Biochemistry Of Drug Metabolizing Enzymes

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Biochemistry of Drug Metabolizing Enzymes

Muhammad Sajid Hamid Akash,Kanwal Rehman
Biochemistry of Drug Metabolizing Enzymes Book PDF

Author : Muhammad Sajid Hamid Akash,Kanwal Rehman
Publisher : Academic Press
Page : 588 pages
File Size : 54,5 Mb
Release : 2022-05-28
Category : Medical
ISBN : 9780323951210

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Biochemistry of Drug Metabolizing Enzymes by Muhammad Sajid Hamid Akash,Kanwal Rehman Pdf

Biochemistry of Drug Metabolizing Enzymes: Trends and Challenges is a complete and well-integrated reference on their mechanisms of action, their role in diseases, agents responsible for their deactivation, and their malfunction. Chapters explain the biochemistry of DMEs, including biochemical activation, functions, computational approaches, different contaminants on the action and function of DMEs, and describe the importance of DMEs in the drug development process. Conditions covered include metabolic diseases, cardiovascular diseases, neurological diseases, physiological diseases, xenobiotics and inflammatory responses, and their contribution in the malfunctioning of drug metabolizing enzymes. This book is the perfect resource for pharmacology and biochemistry researchers to understand the principles of DMEs. Researchers in the corporate environment will also benefit from the comprehensive list of diseases associated with malfunction of DMEs. Includes extensive classification of DMEs, their mechanism of action and computational analysis Covers the biotransformation of drug by DMEs and the possible impact of environmental contaminants Discusses the activity of DMEs in different clinical conditions such as cardiovascular disease, metabolic disorders, inflammation and neurotoxicity Includes modern and novel bioanalytical techniques to predict the effect of DMEs

Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes

Emel Arinç,John B. Schenkman,Ernest Hodgson
Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes Book PDF

Author : Emel Arinç,John B. Schenkman,Ernest Hodgson
Publisher : Springer Science & Business Media
Page : 297 pages
File Size : 45,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461548553

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Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes by Emel Arinç,John B. Schenkman,Ernest Hodgson Pdf

Proceedings of a NATO ASI held in Antalya, Turkey, August 31 - September 11, 1997

Introduction to Drug Metabolism

G. Gordon Gibson,Paul Skett
Introduction to Drug Metabolism Book PDF

Author : G. Gordon Gibson,Paul Skett
Publisher : Springer
Page : 304 pages
File Size : 55,9 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9781489931887

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Introduction to Drug Metabolism by G. Gordon Gibson,Paul Skett Pdf

Although the scientific literature on drug metabolism is extensive, it suffers from the disadvantage that the material is diffuse and consists largely of specialist monographs dealing with particular aspects of the subject. In addi tion, although there are a few excellent texts on drug metabolism in print, these tend to be earlier publications and hence do not take into account the many recent advances in this area. Our motivations for writing this book therefore arose from the clear need for a recent and cohesive introductory text on this subject, specifically designed to cater for the needs of undergraduate and postgraduate students. Much of the subject matter in this text is derived from various courses on drug metabolism given at the University of Surrey and the University of Glasgow to basic science students in pharmacology, biochemistry, nutrition and nursing studies, to pre-clinical medical students and to under graduate and post-graduate students in toxicology. Therefore, it is our inten tion that this text will serve as a primer in drug metabolism to a variety of students in the life sciences taking courses in this subject. The term 'drug metabolism' in its broadest sense may be considered as the absorption, distribution, biotransformation and excretion of drugs. To cover all these facets of drug metabolism in a single text is a voluminous task and therefore we have focused primarily on the biotransformation aspects of the subject.

Drug Metabolism

Corina Ionescu,Mino R. Caira
Drug Metabolism Book PDF

Author : Corina Ionescu,Mino R. Caira
Publisher : Springer Science & Business Media
Page : 444 pages
File Size : 54,9 Mb
Release : 2006-02-28
Category : Medical
ISBN : 1402041411

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Drug Metabolism by Corina Ionescu,Mino R. Caira Pdf

Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.

Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters

Shuguang Ma,Swapan Chowdhury
Identification and Quantification of Drugs Metabolites Drug Metabolizing Enzymes and Transporters Book PDF

Author : Shuguang Ma,Swapan Chowdhury
Publisher : Elsevier Science
Page : 708 pages
File Size : 55,6 Mb
Release : 2020-07-24
Category : Science
ISBN : 9780128200186

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Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters by Shuguang Ma,Swapan Chowdhury Pdf

Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters, Second Edition, is completely updated to provide an overview of the last decade's numerous advances in analytical technologies for detection and quantification of drugs, metabolites, and biomarkers. This new edition goes beyond LC-MS and features all-new chapters on how to evaluate drug absorption, distribution, metabolism, and excretion, potential for hepatic and renal toxicity, immunogenicity of biotherapeutics and translational tools for predicting human dosage, safety and efficacy of small molecules and biologics. This book will be an important handbook and desk reference for pharmacologists, toxicologists, clinical scientists, and students interested in the fields of pharmacology, biochemistry, and drug metabolism. Four sections in the book with 24 chapters give readers an overview of state-of-the-art techniques for identifying and quantifying drugs, metabolites and biomarkers, including a chapter on new approaches for quantification of enzymes and transporters in different tissues Focuses on the role of drug metabolism enzymes, transporters in disposition and drug-drug interactions, as well as strategies for evaluating drug metabolism and safety using advanced liver and kidney models. Discussions on immunogenicity risks of biologics and their evaluation methods have been included Includes several chapters on advanced translational sciences to predict human dosage, pharmacokinetics and efficacy for small molecules and biotherapeutics All chapters are written by experts with a wide range of practical experience from the industry and academia

The Biochemistry of Drug Metabolism

Bernard Testa
The Biochemistry of Drug Metabolism Book PDF

Author : Bernard Testa
Publisher : Unknown
Page : 128 pages
File Size : 44,5 Mb
Release : 2008
Category : Electronic
ISBN : OCLC:874361356

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The Biochemistry of Drug Metabolism by Bernard Testa Pdf

Offering a conceptual and factual presentation of the metabolism of drugs and other xenobiotics, these two volumes distinctly focus on the biochemistry, with an emphasis on xenobiotic-metabolizing enzymes, their reactions and regulations. The first volume is divided into three parts. Part One begins by introducing xenobiotics in the broad context of physiological metabolism, and continues with an overview of the processes of drug disposition and metabolism. It then goes on to summarize the macroscopic and microscopic locations of drug ...

Molecular Aspects of Oxidative Drug Metabolizing Enzymes

Emel Arinc,John B. Schenkman,Ernest Hodgson
Molecular Aspects of Oxidative Drug Metabolizing Enzymes Book PDF

Author : Emel Arinc,John B. Schenkman,Ernest Hodgson
Publisher : Springer Science & Business Media
Page : 615 pages
File Size : 46,8 Mb
Release : 2013-06-29
Category : Science
ISBN : 9783642795282

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Molecular Aspects of Oxidative Drug Metabolizing Enzymes by Emel Arinc,John B. Schenkman,Ernest Hodgson Pdf

Presented here are recent advances in biochemical, toxicological, and regulatory aspects of oxidative drug metabolizing enzymes. Mainly cytochrome P450-dependent and flavin-containing monooxygenases (FMO) are covered. Moreover, the book deals with genotoxicity studies and toxicological interactions of environmental chemicals and mechanisms of mutagenicity and tumor formation. The construction of genetically engineered mammalian cells for the production of a specific P450 isozyme and the application of these cell lines in drug metabolism, mutagenicity and toxicity studies are described in detail. Further, insight is provided into how a number of aquatic species cope with pollutants and their genotoxicity.

Drug Metabolizing Enzymes

Jae Lee,R. Scott Obach,Michael B. Fisher
Drug Metabolizing Enzymes Book PDF

Author : Jae Lee,R. Scott Obach,Michael B. Fisher
Publisher : CRC Press
Page : 608 pages
File Size : 47,5 Mb
Release : 2003-09-03
Category : Medical
ISBN : 0824742931

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Drug Metabolizing Enzymes by Jae Lee,R. Scott Obach,Michael B. Fisher Pdf

Critical in the elimination of drugs and other xenobiotics from the body, cytochrome P450 has strong bearing on scientific assessments of genetic polymorphism in metabolism, possible drug-drug interactions, and bioavailability of candidate drugs. This text systematizes findings on P450 and similar enzymes - as well as parallel issues shaping the pharmaceutical industry - to promote the next generation of safer, more effective drugs.

Enzyme Inhibition in Drug Discovery and Development

Chuang Lu,Albert P. Li
Enzyme Inhibition in Drug Discovery and Development Book PDF

Author : Chuang Lu,Albert P. Li
Publisher : John Wiley & Sons
Page : 878 pages
File Size : 43,8 Mb
Release : 2010-01-26
Category : Medical
ISBN : 9780470538944

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Enzyme Inhibition in Drug Discovery and Development by Chuang Lu,Albert P. Li Pdf

