Antimalarial Drugs I

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Assessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis

National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice
Assessment of Long Term Health Effects of Antimalarial Drugs When Used for Prophylaxis Book PDF

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice
Publisher : National Academies Press
Page : 427 pages
File Size : 54,5 Mb
Release : 2020-04-24
Category : Medical
ISBN : 9780309672108

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Assessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice Pdf

Among the many who serve in the United States Armed Forces and who are deployed to distant locations around the world, myriad health threats are encountered. In addition to those associated with the disruption of their home life and potential for combat, they may face distinctive disease threats that are specific to the locations to which they are deployed. U.S. forces have been deployed many times over the years to areas in which malaria is endemic, including in parts of Afghanistan and Iraq. Department of Defense (DoD) policy requires that antimalarial drugs be issued and regimens adhered to for deployments to malaria-endemic areas. Policies directing which should be used as first and as second-line agents have evolved over time based on new data regarding adverse events or precautions for specific underlying health conditions, areas of deployment, and other operational factors At the request of the Veterans Administration, Assessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis assesses the scientific evidence regarding the potential for long-term health effects resulting from the use of antimalarial drugs that were approved by FDA or used by U.S. service members for malaria prophylaxis, with a focus on mefloquine, tafenoquine, and other antimalarial drugs that have been used by DoD in the past 25 years. This report offers conclusions based on available evidence regarding associations of persistent or latent adverse events.

Saving Lives, Buying Time

Institute of Medicine,Board on Global Health,Committee on the Economics of Antimalarial Drugs
Saving Lives Buying Time Book PDF

Author : Institute of Medicine,Board on Global Health,Committee on the Economics of Antimalarial Drugs
Publisher : National Academies Press
Page : 384 pages
File Size : 45,7 Mb
Release : 2004-09-09
Category : Medical
ISBN : 9780309165938

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Saving Lives, Buying Time by Institute of Medicine,Board on Global Health,Committee on the Economics of Antimalarial Drugs Pdf

For more than 50 years, low-cost antimalarial drugs silently saved millions of lives and cured billions of debilitating infections. Today, however, these drugs no longer work against the deadliest form of malaria that exists throughout the world. Malaria deaths in sub-Saharan Africaâ€"currently just over one million per yearâ€"are rising because of increased resistance to the old, inexpensive drugs. Although effective new drugs called "artemisinins" are available, they are unaffordable for the majority of the affected population, even at a cost of one dollar per course. Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance examines the history of malaria treatments, provides an overview of the current drug crisis, and offers recommendations on maximizing access to and effectiveness of antimalarial drugs. The book finds that most people in endemic countries will not have access to currently effective combination treatments, which should include an artemisinin, without financing from the global community. Without funding for effective treatment, malaria mortality could double over the next 10 to 20 years and transmission will intensify.

CDC Yellow Book 2018: Health Information for International Travel

Centers for Disease Control and Prevention CDC
CDC Yellow Book 2018 Health Information for International Travel Book PDF

Author : Centers for Disease Control and Prevention CDC
Publisher : Oxford University Press
Page : 672 pages
File Size : 49,5 Mb
Release : 2017-04-17
Category : Medical
ISBN : 9780190628635

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CDC Yellow Book 2018: Health Information for International Travel by Centers for Disease Control and Prevention CDC Pdf

THE ESSENTIAL WORK IN TRAVEL MEDICINE -- NOW COMPLETELY UPDATED FOR 2018 As unprecedented numbers of travelers cross international borders each day, the need for up-to-date, practical information about the health challenges posed by travel has never been greater. For both international travelers and the health professionals who care for them, the CDC Yellow Book 2018: Health Information for International Travel is the definitive guide to staying safe and healthy anywhere in the world. The fully revised and updated 2018 edition codifies the U.S. government's most current health guidelines and information for international travelers, including pretravel vaccine recommendations, destination-specific health advice, and easy-to-reference maps, tables, and charts. The 2018 Yellow Book also addresses the needs of specific types of travelers, with dedicated sections on: · Precautions for pregnant travelers, immunocompromised travelers, and travelers with disabilities · Special considerations for newly arrived adoptees, immigrants, and refugees · Practical tips for last-minute or resource-limited travelers · Advice for air crews, humanitarian workers, missionaries, and others who provide care and support overseas Authored by a team of the world's most esteemed travel medicine experts, the Yellow Book is an essential resource for travelers -- and the clinicians overseeing their care -- at home and abroad.

