Bioactive Phytochemicals Drug Discovery To Product Development

Author : Javed Ahmad,Javed Ahamad
Publisher : Bentham Science Publishers
Page : 238 pages
File Size : 52,9 Mb
Release : 2020-10-28
Category : Medical
ISBN : 9789811464461

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Bioactive Phytochemicals: Drug Discovery to Product Development by Javed Ahmad,Javed Ahamad Pdf

Natural bioactive compounds from medicinal plants are inexplicably diverse in chemical structure and biological properties. The unmet therapeutic requirements for various diseases serve as a guide for researchers to study natural compounds. These studies are intended to isolate, identify the structural characterization and eventually discover the pharmacological activity of natural compounds from their plant sources with the goal of treating specific diseases. Bioactive Phytochemicals: Drug Discovery to Product Development explores the scope and approaches of drug discovery from natural products. Chapters in the book cover information about the cultivation, collection and processing of medicinal plants, the methods and high throughput techniques for isolation and characterization of bioactive phytochemicals and pharmacological screening for activity, formulation and quality control. Information about the regulations specified for natural medicinal products in different region of the world is also presented, followed by a concluding chapter devoted to the role of natural herbal products for treatment of human diseases such as cancer, cardiovascular diseases, diabetes, obesity, inflammation and neurological disorders. Each chapter concludes with a general reference section, which is a bibliographic guide to more advanced texts. The contributing authors for this volume are drawn from a rich blend of experts in various areas of herbal medicine which encompass herbal drug discovery to product development. The concise and organized layout along with a broad coverage of phytochemistry and drug discovery makes this book a suitable reference for students of medicinal chemistry, researchers and industry professionals interested in herbal product development.

Author : Pinarosa Avato
Publisher : MDPI
Page : 392 pages
File Size : 43,8 Mb
Release : 2020-04-22
Category : Medical
ISBN : 9783039287468

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Natural Products and Drug Discovery by Pinarosa Avato Pdf

Natural products hold a prominent position in the current discovery and development of drugs and have diverse indications for both human and animal health. Plants, in particular, play a leading role as a source of specialized metabolites with medical effects. Other organisms, such as marine and terrestrial animals and microorganisms, produce very important drug candidate molecules. Specialized metabolites from these varied natural sources can be used directly as bioactive compounds or drug precursors. In addition, due to their broad chemical diversity, they can act as drug prototypes and/or be used as pharmacological tools for different targets. Some examples of natural metabolites that have been developed into useful medical drug are cardiotonic digoxin from Digitalis sp., antimalarial artemisinin from Artemisia annua, anti-cancer taxol from Taxus sp., or podophyllotoxin from Podophyllum peltatum, which served as a synthetic model for the anti-cancer etoposide. The study of natural products is still attracting great scientific attention and their current importance, as a valuable lead for drug discovery, is undebatable. I cordially invite authors to contribute original articles, as well as survey articles, that give the readers of Molecules **MOLECULES NEEDS TO BE ITALICIZED** updated and new perspectives on natural products in drug discovery, including but not limited to natural sources, identification and separation of bioactive phytochemicals, standardization, new biological targets, pre-clinical and clinical trials, pharmacological effects/side effects, and bioassays.

Author : Joginder Singh,Vineet Meshram,Mahiti Gupta
Publisher : Springer Nature
Page : 733 pages
File Size : 45,8 Mb
Release : 2020-04-30
Category : Medical
ISBN : 9789811513947

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Bioactive Natural products in Drug Discovery by Joginder Singh,Vineet Meshram,Mahiti Gupta Pdf

This book highlights different natural products that are derived from the plants and microbes that have shown potential as the lead compounds against infectious diseases and cancer. Natural products represent an untapped source of strikingly diverse chemotypes with novel mechanisms of action and the potential to serve as anticancer and anti-infective agents. The book discusses a range of biotechnologically valuable bioactive compounds and secondary metabolites that have been derived from plant and microorganisms from various ecological niches. It also reviews the latest developments in the field of genomics, bioinformatics and industrial fermentation for harnessing the microbial products for commercial applications. In turn, the book’s closing section reviews important biotechnological applications of various natural products. Combining the expertise of specialists in this field, the book’s goal is to promote the further investigation of natural sources for the development of standardized, safe and effective therapies.

