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Author : Vincenzo Flati,Giovanni Corsetti,Salvatore Papa
Publisher : Frontiers Media SA
Page : 86 pages
File Size : 48,8 Mb
Release : 2021-06-28
Category : Science
ISBN : 9782889669080
Author : Siim Land
Publisher : Metabolic Autophagy Diet
Page : 534 pages
File Size : 40,7 Mb
Release : 2019-02-09
Category : Science
ISBN : 1790686393
Intermittent Fasting for Longevity and Performance Your cells are constantly monitoring the nutrient status of the cells to determine whether or not to conserve energy or to promote growth. **One of the few known ways of increasing lifespan in almost all species is caloric restriction and energy deprivation.** This triggers many metabolic pathways and processes that make the organism more adaptable to environmental stressors and thus live longer. **The metabolism has two sub-categories or sub-processes called anabolism and catabolism. ** * Anabolism, meaning 'upward' in Greek, describes the synthesis of biological molecules to build up new physical matter in the body. * Catabolism, meaning 'downward' in Greek, describes the breaking down of biological molecules to release energy. This can apply to the breakdown of bodily tissue as well as the digestion of food that then gets assimilated into the body through anabolic processes. In addition to 'Metabolic', you can also find another word in the title - 'Autophagy', which translates from Ancient Greek into 'self-devouring' or 'eating of self'. This is central to the main practice of this book. By maintaining a balance between anabolism and catabolism, you can effectively extend your lifespan. The process of autophagy entails your healthy cells devouring the old, worn-out, weak ones and converting them back into energy. It's literally your body eating itself and using that to maintain homeostasis. There are many longevity-boosting benefits to this as illustrated in virtually all other species. This book is a collection of guidelines about the principles of the anabolic-catabolic cycles in regards to nutrition and exercise. It's definitely not a panacea - a solution or remedy for all conditions and circumstances. Instead, it's a very specific protocol that's not supposed to apply for all situations. **Metabolic Autophagy will teach you:** * What increases lifespan in humans and other species * Why there's so much disease and obesity in society * How to promote health and longevity with intermittent fasting * What is Autophagy and how it works * How to age slower and be vigorous throughout your life * Which foods make you live longer and build muscle * How the nutrient regulators of mTOR, AMPK, sirtuins, FOXO proteins, hormesis and others affect longevity * What are circadian rhythms and how they affect your health * Metabolic Autophagy Foods list and their anabolic-catabolic score * Supplements that support muscle growth and longevity * Many extras and bonuses in regards to food and exerciseSiim Land is a best-selling author, anthropologist, entrepreneur, high-performance coach and a biohacker who writes about optimizing health and human performance.This book incorporates daily lifestyle and dietary practices that help to cross the chasm between longevity and high performance.
Author : Zheng-Hong Qin
Publisher : Springer Nature
Page : 727 pages
File Size : 43,7 Mb
Release : 2019-11-27
Category : Science
ISBN : 9789811506024
This book series consists of 3 volumes covering the basic science (Volume 1), clinical science (Volume 2) and the technology and methodology (Volume 3) of autophagy. Volume 1 focuses on the biology of autophagy, including the signaling pathways, regulating processes and biological functions. Autophagy is a fundamental physiological process in eukaryotic cells. It not only regulates normal cellular homeostasis, and organ development and function, but also plays an important role in the pathogenesis of a wide range of human diseases. Thanks to the rapid development of molecular biology and omic technologies, research on autophagy has boomed in recent decades, and more and more cellular and animal models and state-of the-art technologies are being used to shed light on the complexity of signaling networks involved in the autophagic process. Further, its involvement in biological functions and the pathogenesis of various diseases has attracted increased attention around the globe. Presenting cutting-edge knowledge, this book series is a useful reference resource for researchers and clinicians who are working on or interested in autophagy.
