In addition to those associated with the disruption of their home life and potential for combat, they may face distinctive disease threats that are specific to the locations to which they are deployed. U.S. forces have been deployed many times over the years to areas in which malaria is endemic, including in parts of Afghanistan and Iraq. Department of Defense (DoD) policy requires that antimalarial drugs be issued and regimens adhered to for deployments to malaria-endemic areas. Policies directing which should be used as first and as second-line agents have evolved over time based on new data regarding adverse events or precautions for specific underlying health conditions, areas of deployment, and other operational factors At the request of the Veterans Administration, Assessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis assesses the scientific evidence regarding the potential for long-term health effects resulting from the use of antimalarial drugs that were approved by FDA or used by U.S. service members for malaria prophylaxis, with a focus on mefloquine, tafenoquine, and other antimalarial drugs that have been used by DoD in the past 25 years. This report offers conclusions based on available evidence regarding associations of persistent or latent adverse events.

Author : Wallace Peters
Publisher : Springer
Page : 491 pages
File Size : 47,6 Mb
Release : 2013-11-09
Category : Medical
ISBN : 9783662353264

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Antimalarial Drugs I by Wallace Peters Pdf

Author : Graham L. Patrick
Publisher : Elsevier
Page : 624 pages
File Size : 42,7 Mb
Release : 2020-05-30
Category : Science
ISBN : 9780081012413

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Antimalarial Agents by Graham L. Patrick Pdf

Antimalarial Agents: Design and Mechanism of Action seeks to support medicinal chemists in their work toward antimalarial solutions, providing practical guidance on past and current developments and highlighting promising leads for the future. Malaria is a deadly disease which threatens half of the world’s population. Advances over several decades have seen vast improvements in the eff ectiveness of both preventative measures and treatments, but the rapid adaptability of the disease means that the ongoing search for improved and novel antimalarial drugs is essential. Beginning with a historical overview of malaria and antimalarial research, this book goes on to describe the biological aspects of malaria, highlighting the lifecycle of the parasite responsible for malaria, the problem of resistance, genetic mapping of the parasite’s genome, established drug targets, and potential drug targets for the future. This sets the scene for the following chapters which provide a detailed study of the medicinal chemistry of antimalarial agents, with a focus on the design of antimalarial drugs. Drawing on the knowledge of its experienced authors, and coupling historic research with current fi ndings to provide a full picture of both past and current milestones, Antimalarial Agents: Design and Mechanism of Action is a comprehensive yet accessible guide for all those involved in the design, development, and administration of antimalarial drugs, including student academic researchers, medicinal chemists, malaria researchers, and pharmaceutical scientists. Consolidates both past and current developments in the discovery and design of antimalarial drugs Presents content in a style that is both thorough and engaging, providing a supportive and guiding reference to students and researchers from interdisciplinary backgrounds Highlights drug targets currently considered to be the most promising for future therapies, and the classes of compounds that are currently being studied and perfected