Axoplasmic Transport In Physiology And Pathology

Author : D. G. Weiss,A. Gorio
Publisher : Springer Science & Business Media
Page : 206 pages
File Size : 43,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642857140

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Axoplasmic Transport in Physiology and Pathology by D. G. Weiss,A. Gorio Pdf

Cajal and contemporary scientists have laid the basis of the modem concepts of the organization of the nervous system: the cir cuits of the brain are made up of individual neurons which transfer information via specialized structures called synapses. Soma and den drites usually receive the inputs, then the signal is carried all along the axon to the target areas. To fulfIll this task several types of neurons have developed their unique geometry characterized by a large recep tive area (soma and dendrites) and an often very extensive distal branching with the axon terminals. The volume of cytoplasm which constitutes the neuronal periphery is often far larger than the cell body, where the synthetic machinery is located. It is one of the roles ofaxoplasmic transport to supply the periphery with proper material and to sustain the specialized structures necessary for the physiological activity of the neuron. Furthermore, it has become more and more clear that target areas also exert effects on the innervating neurons, and these effects are not only mediated via recurrent fibers. Synapses have been shown to be able to pick up material from the synaptic left which is then intra axon ally transported back to the cell body. This retrograde axoplasmic transport has therefore been recognized as another basic mechanism to convey signals from the periphery to the centre.

Author : Zafar Iqbal
Publisher : CRC Press
Page : 328 pages
File Size : 46,7 Mb
Release : 2018-05-04
Category : Science
ISBN : 9781351078450

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Axoplasmic Transport by Zafar Iqbal Pdf

Axoplasmic transport is the intracellular movement of cellular components required for the maintenance and normal physiological functioning of neuronal cells. This book provides an up to date reference for both established investigators as well as for those entering in the field.This volume describes the history and methods of the study of transport and the involvement of energy, ions, calmodulin, microtubules and other cellular components in transport. It also discusses the transport of polypeptides, lipids, nucleic acids, neutrotransmitter containing components and various other particles in nerve fibres. A significant portion of this book is devoted to axoplasmic transport, regeneration and the relevance of transport in neurotropic functions are described in the alst four chapters, followed by a discussion on the mechanism of axoplasmic transport.

Author : M. E. Schläfke,H. P. Koepchen,W. See
Publisher : Springer Science & Business Media
Page : 283 pages
File Size : 49,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642686573

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Central Neurone Environment and the Control Systems of Breathing and Circulation by M. E. Schläfke,H. P. Koepchen,W. See Pdf

This volume contains the papers presented at the symposion on Central Neurone Environment and the Control Systems of Breathing and Circulation held at Bochum, October 5-7,1981 in honour of Prof. Dr. Dr. h.c. Hans H. Loeschcke, who retired in March 1981. His discovery of ventral medullary substrates forming an essential drive for the ventilatory as well as for circulatory control systems, and the elaboration of this concept during the last 25 years have profoundly influenced the concepts in this field. In an age of proceeding specializa tion on partial mechanisms, his approach has always emphasized the integrative aspects of the control systems, especially the role of the respiratory control system for the ionic homeostasis of the brain and the close interrelation between neuronal respiratory and cardiovascular control. This general intention implies the combination of physico chemical and neurophysiological approaches as well as the study of peripheral function of respiration and circulation, topics which are usually handled separately according to the different methods.

Author : P. P. Liberski
Publisher : CRC Press
Page : 520 pages
File Size : 47,7 Mb
Release : 2019-08-08
Category : Science
ISBN : 9781351090933

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Light And Electron Microscopic Neuropathology of Slow Virus Disorders by P. P. Liberski Pdf

Light and Electron Microscopic Neuropathology of Slow Virus Disorders provides extensive coverage of the neurobiology and neuropathology of slow, unconventional virus disorders also known as prion diseases. The book features an outstanding group of contributers, including Nobel Laureate Dr. D. Carleton Gajdusek and his co-workers. Studies range from the classical to the modern and are based on light microscopy, electron microscopy, and immunohistochemistry. Specific topics covered include spongiform encephalopathies and the hypothesis of infectious polypeptides, structure of the agent, neuropathology of kuru, Creutzfeldt-Jakob disease, Gerstmann-Str‘sler-Scheinker diseases, scrapie, bovine spongiform encephalopathy, and chronic wasting disease. Many chapters are based on findings from over 15,000 unpublished micrographs from cases and experimental models. The book also features an extensive list of references ranging from classic 19th century studies to studies through mid-1992. Light and Electron Microscopic Neuropathology of Slow Virus Disorders will be an excellent reference for neurologists, neuropathologists, virologists, neurobiologists, and other scientists interested in these virus disorders.