Author : Pinarosa Avato
Publisher : Unknown
Page : 392 pages
File Size : 53,9 Mb
Release : 2020
Category : Biology (General)
ISBN : 3039287478

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Natural Products and Drug Discovery by Pinarosa Avato Pdf

Natural products hold a prominent position in the current discovery and development of drugs and have diverse indications for both human and animal health. Plants, in particular, play a leading role as a source of specialized metabolites with medical effects. Other organisms, such as marine and terrestrial animals and microorganisms, produce very important drug candidate molecules. Specialized metabolites from these varied natural sources can be used directly as bioactive compounds or drug precursors. In addition, due to their broad chemical diversity, they can act as drug prototypes and/or be used as pharmacological tools for different targets. Some examples of natural metabolites that have been developed into useful medical drug are cardiotonic digoxin from Digitalis sp., antimalarial artemisinin from Artemisia annua, anti-cancer taxol from Taxus sp., or podophyllotoxin from Podophyllum peltatum, which served as a synthetic model for the anti-cancer etoposide. The study of natural products is still attracting great scientific attention and their current importance, as a valuable lead for drug discovery, is undebatable. I cordially invite authors to contribute original articles, as well as survey articles, that give the readers of Molecules **MOLECULES NEEDS TO BE ITALICIZED** updated and new perspectives on natural products in drug discovery, including but not limited to natural sources, identification and separation of bioactive phytochemicals, standardization, new biological targets, pre-clinical and clinical trials, pharmacological effects/side effects, and bioassays.

Author : Chukwuebuka Egbuna,Shashank Kumar,Jonathan C. Ifemeje,Shahira M. Ezzat,Saravanan Kaliyaperumal
Publisher : Elsevier
Page : 382 pages
File Size : 41,9 Mb
Release : 2019-09-07
Category : Science
ISBN : 9780128178911

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Phytochemicals as Lead Compounds for New Drug Discovery by Chukwuebuka Egbuna,Shashank Kumar,Jonathan C. Ifemeje,Shahira M. Ezzat,Saravanan Kaliyaperumal Pdf

Phytochemicals as Lead Compounds for New Drug Discovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the development of new drugs and chemical entities. Functional bioactive compounds of plant origin have been an invaluable source for many human therapeutic drugs and have played a major role in the treatment of diseases around the world. These compounds possess enormous structural and chemical diversity and have led to many important discoveries. This book presents fundament concepts and factors affecting the choice for plant-based products, as well as recent advances in computer-aided drug discovery and FDA drug candidacy acceptance criteria. It also details the various bioactive lead compounds and molecular targets for a range of life-threatening diseases including cancer, diabetes, and neurodegenerative diseases. Written by a global team of experts, Phytochemicals as Lead Compounds for New Drug Discovery is an ideal resource for drug developers, phytochemists, plant biochemists, food and medicinal chemists, nutritionists and toxicologists, chemical ecologists, taxonomists, analytical chemists, and other researchers in those fields. It will also be very valuable to professors, students, and researchers in this domain. Presents fundamental concepts and factors affecting choice for plant-based products Details the FDA drug candidacy acceptance criteria, including bottlenecks and way forward Highlights recent advances in computational-based drug discovery Focuses on the discovery of new drugs and potential druggable targets for the treatment of chronic diseases of world importance

Author : Vijay Kumar Gupta
Publisher : Unknown
Page : 530 pages
File Size : 46,6 Mb
Release : 2012-01-01
Category : Electronic
ISBN : 8170359643

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Bioactive Phytochemicals by Vijay Kumar Gupta Pdf

