Pharmacogenomics In Clinical Therapeutics

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Pharmacogenomics in Clinical Therapeutics

Loralie J. Langman,Amitava Dasgupta
Pharmacogenomics in Clinical Therapeutics Book PDF

Author : Loralie J. Langman,Amitava Dasgupta
Publisher : John Wiley & Sons
Page : 400 pages
File Size : 45,6 Mb
Release : 2012-01-09
Category : Medical
ISBN : 9781119959588

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Pharmacogenomics in Clinical Therapeutics by Loralie J. Langman,Amitava Dasgupta Pdf

Pharmacogenomics is the basis of personalized medicine which will be the medicine of the future. Through both reducing the numbers of adverse drug reactions and improving the use of existing drugs in targeted populations, pharmacogenomics represents a real advance on traditional therapeutic drug monitoring. Pharmacogenomics in Clinical Therapeutics provides an introduction to the principles of pharmacogenomics before addressing the pharmacogenomic aspects of key therapeutic areas such as warfarin therapy, cancer chemotherapy, therapy with immunosuppressants, antiretroviral therapy, and psychoactive drugs. It also includes methods of pharmacogenomic testing and the pharmacogenomic aspects of drug–drug interactions. From a team of expert contributors, Pharmacogenomics in Clinical Therapeutics is a comprehensive overview of the current state of pharmacogenomics in pharmacotherapy for all clinicians, pharmacologists and clinical laboratory professionals. It is also a guide for practicing clinicians and health care professionals to the basic principles of pharmacogenomics, laboratory tests currently available to aid clinicians, and the future promise of this developing field.

Applying Pharmacogenomics in Therapeutics

Xiaodong Feng,Hong-Guang Xie
Applying Pharmacogenomics in Therapeutics Book PDF

Author : Xiaodong Feng,Hong-Guang Xie
Publisher : CRC Press
Page : 260 pages
File Size : 48,7 Mb
Release : 2016-01-06
Category : Medical
ISBN : 9781498782456

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Applying Pharmacogenomics in Therapeutics by Xiaodong Feng,Hong-Guang Xie Pdf

Recent advances in high-throughput gene sequencing and other omics biotechnologies have served as a springboard for the field of pharmacogenomics. Pharmacogenomics is now generally accepted as the major determinant of variable drug safety, efficacy, and cost-effectiveness. Therefore, widespread use of pharmacogenomics for patient care has become a

Pharmacogenomics

Yui-Wing Francis Lam,Larisa H. Cavallari
Pharmacogenomics Book PDF

Author : Yui-Wing Francis Lam,Larisa H. Cavallari
Publisher : Academic Press
Page : 515 pages
File Size : 53,9 Mb
Release : 2013-02-12
Category : Science
ISBN : 9780123983039

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Pharmacogenomics by Yui-Wing Francis Lam,Larisa H. Cavallari Pdf

Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation includes discussions and viewpoints from the academic, regulatory, pharmaceutical, clinical, socio-ethical and economic perspectives. Each chapter presents an overview of the potential or opportunity within the areas discussed and also outlines foreseeable challenges and limitations in moving pharmacogenomics into drug development and direct therapeutic applications. This edited book contains review questions for a more in-depth analysis of the implications of pharmacogenomics and discussion points to generate ideas on best to move the field forward. Clinical pearls and case studies are used to illustrate real-life experiences and both successful and unsuccessful applications. Tables, figures, and annotations are included throughout the book to facilitate understanding and further reference. Multi-contributed book and chapters are written by contributors who are experts in their field Provides perspectives from those involved in all aspects of pharmacogenomics—including academic, regulatory, economic, industry and medical—to illustrate how all of the pieces fit together and where the challenges may be Includes case studies of both successful and unsuccessful applications so readers can consider the potential and challenges in moving the science into drug development and direct therapeutic applications Chapters contain discussion questions and clinical pearls and enable readers to reflect on how to move pharmacogenomics forward and apply these observations and useful tips to their own work and research

Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response

Federico Innocenti
Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response Book PDF

Author : Federico Innocenti
Publisher : Springer Science & Business Media
Page : 379 pages
File Size : 43,5 Mb
Release : 2008-10-30
Category : Medical
ISBN : 9781603270885

