Rna Exosome

Author : Torben Heick Jensen
Publisher : Springer Science & Business Media
Page : 161 pages
File Size : 55,6 Mb
Release : 2011-06-29
Category : Medical
ISBN : 9781441978417

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RNA Exosome by Torben Heick Jensen Pdf

The diversity of RNAs inside living cells is amazing. We have known of the more “classic” RNA species: mRNA, tRNA, rRNA, snRNA and snoRNA for some time now, but in a steady stream new types of molecules are being described as it is becoming clear that most of the genomic information of cells ends up in RNA. To deal with the enormous load of resulting RNA processing and degradation reactions, cells need adequate and efficient molecular machines. The RNA exosome is arising as a major facilitator to this effect. Structural and functional data gathered over the last decade have illustrated the biochemical importance of this multimeric complex and its many co-factors, revealing its enormous regulatory power. By gathering some of the most prominent researchers in the exosome field, it is the aim of this volume to introduce this fascinating protein complex as well as to give a timely and rich account of its many functions. The exosome was discovered more than a decade ago by Phil Mitchell and David Tollervey by its ability to trim the 3’end of yeast, S. cerevisiae, 5. 8S rRNA. In a historic account they laid out the events surrounding this identification and the subsequent birth of the research field. In the chapter by Kurt Januszyk and Christopher Lima the structural organization of eukaryotic exosomes and their evolutionary counterparts in bacteria and archaea are discussed in large part through presentation of structures.

Author : John LaCava,Štěpánka Vaňáčová
Publisher : Springer Nature
Page : 513 pages
File Size : 47,6 Mb
Release : 2019-11-25
Category : Medical
ISBN : 9781493998227

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The Eukaryotic RNA Exosome by John LaCava,Štěpánka Vaňáčová Pdf

This volume provides a cross-section of RNA exosome research protocols, applied to a diversity of model organisms. Chapters guide readers through methods that e.g. delineate eukaryotic exosomes’ origins in prokaryotes, probe its RNA substrates, adapter complexes and macromolecular interaction of networks, and establish critical structural-function relationships. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, The Eukaryotic RNA Exosome: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Author : Richard J Simpson,David W Greening
Publisher : Humana Press
Page : 412 pages
File Size : 47,9 Mb
Release : 2016-05-01
Category : Electronic
ISBN : 1493958011

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Serum/Plasma Proteomics by Richard J Simpson,David W Greening Pdf

Blood science has become a cornerstone of multiple disciplines. This book, contributed to by leading experts in the field, provides a comprehensive resource of protocols for areas, pre-analytical through to analytical, of plasma and serum proteomics.

Author : Debalina Bhattacharya,Mainak Mukhopadhyay,Kursad Turksen
Publisher : Elsevier
Page : 378 pages
File Size : 53,9 Mb
Release : 2024-04-15
Category : Science
ISBN : 9780443140075

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Exosomal RNA by Debalina Bhattacharya,Mainak Mukhopadhyay,Kursad Turksen Pdf

Exosomal RNA: Role in Human Diseases and Therapy provides an in-depth study of exosomes and their RNA in the context of a variety of diseases. The book explores the diagnostic and therapeutic potential of exosomal RNA as biomarkers across a range of different conditions, including cancer, type 2 diabetes, cardiovascular and renal disease, as well as bacterial infections and tissue repair. The link between exosomal RNA expression and neurodegenerative disease is also explored. The book goes on to share the significance of exosomal RNA in preserving cellular function, with special attention given to their role in the autophagy process. This book gives an overview of the isolation, characterization, and potential applications of exosomal RNA, providing researchers with an understanding of how they can be manipulated and utilized for the treatment of various diseases and conditions. This is an ideal reference for researchers in the field of molecular biology, cell biology, and related fields, as well as those involved in the development of therapeutics and personalized medicine. Provides an introduction into exosomal RNA and their potential as predictive and diagnostic biomarkers for various conditions Considers exosomal RNA in a variety of human disorders, including metabolic diseases, inflammatory diseases, and cancer Discusses the role of exosomal RNA in preserving the cellular environment and its role in the autophagy process

Author : Guillaume F. Chanfreau,Fuyuhiko Tamanoi
Publisher : Academic Press
Page : 295 pages
File Size : 46,5 Mb
Release : 2012
Category : Enzymes
ISBN : 9780124047402

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Eukaryotic RNases and Their Partners in RNA Degradation and Biogenesis by Guillaume F. Chanfreau,Fuyuhiko Tamanoi Pdf

Author : Lynne E. Maquat,Megerditch Kiledjian
Publisher : Academic Press
Page : 656 pages
File Size : 54,8 Mb
Release : 2009-01-30
Category : Science
ISBN : 0080922074

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RNA Turnover in Eukaryotes: Nucleases, Pathways and Analysis of mRNA Decay by Lynne E. Maquat,Megerditch Kiledjian Pdf