Plant kingdom represents a vast emporium of untapped medicinal potential and play a vital role for the development of new drugs. The medicinal value of drug plants is due to the presence of some chemical compounds in the plant tissue that produce a definite physiological action on human body. Early societies learned through trial and error that many plants contained substances with significant curative properties and over the years the natural products became used in more refined ways leading ultimately to the use of pure single component "active ingredient" as drugs. However, the demands of modern medicine requires the evaluation of these plant bioactives using scientific methodologies and assays in order to gauge their potential in the management of the disease. Therefore, extracts and biomolecules with promising activity are unscrupulously screened for efficacy in order to determine if these products have a potential for commercial development. The present book "Bioactive Phytochemicals: Perspectives for Modern Medicine Vol. 1" presents the vast body of research on the subject and includes fifteen research and review communications written by eminent scientists and researchers from India, Brazil, China, Japan, Maxico, Singapore and South Africa and includes topics like - Bioactive pregnanes and cardenolides from Nerium olander; Chemical characteristics and health promoting potentials of flavonoids in the management of diabetes; Limonene: A systematic overview for its chemistry and bioactivity; Phytochemicals against liver disease I: Recent progress in the treatment of AFLD and NAFLD by natural drug products and their active chemical entities, in China and other countries; Phytochemicals against liver disease II: Recent progress in the treatment of liver fibrosis by natural drug products and their active chemical entities, in China and other countries; Anti-allergic leads from Indian medicinal plant; Essential oils from Brazilian Amazonia; Phytochemical and pharmacological profile of plants belonging to Strychnos genus; Phytochemicals as natural antimicrobials; Biomedical potentials of filamentous marine cyanobacterial natural products; Natural bioactive compound from marine plants with anticancer potential; The lauraceae alkaloids; Phytochemical and pharmacological profile of Lepidium sativum Linn.; Chemistry and pharmacology of selected Asian and American medicinal species of Justicia; Biological activities of Anoectochilus formosanus Hayat and its active component. We hope that this volume shall generate further database and interest for the benefit of academicians, researchers and scientists working on bioactive phytochemicals who shall find the compendium very useful and indispensable in their relevant research pursuits.

Author : Marianna Kulka
Publisher : BoD – Books on Demand
Page : 428 pages
File Size : 48,7 Mb
Release : 2013-06-19
Category : Medical
ISBN : 9789535111580

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Using Old Solutions to New Problems by Marianna Kulka Pdf

The medicinal use of plants, animals and microorganisms has been a part of human evolution and likely began before recorded history. Is it possible that this knowledge can be used to create powerful new drugs and solve some of the human health problems facing us today? This book is a collection of an expert team of agronomists, chemists, biologists and policy makers who discuss some of the processes involved in developing a naturally-sourced bioactive compound into a drug therapy. These experts define a natural compound and elucidate the processes required to find, extract and define a naturally-derived bioactive molecule. Finally, they describe the necessity for understanding the fundamental mechanisms of disease before applying bioactive molecules in bioassay-guided drug discovery platforms.

Author : Goutam Brahmachari
Publisher : World Scientific
Page : 695 pages
File Size : 40,9 Mb
Release : 2012
Category : Science
ISBN : 9789814335379

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Bioactive Natural Products by Goutam Brahmachari Pdf

Bioactive natural products are a rich source of novel therapeutics. Thus, the search for bioactive molecules from nature continues to play an important role in fashioning new medicinal agents. This volume, which comprises sixteen chapters written by active researchers and leading experts in natural products chemistry, brings together an overview of current discoveries in this remarkable field. It also provides information on the industrial application of natural products for medicinal purposes. This book will serve as a valuable resource for researchers to predict promising leads for developing pharmaceuticals to treat various ailments and disease manifestations.