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Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response by Federico Innocenti Pdf

Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response provides the most comprehensive body of knowledge available on the role of genetic and genomic variation in the individualization of drug therapies in cancer patients. As a consequence of the intrinsic chromosomal and genetic instability of the tumor genome, it is generally believed that tailoring of chemotherapy in cancer - tients might be achieved by molecular analysis of patient tumor DNA. In addition, to reduce the toxicity risk of patients, the tumor DNA information should be in- grated with the available data on polymorphic drug-metabolizing enzyme and tra- porter genes mediating the exposure of patients to active drugs and/or their active metabolites. The chapters of this book clearly show how DNA information from both the host (germline) and the tumor should be taken into account for rational selection of drug therapies in cancer patients, an aspect that received little attention, despite its importance. The availability of new molecular approaches to the selection of drug therapy is an emerging need, because the traditional approach based on the evaluation of patient and tumor characteristics is clearly far from optimal. Many treated patients do not experience signi?cant bene?ts from the treatment, while they often experience moderate to severe toxicities. In addition, the development and clinical use of novel molecularly targeted agents (alone or in combination with classical cytotoxic therapy) requires the und- standing of the molecular features of the tumors and the identi?cation of tumor markers of response.

Pharmacogenetics and Individualized Therapy

Anke-Hilse Maitland-van der Zee,Ann K. Daly
Pharmacogenetics and Individualized Therapy Book PDF

Author : Anke-Hilse Maitland-van der Zee,Ann K. Daly
Publisher : John Wiley & Sons
Page : 32 pages
File Size : 55,9 Mb
Release : 2012-04-02
Category : Medical
ISBN : 9781118116487

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Pharmacogenetics and Individualized Therapy by Anke-Hilse Maitland-van der Zee,Ann K. Daly Pdf

This resource provides thorough coverage of pharmacogenetics and its impact on pharmaceuticals, therapeutics, and clinical practice. It opens with the basics of pharmacogenetics, including drug disposition and pharmacodynamics. The following section moves into specific disease areas, including cardiovascular, psychiatry, cancer, asthma/COPD, adverse drug reactions, transplantation, inflammatory bowel disease, and pain medication. Clinical practice and ethical issues make up the third section, with the fourth devoted to technologies like genotyping, genomics, and proteomics. In the fifth part, chapters discuss the impact of key regulatory issues on the pharmaceutical industry.

Applying Pharmacogenomics in Therapeutics

Xiaodong Feng,Hong-Guang Xie
Applying Pharmacogenomics in Therapeutics Book PDF

Author : Xiaodong Feng,Hong-Guang Xie
Publisher : CRC Press
Page : 308 pages
File Size : 44,5 Mb
Release : 2016-01-06
Category : Medical
ISBN : 9781466582682

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Applying Pharmacogenomics in Therapeutics by Xiaodong Feng,Hong-Guang Xie Pdf

Recent advances in high-throughput gene sequencing and other omics biotechnologies have served as a springboard for the field of pharmacogenomics. Pharmacogenomics is now generally accepted as the major determinant of variable drug safety, efficacy, and cost-effectiveness. Therefore, widespread use of pharmacogenomics for patient care has become a critical requirement. There is an unprecedented urgency for aspiring and practicing clinicians to become trained on how to interpret data from pharmacogenomic testing in preparation for the future of healthcare—i.e., personalized medicine. Applying Pharmacogenomics in Therapeutics provides timely coverage of the principles, practice, and potential of pharmacogenomics and personalized medicine. Comprised of chapters contributed by well-established pharmacologists and scientists from US and Chinese academia and industry, this authoritative text: Demonstrates how to apply the principles of pharmacogenomics and its biotechnologies in patient care Depicts the use of genetic biomarkers in drug discovery and development, laboratory medicine, and clinical services Describes the practice of pharmacogenomics in the treatment of cancers, cardiovascular diseases, neurologic and psychiatric disorders, and pulmonary diseases Discusses the merging of pharmacogenomics and alternative medicine, as well as the integration of pharmacogenomics into pharmacoeconomics Each chapter begins with the key concepts, followed by in-depth explorations of case reports or critical evaluations of genetic variants/biomarkers, and concludes with questions for self-examination.

