Bidirectional Gene Promoters

Author : Fumiaki Uchiumi
Publisher : Elsevier
Page : 236 pages
File Size : 45,9 Mb
Release : 2022-11-25
Category : Science
ISBN : 9780128194614

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Bidirectional Gene Promoters by Fumiaki Uchiumi Pdf

Recent studies in human genetics and in silico analyses have revealed that a number of genes are head-head orientated with other genes or non-coding RNAs. The expression of regulatory element-containing 5’-upstream regions of gene pairs are referred to as bi-directional promoters and are thought to have a key role in biological regulatory mechanisms. For example, tumor suppressor protein-encoding TP53 and BRCA1 genes are head-head bound with WRAP53 and NBR2, respectively. DNA-repair factor-encoding ATM and PRKDC (DNA-PKcs) genes have bidirectional partner NPAT and MCM4, respectively. Surveillance of the human DNA database has revealed that the numbers of DNA repair/mitochondrial function/immune response-associated genes are bound with other genes that are transcribed to opposite direction. The observations may encourage us to investigate in the molecular mechanisms how DNA repair/mitochondrial function/immune response-associated genes are regulated by bidirectional promoters. Not only protein-coding genes, but also quite a few ncRNAs, which play important roles in various cellular events, are transcribed under the regulation of the bidirectional promoters. More importantly, we know that dysregulation in the promoter activity and transcription initiation of genes might cause human diseases. Provides an overview of the process of transcription Explains why there so many bidirectional promoters present in human genomes Covers how the diverse biological functions of (non-coding RNAs) ncRNAs are controlled

Author : Guenter Kahl
Publisher : John Wiley & Sons
Page : 2742 pages
File Size : 46,5 Mb
Release : 2015-05-21
Category : Science
ISBN : 9783527678648

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The Dictionary of Genomics, Transcriptomics and Proteomics by Guenter Kahl Pdf

Now in its fifth edition and for the first time available as an electronic product with all entries cross-linked. This very successful long-seller has once again been thoroughly updated and greatly expanded. It now contains over 13,000 entries, and comprehensively covering genomics, transcriptomics, and proteomics. Each entry contains an extensive explanation, including a comprehensive listing of synonyms and acronyms, and all formulas have been redrawn to create a uniform style, while most of the figures are custom designed for this dictionary. The ultimate reference for all terms in the -omics fields.

Author : Torben Heick Jensen
Publisher : Springer Science & Business Media
Page : 161 pages
File Size : 41,7 Mb
Release : 2011-06-29
Category : Medical
ISBN : 9781441978417

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RNA Exosome by Torben Heick Jensen Pdf

The diversity of RNAs inside living cells is amazing. We have known of the more “classic” RNA species: mRNA, tRNA, rRNA, snRNA and snoRNA for some time now, but in a steady stream new types of molecules are being described as it is becoming clear that most of the genomic information of cells ends up in RNA. To deal with the enormous load of resulting RNA processing and degradation reactions, cells need adequate and efficient molecular machines. The RNA exosome is arising as a major facilitator to this effect. Structural and functional data gathered over the last decade have illustrated the biochemical importance of this multimeric complex and its many co-factors, revealing its enormous regulatory power. By gathering some of the most prominent researchers in the exosome field, it is the aim of this volume to introduce this fascinating protein complex as well as to give a timely and rich account of its many functions. The exosome was discovered more than a decade ago by Phil Mitchell and David Tollervey by its ability to trim the 3’end of yeast, S. cerevisiae, 5. 8S rRNA. In a historic account they laid out the events surrounding this identification and the subsequent birth of the research field. In the chapter by Kurt Januszyk and Christopher Lima the structural organization of eukaryotic exosomes and their evolutionary counterparts in bacteria and archaea are discussed in large part through presentation of structures.

