Apoptosis And Autoimmunity

Author : Joachim R. Kalden,Martin Herrmann
Publisher : John Wiley & Sons
Page : 392 pages
File Size : 52,9 Mb
Release : 2006-03-06
Category : Medical
ISBN : 9783527605293

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Apoptosis and Autoimmunity by Joachim R. Kalden,Martin Herrmann Pdf

This is the first comprehensive book about the relationship between apoptosis and autoimmune diseases. It offers a unique up-to-date overview on research results on the defective execution of apoptosis and the incomplete clearance of apoptotic cells. The molecular and cellular mechanisms involved are described in detail. As a possible consequence of apoptotic dysfunction, the development of severe autoimmune diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus) is discussed. An outlook on future research topics includes the evaluation of novel therapeutic strategies.

Author : Keith B. Elkon
Publisher : Karger Medical and Scientific Publishers
Page : 219 pages
File Size : 50,7 Mb
Release : 2006
Category : Science
ISBN : 9783805580366

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Apoptosis and Its Relevance to Autoimmunity by Keith B. Elkon Pdf

This volume highlights the recent advances in the basic mechanisms of apoptosis and the application of that knowledge to understanding the impact of defective apoptosis or defective clearance of apoptotic cells on the immune function and the expression of

Author : Dr. Martin Herrmann,Joachim Robert Kalden
Publisher : Wiley-VCH Verlag GmbH
Page : 381 pages
File Size : 53,7 Mb
Release : 2003
Category : Medical
ISBN : 3527304428

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Apoptosis and Autoimmunity by Dr. Martin Herrmann,Joachim Robert Kalden Pdf

This is the first comprehensive book about the relationship between apoptosis and autoimmune diseases. It offers a unique up–to–date overview on research results on the defective execution of apoptosis and the incomplete clearance of apoptotic cells. The molecular and cellular mechanisms involved are described in detail. As a possible consequence of apoptotic dysfunction, the development of severe autoimmune diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus) is discussed. An outlook on future research topics includes the evaluation of novel therapeutic strategies.

Author : Katerina Chatzidionysiou
Publisher : BoD – Books on Demand
Page : 212 pages
File Size : 46,7 Mb
Release : 2015-06-17
Category : Medical
ISBN : 9789535121343

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Autoimmunity by Katerina Chatzidionysiou Pdf

Autoimmunity is defined as an immune response against a self-antigen. This abnormal immune response can lead to tissue damage and to the development of autoimmune disease. From organ-specific autoimmune diseases, such as myasthenia gravis, to non-organ-specific, such as systemic lupus erythematosus, autoimmune diseases represent a heterogeneous group of disorders which affect approximately 6% of the population. The pathogenesis of many autoimmune diseases is complex and remains not completely understood. The aim of this book is to present current knowledge regarding pathogenic mechanisms of autoimmune diseases, clinical aspects of specific autoimmune diseases, like vitiligo, celiac disease and autoimmune liver disease, as well as insights regarding specific therapies.

Author : Moncef Zouali
Publisher : IOS Press
Page : 378 pages
File Size : 49,8 Mb
Release : 2003
Category : Autoimmune diseases
ISBN : 1586033611

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Frontiers in Autoimmunity by Moncef Zouali Pdf

Author : Andrzej Górski,Hubert Krotkiewski,Michal Zimecki
Publisher : Springer Science & Business Media
Page : 209 pages
File Size : 51,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401009812

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Autoimmunity by Andrzej Górski,Hubert Krotkiewski,Michal Zimecki Pdf

This book presents an excellent review of the mechanisms underlying the phenomena of autoimmunity. It provides not only an update of the field's state of the art, but also presents new concepts in the fundamentals and treatment of autoimmune disorders. The finest example of the new approach is understanding the nature of autoimmunity and the treatment of autoimmune diseases is the introductory article. The author opposes the current dogma that autoimmune disorders should be treated with immunosuppressors, and postulates rather the activation of the immune system, which may lead to redirecting the immune response to the protective, Th-2 type of immunity. A series of articles deals with several aspects of the subject, such as the generation, progression, and regulation of autoimmune phenomena. The roles of pathogens, apoptosis, cytokines, complement components, and regulatory T cells are described, as well as the association between the immune and neurohormonal systems in major autoimmune disorders. This is not a textbook, but it is highly recommended for clinicians and university workers, and as supplementary reading for lecturers and students.