Principles of Pharmacogenetics and Pharmacogenomics

Russ B. Altman,Russ Altman,David Flockhart,David B. Goldstein
Principles of Pharmacogenetics and Pharmacogenomics Book PDF

Author : Russ B. Altman,Russ Altman,David Flockhart,David B. Goldstein
Publisher : Cambridge University Press
Page : 283 pages
File Size : 40,7 Mb
Release : 2012-01-23
Category : Medical
ISBN : 9780521885379

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Principles of Pharmacogenetics and Pharmacogenomics by Russ B. Altman,Russ Altman,David Flockhart,David B. Goldstein Pdf

This textbook presents the latest information on pharmacogenetics and pharmacogenomics for students, professionals and researchers.

Pharmacogenomics An Introduction and Clinical Perspective

Joseph S. Bertino,Angela Kashuba,Joseph D. Ma,Uwe Fuhr,C. Lindsay DeVane
Pharmacogenomics An Introduction and Clinical Perspective Book PDF

Author : Joseph S. Bertino,Angela Kashuba,Joseph D. Ma,Uwe Fuhr,C. Lindsay DeVane
Publisher : McGraw Hill Professional
Page : 289 pages
File Size : 47,9 Mb
Release : 2012-10-12
Category : Medical
ISBN : 9780071813716

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Pharmacogenomics An Introduction and Clinical Perspective by Joseph S. Bertino,Angela Kashuba,Joseph D. Ma,Uwe Fuhr,C. Lindsay DeVane Pdf

A COMPLETE INTRODUCTORY TEXT TO THE FIELD OF PHARMACOGENOMICS The only pharmacogenomics resource to feature a global author team comprised of PharmDs, MDs, PhDs and social scientists, Pharmacogenomics offers an essential, highly accessible survey of this dynamic discipline. You will find thorough coverage of all need-to-know topics, from individual molecules to systemic diseases, plus an examination of the latest technologies that are constantly reshaping the field. Pharmacogenomics is cohesively organized into two sections, the first of which reviews basic aspects of pharmacogenomics, including ethics, regulatory, science, and drug metabolism, along with a "mini" course in molecular genetics and testing. The second section highlights the practical application of pharmacogenomics in cardiovascular medicine, immunology, neurology, and other specialties. FEATURES Important overview of general pharmacogenomics and pharmacogenetics concepts, including genetic variation in signal transduction and targets, plus a review of the genetic concepts of pharmacogenomics Discussion of regulatory considerations in pharmacogenomics Focus on the role of health care professionals along with a review of related privacy issues, as well as broader ethical, legal, and social considerations In-depth chapters on drug metabolism and transporters Practical, step-by-step guidance on public access to pharmacogenomic testing and patient counseling Up-to-date coverage of non-genetic influences on pharmacogenomics Emphasis on gene-drug interactions Numerous tables and figures Chapter-ending references Concise learning objectives at the beginning of each chapter Case studies to familiarize you with the clinical relevance of pharmacogenomics in each specialty

Concepts in Pharmacogenomics

Martin M. Zdanowicz
Concepts in Pharmacogenomics Book PDF

Author : Martin M. Zdanowicz
Publisher : ASHP
Page : 425 pages
File Size : 54,7 Mb
Release : 2010
Category : Medical
ISBN : 9781585282340

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Concepts in Pharmacogenomics by Martin M. Zdanowicz Pdf

The new science of pharmacogenomics aims to understand how an individual's genetic composition affects his/her response to a specific drug or class of drugs. By studying such characteristics as drug metabolizing enzymes, drug transporter activity, and receptor sensitivity, a pharmacist is better able to prescribe the right drug the first time.If you are pharmacist, resident, or student curious about this new field, start withConcepts in Pharmacogenomics. In this practical guide, you will find an overview of the science behind pharmacogenomics, followed by detailed chapters related to its clinical application and implementation.Features include: case studies in each chapter clinical pearls illustrations of key concepts figures, diagrams, and flow charts for visual learners key points summarized.

