Axonal Regeneration In The Mammalian Central Nervous System
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Author : Dorothy E. Oorschot,David G. Jones Publisher : Springer Science & Business Media Page : 121 pages File Size : 48,7 Mb Release : 2012-12-06 Category : Medical ISBN : 9783642751080
Axonal Regeneration in the Mammalian Central Nervous System by Dorothy E. Oorschot,David G. Jones Pdf
This state-of-the-art review links the experimental data into a cohesive and critical account of CNS regeneration. Research findings are discussed in terms of their relevance to one (or more) of thirteen hypotheses concerned with regeneration in the mammalian CNS. Research findings reviewed include: regeneration in developing mammals and in submammalian vertebrates, the use of transplants and/or pharmacological treatments, in vitro studies on neurotrophic and neurite promoting factors and their potential relevance to CNS regeneration in vivo, and in vitro studies on the types of glial cells that may be responsible for enhancing or suppressing axonal re-growth.
Axonal Regeneration in the Central Nervous System by Nicholas A Ingoglia,Marion Murray Pdf
Summarizing a review of research into factors that regulate, stimulate, and prevent regeneration in the central nervous system (CNS), this comprehensive reference progresses further into answering and resolving neuron capacity for axon regeneration in the mammalian CNS. Axonal Regeneration in the Central Nervous System analyzes axonal regeneration, reinnervation, and functional recovery in lower vertebrates examines the correlation between developmental age and the ability to regenerate considers mammalian neuron responses at the cell body, site of injury, and in the distal nerve, including apoptic cell death, and inflammatory and glial responses to injury reviews genomic responses to axotomy with a comparative description of transcribed genes from successfully regenerating neurons and neurons incapable of regrowth discusses how growing axons may induce the expression of genes in glia/Schwann cells following axotomy and regeneration describes the use of gene therapy to deliver trophic and survival factors to injured neurons explores the hospitable environments of the peripheral nerve, olfactory ensheathing cells, and fetal cell transplants for regeneration discusses results from applications of fetal CNS tissue to human spinal cord injuries and much more!
Degeneration and Regeneration in the Nervous System by Norman Saunders,Katarzyna Dziegielewska Pdf
Degeneration and Regeneration in the Nervous System brings together an international team of contributors to produce a series of critical reviews appraising key papers in the field. The pace of research on brain and spinal cord injury quickened considerably in the last ten years and there is much that is new and important that is covered in this book. However, there is still a long way to go before our knowledge will explain fully why the central nervous system has such a limited capacity for regeneration, and before experimental solutions can be applied to the patient. With emphasis on actual and therapeutic importance of the work reviewed, Degeneration and Regeneration in the Nervous System is a useful overview for graduate students, their teachers and researchers working in this field.
Michael E. Selzer,Stephanie Clarke,Leonardo G. Cohen,Gert Kwakkel (Professor),Robert H. Miller (Professor)
Author : Michael E. Selzer,Stephanie Clarke,Leonardo G. Cohen,Gert Kwakkel (Professor),Robert H. Miller (Professor) Publisher : Cambridge University Press Page : 693 pages File Size : 46,7 Mb Release : 2014 Category : Nervous system ISBN : 9781107011670
Textbook of Neural Repair and Rehabilitation by Michael E. Selzer,Stephanie Clarke,Leonardo G. Cohen,Gert Kwakkel (Professor),Robert H. Miller (Professor) Pdf
In two freestanding volumes, the Textbook of Neural Repair and Rehabilitation provides comprehensive coverage of the science and practice of neurological rehabilitation. Revised throughout, bringing the book fully up to date, this volume, Neural Repair and Plasticity, covers the basic sciences relevant to recovery of function following injury to the nervous system, reviewing anatomical and physiological plasticity in the normal central nervous system, mechanisms of neuronal death, axonal regeneration, stem cell biology, and research strategies targeted at axon regeneration and neuron replacement. New chapters have been added covering pathophysiology and plasticity in cerebral palsy, stem cell therapies for brain disorders and neurotrophin repair of spinal cord damage, along with numerous others. Edited and written by leading international authorities, it is an essential resource for neuroscientists and provides a foundation for the work of clinical rehabilitation professionals.
Nerve, Organ, and Tissue Regeneration: Research Perspectives by Fredrick Seil Pdf
Nerve, Organ, and Tissue Regeneration: Research Perspectives presents the proceedings of a symposium held in Harpers Ferry, West Virginia, on September 21–24, 1982. This book explores the neural and nonneural areas of regeneration, with emphasis on the nervous system. Organized into six parts encompassing 22 chapters, this compilation of papers examines the commitment of the Veterans Administration to deal with the clinical problem of spinal cord injury by establishing 19spinal cord injury treatment and rehabilitation centers throughout the United States. This book then discusses the characteristics of the neuronal response to axon injury, which vary from cellular hypertrophy and heightened metabolism to cell death. Other chapters consider the three phases of axonal regeneration, including sprout formation, elongation, and maturation. The final chapter deals with the structural and functional alterations that developed when the length of the mammalian intestine is shortened by excision or by-pass of a long segment. This book is a valuable resource for biologists, orthopedic surgeons, and neuroscientists.
Axon Growth and Regeneration: Part 1 by Anonim Pdf
Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume reviews existing theories and current research surrounding Axon Growth and Regeneration. Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist
Reviews research findings, and outlines directions for research, on neural regeneration after injury in the mammalian nervous system. Topics discussed include: axonal dynamics during regeneration; the fate of denervated neurons; and supporting cells in the central and peripheral nervous systems.