Treatment and Prevention of Malaria

Henry M. Staines,Sanjeev Krishna
Treatment and Prevention of Malaria Book PDF

Author : Henry M. Staines,Sanjeev Krishna
Publisher : Springer Science & Business Media
Page : 318 pages
File Size : 55,8 Mb
Release : 2012-01-06
Category : Medical
ISBN : 9783034604796

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Treatment and Prevention of Malaria by Henry M. Staines,Sanjeev Krishna Pdf

Malaria has defeated previous efforts at eradication and remains a massive global public health problem despite being readily preventable and treatable. It is a devastating disease that also extracts huge economic costs from the poorest countries in endemic regions. Starting with an overview of the disease and its current political, financial and technical context, this Milestones in Drug Therapy volume describes the history, chemistry, mechanisms of action and resistance, preclinical and clinical use, pharmacokinetics and safety and tolerability of the current range of antimalarial drugs. There is particular emphasis on artemisinins and related peroxides, as these drugs have now become the frontline treatment for malaria. Next generation antimalarials, molecular markers for detecting resistance, the importance of diagnostics and disease prevention are also covered in detail.

Malaria Control During Mass Population Movements and Natural Disasters

Program on Forced Migration and Health at the Mailman School of Public Health of Columbia University,National Research Council,Committee on Population,Roundtable on the Demography of Forced Migration,Holly A. Williams,Peter B. Bloland
Malaria Control During Mass Population Movements and Natural Disasters Book PDF

Author : Program on Forced Migration and Health at the Mailman School of Public Health of Columbia University,National Research Council,Committee on Population,Roundtable on the Demography of Forced Migration,Holly A. Williams,Peter B. Bloland
Publisher : National Academies Press
Page : 181 pages
File Size : 55,7 Mb
Release : 2003-01-16
Category : Medical
ISBN : 9780309086158

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Malaria Control During Mass Population Movements and Natural Disasters by Program on Forced Migration and Health at the Mailman School of Public Health of Columbia University,National Research Council,Committee on Population,Roundtable on the Demography of Forced Migration,Holly A. Williams,Peter B. Bloland Pdf

Admittedly, the world and the nature of forced migration have changed a great deal over the last two decades. The relevance of data accumulated during that time period can now be called into question. The roundtable and the Program on Forced Migration at the Mailman School of Public Health of Columbia University have commissioned a series of epidemiological reviews on priority public health problems for forced migrants that will update the state of knowledge. Malaria Control During Mass Population Movements and Natural Disasters- the first in the series, provides a basic overview of the state of knowledge of epidemiology of malaria and public health interventions and practices for controlling the disease in situations involving forced migration and conflict.

Antimalarial Agents

Graham L. Patrick
Antimalarial Agents Book PDF

Author : Graham L. Patrick
Publisher : Elsevier
Page : 624 pages
File Size : 53,5 Mb
Release : 2020-05-30
Category : Science
ISBN : 9780081012413

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Antimalarial Agents by Graham L. Patrick Pdf

