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Author : Effrossyni Boutou,Horst-Werner Stürzbecher
Publisher : Unknown
Page : 0 pages
File Size : 42,5 Mb
Release : 2018
Category : Microbiology
ISBN : 1838812644
Author : Kishor K. Bhakat,Tapas K. Hazra
Publisher : Springer Nature
Page : 267 pages
File Size : 49,8 Mb
Release : 2023-09-14
Category : Science
ISBN : 9781071633731
This detailed volume provides a comprehensive set of experimental protocols and useful strategies to examine the repair of damaged bases via the Base Excision Repair (BER) pathway in vitro and in cells. Beginning with multiple molecular and cellular techniques to examine the excision of damaged bases from double-stranded DNA or DNA wrapped in a nucleosome, the book continues with sections covering procedures to detect and quantify the damaged bases, protein DNA crosslinks, and double-strand breaks, experimental procedures to identify DNA repair protein interactome by conventional tandem affinity purification followed by mass spectroscopy analysis, as well as the analysis of genome-wide binding of DNA repair proteins and copy number variations of the DNA damage response gene in tumors. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Base Excision Repair Pathway: Methods and Protocols serves as a valuable resource for novices and experts trying to examine the repair of various types of DNA lesions in vitro and in cell by the distinct set of proteins in the BER pathway.
Author : Errol C. Friedberg,Graham C. Walker,Wolfram Siede,Richard D. Wood
Publisher : American Society for Microbiology Press
Page : 2587 pages
File Size : 40,6 Mb
Release : 2005-11-22
Category : Science
ISBN : 9781555813192
An essential resource for all scientists researching cellular responses to DNA damage. • Introduces important new material reflective of the major changes and developments that have occurred in the field over the last decade. • Discussed the field within a strong historical framework, and all aspects of biological responses to DNA damage are detailed. • Provides information on covering sources and consequences of DNA damage; correcting altered bases in DNA: DNA repair; DNA damage tolerance and mutagenesis; regulatory responses to DNA damage in eukaryotes; and disease states associated with defective biological responses to DNA damage.
Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 43,8 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181
Author : Wilson Iii David M
Publisher : World Scientific
Page : 824 pages
File Size : 52,8 Mb
Release : 2016-12-08
Category : Science
ISBN : 9789814719742
This book will serve as the preeminent text book on the topic of "base excision repair", a key DNA repair pathway that protects cells from most spontaneous forms of DNA damage, including oxidative lesions that arise both in the nuclear and mitochondrial genomes. The book, which includes contributions from many of the world leaders in the field, provides a detailed description of the molecular mechanisms of base excision repair, as well as its emerging relationship to epigenetic regulation, the aging process and human disease, such as cancer susceptibility, immunological defects and neurological disorders. The book will also cover the state-of-the-art technologies being developed to assess base excision repair capacity among individuals in the population, in addition to the strategies being employed to target base excision repair as part of therapeutic paradigms to eradicate disease, namely cancer. This book represents one of the most extensive efforts to date to cover the topic of "base excision repair". It includes chapters by many of the most established investigators in the field, from all over the world.
Author : Miral Dizdaroglu,R Stephen Lloyd
Publisher : Royal Society of Chemistry
Page : 509 pages
File Size : 45,8 Mb
Release : 2020-11-11
Category : Science
ISBN : 9781839162565
The DNA of all organisms is constantly being damaged by endogenous and exogenous sources. Oxygen metabolism generates reactive species that can damage DNA, proteins and other organic compounds in living cells. Exogenous sources include ionizing and ultraviolet radiations, carcinogenic compounds and environmental toxins among others. The discovery of multiple DNA lesions and DNA repair mechanisms showed the involvement of DNA damage and DNA repair in the pathogenesis of many human diseases, most notably cancer. These books provide a comprehensive overview of the interdisciplinary area of DNA damage and DNA repair, and their relevance to disease pathology. Edited by recognised leaders in the field, this two-volume set is an appealing resource to a variety of readers including chemists, chemical biologists, geneticists, cancer researchers and drug discovery scientists.
Author : Wolfram Siede,Paul W. Doetsch
Publisher : CRC Press
Page : 871 pages
File Size : 54,8 Mb
Release : 2005-09-19
Category : Medical
ISBN : 9780849352683
Stands as the most comprehensive guide to the subject-covering every essential topic related to DNA damage identification and repair. Covering a wide array of topics from bacteria to human cells, this book summarizes recent developments in DNA damage repair and recognition while providing timely reviews on the molecular mechanisms employe
Author : Mark D. Evans,Marcus S. Cooke
Publisher : Springer Science & Business Media
Page : 228 pages
File Size : 40,6 Mb
Release : 2009-06-11
Category : Science
ISBN : 9780387729749
This book provides up-to-date coverage of selected topics in nucleic acid oxidation. The topics have been selected to cover everything from basic chemical mechanisms, repair of damage and the biological and pathological meaning of DNA oxidation. The chapters are authored by leading, research active, international experts in the respective topics.