Pharmacogenomics and Personalized Medicine

Erika Cecchin,Gabriele Stocco
Pharmacogenomics and Personalized Medicine Book PDF

Author : Erika Cecchin,Gabriele Stocco
Publisher : Unknown
Page : 208 pages
File Size : 50,7 Mb
Release : 2020
Category : Electronic
ISBN : 3039367315

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Pharmacogenomics and Personalized Medicine by Erika Cecchin,Gabriele Stocco Pdf

Pharmacogenomics is one of the emerging approaches to precision medicine, tailoring drug selection and dosing to the patient's genetic features. In recent years, several pharmacogenetic guidelines have been published by international scientific consortia, but the uptake in clinical practice is still poor. Many coordinated international efforts are ongoing in order to overcome the existing barriers to pharmacogenomic implementation. On the other hand, existing validated pharmacogenomic markers can explain only a minor part of the observed clinical variability in the therapeutic outcome. New investigational approaches are warranted, including a study of the pharmacogenomic role of the immune system genetics and of previously neglected rare genetic variants, reported to account for a large part of inter-individual variability in drug metabolism. In this book, we have collected a series of articles covering many aspects of pharmacogenomics. These include clinical implementation of pharmacogenomics in clinical practice, development of tools or infrastructures to support this process, research of new pharmacogenomics markers to increase drug efficacy and safety, and the impact of rare genetic variants in pharmacogenomics.

Textbook of Personalized Medicine

Kewal K. Jain
Textbook of Personalized Medicine Book PDF

Author : Kewal K. Jain
Publisher : Humana Press
Page : 762 pages
File Size : 48,6 Mb
Release : 2015-03-17
Category : Medical
ISBN : 9781493925537

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Textbook of Personalized Medicine by Kewal K. Jain Pdf

Advances in the technology used in personalized medicine and increased applications for clinical use have created a need for this expansion and revision of Kewal K. Jain’s Textbook of Personalized Medicine. As the first definitive work on this topic, this book reviews the fundamentals and development of personalized medicine and subsequent adoptions of the concepts by the biopharmaceutical industry and the medical profession. It also discusses examples of applications in key therapeutic areas, as well as ethical and regulatory issues, providing a concise and comprehensive source of reference for those involved in healthcare management, planning and politics. Algorithms are included as a guide to those involved in the management of important diseases where decision-making is involved due to the multiple choices available. Textbook of Personalized Medicine, Second Edition will serve as a convenient source of information for physicians, scientists, decision makers in the biopharmaceutical and healthcare industries and interested members of the public.

Pharmacogenomics in Precision Medicine

Weimin Cai,Zhaoqian Liu,Liyan Miao,Xiaoqiang Xiang
Pharmacogenomics in Precision Medicine Book PDF

Author : Weimin Cai,Zhaoqian Liu,Liyan Miao,Xiaoqiang Xiang
Publisher : Springer Nature
Page : 290 pages
File Size : 54,7 Mb
Release : 2020-06-12
Category : Medical
ISBN : 9789811538957

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Pharmacogenomics in Precision Medicine by Weimin Cai,Zhaoqian Liu,Liyan Miao,Xiaoqiang Xiang Pdf

This book provides an introduction to the principles of pharmacogenomics and precision medicine, followed by the pharmacogenomics aspects of major therapeutic areas such as cardiovascular disease, cancer, organ transplantation, psychiatry, infection, antithrombotic drugs. It also includes genotyping technology and therapeutic drug monitoring in Pharmacogenomics; ethical, Legal and Regulatory Issues; cost-effectiveness of pharmacogenetics-guided treatment; application of pharmacogenomics in drug discovery and development and clinical Implementation of Pharmacogenomics for Personalized Precision Medicine. The contributors of Pharmacogenomics in Precision Medicine come from a team of experts, including professors from academic institutions and practitioner from hospital. It will give an in-depth overview of the current state of pharmacogenomics in drug therapy for all health care professionals and graduate students in the era of precision medicine.