Antimalarial Agents: Design and Mechanism of Action seeks to support medicinal chemists in their work toward antimalarial solutions, providing practical guidance on past and current developments and highlighting promising leads for the future. Malaria is a deadly disease which threatens half of the world’s population. Advances over several decades have seen vast improvements in the eff ectiveness of both preventative measures and treatments, but the rapid adaptability of the disease means that the ongoing search for improved and novel antimalarial drugs is essential. Beginning with a historical overview of malaria and antimalarial research, this book goes on to describe the biological aspects of malaria, highlighting the lifecycle of the parasite responsible for malaria, the problem of resistance, genetic mapping of the parasite’s genome, established drug targets, and potential drug targets for the future. This sets the scene for the following chapters which provide a detailed study of the medicinal chemistry of antimalarial agents, with a focus on the design of antimalarial drugs. Drawing on the knowledge of its experienced authors, and coupling historic research with current fi ndings to provide a full picture of both past and current milestones, Antimalarial Agents: Design and Mechanism of Action is a comprehensive yet accessible guide for all those involved in the design, development, and administration of antimalarial drugs, including student academic researchers, medicinal chemists, malaria researchers, and pharmaceutical scientists. Consolidates both past and current developments in the discovery and design of antimalarial drugs Presents content in a style that is both thorough and engaging, providing a supportive and guiding reference to students and researchers from interdisciplinary backgrounds Highlights drug targets currently considered to be the most promising for future therapies, and the classes of compounds that are currently being studied and perfected

Hepatotoxicity

Hyman J. Zimmerman
Hepatotoxicity Book PDF

Author : Hyman J. Zimmerman
Publisher : Lippincott Williams & Wilkins
Page : 848 pages
File Size : 43,8 Mb
Release : 1999
Category : Medical
ISBN : 0781719526

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Hepatotoxicity by Hyman J. Zimmerman Pdf

Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

Malaria

Institute of Medicine,Division of International Health,Committee for the Study on Malaria Prevention and Control
Malaria Book PDF

Author : Institute of Medicine,Division of International Health,Committee for the Study on Malaria Prevention and Control
Publisher : National Academies Press
Page : 312 pages
File Size : 44,5 Mb
Release : 1991-02-01
Category : Medical
ISBN : 0309045274

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Malaria by Institute of Medicine,Division of International Health,Committee for the Study on Malaria Prevention and Control Pdf

Malaria is making a dramatic comeback in the world. The disease is the foremost health challenge in Africa south of the Sahara, and people traveling to malarious areas are at increased risk of malaria-related sickness and death. This book examines the prospects for bringing malaria under control, with specific recommendations for U.S. policy, directions for research and program funding, and appropriate roles for federal and international agencies and the medical and public health communities. The volume reports on the current status of malaria research, prevention, and control efforts worldwide. The authors present study results and commentary on the: Nature, clinical manifestations, diagnosis, and epidemiology of malaria. Biology of the malaria parasite and its vector. Prospects for developing malaria vaccines and improved treatments. Economic, social, and behavioral factors in malaria control.

CDC Yellow Book 2020

CENTERS FOR DISEASE CONTROL AND PREVENTION. (CDC)
CDC Yellow Book 2020 Book PDF

Author : CENTERS FOR DISEASE CONTROL AND PREVENTION. (CDC)
Publisher : Oxford University Press, USA
Page : 721 pages
File Size : 53,8 Mb
Release : 2019-06-11
Category : Medical
ISBN : 9780190065973

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CDC Yellow Book 2020 by CENTERS FOR DISEASE CONTROL AND PREVENTION. (CDC) Pdf

The definitive reference for travel medicine, updated for 2020! "A beloved travel must-have for the intrepid wanderer." -Publishers Weekly "A truly excellent and comprehensive resource." -Journal of Hospital Infection The CDC Yellow Book offers everything travelers and healthcare providers need to know for safe and healthy travel abroad. This 2020 edition includes: · Country-specific risk guidelines for yellow fever and malaria, including expert recommendations and 26 detailed, country-level maps · Detailed maps showing distribution of travel-related illnesses, including dengue, Japanese encephalitis, meningococcal meningitis, and schistosomiasis · Guidelines for self-treating common travel conditions, including altitude illness, jet lag, motion sickness, and travelers' diarrhea · Expert guidance on food and drink precautions to avoid illness, plus water-disinfection techniques for travel to remote destinations · Specialized guidelines for non-leisure travelers, study abroad, work-related travel, and travel to mass gatherings · Advice on medical tourism, complementary and integrative health approaches, and counterfeit drugs · Updated guidance for pre-travel consultations · Advice for obtaining healthcare abroad, including guidance on different types of travel insurance · Health insights around 15 popular tourist destinations and itineraries · Recommendations for traveling with infants and children · Advising travelers with specific needs, including those with chronic medical conditions or weakened immune systems, health care workers, humanitarian aid workers, long-term travelers and expatriates, and last-minute travelers · Considerations for newly arrived adoptees, immigrants, and refugees Long the most trusted book of its kind, the CDC Yellow Book is an essential resource in an ever-changing field -- and an ever-changing world.