Author : Valdir Cechinel-Filho
Publisher : John Wiley & Sons
Page : 600 pages
File Size : 43,7 Mb
Release : 2012-05-22
Category : Science
ISBN : 9780470582268

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Plant Bioactives and Drug Discovery by Valdir Cechinel-Filho Pdf

An in-depth exploration of the applications of plant bioactive metabolites in drug research and development Highlighting the complexity and applications of plant bioactive metabolites in organic and medicinal chemistry, Plant Bioactives and Drug Discovery: Principles, Practice, and Perspectives provides an in-depth overview of the ways in which plants can inform drug research and development. An edited volume featuring multidisciplinary international contributions from acclaimed scientists researching bioactive natural products, the book provides an incisive overview of one of the most important topics in pharmaceutical studies today. With coverage of strategic methods of natural compound isolation, structural manipulation, natural products in clinical trials, quality control, and more, and featuring case studies on medicinal plants, the book serves as a definitive guide to the field of plant biodiversity as it relates to medicine. In addition, chapters on using natural products as drugs that target specific disease areas, including neurological disorders, inflammation, infectious diseases, and cancer, illustrate the myriad possibilities for therapeutic applications. Wide ranging and comprehensive, Plant Bioactives and Drug Discovery also includes important information on marketing, regulations, intellectual property rights, and academic-industry collaboration as they relate to plant-based drug research, making it an essential resource for advanced students and academic and industry professionals working in biochemical, pharmaceutical, and related fields.

Author : Bikarma Singh
Publisher : Springer Nature
Page : 481 pages
File Size : 53,8 Mb
Release : 2020-10-05
Category : Medical
ISBN : 9789811559174

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Botanical Leads for Drug Discovery by Bikarma Singh Pdf

Active botanical ingredients are a prime requirement for herbal formulations and discovering a drug is all about integration of science disciplines. In recent decades there has been a growing interest in treating wounds and diseases using traditional remedies based on local herbs, combined with chemical advances. Although this has led to the development of new bioactive ingredients from plants, there has been little success in terms of clinical trials and post-marketing studies to comply with FDA guidelines. Plants have been used as a source of medicine throughout history and continue to serve as the basis for many pharmaceuticals used today. However, despite the modern pharmaceutical industry being founded on botanical medicine, synthetic approaches to drug discovery have now become standard. Science-driven translational discovery and botanical development has created a new reality, leading to enormous changes in strategies, technologies and the disciplines involved, which have been embraced by the pharmaceutical and biotech industries. This book gathers scientific expertise and traditional knowledge to promote the discovery and development of new formulations and drugs based on active ingredients and to provide guidance on taking these to clinical trials. It discusses major topics, such as how the phytochemical composition of many plants has changed over time due to factors like cultivation, which can have both positive and negative effects on the levels of bioactive compounds. It also explores the importance of plants as a valuable source of therapeutic compounds as a result of their vast biosynthetic capacity, and classifies them according to their intended use, safety and regulatory status. Further, the book offers insights into the regulatory aspects of botanical products, which is an important issue when considering standardization and quality assessment, and also examines the commercial aspects of plant-derived medications and their proven role in the treatment of chronic diseases such as heart disease, high blood pressure, pain, asthma, and other associated conditions. Given its scope, this book is a valuable tool for botanists, natural product chemists, pharmacologists and microbiologists involved in the study of phytochemicals for drug discovery.

Author : Dilipkumar Pal,Amit Kumar Nayak
Publisher : Springer Nature
Page : 862 pages
File Size : 47,8 Mb
Release : 2020-12-14
Category : Technology & Engineering
ISBN : 9783030540272

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Bioactive Natural Products for Pharmaceutical Applications by Dilipkumar Pal,Amit Kumar Nayak Pdf

This book covers the recent innovations relating to various bioactive natural products (such as alkaloids, glycosides, flavonoids, anthraquinones, steroids, polysaccharides, tannins and polyphenolic compounds, volatile oils, fixed oils, fats and waxes, proteins and peptides, vitamins, marine products, camptothecin, piperines, carvacrol, gedunin, GABA, ginsenosides) and their applications in the pharmaceutical fields related to academic, research and industry.