Author : Carlos Pérez-Plasencia,Nadia Judith Jacobo-Herrera,Luis Enrique Gomez-Quiroz
Publisher : Frontiers Media SA
Page : 233 pages
File Size : 46,6 Mb
Release : 2021-02-24
Category : Medical
ISBN : 9782889665006
Author : Maria Ines Vaccaro,Vincenzo De Tata
Publisher : Frontiers Media SA
Page : 142 pages
File Size : 42,9 Mb
Release : 2020-12-11
Category : Medical
ISBN : 9782889660797
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Author : Joilson O. Martins,William T. Festuccia,Karen Yvonne Stokes,Stephen Fernandes Rodrigues
Publisher : Frontiers Media SA
Page : 224 pages
File Size : 54,5 Mb
Release : 2021-12-01
Category : Science
ISBN : 9782889717477
Author : Karen Forester
Publisher : Independently Published
Page : 194 pages
File Size : 41,6 Mb
Release : 2019-11-06
Category : Electronic
ISBN : 1706151187
Do you know how your metabolism work for real? Have you ever heard about the Metabolic Autophagy? Keep reading to find out more! Discovered over fifty years ago, autophagy is a double-edged blade. On one hand, it regulates cellular energy sources by "cannibalization" of its own cellular components, feeding on proteins and other unused cytoplasmic factors. On the other, it is a recycling process that removes dangerous waste from the cytoplasm keeping the cell clean and healthy. The global prevalence of metabolic disorders is an immediate threat to human health. Genetic features, environmental aspects and lifestyle changes are the major risk factors determining metabolic dysfunction in the body. Autophagy is a housekeeping stress-induced lysosomal degradation pathway, which recycles macromolecules and metabolites for new protein synthesis and energy production and regulates cellular homeostasis by clearance of damaged protein or organelles. To find out everything about it you will need a professional guide like this! Here it is what you will find inside: What is the Metabolic Autophagy and how does it work? What is the connection between the Autophagy and Oxidation How to have an intermittent fasting The connection between Autophagy and Metabolism ...and much more! Autophagy is indeed an important physiological process. However, what seems the answer in certain circumstances can be the problem in others. But if you want to find out more about the subject, the only thing you have to do is scrolling the page and pressing the buy button!
Author : Esther Bennett
Publisher : Hayle Medical
Page : 0 pages
File Size : 53,8 Mb
Release : 2023-09-26
Category : Medical
ISBN : 1646475593
Autophagy is a process in which cells capture their own cytoplasm and organelles and consume them in lysosomes. This mechanism preserves the health of cells and tissues through the replacement of damaged and outdated cellular components with new ones. The breakdown products serve as inputs to cellular metabolism. Autophagy prevents degenerative diseases as it is a powerful promoter of metabolic homeostasis at both the cellular and whole animal level. It reduces ubiquitinated protein accumulation in the brain, and disposes-off the aggregation-prone proteins and damaged organelles that cause Huntington's disease and Parkinson's disease. The metabolic syndrome refers to a group of medical conditions which increase the likelihood of heart disease, diabetes and stroke. It encompasses high blood sugar, hypertension, high cholesterol levels and excess fat around the waist. The process of autophagy has an effect on the development of metabolic syndrome since the metabolic syndrome is caused due to the accumulation of damaged cellular constituents. This book includes some of the vital pieces of works being conducted across the world, on various topics related to autophagy and metabolic syndrome. It is appropriate for students seeking detailed information in this area of medicine as well as for experts.
Author : Dhruv Kumar
Publisher : Springer
Page : 0 pages
File Size : 44,5 Mb
Release : 2021-02-14
Category : Medical
ISBN : 9811519935
This book illustrates various aspects of cancer cell metabolism, including metabolic regulation in solid tumours vs. non-solid tumours, the molecular pathways involved in its metabolism, and the role of the tumour microenvironment in the regulation of cancer cell metabolism. It summarizes the complexity of cancer cell metabolism in terms of the switch from anaerobic to aerobic glycolysis and how mitochondrial damage promotes aerobic glycolysis in cancer cells. The respective chapters provide the latest information on the metabolic remodelling of cancer cells and elucidate the important role of the signalling pathways in reprogramming of cancer cell metabolism. In addition, the book highlights the role of autophagy in cancer cell metabolism, and how metabolic crosstalk between cancer cells and cancer-associated fibroblasts promotes cancer cell progression. In closing, it summarizes recent advancements in drug development through targeting cancer metabolism.