Antimalarial Chemotherapy

Philip J. Rosenthal
Antimalarial Chemotherapy Book PDF

Author : Philip J. Rosenthal
Publisher : Springer Science & Business Media
Page : 393 pages
File Size : 43,9 Mb
Release : 2001-04-01
Category : Medical
ISBN : 9781592591114

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Antimalarial Chemotherapy by Philip J. Rosenthal Pdf

Philip Rosenthal, MD, and a panel of leading malaria experts drawn from academia, the military, and international health organizations survey the latest scientific understanding of antimalarial chemotherapy, emphasizing the molecular mechanisms of resistance and the description of important new targets. Their survey covers the current status of malarial and antimalarial chemotherapy, the relevant biology and biochemistry of malaria parasites, the antimalarial drugs currently available, new chemical approaches to chemotherapy, and possible new targets for chemotherapy. Comprehensive and cutting-edge, Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery clearly delineates all the basic and clinical research now addressing one of the world's major unresolved disease problems, work that is now powerfully driving the rapid pace of antimalarial drug discovery today.

Artemisinin-Based and Other Antimalarials

Guoqiao Li,Ying Li,Zelin Li,Meiyi Zeng
Artemisinin Based and Other Antimalarials Book PDF

Author : Guoqiao Li,Ying Li,Zelin Li,Meiyi Zeng
Publisher : Academic Press
Page : 736 pages
File Size : 53,9 Mb
Release : 2017-11-28
Category : Medical
ISBN : 9780128132111

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Artemisinin-Based and Other Antimalarials by Guoqiao Li,Ying Li,Zelin Li,Meiyi Zeng Pdf

Artemisinin-Based and Other Antimalarials: Detailed Account of Studies by Chinese Scientists Who Discovered and Developed Them provides a historical and scientific background of the discovery and development of artemisinin, artemisinin derivatives, combination drugs and related chemicals. It is a historical document, a scientific treatise, and a fascinating description of innovative research on new drug development that is carried out under extremely difficult conditions. The book also includes detailed experiments, physical-chemical procedures, practical methodologies and clinical trials. It is a valuable reference for students and researchers in the fields of scientific history, medicine, pharmaceutical science, chemistry, pharmacology and toxicology. Presents details of all stages of drug development, including in vitro experiment, animal exploratory studies, animal tests for toxicity, safety and efficacy followed by stages I, II, III and IV, safety and efficacy in human volunteers and patients with malaria Provides many physical-chemical laboratory procedures, such as NMR, MS, HPLC and X-ray diffraction used in drug development Includes practical methodology of clinical trials from many research centers and countries to demonstrate the importance of this discovery

Antimalarial Drugs

Qigui Li
Antimalarial Drugs Book PDF

Author : Qigui Li
Publisher : Nova Science Publishers
Page : 0 pages
File Size : 50,5 Mb
Release : 2013-12
Category : Artemisinin
ISBN : 1629480134

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Antimalarial Drugs by Qigui Li Pdf

Anti-malarial drugs are medicines that prevent or treat malaria, a disease which takes a great toll on human health and well-being, particularly in tropical regions including Africa south of the Sahara, South and Southeast Asia, Oceania, and parts of the Americas. In recent years, strains of Plasmodium have become increasingly resistant to more anti-malarial drugs and researchers have stepped up efforts to revise anti-malarial drug policies and develop new anti-malarial strategies. Resistance has arisen to all classes of antimalarials (chloroquine, amodiaquine, mefloquine and sulfadoxine-pyrimethamine) except, as yet, definitively to the artemisinin derivatives. In order to prevent widespread resistance, the concept of anti-malarial combination therapy (CT) has been employed and a global resistance surveillance system (World Anti-malarial Resistance Networks) has been established. This book explores the use of these drugs in current health care.

