Drug Metabolism

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Human Drug Metabolism

Michael D. Coleman
Human Drug Metabolism Book PDF

Author : Michael D. Coleman
Publisher : John Wiley & Sons
Page : 360 pages
File Size : 45,9 Mb
Release : 2010-03-30
Category : Science
ISBN : 047068934X

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Human Drug Metabolism by Michael D. Coleman Pdf

Human Drug Metabolism, An Introduction, Second Edition provides an accessible introduction to the subject and will be particularly invaluable to those who already have some understanding of the life sciences. Completely revised and updated throughout, the new edition focuses only on essential chemical detail and includes patient case histories to illustrate the clinical consequences of changes in drug metabolism and its impact on patient welfare. After underlining the relationship between efficacy, toxicity and drug concentration, the book then considers how metabolizing systems operate and how they impact upon drug concentration, both under drug pressure and during inhibition. Factors affecting drug metabolism, such as genetic polymorphisms, age and diet are discussed and how metabolism can lead to toxicity is explained. The book concludes with the role of drug metabolism in the commercial development of therapeutic agents as well as the pharmacology of some illicit drugs.

Drug Metabolism in Diseases

Wen Xie
Drug Metabolism in Diseases Book PDF

Author : Wen Xie
Publisher : Academic Press
Page : 294 pages
File Size : 49,5 Mb
Release : 2016-09-12
Category : Medical
ISBN : 9780128029633

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Drug Metabolism in Diseases by Wen Xie Pdf

Drug Metabolism in Diseases is a comprehensive reference devoted to the current state of research on the impact of various disease states on drug metabolism. The book contains valuable insights into mechanistic effects and examples of how to accurately predict drug metabolism during these different pathophysiological states. Each chapter clearly presents the effects of changes in drug metabolism and drug transporters on pharmacokinetics and disposition. This is a unique and useful approach for all those involved in drug discovery and development, and for clinicians and researchers in drug metabolism, pharmacology, and clinical pharmacology. Written and edited by leaders in drug metabolism from academia and industry Covers important topics, such as pharmacogenomics, drug metabolism in transplant patients, xenobiotic receptors, drug metabolism in geriatric and pediatric populations, and more Highlights topics of importance in drug discovery and development, and for safe and effective drug use in the clinic

Drug Metabolism

Jack P. Uetrecht,William Trager
Drug Metabolism Book PDF

Author : Jack P. Uetrecht,William Trager
Publisher : CRC Press
Page : 200 pages
File Size : 43,9 Mb
Release : 2007-06-21
Category : Medical
ISBN : 9781420061086

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Drug Metabolism by Jack P. Uetrecht,William Trager Pdf

In order to understand drug metabolism at its most fundamental level, pharmaceutical scientists must be able to analyze drug compound structures and predict possible metabolic pathways in order to avoid the risk of adverse reactions that lead to the withdrawal of a drug from the market. This comprehensive textbook will aid in guiding students throu

Handbook of Drug Metabolism, Third Edition

Paul G. Pearson,Larry C. Wienkers
Handbook of Drug Metabolism Third Edition Book PDF

Author : Paul G. Pearson,Larry C. Wienkers
Publisher : CRC Press
Page : 755 pages
File Size : 49,7 Mb
Release : 2019-05-20
Category : Medical
ISBN : 9781482262049

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Handbook of Drug Metabolism, Third Edition by Paul G. Pearson,Larry C. Wienkers Pdf

This book continues to be the definitive reference on drug metabolism with an emphasis on new scientific and regulatory developments. It has been updated based on developments that have occurred in the last 5 years, with new chapters on large molecules disposition, stereo-selectivity in drug metabolism, drug transporters and metabolic activation of drugs. Some chapters have been prepared by new authors who have emerged as subject area experts in the decade that has passed since publication of the first edition.