Author : Dhruv Kumar,Shailendra Asthana
Publisher : Elsevier
Page : 364 pages
File Size : 54,9 Mb
Release : 2022-08-06
Category : Science
ISBN : 9780323999458
Autophagy and Metabolism: Potential Target for Cancer Therapy presents updates on autophagy in cancer metabolism and how it can be used to develop new, more efficient treatments. Written by experts in the field, the book presents recent research and explains how to translate it to the clinical setting. Sections discuss tumor cell metabolism and autophagy as therapeutic targets, autophagy regulation in cancer, signaling pathways in metabolic dysregulation in solid tumors, metabolic stress and cell death pathways, and the role of the tumor microenvironment. In addition, topics cover combined targeting autophagy, metabolism for cancer therapy, and the autophagy effect on immune cell metabolism. This will be a valuable resource for researchers, oncologists, graduate students, and members of the biomedical field who are interested in learning more about the interaction between autophagy and cancer metabolism. Presents valuable and updated information on the mechanisms of autophagy in cancer metabolism Discusses the various metabolic pathways linked with autophagy that can be a major target for chemotherapeutic strategies Explains how autophagy supports tumor growth by activating metabolic phenotypes in cancer cells and the therapeutic interventions available to halt the process
Author : Sarah-Maria Fendt,Sophia Y. Lunt
Publisher : Humana
Page : 0 pages
File Size : 55,5 Mb
Release : 2018-10-13
Category : Science
ISBN : 1493987682
This book provides protocols to quantify metabolism, to identify metabolic crosstalk, and to setup and develop tools and models to gain insight into metabolic signaling using experimental and computational approaches. Chapters detail protocols to quantify metabolism, identify metabolic crosstalk, and develop tools and models to gain a systems-level insight into metabolic signaling. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Metabolic Signaling: Methods and Protocols aims to provide researchers with methods to study, perturb, and functionally interpret metabolism and metabolic signaling from the sub-cellular to the whole-body level.
Author : Rachel Dash
Publisher : Unknown
Page : 124 pages
File Size : 55,9 Mb
Release : 2019-08-30
Category : Electronic
ISBN : 1689545674
★★Buy the Paperback Version of this Book on Amazon.com and get the Kindle Book version for FREE ★★ If you want to lose weight safely and discover how to live healthy and longer, keep reading... Several of the most popular diets today work by tapping into autophagy, an important pathway taking place in your body right now. In Metabolic Autophagy: Discover How to Live Healthy and Longer with Your Self-Cleansing Body's Natural Intelligence, you will learn about all of the health benefits this pathway has to offer. These benefits include weight loss, increased energy, improved immune system functioning, anti-aging, improved metabolic functioning, and cancer-fighting ability. Autophagy is already taking place in your body's cells and tissues. All you need to do is learn the tools that you can use to stimulate this critically beneficial process. The good things that stimulating autophagy can introduce into your life will be explored to help you learn how you can improve your life by taking advantage of this natural cellular process. Autophagy has quickly become a buzz word in the health and fitness industry, much like the Atkins Diet and the Ketogenic Diet. Like other buzz words, autophagy is a term that many uses but relatively few truly comprehend. Many equate autophagy with the more familiar apoptosis, which many will have learned about in school. But autophagy is very different from this, the other major form of cell death. It is this difference that you will tap into to help you add longevity, lose weight, and reduce your risk for cancer. In Metabolic Autophagy: Discover How to Live Healthy and Longer with Your Self-Cleansing Body's Natural Intelligence, you will learn how autophagy can be stimulated by fasting, dieting, and exercise to help you bring these benefits and many more into your life. Some of you may be familiar with diets like intermittent fasting, water fasting, fasting-mimicking, and the Ketogenic diet. In Metabolic Autophagy: Discover How to Live Healthy and Longer with Your Self-Cleansing Body's Natural Intelligence, you will learn how these diets tap into autophagy to cause you to lose weight and keep the weight off. And for those of you interested in maintaining muscle mass, protecting yourself from illness and disease, and improving your metabolism, you will learn how you can best use the process of autophagy to help you achieve your goals. In Metabolic Autophagy: Discover How to Live Healthy and Longer with Your Self-Cleansing Body's Natural Intelligence, you will discover how autophagy enhances survival. Autophagy is how the body engages in the survival of the fittest on a cellular level. This process allows the human body to consume and recycle components for energy. In Metabolic Autophagy: Discover How to Live Healthy and Longer with Your Self-Cleansing Body's Natural Intelligence, you will also learn about the foods you can eat in order to stimulate autophagy effectively, allowing you reap all of the health benefits. Some of the benefits of autophagy that will be explored in this book include: Dramatic weight loss Improved metabolism and insulin sensitivity Improved immune functioning Anti-aging effects Anti-cancer effects Improved cardiovascular function Improved nervous system functioning Protection from neurodegenerative disease Protection from infection Improved sense of health and wellness So, are you ready to start a new healthy way of life? Scroll Up and Click the Buy Now Button to Get Your Copy NOW!