Author : David Neil Cooper
Publisher : Elsevier
Page : 520 pages
File Size : 44,7 Mb
Release : 1999-11-03
Category : Science
ISBN : 0121878708

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Human Gene Evolution by David Neil Cooper Pdf

Presents the principles of human gene evolution in a concise and easy to understand fashion. Uses examples of how evolutionary processes have molded present day genes, drawn from the evolution of humans and other primates, as well as from more primitive organisms. With increasing attention in this expanding area, this review forms a timely publication of our current knowledge of this important field. Structure and function in the human genome The evolution of gene structure Mutational mechanisms in evolution

Author : Haitao Shi,Wei Hu,Jone Love
Publisher : Frontiers Media SA
Page : 299 pages
File Size : 44,9 Mb
Release : 2017-11-03
Category : Electronic book
ISBN : 9782889453115

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Melatonin in Plants by Haitao Shi,Wei Hu,Jone Love Pdf

This topic focuses on distribution, synthesis, metabolism, and the in vivo roles of melatonin in plants, with 1 editorial, 3 reviews, 21 original research studies and 1 corrigendum.

Author : Clark Chen
Publisher : BoD – Books on Demand
Page : 498 pages
File Size : 51,5 Mb
Release : 2015-11-18
Category : Medical
ISBN : 9789535122098

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Advances in DNA Repair by Clark Chen Pdf

This book edition is intended to provide a concise summary for select topics in DNA repair, a field that is ever-expanding in complexity and biologic significance. The topics reviewed ranged from fundamental mechanisms of DNA repair to the interface between DNA repair and a spectrum on cellular process to the clinical relevance of DNA repair in oncologic paradigms. The information in this text should provide a foundation from which one can explore the various topics in depth. The book serve as a supplementary text in seminar courses with focus on DNA repair as well as a general reference for scholars with an interest in DNA repair.

Author : Roberto Scatena,Patrizia Bottoni,Bruno Giardina
Publisher : Springer Science & Business Media
Page : 459 pages
File Size : 41,6 Mb
Release : 2012-03-08
Category : Medical
ISBN : 9789400728691

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Advances in Mitochondrial Medicine by Roberto Scatena,Patrizia Bottoni,Bruno Giardina Pdf

Mitochondria are far more than the “powerhouse” of the cell as they have classically been described. In fact, mitochondria biological activities have progressively expanded to include not only various bioenergetic processes but also important biosynthetic pathways, calcium homeostasis and thermogenesis, cell death by apoptosis, several different signal transduction pathways mainly related to redox control of gene expression and so on. This functional and structural complexity may undergo important derangements so to justify the definition of ‘mitochondrial medicine’, which should include all the clinical consequences of congenital or acquired mitochondrial dysfunctions. There are actually a growing number of studies which assign a significant pathogenic role to damaged mitochondria in different diseases: ischemia/reperfusion injury, neurodegenerative diseases, cancer with its dramatic sequelae (i.e, metastasis), metabolic syndrome, hyperlipidemias, just to mention a few of the most important pathologies. In this context, a further aspect that should not be disregarded is the interaction of pharmacological agents with mitochondria, not only in regard of the toxicological aspects but, above all, of the potential therapeutic applications. In fact, it is interesting to note that, while the properties of different so-called “mitoxicants” are well-known, the subtle linkages between drugs and mitochondria is still in need of a real pharmacological and therapeutic control at the clinical level. This lack of consideration can often lead to an underestimation of unwanted toxic effects but also of desirable therapeutic activities. A reevaluation of the potential clinical role of mitochondria could give a new light on some yet obscure aspects of human pathophysiology.

Author : Oscar Lorenzo,Andrea Chini,Myriam Calonje
Publisher : Frontiers Media SA
Page : 268 pages
File Size : 40,5 Mb
Release : 2021-07-01
Category : Science
ISBN : 9782889669547

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Proceedings of RBMP 2018 - Plant Molecular Biology by Oscar Lorenzo,Andrea Chini,Myriam Calonje Pdf

Author : Ion Mandoiu,Alexander Zelikovsky
Publisher : Springer
Page : 656 pages
File Size : 55,9 Mb
Release : 2007-08-06
Category : Science
ISBN : 9783540720317

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Bioinformatics Research and Applications by Ion Mandoiu,Alexander Zelikovsky Pdf

This book constitutes the refereed proceedings of the Third International Symposium on Bioinformatics Research and Applications, ISBRA 2007, held in Atlanta, GA, USA in May 2007. The 55 revised full papers presented together with three invited talks cover a wide range of topics, including clustering and classification, gene expression analysis, gene networks, genome analysis, motif finding, pathways, protein structure prediction, protein domain interactions, phylogenetics, and software tools.

