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Approaches to Understanding Breast Cancer by Anonim Pdf
Approaches to Understanding Breast Cancer, Volume 151, the latest volume in the Progress in Molecular Biology and Translational Science series focuses on breast cancer, with new chapters that include information on Breast Cancer Epidemiology, Prevention, and Screening, DCIS: Current Principles of Management, Pregnancy and Hormonal Prevention of Breast Cancer, Chemokines: Key Players in Pathobiology of Breast Cancer, Mircrobiota and Breast Cancer, Experimental Therapeutic Use of Estrogen Receptor Beta Agonists in Prevention and Treatment of Endocrine Therapy Resistant Breast Cancers: Observations from Pre-Clinical Models, Targeting Breast Cancer Stem Cells: Key for Anti-Metastatic Therapy, and Experimental Therapy of Advanced Breast Cancer: Target NFAT1-MDM2-p53 Pathway. Accessible to students and researchers alike Written by leading authorities in the field
Approaches to Breast Cancer Prevention by B.A. Stoll Pdf
This book is a logical companion volume to Women at High Risk to Breast Cancer (Kluwer, 1989) edited by me previously. It distinguishes two aspects of current ap proaches to clinical breast cancer prevention. The first is the need to advise individ ual women on how they might reduce their personal risk, while the second is the design of measures aimed at reducing the total incidence of breast cancer in the community. While the former is a problem faced daily by clinicians, the latter is a goal which will involve large scale, carefully planned interventional studies. Because knowledge of the risk factors for breast cancer is incomplete and clinical trial reports are scarce, there is as yet, no scientifically-based model for personal breast cancer prevention. Nevertheless, widespread publicity associated with breast screening programmes has created a large group of highly anxious women who have been informed that they are at higher than average risk to the disease. They are con cerned by the personal threat posed by a family history of the disease and by the al leged dangers of obesity, diet, alcohol, or the use of hormonal agents such as oral contraceptives or hormone replacement therapy.
Omics Approaches in Breast Cancer by Debmalya Barh Pdf
Breast cancer is the most common cancer in females that accounts for highest cancer specific deaths worldwide. In the last few decades research has proven that breast cancer can be treated if diagnosed at early stages and proper therapeutic strategy is adopted. Omics-based recent approaches have unveiled the molecular mechanism behind the breast tumorigenesis and aid in identification of next-generation molecular markers for early diagnosis, prognosis and even the effective targeted therapy. Significant development has taken place in the field of omics in breast cancer in the last decade. The most promising omics approaches and their outcomes in breast cancer have been presented in this book for the first time. The book covers omics technologies and budding fields such as breast cancer miRNA, lipidomics, epigenomics, proteomics, nutrigenomics, stem cell, pharmacogenomics and personalized medicine and many more along with conventional topics such as breast cancer management etc. It is a research-based reference book useful for clinician-scientists, researchers, geneticists and health care industries involved in various aspects of breast cancer. The book will also be useful for students of biomedicine, pathology and pharmacy.
Techniques and Methodological Approaches in Breast Cancer Research by Jose Russo,Irma H. Russo Pdf
This volume explores the myriad of techniques and methodological approaches that are being used in breast cancer research. The authors critically evaluate of the advantages and disadvantages of current methodologies, starting with the tools available for understanding the architecture of the human breast, including its tissue and cellular composition. The volume discusses the importance of functional studies in breast cancer research, especially with the help of laser capture microdissection, which allows the separation of small amounts of tissue, as well as specific cells, for biochemical analysis. In addition, the authors address methodologies including stem cell separation, which has helped in significantly understanding their role in normal breast development, but also further the understanding of breast cancer and its therapeutic management. The use of in vitro techniques and established cell lines for mechanistic studies in chemotherapeutic approaches have been invaluable will be discussed. Imaging techniques for evaluating in vitro and in vivo behavior of normal and cancerous breast tissue will be explored, as it provides a better understanding of the physiopathology of cancer. The volume will also discuss the molecular analysis of gene function in breast cancer through the transcriptomic and epigenomic profile. More importantly, the advancement of more refined techniques in sequencing will be covered. This monograph will be a comprehensive, authoritative and timely, as it addresses the emerging approaches used in breast cancer research.