Author : James W. Clement
Publisher : Simon and Schuster
Page : 320 pages
File Size : 40,9 Mb
Release : 2021-04-27
Category : Health & Fitness
ISBN : 9781982115401
"How can you lose dramatic weight, reverse chronic conditions, and stay healthier longer? Flip the switch on your metabolism with intermittent fasting, protein restriction, and ketosis! Lose weight. Reverse Chronic Conditions. Live Healthier Longer. Within each of us is an ancient mechanism that eliminates toxic materials, initiates fat burning, and protects cells against stress. It's called autophagy, and when it's turned on, the complex operation can not only slow down the aging process, but can optimize biological function as a whole, helping to stave off all manner of disease-from diabetes to dementia-and affording us the healthy lifespan we never thought possible. So how can we activate this switch through diet? How frequently should we fast and for how long? Must we abstain from all foods or just specific macronutrients? What's the sweet spot between intermittent fasting, protein restriction, and ketogenic eating? Backed by a wealth of data, and with a practical program anyone can follow for lasting results, The Switch not only decodes the science of autophagy, but also teaches you how to control it and benefit from its profound impact"--
Author : Daniel Klionsky
Publisher : Academic Press
Page : 560 pages
File Size : 54,8 Mb
Release : 2009-03-05
Category : Science
ISBN : 0080923259
This is the companion volume to Daniel Klionsky’s Autophagy: Lower Eukaryotes, which features the basic methods in autophagy covering yeasts and alternative fungi (aspergillus, podospora, magnaporthe). Klionsky is one of the leading authorities in the field. He is the editor-in-chief of Autophagy. The November 2007 issue of Nature Reviews highlighted his article, “Autophagy: From phenomenology to molecular understanding in less than a decade. He is currently editing guidelines for the field, with 230 contributing authors, that will publish in Autophagy. Particularly in times of stress, like starvation and disease, higher organisms have an internal mechanism in their cells for chewing up and recycling parts of themselves. The process of internal “house cleaning in the cell is called autophagy – literally self-eating. Breakthroughs in understanding the molecular basis of autophagy came after the cloning of ATG1 (autophagy-related gene 1) in yeast. (To date, 30 additional yeast genes have been identified.) These ATG genes in yeast were the stepping stones to the explosion of research into the molecular analysis of autophagy in higher eukaryotes. In the future, this research will help to design clinical approaches that can turn on autophagy and halt tumor growth.
Author : Anne Le
Publisher : Springer Nature
Page : 283 pages
File Size : 46,7 Mb
Release : 2021-05-20
Category : Medical
ISBN : 9783030657680
This open access volume will introduce recent discoveries in cancer metabolism since the publication of the first edition in 2018, providing readers with an up-to-date understanding of developments in the field. Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, the authors delve into the complexity and diversity of cancer metabolism and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies for cancer treatment. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer treatment. This book has four major parts. Part one will cover the basic metabolism of cancer cells, followed by a discussion of the heterogeneity of cancer metabolism in part two. Part three addresses the relationship between cancer cells and cancer-associated fibroblasts, and the new part four will explore the metabolic interplay between cancer and other diseases. This new section makes the book unique from other texts currently available on the market. The second edition will be useful for cancer metabolism researchers, cancer biologists, epidemiologists, physicians, health care professionals in related disciplines, policymakers, marketing and economic strategists, among others. It may also be used in courses such as intro to cancer metabolism, cancer biology, and related biochemistry courses for undergraduate and graduate students.
