Applying Pharmacogenomics In Therapeutics

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Applying Pharmacogenomics in Therapeutics

Xiaodong Feng,Hong-Guang Xie
Applying Pharmacogenomics in Therapeutics Book PDF

Author : Xiaodong Feng,Hong-Guang Xie
Publisher : CRC Press
Page : 308 pages
File Size : 45,6 Mb
Release : 2016-01-06
Category : Medical
ISBN : 9781466582682

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Applying Pharmacogenomics in Therapeutics by Xiaodong Feng,Hong-Guang Xie Pdf

Recent advances in high-throughput gene sequencing and other omics biotechnologies have served as a springboard for the field of pharmacogenomics. Pharmacogenomics is now generally accepted as the major determinant of variable drug safety, efficacy, and cost-effectiveness. Therefore, widespread use of pharmacogenomics for patient care has become a critical requirement. There is an unprecedented urgency for aspiring and practicing clinicians to become trained on how to interpret data from pharmacogenomic testing in preparation for the future of healthcare—i.e., personalized medicine. Applying Pharmacogenomics in Therapeutics provides timely coverage of the principles, practice, and potential of pharmacogenomics and personalized medicine. Comprised of chapters contributed by well-established pharmacologists and scientists from US and Chinese academia and industry, this authoritative text: Demonstrates how to apply the principles of pharmacogenomics and its biotechnologies in patient care Depicts the use of genetic biomarkers in drug discovery and development, laboratory medicine, and clinical services Describes the practice of pharmacogenomics in the treatment of cancers, cardiovascular diseases, neurologic and psychiatric disorders, and pulmonary diseases Discusses the merging of pharmacogenomics and alternative medicine, as well as the integration of pharmacogenomics into pharmacoeconomics Each chapter begins with the key concepts, followed by in-depth explorations of case reports or critical evaluations of genetic variants/biomarkers, and concludes with questions for self-examination.

Pharmacogenomics

Yui-Wing Francis Lam,Larisa H. Cavallari
Pharmacogenomics Book PDF

Author : Yui-Wing Francis Lam,Larisa H. Cavallari
Publisher : Academic Press
Page : 515 pages
File Size : 51,8 Mb
Release : 2013-02-12
Category : Science
ISBN : 9780123983039

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Pharmacogenomics by Yui-Wing Francis Lam,Larisa H. Cavallari Pdf

Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation includes discussions and viewpoints from the academic, regulatory, pharmaceutical, clinical, socio-ethical and economic perspectives. Each chapter presents an overview of the potential or opportunity within the areas discussed and also outlines foreseeable challenges and limitations in moving pharmacogenomics into drug development and direct therapeutic applications. This edited book contains review questions for a more in-depth analysis of the implications of pharmacogenomics and discussion points to generate ideas on best to move the field forward. Clinical pearls and case studies are used to illustrate real-life experiences and both successful and unsuccessful applications. Tables, figures, and annotations are included throughout the book to facilitate understanding and further reference. Multi-contributed book and chapters are written by contributors who are experts in their field Provides perspectives from those involved in all aspects of pharmacogenomics—including academic, regulatory, economic, industry and medical—to illustrate how all of the pieces fit together and where the challenges may be Includes case studies of both successful and unsuccessful applications so readers can consider the potential and challenges in moving the science into drug development and direct therapeutic applications Chapters contain discussion questions and clinical pearls and enable readers to reflect on how to move pharmacogenomics forward and apply these observations and useful tips to their own work and research

Pharmacogenomics in Clinical Therapeutics

Loralie J. Langman,Amitava Dasgupta
Pharmacogenomics in Clinical Therapeutics Book PDF

Author : Loralie J. Langman,Amitava Dasgupta
Publisher : John Wiley & Sons
Page : 400 pages
File Size : 44,5 Mb
Release : 2012-01-09
Category : Medical
ISBN : 9781119959588

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Pharmacogenomics in Clinical Therapeutics by Loralie J. Langman,Amitava Dasgupta Pdf