Techniques and Methodological Approaches in Breast Cancer Research by Jose Russo,Irma H. Russo Pdf
This volume explores the myriad of techniques and methodological approaches that are being used in breast cancer research. The authors critically evaluate of the advantages and disadvantages of current methodologies, starting with the tools available for understanding the architecture of the human breast, including its tissue and cellular composition. The volume discusses the importance of functional studies in breast cancer research, especially with the help of laser capture microdissection, which allows the separation of small amounts of tissue, as well as specific cells, for biochemical analysis. In addition, the authors address methodologies including stem cell separation, which has helped in significantly understanding their role in normal breast development, but also further the understanding of breast cancer and its therapeutic management. The use of in vitro techniques and established cell lines for mechanistic studies in chemotherapeutic approaches have been invaluable will be discussed. Imaging techniques for evaluating in vitro and in vivo behavior of normal and cancerous breast tissue will be explored, as it provides a better understanding of the physiopathology of cancer. The volume will also discuss the molecular analysis of gene function in breast cancer through the transcriptomic and epigenomic profile. More importantly, the advancement of more refined techniques in sequencing will be covered. This monograph will be a comprehensive, authoritative and timely, as it addresses the emerging approaches used in breast cancer research.
Understanding Breast Cancer Genetics by Barbara T. Zimmerman Pdf
This book by a scientist whose background is in cellular and molecular biology examines the fearsome disease that strikes one in eight women in the United States. Although women are more likely to die of heart disease or of lung cancer, a diagnosis of breast cancer is the medical pronouncement that a woman is most likely to fear. It kills more than 40,000 Americans annually. Why are some women more vulnerable than others? The interplay between genetics and environment is suspected. Thus this book for general readers will help them understand the genetic basis of both sporadic and inherited breast cancers. Although only five to ten percent of breast cancer patients have inherited mutations in these genes, all women need to understand the genetic implications of the disease. In clear, concise language Barbara T. Zimmerman guides the reader through the complexities, discussing in detail the genes that are known to increase susceptibility and the ways they are passed on. Examining the general biology of breast cancer, Zimmerman describes how sporadic and inherited forms of the disease arise and how the location of the tumors can affect the body. She discusses genetic mutations and their roles in the development of tumors and tells how these potentially cancer-inducing genes were discovered. Covered too are the issues of risk, prevention, screening, diagnosis, therapy, and genetic testing and counseling. Zimmerman concludes with a comprehensive analysis of current research and with an emphasis on how a woman's understanding of inherited breast cancer can help doctors seeking to design better methods for prevention and therapy. A useful list of resources for further information about the genetic causes of breast cancer is included.
National Research Council,Institute of Medicine,Policy and Global Affairs,Board on Science, Technology, and Economic Policy,National Cancer Policy Board,Committee on New Approaches to Early Detection and Diagnosis of Breast Cancer
Author : National Research Council,Institute of Medicine,Policy and Global Affairs,Board on Science, Technology, and Economic Policy,National Cancer Policy Board,Committee on New Approaches to Early Detection and Diagnosis of Breast Cancer Publisher : National Academies Press Page : 385 pages File Size : 52,6 Mb Release : 2005-04-18 Category : Medical ISBN : 9780309092135
Saving Women's Lives by National Research Council,Institute of Medicine,Policy and Global Affairs,Board on Science, Technology, and Economic Policy,National Cancer Policy Board,Committee on New Approaches to Early Detection and Diagnosis of Breast Cancer Pdf
The outlook for women with breast cancer has improved in recent years. Due to the combination of improved treatments and the benefits of mammography screening, breast cancer mortality has decreased steadily since 1989. Yet breast cancer remains a major problem, second only to lung cancer as a leading cause of death from cancer for women. To date, no means to prevent breast cancer has been discovered and experience has shown that treatments are most effective when a cancer is detected early, before it has spread to other tissues. These two facts suggest that the most effective way to continue reducing the death toll from breast cancer is improved early detection and diagnosis. Building on the 2001 report Mammography and Beyond, this new book not only examines ways to improve implementation and use of new and current breast cancer detection technologies but also evaluates the need to develop tools that identify women who would benefit most from early detection screening. Saving Women's Lives: Strategies for Improving Breast Cancer Detection and Diagnosis encourages more research that integrates the development, validation, and analysis of the types of technologies in clinical practice that promote improved risk identification techniques. In this way, methods and technologies that improve detection and diagnosis can be more effectively developed and implemented.