Author : Estee Kurant,Amiram Ariel,Kirsten Lauber
Publisher : Frontiers Media SA
Page : 294 pages
File Size : 53,5 Mb
Release : 2018-12-27
Category : Electronic
ISBN : 9782889456888

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Apoptotic Cell Clearance in Health and Disease by Estee Kurant,Amiram Ariel,Kirsten Lauber Pdf

Clearance of apoptotic cells is essential for proper development, homeostasis and termination of immune responses in multicellular organisms. Thus, cellular and molecular players taking part in the sequential events of this process are of great interest. Research in the last 20 years has indicated that specific ligands and receptors take part in the attraction of immune cells toward apoptotic targets and in the interactions between apoptotic cells and professional as well as non-professional phagocytes that engulf them. Moreover, phagocytosis of apoptotic cells (efferocytosis) leads to significant phenotypic changes in the engulfing cells suggesting that it is a major fate-determining event for phagocytes. Particularly, efferocytosis has an important impact on the inflammation-resolution axis as well as embryonic development and tissue morphogenesis. Deficiencies in these processes can result in health threats, such as autoimmunity, atherosclerosis, bone loss, obesity, infertility, neurodegeneration, fibrosis and cancer. This eBook brings together 24 original research and review manuscripts that cover various aspects of apoptotic cell removal during normal development and homeostasis as well as in tumorigenesis and regenerative processes following injury.

Author : Vijay K. Kuchroo,Nora Sarvetnick,David A. Hafler,Lindsay B. Nicholson
Publisher : Springer Science & Business Media
Page : 421 pages
File Size : 41,8 Mb
Release : 2001-11-09
Category : Medical
ISBN : 9781592591299

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Cytokines and Autoimmune Diseases by Vijay K. Kuchroo,Nora Sarvetnick,David A. Hafler,Lindsay B. Nicholson Pdf

Leading researchers synthesize scattered experimental data to help develop an intimate understanding of how cytokines and chemokines are involved in the pathogenesis of autoimmune diseases. The many chapters offer critical reviews the basic mechanisms controlling cytokine induction and regulation, as well as the resulting production of proinflammatory and anti-inflammatory cytokines, the former of which induces organ-specific autoimmune diseases. From the vantage of these insights, they address the role of cytokines in a wide variety of autoimmune diseases, uvetis, encephalomyelitis, multiple sclerosis, human type 1 diabetes, rheumatoid arthritis, SLE, and myasthenia gravis. Authoritative and state-of-the-art, Cytokines and Autoimmune Disease highlights the enormous therapeutic potential of cytokine modulation in the treatment of autoimmune disease.

Author : Kenneth Michael Pollard
Publisher : John Wiley & Sons
Page : 633 pages
File Size : 48,8 Mb
Release : 2006-05-12
Category : Medical
ISBN : 9783527607228

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Autoantibodies and Autoimmunity by Kenneth Michael Pollard Pdf

This is the first book to address all aspects of the biology of autoantibodies in a single volume, including a discussion of immunology, experimental models, clinical aspects, and the use of autoantibodies as probes in molecular and cellular biology. The editor, currently professor at the W.M. Keck Autoimmune Disease Center of The Scripps Research Institute, has assembled an all-star team of authors to report on the latest research, technologies, and applications. Following an introductory chapter, the book goes on to cover such topics as cellular mechanisms of autoantibody production, clinical and diagnostic usefulness in human disease, and animal models used to study the elicitation of autoantibodies. The whole is rounded off with a look at future perspectives. With its comprehensive coverage, this volume will appeal not only to immunologists and clinicians but also to cell and molecular biologists.