Myelin-Mediated Inhibition of Axonal Regeneration: Past, Present, and Future by Sari Hannila,Wilfredo Mellado Pdf
Pioneering studies conducted in the 1980’s laid the foundation for the hypothesis that axonal regeneration is limited by CNS myelin, and the identification of myelin-associated glycoprotein (MAG), Nogo, and oligodendrocyte myelin glycoprotein (OMgp) as inhibitors of neurite outgrowth firmly established myelin as a key factor in regenerative failure. Mechanistically, it has been shown that MAG, Nogo, and OMgp mediate inhibition by binding to either Nogo receptor (NgR) or paired immunoglobulin receptor B (PirB), and initiating a signaling cascade that culminates in the activation of RhoA. Since the discovery of these proteins, there has been tremendous interest in identifying compounds and molecular mechanisms that are capable of overcoming myelin-mediated inhibition. Many studies have focused on pharmacological antagonism of receptors and signaling intermediates, while others have sought to identify and enhance endogenous pro-regenerative pathways. The most notable example of the latter is the conditioning lesion effect, which led to the discovery of cyclic AMP’s ability to overcome inhibition by MAG and myelin. Many of the agents tested in these studies have been shown to promote axonal regeneration in vivo, and this research topic allows researchers to share information about new treatments that have been developed in both academia and industry. As we look toward the future, it is becoming increasingly clear that reversal of myelin-mediated inhibition alone will not be sufficient to produce functional recovery from spinal cord injury, and that other factors, such as astroglial scarring, the expression of chondroitin sulfate proteoglycans, neuronal cell death, and lack of neurotrophic support, must also be taken into consideration. Combinatorial approaches therefore hold a great deal of promise, and we hope to initiate a dialogue on how stem cell transplantation, chondroitinase ABC, gene therapy, growth-promoting agents, and other methods can be combined to optimize functional recovery. We introduce this topic in honor of the life and work of Dr. Marie T. Filbin (1955-2014). Through these articles, we highlight past achievements in the field, novel findings, unanswered questions and innovative ideas that we hope will lead to new advances in axonal regeneration.
Author : Santiago Ramón y Cajal Publisher : History of Neuroscience Page : 977 pages File Size : 46,6 Mb Release : 1991 Category : Nervous system ISBN : 9780195065169
Cajal's Degeneration and Regeneration of the Nervous System by Santiago Ramón y Cajal Pdf
This book is a reprint of an English translation of Cajal's original work, with abundant notes and commentaries by the editor. This text describes Cajal's fundamental contributions to neuroscience, which continue to be important today. It accurately details Cajal's ideas and data, and providesreaders with the opportunity to learn what Cajal thought about his research career and the significance of his observations. Excerpts from Tello's memorial lectures also provide a contemporary view of Cajal's work.
CNS Regeneration by Mark H. Tuszynski,Jeffrey Kordower Pdf
CNS Regeneration focuses on some of the leading current neurological disease models and methods for promoting central nervous system regeneration. Editors and authors are experts in the field, with experience in basic as well as applied neuroscience. In a comprehensive, logical manner, the book unites important basic science advances in neuroscience with novel medical strategies. The first comprehensive, authoritative volume on the topic of CNS regeneration Reviews current therapeutic approaches Editors and authors are experts in the field Appeals to those interested in basic science as well as those concerned with its medical application
Axonal Transport in Neuronal Growth and Regeneration by John Elam Pdf
Over the past several years, the pace of research on the control of axonal growth has increased at a remarkable rate, and this activity is reflected in a growing literature dealing with various aspects of axonal growth and regener ation. It appears timely to review the role played by axonal transport in the intrinsic responses of neurons in the growth and regrowth processes. Through the cooperation of the senior editors of this series, we have been given the opportunity to bring such a focus to the current volume. We wish to acknowledge that the contributing authors attended a confer ence on "The Role of Axonal Transport in Neuronal Growth and Regenera tion" held in Tallahassee, Florida in March, 1983, sponsored by the Psycho biology Research Center of the Florida State University. It is our hope that many of the perceptions and insights expressed in these chapters resulted from our interactions.
Mechanisms of Secondary Brain Damage by A. Baethmann,K. G. Go,A. Unterberg Pdf
A distinction between primary and secondary brain damage of vari ous origin, particularly in acute lesions, such as head injury and ische mia is not entirely new. The concept is of practical significance, be cause it is the foremost intention of all clinical efforts to prevent, or at least attenuate the development of secondary sequelae. Primary dam age to nervous elements usually cannot be influenced by treatment. Its prevention is the objective of prophylactic measures. The current volume gathered prominent scientists and clinicians from various fields to pro vide a competent introduction and survey of the various aspects involved in secondary brain damage. It was attempted to provide criteria for the distinction between the primary and secondary phenomena on a morpho logical and functional level, on the basis of the kinetics involved and, most importantly, regarding the different specific manifestations, such as disturbances of microcirculation, aspects of the blood-brain barrier, and of cellular structure and function at a molecular level. Although it was not expected that a grand unifying hypothesis will be reached recon cilable with the many, occasionally opposing views on such a complex subject, nevertheless, the present volume attains an appropriate result. It can best be described as a mosaic of many different pieces which only as an ensemble reflect the current state of the art.