Pharmacogenomics is the basis of personalized medicine which will be the medicine of the future. Through both reducing the numbers of adverse drug reactions and improving the use of existing drugs in targeted populations, pharmacogenomics represents a real advance on traditional therapeutic drug monitoring. Pharmacogenomics in Clinical Therapeutics provides an introduction to the principles of pharmacogenomics before addressing the pharmacogenomic aspects of key therapeutic areas such as warfarin therapy, cancer chemotherapy, therapy with immunosuppressants, antiretroviral therapy, and psychoactive drugs. It also includes methods of pharmacogenomic testing and the pharmacogenomic aspects of drug–drug interactions. From a team of expert contributors, Pharmacogenomics in Clinical Therapeutics is a comprehensive overview of the current state of pharmacogenomics in pharmacotherapy for all clinicians, pharmacologists and clinical laboratory professionals. It is also a guide for practicing clinicians and health care professionals to the basic principles of pharmacogenomics, laboratory tests currently available to aid clinicians, and the future promise of this developing field.

Textbook of Personalized Medicine

Kewal K. Jain
Textbook of Personalized Medicine Book PDF

Author : Kewal K. Jain
Publisher : Humana Press
Page : 762 pages
File Size : 55,9 Mb
Release : 2015-03-17
Category : Medical
ISBN : 9781493925537

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Textbook of Personalized Medicine by Kewal K. Jain Pdf

Advances in the technology used in personalized medicine and increased applications for clinical use have created a need for this expansion and revision of Kewal K. Jain’s Textbook of Personalized Medicine. As the first definitive work on this topic, this book reviews the fundamentals and development of personalized medicine and subsequent adoptions of the concepts by the biopharmaceutical industry and the medical profession. It also discusses examples of applications in key therapeutic areas, as well as ethical and regulatory issues, providing a concise and comprehensive source of reference for those involved in healthcare management, planning and politics. Algorithms are included as a guide to those involved in the management of important diseases where decision-making is involved due to the multiple choices available. Textbook of Personalized Medicine, Second Edition will serve as a convenient source of information for physicians, scientists, decision makers in the biopharmaceutical and healthcare industries and interested members of the public.

Pharmacogenomics and Personalized Medicine

Nadine Cohen
Pharmacogenomics and Personalized Medicine Book PDF

Author : Nadine Cohen
Publisher : Humana Press
Page : 509 pages
File Size : 41,7 Mb
Release : 2010-10-28
Category : Medical
ISBN : 1617379212

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Pharmacogenomics and Personalized Medicine by Nadine Cohen Pdf

concerns within the pharmaceutical industry about generating data that might be difficult to interpret in a regulated environment. There is also a growing apprec- tion for the challenges in translating this new information into clinical utility, including scientific, commercial, ethical, and policy challenges. Pharmacogenomics and Personalized Medicine, which is part of the Methods in Pharmacology and Toxicology series, comprises chapters on selected aspects of pharmacogenomics and personalized medicine. Our overall intent is to assist both novice and experienced investigators in understanding the current scientific ch- lenges in applying PGx to discovery and clinical development and in making app- priate decisions to engage in and interpret PGx research. Designed to share the experiences of leading experts in the field, the book is a useful guide for conducting PGx research--from discovery to the market, but we also aim to present a realistic perspective on the challenges, practicalities, and obstacles in applying pharmac- enomics. Generally, the book avoids statements such as “Pharmacogenomics is going to revolutionize the practice of medicine,” which are neither realistic nor particularly useful to anyone. The book presents an industry perspective on the implementation of PGx in research and development, in drug discovery, and in clinical trials, including rec- mendations for a systematic approach for assessing the feasibility and added value of PGx studies in clinical trials.

Principles of Pharmacogenetics and Pharmacogenomics

Russ B. Altman,Russ Altman,David Flockhart,David B. Goldstein
Principles of Pharmacogenetics and Pharmacogenomics Book PDF

Author : Russ B. Altman,Russ Altman,David Flockhart,David B. Goldstein
Publisher : Cambridge University Press
Page : 283 pages
File Size : 44,5 Mb
Release : 2012-01-23
Category : Medical
ISBN : 9780521885379

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Principles of Pharmacogenetics and Pharmacogenomics by Russ B. Altman,Russ Altman,David Flockhart,David B. Goldstein Pdf

This textbook presents the latest information on pharmacogenetics and pharmacogenomics for students, professionals and researchers.