Drug Metabolism and Pharmacokinetics Quick Guide

Siamak Cyrus Khojasteh,Harvey Wong,Cornelis E.C.A. Hop
Drug Metabolism and Pharmacokinetics Quick Guide Book PDF

Author : Siamak Cyrus Khojasteh,Harvey Wong,Cornelis E.C.A. Hop
Publisher : Springer Science & Business Media
Page : 214 pages
File Size : 46,9 Mb
Release : 2011-04-07
Category : Medical
ISBN : 9781441956293

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Drug Metabolism and Pharmacokinetics Quick Guide by Siamak Cyrus Khojasteh,Harvey Wong,Cornelis E.C.A. Hop Pdf

Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical structure, nomenclature, and moieties leading to bioactivation (with examples). Overall it includes a number of key topics useful at the drug discovery stage, which would serve as a quick reference with several examples from the literature to illustrate the concept.

Drug Metabolism

Mino R. Caira,Corina Ionescu
Drug Metabolism Book PDF

Author : Mino R. Caira,Corina Ionescu
Publisher : Springer Science & Business Media
Page : 422 pages
File Size : 54,5 Mb
Release : 2006-07-10
Category : Medical
ISBN : 9781402041426

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Drug Metabolism by Mino R. Caira,Corina Ionescu Pdf

Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.

Introduction to Drug Metabolism

G. Gordon Gibson,Paul Skett
Introduction to Drug Metabolism Book PDF

Author : G. Gordon Gibson,Paul Skett
Publisher : Nelson Thornes
Page : 274 pages
File Size : 50,8 Mb
Release : 2001
Category : Medical
ISBN : 0748760113

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Introduction to Drug Metabolism by G. Gordon Gibson,Paul Skett Pdf

Of drug-metabolising reactions. p. 25.

Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters

Shuguang Ma,Swapan Chowdhury
Identification and Quantification of Drugs Metabolites Drug Metabolizing Enzymes and Transporters Book PDF

Author : Shuguang Ma,Swapan Chowdhury
Publisher : Elsevier Science
Page : 708 pages
File Size : 43,5 Mb
Release : 2020-07-24
Category : Science
ISBN : 9780128200186

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Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters by Shuguang Ma,Swapan Chowdhury Pdf

Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters, Second Edition, is completely updated to provide an overview of the last decade's numerous advances in analytical technologies for detection and quantification of drugs, metabolites, and biomarkers. This new edition goes beyond LC-MS and features all-new chapters on how to evaluate drug absorption, distribution, metabolism, and excretion, potential for hepatic and renal toxicity, immunogenicity of biotherapeutics and translational tools for predicting human dosage, safety and efficacy of small molecules and biologics. This book will be an important handbook and desk reference for pharmacologists, toxicologists, clinical scientists, and students interested in the fields of pharmacology, biochemistry, and drug metabolism. Four sections in the book with 24 chapters give readers an overview of state-of-the-art techniques for identifying and quantifying drugs, metabolites and biomarkers, including a chapter on new approaches for quantification of enzymes and transporters in different tissues Focuses on the role of drug metabolism enzymes, transporters in disposition and drug-drug interactions, as well as strategies for evaluating drug metabolism and safety using advanced liver and kidney models. Discussions on immunogenicity risks of biologics and their evaluation methods have been included Includes several chapters on advanced translational sciences to predict human dosage, pharmacokinetics and efficacy for small molecules and biotherapeutics All chapters are written by experts with a wide range of practical experience from the industry and academia

Drug Metabolism Handbook

Ala F. Nassar
Drug Metabolism Handbook Book PDF

Author : Ala F. Nassar
Publisher : John Wiley & Sons
Page : 1059 pages
File Size : 42,5 Mb
Release : 2009-01-28
Category : Medical
ISBN : 9780470439258

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Drug Metabolism Handbook by Ala F. Nassar Pdf

A valuable reference tool for professionals involved in the industry, Drug Metabolism in Pharmaceuticals covers new tools such as LC-MS and LC-MS-NMR along with experimental aspects of drug metabolism. This work fills a gap in the literature by covering the concepts and applications of pharmaceutical research, development, and assessment from the point of view of drug metabolism. By providing both a solid conceptual understanding of the drug metabolism system, and a well illustrated, detailed demonstration and explanation of cutting edge tools and techniques, this book serves as a valuable reference tool for bench scientists, medical students, and students of general health sciences.