Author : Mallappa Kumara Swamy,Mohd Sayeed Akhtar
Publisher : Springer Nature
Page : 492 pages
File Size : 49,7 Mb
Release : 2019-09-19
Category : Science
ISBN : 9789811372056

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Natural Bio-active Compounds by Mallappa Kumara Swamy,Mohd Sayeed Akhtar Pdf

Nature has consistently provided human beings with bioactive compounds that can be used directly as drugs or indirectly as drug leads. Some of the major classes of natural bioactive compounds include phenolics, alkaloids, tannins, saponins, lignin, glycosides, terpenoids, and many more. They possess a broad range of biological activities and are primarily useful in the treatment of various health issues. At the same time, the search for new and novel drugs is never-ending and, despite major advances in synthetic chemistry, nature remains an essential resource for drug discovery. Therefore, more and more researchers are interested in understanding the chemistry, clinical pharmacology, and beneficial effects of bioactive compounds in connection with solving human health problems. This book presents a wealth of information on natural metabolites that have been or are currently being used as drugs or leads for the discovery of new drugs. In addition, it highlights the importance of natural products against various human diseases, and their applications in the drug, nutraceuticals, cosmetics and herbal industries. Accordingly, the book offers a valuable resource for all students, educators, and healthcare experts involved in natural product research, phytochemistry, and pharmacological research.

Author : Vijay Kumar Gupta
Publisher : Unknown
Page : 128 pages
File Size : 53,7 Mb
Release : 2014-01-01
Category : Botanical chemistry
ISBN : 9351300927

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BIOACTIV PHYTOCHEMCLS PERSP MOD MED by Vijay Kumar Gupta Pdf

Author : Singh, Ajeet
Publisher : IGI Global
Page : 754 pages
File Size : 48,8 Mb
Release : 2022-06-24
Category : Science
ISBN : 9781668451304

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Handbook of Research on Advanced Phytochemicals and Plant-Based Drug Discovery by Singh, Ajeet Pdf

A great deal of interest has been generated recently in the isolation, characterization, and biological activity of phytochemicals. Phytochemicals have the potential to enhance pharmaceuticals and drug discovery. As such, there is an urgent need for current research in the global scope of phytochemicals including the chemical and physical characteristics, analytical procedures, biological activity, safety, and industrial applications. The Handbook of Research on Advanced Phytochemicals and Plant-Based Drug Discovery examines the applications of bioactive molecules from a health perspective, examining the pharmacological aspects of medicinal plants, the phytochemical and biological activities of different natural products, and ethnobotany and medicinal properties. Moreover, it presents a novel dietary approach for human disease management. Covering topics such as computer-aided drug design, government regulation, and medicinal plant taxonomy, this major reference work is beneficial to pharmacists, medical practitioners, phytologists, hospital administrators, government officials, faculty and students of higher education, librarians, researchers, and academicians.

Author : Deepak Kumar Verma,Mamta Thakur
Publisher : CRC Press
Page : 294 pages
File Size : 55,6 Mb
Release : 2021-09-15
Category : Medical
ISBN : 9781000164565

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Phytochemicals in Food and Health by Deepak Kumar Verma,Mamta Thakur Pdf

This volume brings together information on the available and newly emerging technologies related to using plant compounds that have a beneficial role in food production. It is divided into sections focusing on phytochemistry of cereals and legumes, phytochemistry of medicinal plants, and technological advances in phytochemical study. Topics include the role of anti-nutritional substances of legumes in human health and on the elimination of such through technological processing sorghum phytochemicals and their processing and use in the development of food products production of nutraceuticals and functional foods of pharmaceutical importance T. cordifolia in the development of its therapeutic use in the food, health, and pharmacology industries polyphenolic compounds of plants, including their biosynthesis process, their classification, function, and role as bioactive compounds