Specific complexes of protein and RNA carry out many essential biological functions, including RNA processing, RNA turnover, RNA folding, as well as the translation of genetic information from mRNA into protein sequences. Messenger RNA (mRNA) decay is now emerging as an important control point and a major contributor to gene expression. Continuing identification of the protein factors and cofactors, and mRNA instability elements responsible for mRNA decay allow researchers to build a comprehensive picture of the highly orchestrated processes involved in mRNA decay and its regulation. Covers the nonsense-mediated mRNA decay (NMD) or mRNA surveillance pathway Expert researchers introduce the most advanced technologies and techniques to identify mRNA processing, transport, localization and turnover, which are central to the process of gene expression Offers step-by-step lab instructions, including necessary equipment and reagents

Author : Frederick W. Alt
Publisher : Academic Press
Page : 332 pages
File Size : 47,9 Mb
Release : 2015-06-09
Category : Medical
ISBN : 9780128024331

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Advances in Immunology by Frederick W. Alt Pdf

Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future. Contributions from leading authorities Informs and updates on all the latest developments in the field

Author : Tushar Patel
Publisher : Unknown
Page : 216 pages
File Size : 52,8 Mb
Release : 2018
Category : RNA
ISBN : 1493976524

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Extracellular RNA by Tushar Patel Pdf

Author : Thomas D. Pollard,William C. Earnshaw,Jennifer Lippincott-Schwartz,Graham Johnson
Publisher : Elsevier Health Sciences
Page : 947 pages
File Size : 43,7 Mb
Release : 2022-12-13
Category : Science
ISBN : 9780323758024

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Cell Biology E-Book by Thomas D. Pollard,William C. Earnshaw,Jennifer Lippincott-Schwartz,Graham Johnson Pdf

Reader-friendly Cell Biology, 4th Edition, provides a concise but comprehensive foundation for students entering research or health care career paths. Award winning illustrations help readers quickly grasp general principles. The authors have thoroughly updated this popular text to provide readers with the current understanding of the principles of normal cellular function along with examples of how molecular defects predispose to human disease. Major new themes in the 4th edition include the roles of intrinsically disordered polypeptides and phase separation in cellular functions, the influence of new molecular structures on understanding mechanisms, and the impact of exciting new methods—from single cell RNA sequencing to second generation super resolution fluorescence microscopy—on advancing our understanding. Clear, readable explanations provide a concise story about how cells function at the molecular level. An intuitive chapter flow starts with genome organization, gene expression, and RNA processing as a foundation for understanding every aspect of cellular function and physiology. Brings cellular biology to life for students interested in medical science by explaining how mutations in genes can compromise virtually every cellular system and predispose to human disease. Knowledge of cell biology has led to new treatments for cancer, heart failure, cystic fibrosis, and many other diseases. Unique illustrations with realistic proportions and relationships explain every cellular process including the assembly of SARS CoV-2, the structures attaching mitotic chromosomes to microtubules, the mechanism of DNA replication and how pumps, carriers and channels orchestrate physiological processes from synaptic transmission to cellular volume regulation. Covers exciting breakthroughs such as SMC motor proteins actively organizing chromosomal DNA, TOR kinases regulating metabolism, new types of immunotherapy for cancer treatment, mechanisms regulating fast axonal transport and their relation to neurodegenerative diseases, how completion of DNA replication sets the time for cells to enter mitosis, how a cascade of signals specifies the site of cell division, and newly understood pathways of normal and pathological cell death.

Author : Peixuan Guo,Kirill A. Afonin
Publisher : CRC Press
Page : 644 pages
File Size : 43,8 Mb
Release : 2022-07-18
Category : Medical
ISBN : 9781000552676

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RNA Nanotechnology and Therapeutics by Peixuan Guo,Kirill A. Afonin Pdf

Interest in RNA nanotechnology has increased in recent years as recognition of its potential for applications in nanomedicine has grown. Edited by the world's foremost experts in nanomedicine, this comprehensive, state-of-the-art reference details the latest research developments and challenges in the biophysical and single molecule approaches in RNA nanotechnology. In addition, the text also provides in-depth discussions of RNA structure for nanoparticle construction, RNA computation and modeling, single molecule imaging of RNA, RNA nanoparticle assembly, RNA nanoparticles in therapeutics, immunorecognition of RNA nanomaterials, RNA chemistry for nanoparticle synthesis, and conjugation and labeling. Presents the latest research and discoveries in RNA nanotechnology Features contributions from world-class experts in the field Covers RNA nanoparticles in therapeutics Describes self-assembled RNA nanoparticles

Author : Dóra Szakonyi,Ana Confraria,Concetta Valerio,Paula Duque,Dorothee Staiger
Publisher : Frontiers Media SA
Page : 167 pages
File Size : 55,8 Mb
Release : 2019-11-18
Category : Electronic
ISBN : 9782889630257

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Plant RNA Biology by Dóra Szakonyi,Ana Confraria,Concetta Valerio,Paula Duque,Dorothee Staiger Pdf