Author : Pierre Dustin
Publisher : Springer Science & Business Media
Page : 499 pages
File Size : 42,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642696527

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Microtubules by Pierre Dustin Pdf

The decision, in 1975, to write alone a monograph on micro tubules was not without risks. While I was familiar from its start in Brussels in 1934 with the work on col chicine and other mitotic poisons, the literature on microtubules was, 8 years ago, already increasing at an impressive rate. However, this monograph, which, contrary to other works on microtubules, tried to cover the whole field of research, from the fundamentals of the tubulin molecule and the possible role of these organelles in some aspects of human pathology, to some medical applications of microtubule poisons, has been accepted as a useful tool for workers in these fields. Since 1976, (date of the last references mentioned in the monograph) until the middle of 1983, papers on microtubule research have literally been pouring in, at the rate of several hundred a year. This may justify a second edition, although the considerable difficulties in keeping the size of the book within the same limits while not forgetting to mention some important work, could not be overlooked. The need for an entirely revised and rewritten edition prompted this new venture and was possible with the help of the considerable amount of reprints kindly sent to me day after day over the years. This work would have been unthinkable if the author had not maintained the same enthusiasm for microtubule research, which has been disclosing new facts every day.

Author : F.L. Margolis,T.V. Getchell
Publisher : Springer Science & Business Media
Page : 388 pages
File Size : 47,9 Mb
Release : 2013-11-11
Category : Science
ISBN : 9781461309895

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Molecular Neurobiology of the Olfactory System by F.L. Margolis,T.V. Getchell Pdf

The sense of smell and the olfactory system have been a subject of intrinsic interest for millenia. Inquiry into the structure and function of the olfactory system is based on a long tradition that dates back at least to the ancient Greeks. The mechanistic basis for the sensitivity and selectivity of this chemosensory detection system has always posed a challenge and remained largely a mystery. Recently, there has been a renaissance of interest in it and especially in the application of contemporary techniques of biochemistry and cellular and molecular biology. In this volume, current research utilizing these ap proaches is discussed in depth by a group of scientists who are among the current leaders in the applications of these techniques to the olfactory system. These authors address a wide range of questions that bear directly on the olfactory system but have broader biological implications as well. The various chapters have been grouped into five broad subject areas that emphasize diverse but related questions. "Transduction and Ligand-Receptor Interactions" considers the biochemical bases of stimulus access, interaction, transduction, elimination, and information processing.

Author : National Library of Medicine (U.S.)
Publisher : Unknown
Page : 1442 pages
File Size : 52,5 Mb
Release : 1983
Category : Medicine
ISBN : UOM:39015074107650

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Current Catalog by National Library of Medicine (U.S.) Pdf

First multi-year cumulation covers six years: 1965-70.

Author : National Library of Medicine (U.S.)
Publisher : Unknown
Page : 1456 pages
File Size : 49,6 Mb
Release : 1983
Category : Medicine
ISBN : MINN:31951D00170007S

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National Library of Medicine Current Catalog by National Library of Medicine (U.S.) Pdf

Author : Bingwei Lu
Publisher : Springer Science & Business Media
Page : 271 pages
File Size : 49,8 Mb
Release : 2011-05-16
Category : Medical
ISBN : 9789400712911

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Mitochondrial Dynamics and Neurodegeneration by Bingwei Lu Pdf

Mitochondria are essential organelles in eukaryotic cells that control such diverse processes as energy metabolism, calcium buffering, and cell death. Recent studies have revealed that changes in mitochondrial morphology by fission and fusion, a process known as mitochondrial dynamics, is particularly important for neuronal function and survival. Defects in this process are commonly found in neurodegenerative diseases, offering a new paradigm for investigating mechanisms of neurodegeneration. To provide researchers working on neurodegenerative diseases and mitochondria with updated information on this rapidly progressing field, we have invited experts in the field to critically review recent progresses and identify future research directions. The topics include genetics of mitochondrial dynamics, mitochondrial dynamics and bioenergetics, autophagy, apoptosis, and axonal transport, and its role in neurological diseases, including Alzheimer’s, Parkinson’s, and Huntington’s diseases.

Author : Anonim
Publisher : Unknown
Page : 268 pages
File Size : 41,6 Mb
Release : 1984
Category : Science
ISBN : UOM:39015038789387

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Revista di scienza, organo internazionale di sintesi scientifica by Anonim Pdf

Author : Marino De León
Publisher : Unknown
Page : 382 pages
File Size : 49,6 Mb
Release : 1987
Category : Electronic
ISBN : UCAL:X33195

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Synthesis and Axonal Transport of Fucosylated Material During Sciatic Nerve Regeneration in Frog by Marino De León Pdf

Author : Anonim
Publisher : Unknown
Page : 714 pages
File Size : 43,8 Mb
Release : 1977
Category : Parkinson's disease
ISBN : MINN:31951002781730U

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Parkinson's Disease and Related Disorders by Anonim Pdf

Author : Anonim
Publisher : Unknown
Page : 246 pages
File Size : 49,8 Mb
Release : 1984
Category : Electronic
ISBN : NWU:35558000092680

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IBRO News by Anonim Pdf

Author : Anonim
Publisher : Unknown
Page : 932 pages
File Size : 55,5 Mb
Release : 1984
Category : Biochemistry
ISBN : UIUC:30112009296580

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Comparative Biochemistry and Physiology by Anonim Pdf

Author : Daniel Laskowitz,Gerald Grant
Publisher : CRC Press
Page : 412 pages
File Size : 42,6 Mb
Release : 2015-12-01
Category : Medical
ISBN : 9781498766579

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Translational Research in Traumatic Brain Injury by Daniel Laskowitz,Gerald Grant Pdf

Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.