Guidelines for the Treatment of Malaria. Third Edition

World Health Organization
Guidelines for the Treatment of Malaria Third Edition Book PDF

Author : World Health Organization
Publisher : World Health Organization
Page : 317 pages
File Size : 52,7 Mb
Release : 2015-08-13
Category : Medical
ISBN : 9789241549127

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Guidelines for the Treatment of Malaria. Third Edition by World Health Organization Pdf

Malaria remains an important cause of illness and death in children and adults in countries in which it is endemic. Malaria control requires an integrated approach including prevention (primarily vector control) and prompt treatment with effective antimalarial agents. Malaria case management consisting of prompt diagnosis and effective treatment remains a vital component of malaria control and elimination strategies. Since the publication of the first edition of the Guidelines for the treatment of malaria in 2006 and the second edition in 2010 all countries in which P. falciparum malaria is endemic have progressively updated their treatment policy from use of ineffective monotherapy to the currently recommended artemisinin-based combination therapies (ACT). This has contributed substantially to current reductions in global morbidity and mortality from malaria. Unfortunately resistance to artemisinins has arisen recently in P. falciparum in South-East Asia which threatens these gains. This third edition of the WHO Guidelines for the treatment of malaria contains updated recommendations based on a firmer evidence base for most antimalarial drugs and in addition include recommendation on the use of drugs to prevent malaria in groups at high risk. The Guidelines provide a framework for designing specific detailed national treatment protocols taking into account local patterns of resistance to antimalarial drugs and health service capacity. It provides recommendations on treatment of uncomplicated and severe malaria in all age groups all endemic areas in special populations and several complex situations. In addition on the use of antimalarial drugs as preventive therapy in healthy people living in malaria-endemic areas who are high risk in order to reduce morbidity and mortality from malaria. The Guidelines are designed primarily for policy-makers in ministries of health who formulate country-specific treatment guidelines. Other groups that may find them useful include health professionals and public health and policy specialists that are partners in health or malaria control and the pharmaceutical industry. The treatment recommendations in the main document are brief; for those who wish to study the evidence base in more detail a series of annexes is provided with references to the appropriate sections of the main document.

Malaria: Drugs, Disease and Post-genomic Biology

David Sullivan,Sanjeev Krishna
Malaria Drugs Disease and Post genomic Biology Book PDF

Author : David Sullivan,Sanjeev Krishna
Publisher : Springer Science & Business Media
Page : 447 pages
File Size : 49,7 Mb
Release : 2006-01-09
Category : Medical
ISBN : 9783540290889

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Malaria: Drugs, Disease and Post-genomic Biology by David Sullivan,Sanjeev Krishna Pdf

Despite rapid increases in knowledge, malaria continues to kill more than a million people each year and causes symptomatic disease in a further 300 million individuals. This volume brings some of the world's best investigators to describe recent advances in both the scientific and clinical aspects of malaria, and bridges between the two.

World malaria report 2017

World Health Organization
World malaria report 2017 Book PDF

Author : World Health Organization
Publisher : World Health Organization
Page : 0 pages
File Size : 46,9 Mb
Release : 2018-02-12
Category : Medical
ISBN : 9241565527

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World malaria report 2017 by World Health Organization Pdf

The World Malaria Report 2017 presents a comprehensive state of play in global progress in the fight against malaria up to the end of 2016. It tracks progress in investments in malaria programs and research, malaria prevention, diagnosis and treatment, surveillance, trends in malaria disease burden, malaria elimination, and threats in tackling malaria and safeguarding the investments made. The report draws on data from 91 countries and areas with ongoing malaria transmission. The information is supplemented by data from national household surveys and databases held by other organizations. This year's report shows that after an unprecedented period of success in global malaria control, progress has stalled. In 2016, there were an estimated 216 million cases of malaria, an increase of about 5 million cases over 2015. Deaths reached 445,000, a similar number to the previous year.