Author : M. Prakash
Publisher : Discovery Publishing House
Page : 344 pages
File Size : 54,7 Mb
Release : 2007
Category : Entrepreneurship
ISBN : 8183561942

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Human Gene Evolution by M. Prakash Pdf

Contents: Entrepreneurship and Small Scale Industry, Design of the Study, Socio- Economic Origins of Entrepreneurship, Entrepreneurial Motivation, Promotion of Enterprise, Performance and Problems, Conclusions and Suggestions.

Author : Inna Kruman
Publisher : BoD – Books on Demand
Page : 652 pages
File Size : 45,6 Mb
Release : 2011-11-07
Category : Medical
ISBN : 9789533076973

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DNA Repair by Inna Kruman Pdf

The book consists of 31 chapters, divided into six parts. Each chapter is written by one or several experts in the corresponding area. The scope of the book varies from the DNA damage response and DNA repair mechanisms to evolutionary aspects of DNA repair, providing a snapshot of current understanding of the DNA repair processes. A collection of articles presented by active and laboratory-based investigators provides a clear understanding of the recent advances in the field of DNA repair.

Author : Maria E. Francia,Mathieu Gissot,Katarzyna Kinga Modrzynska,Mattie Christine Pawlowic
Publisher : Frontiers Media SA
Page : 153 pages
File Size : 50,6 Mb
Release : 2021-06-08
Category : Science
ISBN : 9782889668434

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Molecular Basis of Stage Conversion in Apicomplexan Parasites by Maria E. Francia,Mathieu Gissot,Katarzyna Kinga Modrzynska,Mattie Christine Pawlowic Pdf

Author : Lucy W. Barrett,Sue Fletcher,Steve D. Wilton
Publisher : Springer Science & Business Media
Page : 63 pages
File Size : 54,5 Mb
Release : 2013-06-26
Category : Science
ISBN : 9783034806794

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Untranslated Gene Regions and Other Non-coding Elements by Lucy W. Barrett,Sue Fletcher,Steve D. Wilton Pdf

There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as “junk DNA”, it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5’ and 3’ untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution.​

Author : Yanqing Zhang,Jagath C. Rajapakse
Publisher : John Wiley & Sons
Page : 476 pages
File Size : 44,8 Mb
Release : 2009-02-23
Category : Computers
ISBN : 9780470397411

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Machine Learning in Bioinformatics by Yanqing Zhang,Jagath C. Rajapakse Pdf

An introduction to machine learning methods and their applications to problems in bioinformatics Machine learning techniques are increasingly being used to address problems in computational biology and bioinformatics. Novel computational techniques to analyze high throughput data in the form of sequences, gene and protein expressions, pathways, and images are becoming vital for understanding diseases and future drug discovery. Machine learning techniques such as Markov models, support vector machines, neural networks, and graphical models have been successful in analyzing life science data because of their capabilities in handling randomness and uncertainty of data noise and in generalization. From an internationally recognized panel of prominent researchers in the field, Machine Learning in Bioinformatics compiles recent approaches in machine learning methods and their applications in addressing contemporary problems in bioinformatics. Coverage includes: feature selection for genomic and proteomic data mining; comparing variable selection methods in gene selection and classification of microarray data; fuzzy gene mining; sequence-based prediction of residue-level properties in proteins; probabilistic methods for long-range features in biosequences; and much more. Machine Learning in Bioinformatics is an indispensable resource for computer scientists, engineers, biologists, mathematicians, researchers, clinicians, physicians, and medical informaticists. It is also a valuable reference text for computer science, engineering, and biology courses at the upper undergraduate and graduate levels.

Author : D. Spandidos
Publisher : Springer Science & Business Media
Page : 314 pages
File Size : 43,7 Mb
Release : 2013-06-29
Category : Science
ISBN : 9781475712353

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ras Oncogenes by D. Spandidos Pdf

Proceedings of the workshop held Nov. 1988. Ras genes constitute an important family among the fifty oncogenes which have been discovered so far, and they contribute significantly to the human tumor burden since around 70% of human tumors have an increased level of ras gene product and 40% carry a m