Current Advances in Breast Cancer Research: A Molecular Approach by Shankar Suman,Garima Suman,Sanjay Mishra Pdf
Breast cancer is a recognized disease around the world with varying patient outcomes based on the type of breast cancer, access to healthcare and other factors. Survival rates for breast cancer are significantly lower in metastatic cases than localized cases. Early diagnosis and effective treatments for the efficient management of breast cancer are now in demand , as they help to prolong patient life. There have been many breakthrough developments in the molecular biology of breast cancer research in recent times. Advancements in diagnostic techniques (imaging and biomarker detection) for breast cancer have improved the screening of the disease and have improved patient outcomes. Despite these enhancements, the disease is still lethal for patients and the search for a cure requires a complete understanding of the disease. Current Advances in Breast Cancer Research: A Molecular Approach presents a comprehensive overview of current basic and translational research on the subject. The 14 chapters of the book give emphasis to current knowledge about breast cancer, ongoing challenges, and innovative research findings by different research groups. Readers will find detailed information about breast cancer biology, genetics, clinical diagnostics and treatments. Additional information for advanced readers in life sciences, such as techniques relevant to genomics (including genetic fingerprinting), proteomics, metabolomics and medicine (such as imaging and molecular diagnostics) is also provided. The combination of both basic and advanced information makes this book a useful reference to the student and researcher, alike, seeking an understanding about breast cancer at a molecular level.
National Research Council,Institute of Medicine,National Cancer Policy Board,Committee on New Approaches to Early Detection and Diagnosis of Breast Cancer
Author : National Research Council,Institute of Medicine,National Cancer Policy Board,Committee on New Approaches to Early Detection and Diagnosis of Breast Cancer Publisher : National Academies Press Page : 144 pages File Size : 48,5 Mb Release : 2004-12-18 Category : Medical ISBN : 9780309094382
Saving Women's Lives by National Research Council,Institute of Medicine,National Cancer Policy Board,Committee on New Approaches to Early Detection and Diagnosis of Breast Cancer Pdf
In this report The Breast Cancer Research Foundation (BCRF) and the Institute of Medicine (IOM) present a one-day symposium that was held at the IOM to further disseminate the conclusions and recommendations of the joint IOM and National Research Council report, Saving Women's Lives: Strategies for Improving Breast Cancer Detection and Diagnosis. The committee assembled for this event was asked to share insights and consider ways in which the objectives of the report could be achieved from the standpoint of what women need to know, the best models of screening programs, manpower, risk stratification, basic research, and payment. This symposium seeks to provide continuing food for thought and ideas for actions in support of breast cancer detection and diagnosis and saving women's lives.
Translational Research in Breast Cancer by Erwei Song,Hai Hu Pdf
This book offers a comprehensive introduction to translational efforts in breast cancer, addressing the latest approaches to precision medicine based on the current state of understanding of breast cancer. With the latest developments in breast cancer research, our understanding of the genomic changes and the oncogenic signaling cascade of breast cancer has made considerable strides. Further, the immuno-environment has been demonstrated as the barrier to clinical cancer. In addition, major advances in cancer biology, immunology, genomics and metabolism have broken new ground for designing therapeutic approaches and selecting appropriate treatments on the basis of more precise information on the individual patient. As a result of these two trends, a clearer picture of the molecular landscape of breast cancers has facilitated the development of diagnostic, prognostic and predictive biomarkers for clinical oncology. All these aspects are addressed in this volume, which offers a comprehensive resource for researchers, graduate students and oncologists in cancer research.