Handbook of Pharmacogenomics and Stratified Medicine

Sandosh Padmanabhan
Handbook of Pharmacogenomics and Stratified Medicine Book PDF

Author : Sandosh Padmanabhan
Publisher : Academic Press
Page : 1119 pages
File Size : 50,9 Mb
Release : 2014-04-28
Category : Science
ISBN : 9780123868831

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Handbook of Pharmacogenomics and Stratified Medicine by Sandosh Padmanabhan Pdf

Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in various diseases. The chapters are written by international experts to allow readers from a wide variety of backgrounds, clinical and non-clinical (basic geneticists, pharmacologists, clinicians, trialists, industry personnel, ethicists) to understand the principles underpinning the progress in this area, the successes, failures and the challenges ahead. To be accessible to the widest range of readers, the clinical application section introduces the disease process, existing therapies, followed by pharmacogenomics and stratified medicine details. Medicine is the cornerstone of modern therapeutics prescribed on the basis that its benefit should outweigh its risk. It is well known that people respond differently to medications and in many cases the risk-benefit ratio for a particular drug may be a gray area. The last decade has seen a revolution in genomics both in terms of technological innovation and discovering genetic markers associated with disease. In parallel there has been steady progress in trying to make medicines safer and tailored to the individual. This has occurred across the whole spectrum of medicine, some more than others. In addition there is burgeoning interest from the pharmaceutical industry to leverage pharmacogenomics for more effective and efficient clinical drug development. Provides clinical and non-clinical researchers with practical information normally beyond their usual areas of research or expertise Includes an basic principles section explaining concepts of basic genetics, genetic epidemiology, bioinformatics, pharmacokinetics and pharmacodynamics Covers newer technologies– next generation sequencing, proteomics, metabolomics Provides information on animal models, lymphoblastoid cell lines, stem cells Provides detailed chapters on a wide range of disease conditions, implementation and regulatory issues Includes chapters on the global implications of pharmacogenomics

Concepts in Pharmacogenomics

Martin M. Zdanowicz
Concepts in Pharmacogenomics Book PDF

Author : Martin M. Zdanowicz
Publisher : ASHP
Page : 425 pages
File Size : 40,8 Mb
Release : 2010
Category : Medical
ISBN : 9781585282340

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Concepts in Pharmacogenomics by Martin M. Zdanowicz Pdf

The new science of pharmacogenomics aims to understand how an individual's genetic composition affects his/her response to a specific drug or class of drugs. By studying such characteristics as drug metabolizing enzymes, drug transporter activity, and receptor sensitivity, a pharmacist is better able to prescribe the right drug the first time.If you are pharmacist, resident, or student curious about this new field, start withConcepts in Pharmacogenomics. In this practical guide, you will find an overview of the science behind pharmacogenomics, followed by detailed chapters related to its clinical application and implementation.Features include: case studies in each chapter clinical pearls illustrations of key concepts figures, diagrams, and flow charts for visual learners key points summarized.

Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response

Federico Innocenti
Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response Book PDF

Author : Federico Innocenti
Publisher : Springer Science & Business Media
Page : 379 pages
File Size : 47,5 Mb
Release : 2008-10-30
Category : Medical
ISBN : 9781603270885

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Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response by Federico Innocenti Pdf

Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response provides the most comprehensive body of knowledge available on the role of genetic and genomic variation in the individualization of drug therapies in cancer patients. As a consequence of the intrinsic chromosomal and genetic instability of the tumor genome, it is generally believed that tailoring of chemotherapy in cancer - tients might be achieved by molecular analysis of patient tumor DNA. In addition, to reduce the toxicity risk of patients, the tumor DNA information should be in- grated with the available data on polymorphic drug-metabolizing enzyme and tra- porter genes mediating the exposure of patients to active drugs and/or their active metabolites. The chapters of this book clearly show how DNA information from both the host (germline) and the tumor should be taken into account for rational selection of drug therapies in cancer patients, an aspect that received little attention, despite its importance. The availability of new molecular approaches to the selection of drug therapy is an emerging need, because the traditional approach based on the evaluation of patient and tumor characteristics is clearly far from optimal. Many treated patients do not experience signi?cant bene?ts from the treatment, while they often experience moderate to severe toxicities. In addition, the development and clinical use of novel molecularly targeted agents (alone or in combination with classical cytotoxic therapy) requires the und- standing of the molecular features of the tumors and the identi?cation of tumor markers of response.