Author : Ian D. Hickson
Publisher : Springer Science & Business Media
Page : 204 pages
File Size : 45,9 Mb
Release : 1999-06-08
Category : Science
ISBN : 0412131617
Reviews the latest research in the field for researchers and clinicians. After a general introduction to DNA base excision repair, chapters cover uracil DNA glycosylases, repair of oxidized purines in DNA, mammalian mismatch-specific DNA glycosylases, repair of apurinic/apyrimidic sites in DNA by AP endonucleases, mutagenesis of abasic sites, a pro
Author : Dmitry O. Zharkov
Publisher : Springer Nature
Page : 230 pages
File Size : 54,9 Mb
Release : 2020-05-07
Category : Medical
ISBN : 9783030412838
DNA is under constant challenge from environmental and endogenous metabolic assaults. Several layers of defence and repair systems allow cells to maintain stable genomes; in humans, dysfunction of these systems leads to cancer, neurodegeneration, and other pathologies. At the same time, recently it had emerged that targeted and regulated DNA damage and repair is a mechanism underlying several important cellular processes such as epigenetic demethylation and immunoglobulin gene diversification. The present collection of papers is aimed to cover new developments in the area of protective and regulatory mechanisms associated with DNA damage. The mechanisms ruling the recognition of damaged nucleotides against the vast background of normal ones are reviewed. The role of extended non-catalytic domains that are often found in eukaryotic DNA repair proteins in contrast to their downsized, catalytic-only bacterial counterparts is discussed. Among the proposed subjects are the regulatory functions of bulky covalent modifications such as poly(ADP)ribosylation and ubiquitylation in DNA damage response, especially in the context of chromatin remodelling. As opposed to DNA repair, damage tolerance allows cells to replicate with lesions in the genome; the enzymes responsible are also covered. Finally, we present examples of modern multilevel understanding of the cell function and malfunction in the wake of genotoxic assaults such as oxidative stress, abiotic environmental stress, and DNA-damaging plant toxins.
Author : Maddalena Mognato
Publisher : BoD – Books on Demand
Page : 234 pages
File Size : 43,5 Mb
Release : 2019-06-05
Category : Medical
ISBN : 9781838807825
This book offers a collection of chapters addressing different studies on DNA repair from a cellular and molecular point of view. The various contributions highlight the vastness of DNA repair process and the need for a deeper understanding. To this end, the recent considerations here presented can be a cue for scientists and students working on, or interested in, the subject of DNA repair in human cells. This book may suggest to readers new avenues of interplay between different kinds of DNA damage and cellular response for maintaining nuclear and mitochondrial genomic stability.
Author : Igor Kovalchuk,Olga Kovalchuk
Publisher : Academic Press
Page : 762 pages
File Size : 40,5 Mb
Release : 2021-07-17
Category : Science
ISBN : 9780323856805
Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability and genome diversification in response to environmental factors. Here, across thirty-eight chapters, leading researchers provide a deep analysis of genome stability in DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, examining how epigenetic factors contribute to genome stability and how these species pass memories of encounters to progeny. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, and genome stability in response to aging. This second edition has been fully revised to address evolving research trends, including CRISPRs/Cas9 genome editing; conventional versus transgenic genome instability; breeding and genetic diseases associated with abnormal DNA repair; RNA and extrachromosomal DNA; cloning, stem cells, and embryo development; programmed genome instability; and conserved and divergent features of repair. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability. A deep analysis of genome stability research from various kingdoms, including epigenetics and transgenerational effects Provides comprehensive coverage of mechanisms utilized by different organisms to maintain genomic stability Contains applications of genome instability research and outcomes for human disease Features all-new chapters on evolving areas of genome stability research, including CRISPRs/Cas9 genome editing, RNA and extrachromosomal DNA, programmed genome instability, and conserved and divergent features of repair
Author : David M. Wilson
Publisher : World Scientific Publishing Company
Page : 350 pages
File Size : 44,8 Mb
Release : 2017-02-09
Category : Medical
ISBN : 9814719722
Genomic uracil : dangers and benefits in processing / Hans Krokan -- The GO repair pathway : OGG1 and MUTYH / Sheila David -- The DNA glycosylases that recognize and remove free radical-damaged pyrimidines / Susan Wallace -- Alkyladenine DNA glycosylase / Leona Samson -- The abasic endonuclease APE1 : much more than a DNA repair enzyme / Gianluca Tell -- Central steps in mammalian BER and regulation by PARP1 / Samuel Wilson -- Processing strand break termini in the DNA single strand break repair pathway / Michael Weinfeld -- The PARP-XRCC1 axis in base excision repair / Janet Hall -- DNA ligases in base excision repair / Alan Tomkinson -- Base excision repair and epigenetic regulation / Primo Schär -- Base excision repair in the immune system / Carol Schrader -- Base excision repair in the etiology of lupus and cancer / Joann Sweasy -- Base excision repair in trinucleotide repeat expansion disorders / Margherita Bignami -- Neurodegeneration caused by accumulation of an oxidized base lesion, 8-oxoguanine, in nuclear and mitochondrial DNA: from animal models to human diseases / Yusaku Nakabeppu -- Assessing BER capacity in the human population / Zachary Nagel -- Prognostic and predictive significance of base excision repair in human cancers / Srinivasan Madhusudan -- Enzymes in the base excision repair pathway as targets for small molecule mediated therapeutics / R. Stephen Lloyd -- Mitochondrial base excision repair / Nadja de Souza Pinto -- Base excision repair in aging / Tinna Stevnsner
Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 54,9 Mb
Release : 2024-07-01
Category : Electronic
ISBN : 9789814477116
Author : N. B. Strazhevskaya
Publisher : John Wiley & Sons
Page : 232 pages
File Size : 42,7 Mb
Release : 1975
Category : Science
ISBN : UCAL:B4299953