Breast Cancer: A Comprehensive Resource for Women and Families by Ethan D. Anderson Pdf
"Breast cancer: A journey of resilience and hope." Discover the ultimate guide to understanding, managing, and thriving through breast cancer. "Breast Cancer: A Comprehensive Resource for Women and Families" provides invaluable information and support for those affected by this life-changing diagnosis. From detection and diagnosis to treatment and recovery, this essential resource covers every aspect of breast cancer, offering hope, guidance, and the tools necessary to navigate this challenging journey. In this comprehensive book, you'll find: An in-depth understanding of breast cancer, its causes, and risk factors Detailed information on diagnostic tests and procedures to help you make informed decisions An overview of treatment options, including surgery, radiation, chemotherapy, and targeted therapies Strategies for managing the emotional and psychological impact of breast cancer A guide to maintaining a healthy lifestyle during and after treatment Advice on communicating with healthcare providers, family members, and friends Support for caregivers and loved ones • Real-life stories from breast cancer survivors Resources for financial assistance, support groups, and more Don't face breast cancer alone—arm yourself with the knowledge, resources, and support you need to take control of your health and your life. Whether you're newly diagnosed, currently in treatment, or a long-term survivor, "Breast Cancer: A Comprehensive Resource for Women and Families" will empower you and your loved ones to face this journey with courage, resilience, and hope. Contents: Understanding Breast Cancer What is Breast Cancer? Types of Breast Cancer Stages and Grades Risk Factors Life Expectancy Age and Health Factors Breast Cancer Screening and Detection Mammography Ultrasound MRI Breast Self-Exams Breast Cancer Diagnosis Biopsy Pathology Reports Genetic Testing Treatment Options Surgery Lumpectomy Mastectomy Breast Reconstruction Radiation Therapy Chemotherapy Hormone Therapy Targeted Therapy Immunotherapy Coping with Side Effects and Complications Managing Physical Side Effects Emotional Support and Mental Health Fertility and Pregnancy Concerns Survivorship and Follow-up Care Regular Check-ups and Monitoring Long-term Side Effects Recurrence and Metastatic Breast Cancer Nutrition and Lifestyle Diet and Nutrition During Treatment Exercise and Physical Activity Complementary and Alternative Medicine Support and Resources Building a Support Network Financial Assistance Advocacy and Research Caregivers and Loved Ones How to Provide Support Communicating with Healthcare Team Self-Care for Caregivers Prevention and Risk Reduction Understanding Breast Cancer Risk Factors Genetic Counseling and Testing Lifestyle Choices for Prevention Preventive Medications Breast Cancer in Men Understanding Male Breast Cancer Risk Factors and Detection Treatment and Support Breast Cancer in Young Women Unique Challenges and Considerations Fertility Preservation Support and Resources Breast Cancer and Pregnancy Diagnosis During Pregnancy Treatment Options and Considerations Postpartum Care Navigating Employment and Insurance Understanding Your Rights Workplace Accommodations Managing Insurance Issues Mental Health and Emotional Well-being Coping with Anxiety and Depression Mindfulness and Stress Reduction Support Groups and Counseling Personal Stories and Inspiration Survivor Stories Lessons Learned Finding Hope and Resilience Integrative Medicine and Holistic Approaches Understanding Integrative Medicine Acupuncture and Massage Mind-Body Therapies Post-Treatment Body Image and Intimacy Coping with Body Image Changes Navigating Relationships and Intimacy Reconstruction and Prosthetics Advanced and Metastatic Breast Cancer Understanding Advanced Breast Cancer Treatment Options and Palliative Care Emotional Support and Resources
Immunological Approaches to the Diagnosis and Therapy of Breast Cancer by G.P. Talwar Pdf
Once again we have gathered to discover and evaluate advances made in our ability to understand. diagnose and possibly treat breast cancer with the new reagents provided by monoclonal antibody techniques. In the last two years since our first International Workshop on Monoclonal Antibodies and Breast Cancer there has been an enormous surge in the number and quality of applications for these new reagents. Solid achievements have been made in identification and quantitation of estrogen and progesterone receptors. in histopathological diagnostic procedures. in serum diagnosis. and we are witnessing now the first attempts to treat breast cancer with immunoconjugates. Cytosolic estrogen receptors can now be quantitated with monoclonal antibodies. and also their cellular distribution can be directly assessed histologically. In addition. monoclonal antibodies to progesterone receptors have been generated that show promise in having similar uses as those to the estrogen receptor. In the field of diagnosis. the use of monoclonal antibodies has permitted the development of serological approaches for early diagnosis by identifying and measuring breast epithelial antigens in serum. and of histological approaches for establishing criteria for breast cancer dissemination and prognosis. With great expectations we are all following developments in the area of breast cancer treatment using conjugates of anti-breast epithelial monoclonal antibodies which are now confirming earlier reports in affecting breast tumor control. The recent creation of newer monoclonal antibodies and conjugates await experimentation and clinical trials to determine their value.