The science and applied approaches of enzyme inhibition in drug discovery and development Offering a unique approach that includes both the pharmacologic and pharmaco-kinetic aspects of enzyme inhibition, Enzyme Inhibition in Drug Discovery and Development examines the scientific concepts and experimental approaches related to enzyme inhibition as applied in drug discovery and drug development. With chapters written by over fifty leading experts in their fields, Enzyme Inhibition in Drug Discovery and Development fosters a cross-fertilization of pharmacology, drug metabolism, pharmacokinetics, and toxicology by understanding the "good" inhibitions—desirable pharmacological effects—and "bad" inhibitions—drug–drug interactions and toxicity. The book discusses: The drug discovery process, including drug discovery strategy, medicinal chemistry, analytical chemistry, drug metabolism, pharmacokinetics, and safety biomarker assessment The manipulations of drug metabolizing enzymes and transporters as well as the negative consequences, such as drug–drug interactions The inhibition of several major drug target pathways, such as the GPCR pathway, the NFkB pathway, and the ion channel pathway Through this focused, single-source reference on the fundamentals of drug discovery and development, researchers in drug metabolism and pharmacokinetics (DMPK) will learn and appreciate target biology in drug discovery; discovery biologists and medicinal chemists will also broaden their understanding of DMPK.

Drug Metabolism and Pharmacokinetics Quick Guide

Siamak Cyrus Khojasteh,Harvey Wong,Cornelis E.C.A. Hop
Drug Metabolism and Pharmacokinetics Quick Guide Book PDF

Author : Siamak Cyrus Khojasteh,Harvey Wong,Cornelis E.C.A. Hop
Publisher : Springer Science & Business Media
Page : 222 pages
File Size : 50,8 Mb
Release : 2011-04-07
Category : Medical
ISBN : 9781441956293

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Drug Metabolism and Pharmacokinetics Quick Guide by Siamak Cyrus Khojasteh,Harvey Wong,Cornelis E.C.A. Hop Pdf

Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical structure, nomenclature, and moieties leading to bioactivation (with examples). Overall it includes a number of key topics useful at the drug discovery stage, which would serve as a quick reference with several examples from the literature to illustrate the concept.

Enzyme Kinetics in Drug Metabolism

Swati Nagar,Upendra A. Argikar,Donald J. Tweedie
Enzyme Kinetics in Drug Metabolism Book PDF

Author : Swati Nagar,Upendra A. Argikar,Donald J. Tweedie
Publisher : Humana
Page : 0 pages
File Size : 52,5 Mb
Release : 2014-02-13
Category : Medical
ISBN : 1627037578

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Enzyme Kinetics in Drug Metabolism by Swati Nagar,Upendra A. Argikar,Donald J. Tweedie Pdf

Drug metabolism and transport are very important facets within the discipline of pharmaceutical sciences, with enzyme kinetic concepts utilized regularly in characterizing and modeling the disposition and elimination of drugs. Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications focuses on very practical aspects of applying kinetic principles to drug metabolizing enzymes and transporters. Divided into five convenient sections, topics include the fundamental principles of enzyme kinetics, the kinetics of oxidative and conjugative drug metabolizing enzymes and drug transporters, modeling approaches for both drug metabolizing enzymes and transporters including novel systems biology approaches, understanding of variability both experimental and interindividual (pharmacogenomic), and case studies that provide real life examples of applying these principles. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics especially suitable for the novice, in some cases step-by-step, readily reproducible protocols, and insights to help with troubleshooting and avoiding known pitfalls with extensive cross referencing to assist in learning. Authoritative and easily accessible, Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications serves as a very practical teaching tool for novice, non-mathematically trained scientists interested in these fundamental concepts and as an aid for their supervisors in teaching these principles.

Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters

Shuguang Ma,Swapan Chowdhury
Identification and Quantification of Drugs Metabolites Drug Metabolizing Enzymes and Transporters Book PDF

Author : Shuguang Ma,Swapan Chowdhury
Publisher : Elsevier
Page : 710 pages
File Size : 54,8 Mb
Release : 2020-07-09
Category : Science
ISBN : 9780128200193

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Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters by Shuguang Ma,Swapan Chowdhury Pdf

Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters, Second Edition, is completely updated to provide an overview of the last decade’s numerous advances in analytical technologies for detection and quantification of drugs, metabolites, and biomarkers. This new edition goes beyond LC-MS and features all-new chapters on how to evaluate drug absorption, distribution, metabolism, and excretion, potential for hepatic and renal toxicity, immunogenicity of biotherapeutics and translational tools for predicting human dosage, safety and efficacy of small molecules and biologics. This book will be an important handbook and desk reference for pharmacologists, toxicologists, clinical scientists, and students interested in the fields of pharmacology, biochemistry, and drug metabolism. Four sections in the book with 24 chapters give readers an overview of state-of-the-art techniques for identifying and quantifying drugs, metabolites and biomarkers, including a chapter on new approaches for quantification of enzymes and transporters in different tissues Focuses on the role of drug metabolism enzymes, transporters in disposition and drug-drug interactions, as well as strategies for evaluating drug metabolism and safety using advanced liver and kidney models. Discussions on immunogenicity risks of biologics and their evaluation methods have been included Includes several chapters on advanced translational sciences to predict human dosage, pharmacokinetics and efficacy for small molecules and biotherapeutics All chapters are written by experts with a wide range of practical experience from the industry and academia