Handbook of Pharmacogenomics and Stratified Medicine

Sandosh Padmanabhan
Handbook of Pharmacogenomics and Stratified Medicine Book PDF

Author : Sandosh Padmanabhan
Publisher : Academic Press
Page : 1119 pages
File Size : 45,9 Mb
Release : 2014-04-28
Category : Science
ISBN : 9780123868831

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Handbook of Pharmacogenomics and Stratified Medicine by Sandosh Padmanabhan Pdf

Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in various diseases. The chapters are written by international experts to allow readers from a wide variety of backgrounds, clinical and non-clinical (basic geneticists, pharmacologists, clinicians, trialists, industry personnel, ethicists) to understand the principles underpinning the progress in this area, the successes, failures and the challenges ahead. To be accessible to the widest range of readers, the clinical application section introduces the disease process, existing therapies, followed by pharmacogenomics and stratified medicine details. Medicine is the cornerstone of modern therapeutics prescribed on the basis that its benefit should outweigh its risk. It is well known that people respond differently to medications and in many cases the risk-benefit ratio for a particular drug may be a gray area. The last decade has seen a revolution in genomics both in terms of technological innovation and discovering genetic markers associated with disease. In parallel there has been steady progress in trying to make medicines safer and tailored to the individual. This has occurred across the whole spectrum of medicine, some more than others. In addition there is burgeoning interest from the pharmaceutical industry to leverage pharmacogenomics for more effective and efficient clinical drug development. Provides clinical and non-clinical researchers with practical information normally beyond their usual areas of research or expertise Includes an basic principles section explaining concepts of basic genetics, genetic epidemiology, bioinformatics, pharmacokinetics and pharmacodynamics Covers newer technologies– next generation sequencing, proteomics, metabolomics Provides information on animal models, lymphoblastoid cell lines, stem cells Provides detailed chapters on a wide range of disease conditions, implementation and regulatory issues Includes chapters on the global implications of pharmacogenomics

Clinical Decision Support for Pharmacogenomic Precision Medicine

Beth Devine,Richard David Boyce,Kristin Wiisanen
Clinical Decision Support for Pharmacogenomic Precision Medicine Book PDF

Author : Beth Devine,Richard David Boyce,Kristin Wiisanen
Publisher : Academic Press
Page : 300 pages
File Size : 41,9 Mb
Release : 2022-06-14
Category : Medical
ISBN : 9780128244548

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Clinical Decision Support for Pharmacogenomic Precision Medicine by Beth Devine,Richard David Boyce,Kristin Wiisanen Pdf

Clinical Decision Support for Pharmacogenomic Precision Medicine: Foundations and Implementation offers overviews, methods and strategies for translating genomic medicine to clinical practice. The book's authors explore incorporating pharmacogenetics into electronic health records, CDS methods and infrastructure for delivery, economic evaluation, the hospital administrations’ role and needs in integration, and patient counseling aspects. The book empowers clinicians, researchers, translational scientists, and data and IT experts to effectively navigate the complex landscape of CDS for pharmacogenomic precision medicine. Illustrative case studies of existing gene networks include CSER, eMERGE, the IGNITE network, DIGITIZE, the CDS Learning Network (RTI), ClinGen, Ubiquitous and CDS Hooks. Offers an applied, case-driven discussion of CDS for pharmacogenomic precision medicine Illustrates key concepts, contemporary developments, and future directions using examples of existing gene networks Features contributions from leading voices in precision medicine and clinical decision support

Pharmacogenomics

Julio Licinio,Ma-Li Wong
Pharmacogenomics Book PDF

Author : Julio Licinio,Ma-Li Wong
Publisher : John Wiley & Sons
Page : 599 pages
File Size : 48,9 Mb
Release : 2009-07-30
Category : Science
ISBN : 9783527616305

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Pharmacogenomics by Julio Licinio,Ma-Li Wong Pdf

This work represents the first comprehensive publication in the innovative field of pharmacogenomics, a field which is set to revolutionize pharmaceutical research. In addition to renowned editors, the list of contributors is a "who-is-who" in the field. Broad coverage of all aspects of pharmacogenomics with a full presentation of applications to disease conditions is featured. Anyone involved in pharmaceutical research and drug development needs this book to keep up with this new and revolutionary approach