Pharmacogenomics An Introduction and Clinical Perspective

Joseph S. Bertino,Angela Kashuba,Joseph D. Ma,Uwe Fuhr,C. Lindsay DeVane
Pharmacogenomics An Introduction and Clinical Perspective Book PDF

Author : Joseph S. Bertino,Angela Kashuba,Joseph D. Ma,Uwe Fuhr,C. Lindsay DeVane
Publisher : McGraw Hill Professional
Page : 289 pages
File Size : 55,5 Mb
Release : 2012-10-12
Category : Medical
ISBN : 9780071813716

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Pharmacogenomics An Introduction and Clinical Perspective by Joseph S. Bertino,Angela Kashuba,Joseph D. Ma,Uwe Fuhr,C. Lindsay DeVane Pdf

A COMPLETE INTRODUCTORY TEXT TO THE FIELD OF PHARMACOGENOMICS The only pharmacogenomics resource to feature a global author team comprised of PharmDs, MDs, PhDs and social scientists, Pharmacogenomics offers an essential, highly accessible survey of this dynamic discipline. You will find thorough coverage of all need-to-know topics, from individual molecules to systemic diseases, plus an examination of the latest technologies that are constantly reshaping the field. Pharmacogenomics is cohesively organized into two sections, the first of which reviews basic aspects of pharmacogenomics, including ethics, regulatory, science, and drug metabolism, along with a "mini" course in molecular genetics and testing. The second section highlights the practical application of pharmacogenomics in cardiovascular medicine, immunology, neurology, and other specialties. FEATURES Important overview of general pharmacogenomics and pharmacogenetics concepts, including genetic variation in signal transduction and targets, plus a review of the genetic concepts of pharmacogenomics Discussion of regulatory considerations in pharmacogenomics Focus on the role of health care professionals along with a review of related privacy issues, as well as broader ethical, legal, and social considerations In-depth chapters on drug metabolism and transporters Practical, step-by-step guidance on public access to pharmacogenomic testing and patient counseling Up-to-date coverage of non-genetic influences on pharmacogenomics Emphasis on gene-drug interactions Numerous tables and figures Chapter-ending references Concise learning objectives at the beginning of each chapter Case studies to familiarize you with the clinical relevance of pharmacogenomics in each specialty

Pharmacogenomics

Howard L. McLeod
Pharmacogenomics Book PDF

Author : Howard L. McLeod
Publisher : Unknown
Page : 485 pages
File Size : 55,6 Mb
Release : 2009-01-01
Category : Medical
ISBN : 1932658696

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Pharmacogenomics by Howard L. McLeod Pdf

Pharmacogenomics offers the opportunity for clinicians to dramatically improve the health outcomes of millions of patients receiving drug therapy. However, this opportunity is tempered by the challenge of learning the seemingly limitless amount of genetic information assembled during the past decade, with new knowledge developing rapidly. ACCP has developed this textbook to assist clinicians in meeting this challenge. The enhanced second edition, written by leaders in pharmacogenomics from different practice areas, disciplines, and research environments, combines the basics of pharmacogenomics with disease-specific applications to give students and practitioners a solid foundation for understanding the basic science of pharmacogenomics and the skills for integrating pharmacogenomics into daily clinical practice.

Omics for Personalized Medicine

Debmalya Barh,Dipali Dhawan,Nirmal Kumar Ganguly
Omics for Personalized Medicine Book PDF

Author : Debmalya Barh,Dipali Dhawan,Nirmal Kumar Ganguly
Publisher : Springer Science & Business Media
Page : 832 pages
File Size : 50,6 Mb
Release : 2013-10-14
Category : Medical
ISBN : 9788132211846

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Omics for Personalized Medicine by Debmalya Barh,Dipali Dhawan,Nirmal Kumar Ganguly Pdf