Discoveries from the past decades revealed that RNA molecules are much more than inert intermediates between the coding DNA sequences and their functional products, proteins. Today, RNAs are recognized as active regulatory molecules influencing gene expression, chromatin organization and genome stability, thus impacting all aspects of plant life including development, growth, reproduction and stress tolerance. Innovations in methodologies, the expanding application of next-generation sequencing technologies, and the creation of public datasets and databases have exposed a new universe of RNA-based mechanisms and led to the discovery of new families of non-coding RNAs, uncovered the large extent of alternative splicing events, and highlighted the potential roles of RNA modifications and RNA secondary structures. Furthermore, considerable advances have been made in identifying RNA-binding and processing factors involved in the synthesis and maturation of different forms of RNA molecules as well as in RNA processing, biochemical modifications or degradation. This Research Topic showcases the broad biological significance of RNAs in plant systems and contains eight original research articles, one review and four mini-reviews, covering various RNA-based mechanisms in higher plants. Emerging new technologies and novel multidisciplinary approaches are empowering the scientific community and will expectedly bring novel insights into our understanding of the mechanisms through which RNA is regulated and regulates biological processes in plant cells.

Author : Béatrice Clouet-d'Orval
Publisher : Springer
Page : 269 pages
File Size : 51,9 Mb
Release : 2017-10-28
Category : Science
ISBN : 9783319657950

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RNA Metabolism and Gene Expression in Archaea by Béatrice Clouet-d'Orval Pdf

This book focuses on the regulation of transcription and translation in Archaea and arising insights into the evolution of RNA processing pathways. From synthesis to degradation and the implications of gene expression, it presents the current state of knowledge on archaeal RNA biology in 13 chapters. Topics covered include the modification and maturation of RNAs, the function of small non-coding RNAs and the CRISPR-Cas defense system. While Archaea have long been considered exotic microbial extremophiles, they are now increasingly being recognized as important model microorganisms for the study of molecular mechanisms conserved across the three domains of life, and with regard to the relevance of similarities and differences to eukaryotes and bacteria. This unique book offers a valuable resource for all readers interested in the regulation of gene expression in Archaea and RNA metabolism in general.

Author : Marlene Oeffinger,Daniel Zenklusen
Publisher : Springer Nature
Page : 318 pages
File Size : 47,9 Mb
Release : 2019-12-06
Category : Science
ISBN : 9783030314347

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The Biology of mRNA: Structure and Function by Marlene Oeffinger,Daniel Zenklusen Pdf

The book provides an overview on the different aspects of gene regulation from an mRNA centric viewpoint, including how mRNA is assembled and self-assembles in a complex consisting of RNA and proteins, and how its ability to be translated at the right time and space depends on many processes acting on the mRNAs, leading to a properly folded complex. This book shows how new technologies have led to a better understanding of these processes and their connected diseases.The book is written for scientists in fundamental and applied biomedical research working on different aspects of gene regulation. It is also targeted to an audience that is not implicated in these fields directly, but wants to gain a better understanding of mRNA biology.

Author : Larry Edelstein,John R. Smythies,Peter J. Quesenberry,Denis Noble
Publisher : Academic Press
Page : 548 pages
File Size : 40,9 Mb
Release : 2019-10-16
Category : Science
ISBN : 9780128160541

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Exosomes by Larry Edelstein,John R. Smythies,Peter J. Quesenberry,Denis Noble Pdf

Exosomes: A Clinical Compendium is a comprehensive and authoritative account of exosomes in the context of biomarkers, diagnostics, and therapeutics across a wide spectrum of medical disciplines, as well as their role in cell-cell communication. It is intended to serve as a reference source for clinicians, physicians, and research scientists who wish to gain insight into the most recent advances in this rapidly growing field. The exosome revolution may well be the greatest advance in physiology and medicine since antibiotics. The discovery of their epigenetic role in intercellular signaling in virtually all tissues is a major breakthrough in our understanding of how cells function. Provides readers with a broad and timely overview of exosomes in health and disease, closing with a thought-provoking chapter on transgenerational inheritance, Darwin and Lamarck. Summarizes the most recent laboratory and clinical findings on exosomes across numerous medical disciplines, thereby offering readers a broad-ranging and solid foundation for prospective investigative efforts Twenty-one chapters authored by a global team of peer-acknowledged experts, each representing a key medical disciplineProvides readers with a broad and timely overview of exosomes in health and disease, closing

Author : Cesar Lopez-Camarillo,Laurence A. Marchat
Publisher : CRC Press
Page : 426 pages
File Size : 53,5 Mb
Release : 2013-02-22
Category : Medical
ISBN : 9781466576773

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MicroRNAs in Cancer by Cesar Lopez-Camarillo,Laurence A. Marchat Pdf

MicroRNA (miRNA) biology is a cutting-edge topic in basic as well as biomedical research. This is a specialized book focusing on the current understanding of the role of miRNAs in the development, progression, invasion, and metastasis of diverse types of cancer. It also reviews their potential for applications in cancer diagnosis, prognosis, and th