Author : Xu-jie Zhou,Panayotis Verginis,Jennifer Martinez,Marko Radic
Publisher : Frontiers Media SA
Page : 161 pages
File Size : 50,8 Mb
Release : 2019-05-15
Category : Electronic
ISBN : 9782889458127

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Autophagy in Autoimmunity by Xu-jie Zhou,Panayotis Verginis,Jennifer Martinez,Marko Radic Pdf

Author : Argyrios N Theofilopoulos,Constantin A. Bona
Publisher : CRC Press
Page : 1518 pages
File Size : 52,5 Mb
Release : 2002-12-06
Category : Science
ISBN : 9057026457

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The Molecular Pathology of Autoimmune Diseases by Argyrios N Theofilopoulos,Constantin A. Bona Pdf

Remarkable advances have been made in the pathogenesis of autoimmunity, such as with bone marrow transplantation, which is becoming a powerful strategy in treating certain life-threatening diseases. The Molecular Pathology of Autoimmune Diseases is a concise and centralized resource for information on the topic, with a special focus on the molecular and genetic basis of these disorders. Dozens of international experts devote themselves to illuminating the reader in this volume, with discussions on the basic aspects of autoimmune processes to systemic and organ-specific diseases. This volume is an invaluable reference to students and professionals in immunology and related fields.

Author : David Ahmad Nemazee
Publisher : Karger Medical and Scientific Publishers
Page : 281 pages
File Size : 55,5 Mb
Release : 2003
Category : Medical
ISBN : 9783805574549

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B Cell Biology in Autoimmunity by David Ahmad Nemazee Pdf

B cells play a central role not only in adaptive immunity, but also in autoimmunity. To understand how B cells are normally prevented from reacting to self-tissue, what goes wrong in autoimmunity, and how B cells contribute to it is the aim of this book. This volume includes more than a dozen in-depth reviews by researchers specializing in various aspects of basic B cell biology that have relevance to autoimmune diseases. These up-to-date chapters present the latest information on B cell signal transduction, apoptosis, genetics and molecular biology. Also featured are chapters with special reference to particular autoimmune diseases in which B cells have been shown to play a critical role, such as type 1 diabetes, chronic graft-versus-host disease and lupus erythematosus. Further topics covered include the role of the complement system, rheumatoid factors, and anti-DNA autoantibodies as well as important related areas such as natural autoantibodies, B cell immune tolerance, Toll receptor signaling, and the immunobiology of BAFF/BLyS. Both basic researchers and clinician scientists who wish to understand the role of B lymphocytes in immune tolerance and autoimmunity will benefit from this timely publication.

Author : Amnon Altman
Publisher : Karger Medical and Scientific Publishers
Page : 206 pages
File Size : 44,9 Mb
Release : 2002
Category : Medical
ISBN : 9783805573085

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Signal Transduction Pathways in Autoimmunity by Amnon Altman Pdf

The chapters included in this volume represent but a few examples of the close link between aberrant signaling pathways and autoimmune diseases. They cover a variety of cells (T, B and myeloid/monocytic cells), receptors (for antigen, Fc and cytokines) and intracellular signaling molecules (kinases, phosphatases, adapters and transcription factors) in the immune system. This book brings together clinical and experimental aspects of autoimmune disease and the fundamental science of intracellular signaling pathways. Therefore, it should be of interest to clinical investigators of autoimmune diseases as wll as to basic immunologists and cell biologists interested in the molecular basis of signal transduction in the immune system.

Author : Christopher D. Gregory
Publisher : Wiley-Liss
Page : 440 pages
File Size : 50,7 Mb
Release : 1995-03-02
Category : Medical
ISBN : UOM:39015034018450

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Apoptosis and the Immune System by Christopher D. Gregory Pdf

By offering a broad range of views, Apoptosis and the Immune Response presents a current and complete picture of the various aspects and consequences of this phenomenon.

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 51,9 Mb
Release : 2024-06-02
Category : Electronic
ISBN : 9789814468114

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The Quantal Theory of Immunity by Anonim Pdf