“Omics for Personalized Medicine” will give to its prospective readers the insight of both the current developments and the future potential of personalized medicine. The book brings into light how the pharmacogenomics and omics technologies are bringing a revolution in transforming the medicine and the health care sector for the better. Students of biomedical research and medicine along with medical professionals will benefit tremendously from the book by gaining from the diverse fields of knowledge of new age personalized medicine presented in the highly detailed chapters of the book. The book chapters are divided into two sections for convenient reading with the first section covering the general aspects of pharmaocogenomic technology that includes latest research and development in omics technologies. The first section also highlights the role of omics in modern clinical trials and even discusses the ethical consideration in pharmocogenomics. The second section is focusing on the development of personalized medicine in several areas of human health. The topics covered range from metabolic and neurological disorders to non-communicable as well as infectious diseases, and even explores the role of pharmacogenomics in cell therapy and transplantation technology. Thirty-four chapters of the book cover several aspects of pharmacogenomics and personalized medicine and have taken into consideration the varied interest of the readers from different fields of biomedical research and medicine. Advent of pharmacogenomics is the future of modern medicine, which has resulted from culmination of decades of research and now is showing the way forward. The book is an honest endeavour of researchers from all over the world to disseminate the latest knowledge and knowhow in personalized medicine to the community health researchers in particular and the educated public in general.

Pharmacogenomics in Drug Discovery and Development

Qing Yan
Pharmacogenomics in Drug Discovery and Development Book PDF

Author : Qing Yan
Publisher : Springer Nature
Page : 618 pages
File Size : 47,6 Mb
Release : 2022-09-06
Category : Medical
ISBN : 9781071625736

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Pharmacogenomics in Drug Discovery and Development by Qing Yan Pdf

This new edition offers a state-of-the-art and integrative vision of pharmacogenomics by exploring new concepts and practical methodologies focusing on disease treatments, from cancers to cardiovascular and neurodegenerative disorders and more. The collection of these theoretical and experimental approaches facilitates problem-solving by tackling the complexity of personalized drug discovery and development. Written by leading experts in their fields for the highly successful Methods in Molecular Biology series, the book aims to provide across-the-board resources to support the translation of pharmacogenomics into better individualized health care. Authoritative and up-to-date, Pharmacogenomics in Drug Discovery and Development, Third Edition aims to aid researchers in approaching the challenges in pharmacogenomics and personalized medicine with the introduction of these novel ideas and cutting-edge methodologies.

The Genetics of African Populations in Health and Disease

Muntaser E. Ibrahim,Charles N. Rotimi
The Genetics of African Populations in Health and Disease Book PDF

Author : Muntaser E. Ibrahim,Charles N. Rotimi
Publisher : Cambridge University Press
Page : 351 pages
File Size : 55,6 Mb
Release : 2019-12-19
Category : History
ISBN : 9781107072022

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The Genetics of African Populations in Health and Disease by Muntaser E. Ibrahim,Charles N. Rotimi Pdf

A pioneering work that focuses on the unique diversity of African genetics, offering insights into human biology and genetic approaches.

Genomic and Precision Medicine

Geoffrey S. Ginsburg,Huntington F Willard,John Strickler,Matthew Stuart McKinney
Genomic and Precision Medicine Book PDF

Author : Geoffrey S. Ginsburg,Huntington F Willard,John Strickler,Matthew Stuart McKinney
Publisher : Academic Press
Page : 379 pages
File Size : 48,7 Mb
Release : 2022-04-09
Category : Science
ISBN : 9780128006535

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Genomic and Precision Medicine by Geoffrey S. Ginsburg,Huntington F Willard,John Strickler,Matthew Stuart McKinney Pdf

Genomic and Precision Medicine: Oncology, Third Edition focuses on the applications of genome discovery as research points to personalized cancer therapies. Each chapter is organized to cover the application of genomics and personalized medicine tools and technologies to a) Risk Assessment and Susceptibility, b) Diagnosis and Prognosis, c) Pharmacogenomics and Precision Therapeutics, and d) Emerging and Future Opportunities in the field. Provides a comprehensive volume written and edited by oncology genomic specialists for oncology health providers Includes succinct commentary and key learning points that will assist providers with their local needs for implementation of genomic and personalized medicine into practice Presents an up-to-date overview on major opportunities for genomic and personalized medicine in practice Covers case studies that highlight the practical use of genomics in the management of patients