Translational Research in Breast Cancer by Erwei Song,Hai Hu Pdf
This book offers a comprehensive introduction to translational efforts in breast cancer, addressing the latest approaches to precision medicine based on the current state of understanding of breast cancer. With the latest developments in breast cancer research, our understanding of the genomic changes and the oncogenic signaling cascade of breast cancer has made considerable strides. Further, the immuno-environment has been demonstrated as the barrier to clinical cancer. In addition, major advances in cancer biology, immunology, genomics and metabolism have broken new ground for designing therapeutic approaches and selecting appropriate treatments on the basis of more precise information on the individual patient. As a result of these two trends, a clearer picture of the molecular landscape of breast cancers has facilitated the development of diagnostic, prognostic and predictive biomarkers for clinical oncology. All these aspects are addressed in this volume, which offers a comprehensive resource for researchers, graduate students and oncologists in cancer research.
The mysterious disease of cancer, including breast cancer, has plagued mankind since the dawn of recorded history. Regarding the elusive cause of the disease, the "Father of Medicine," Hippocrates of Athens (460–377 BC), wrote that, "For instability is characteristic of the humours and so they may be easily altered by nature and by chance." The enigma has persisted until today. In 1971, then President Richard Nixon signed the National Cancer Act and declared a "War on Cancer." He believed the counsel of scientists and physicians that if sufficient resources were committed to the fight, cancer could be virtually eliminated within 5 years. The prophesy failed. Although mortality from a few cancers, most notably leukemias, has been significantly reduced, carcinomas, cancers of the epithelium, which account for 80% of cancer deaths, remain unchanged. While tremendous advances have taken place in our understanding of the molecular and cellular mechanisms operant in cancer, it has proven exceedingly difficult to prevent the occurrence or to halt the progress of the disease. The very best therapy remains early detection while the primary tumor is small and localized to a single site, followed by removal of the offending growth by surgery and/or radiation. The great challenge of finding a cure confronts us yet, and it is effective intervention at the molecular level that offers our best hope. We still must find the "magic bullet."
Lida A. Mina,Anna Maria Storniolo,Hal Douglas Kipfer,Cindy Hunter,Kandice K. Ludwig
Author : Lida A. Mina,Anna Maria Storniolo,Hal Douglas Kipfer,Cindy Hunter,Kandice K. Ludwig Publisher : Springer Page : 104 pages File Size : 54,8 Mb Release : 2016-06-02 Category : Medical ISBN : 9783319194370
Breast Cancer Prevention and Treatment by Lida A. Mina,Anna Maria Storniolo,Hal Douglas Kipfer,Cindy Hunter,Kandice K. Ludwig Pdf
Uniquely designed for oncologists and general practitioners, this book offers clinicians comprehensive guidelines when dealing with women at high risk for breast cancer. Written by experts in the field on the cutting edge of this research, the following questions will be answered for the reader by the end of the book: · Who is at elevated risk for breast cancer? · Who should be genetically screened? · When and how often should we obtain imaging? · What type of imaging is adequate? · What medications are available for prevention? · When is surgical intervention appropriate? · What lifestyle changes should be implemented to prevent this disaster? With one in eight women likely to contract breast cancer in her lifetime, the significance of identifying and managing the high-risk patient is evident. Breakthroughs in the identification of genes associated with breast carcinoma, particularly BRCA1 and 2, as well as other risk factors, influence not only how patients are screened, but also how they are treated. Breast Cancer Prevention and Treatment provides a guided approach to prevention of breast cancer in women at elevated risk for this malignancy.