The Biochemistry of Drug Metabolism

Bernard Testa,Stefanie D. Kr?mer
The Biochemistry of Drug Metabolism Book PDF

Author : Bernard Testa,Stefanie D. Kr?mer
Publisher : Wiley-VCH
Page : 620 pages
File Size : 47,9 Mb
Release : 2010-04-26
Category : Medical
ISBN : 3906390543

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The Biochemistry of Drug Metabolism by Bernard Testa,Stefanie D. Kr?mer Pdf

Offering a conceptual and factual presentation of the metabolism of drugs and other xenobiotics, these two volumes distinctly focus on the biochemistry, with an emphasis on xenobiotic-metabolizing enzymes, their reactions and regulations. The first volume is divided into three parts. Part One begins by introducing xenobiotics in the broad context of physiological metabolism, and continues with an overview of the processes of drug disposition and metabolism. It then goes on to summarize the macroscopic and microscopic locations of drug ...

Hydrolysis in Drug and Prodrug Metabolism

Bernard Testa,Joachim M. Mayer
Hydrolysis in Drug and Prodrug Metabolism Book PDF

Author : Bernard Testa,Joachim M. Mayer
Publisher : John Wiley & Sons
Page : 808 pages
File Size : 46,9 Mb
Release : 2003-08
Category : Science
ISBN : 390639025X

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Hydrolysis in Drug and Prodrug Metabolism by Bernard Testa,Joachim M. Mayer Pdf

Many drugs and other xenobiotics (e.g., preservatives, insecticides, and plastifiers) contain hydrolyzable moieties such as ester or amide groups. In biological media, such foreign compounds are, therefore, important substrates for hydrolytic reactions catalyzed by hydrolases or proceeding non-enzymatically. Despite their significance, until now, no book has been dedicated to hydrolysis and hydrolases in the metabolism of drugs and other xenobiotics. This work fills a gap in the literature and reviews metabolic reactions of hydrolysis and hydarion from the point of views of enzymes, substrates, and reactions.

Transporters and Drug-Metabolizing Enzymes in Drug Toxicity

Albert P. Li
Transporters and Drug Metabolizing Enzymes in Drug Toxicity Book PDF

Author : Albert P. Li
Publisher : John Wiley & Sons
Page : 530 pages
File Size : 54,7 Mb
Release : 2021-07-27
Category : Medical
ISBN : 9781119170846

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Transporters and Drug-Metabolizing Enzymes in Drug Toxicity by Albert P. Li Pdf

TRANSPORTERS AND DRUG-METABOLIZING ENZYMES IN DRUG TOXICITY Explore up-to-date coverage on the interaction between drug metabolism enzymes, transporters, and drug toxicity with this leading resources Transporters and Drug-Metabolizing Enzymes in Drug Toxicity delivers a comprehensive and updated review of the relationship between drug metabolism, transporters, and toxicity, providing insights into a major challenge in drug development – accurate assessment of human drug toxicity. Combining two disciplines frequently considered independently of one another, the book combines drug metabolism and toxicology with a focus on the role of biotransformation on drug toxicity and as a major factor for species and individual differences. Mechanism and species differences in drug metabolizing enzymes and transporters are discussed, as are the methods used to investigate the role of drug metabolizing enzymes and transporters in drug toxicity. Finally, the distinguished authors describe promising new experimental approaches to accurately assessing human drug toxicity via the consideration of human-specific drug metabolism in toxicity assays. In addition to topics as diverse as extended clearance models, experimental approaches for the estimation of DILI potential of drug candidates and roles of transporters in renal drug toxicity, readers will also enjoy the inclusion of such subjects as: A thorough overview of and introduction to drug metabolism and transporters and drug toxicity An exploration of drug metabolism enzymes and transporter activities as risk factors of marketed drugs associated with drug-induced fatalities A discussion of human-based in vitro experimental models for the evaluation of metabolism-dependent drug toxicity A treatment of mechanism-based experimental models for the evaluation of BSEP inhibition and DILI An examination of transporters and cochlea toxicity Perfect for scientists, students, and practitioners with interests in metabolism, toxicology, and drug development in the pharmaceutical industry, Transporters and Drug-Metabolizing Enzymes in Drug Toxicity will also earn a place in the libraries of medicinal chemists, pharmacologists, biochemists, toxicologists, and regulators in the pharmaceutical and health industries.