Drug Metabolism, Pharmacokinetics and Bioanalysis

Hye Suk Lee,Kwang-Hyeon Liu
Drug Metabolism Pharmacokinetics and Bioanalysis Book PDF

Author : Hye Suk Lee,Kwang-Hyeon Liu
Publisher : MDPI
Page : 230 pages
File Size : 51,8 Mb
Release : 2019-06-12
Category : Medical
ISBN : 9783038979166

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Drug Metabolism, Pharmacokinetics and Bioanalysis by Hye Suk Lee,Kwang-Hyeon Liu Pdf

Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug transporters, respectively, as well as phase I drug metabolizing enzymes, have been studied. A combination of biochemical advances in the function and regulation of drug metabolizing enzymes and automated analytical technologies are revolutionizing drug metabolism research. There are also potential drug–drug interactions with co-administered drugs due to inhibition and/or induction of drug metabolic enzymes and drug transporters. In addition, drug interaction studies have been actively performed to develop substrate cocktails that do not interfere with each other and a simultaneous analytical method of substrate drugs and their metabolites using a tandem mass spectrometer. This Special Issue has the aim of highlighting current progress in drug metabolism/pharmacokinetics, drug interactions, and bioanalysis.

Drug Metabolism in Drug Design and Development

Donglu Zhang,Mingshe Zhu,William G. Humphreys
Drug Metabolism in Drug Design and Development Book PDF

Author : Donglu Zhang,Mingshe Zhu,William G. Humphreys
Publisher : John Wiley & Sons
Page : 448 pages
File Size : 47,7 Mb
Release : 2007-11-16
Category : Science
ISBN : 0470191686

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Drug Metabolism in Drug Design and Development by Donglu Zhang,Mingshe Zhu,William G. Humphreys Pdf

The essentials of drug metabolism vital to developing new therapeutic entities Information on the metabolism and disposition of candidate drugs is a critical part of all aspects of the drug discovery and development process. Drug metabolism, as practiced in the pharmaceutical industry today, is a complex, multidisciplinary field that requires knowledge of sophisticated analytical technologies and expertise in mechanistic and kinetic enzymology, organic reaction mechanism, pharmacokinetic analysis, animal physiology, basic chemical toxicology, preclinical pharmacology, and molecular biology. With chapters contributed by experts in their specific areas, this reference covers: * Basic concepts of drug metabolism * The role of drug metabolism in the pharmaceutical industry * Analytical techniques in drug metabolism * Common experimental approaches and protocols Drug Metabolism in Drug Design and Development emphasizes practical considerations such as the data needed, the experiments and analytical methods typically employed, and the interpretation and application of data. Chapters highlight facts, common protocols, detailed experimental designs, applications, and limitations of techniques. This is a comprehensive, hands-on reference for drug metabolism researchers as well as other professionals involved in pre-clinical drug discovery and development.

Introduction to Drug Metabolism

G. Gordon Gibson,Paul Skett
Introduction to Drug Metabolism Book PDF

Author : G. Gordon Gibson,Paul Skett
Publisher : Springer
Page : 304 pages
File Size : 43,9 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9781489931887

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Introduction to Drug Metabolism by G. Gordon Gibson,Paul Skett Pdf

Although the scientific literature on drug metabolism is extensive, it suffers from the disadvantage that the material is diffuse and consists largely of specialist monographs dealing with particular aspects of the subject. In addi tion, although there are a few excellent texts on drug metabolism in print, these tend to be earlier publications and hence do not take into account the many recent advances in this area. Our motivations for writing this book therefore arose from the clear need for a recent and cohesive introductory text on this subject, specifically designed to cater for the needs of undergraduate and postgraduate students. Much of the subject matter in this text is derived from various courses on drug metabolism given at the University of Surrey and the University of Glasgow to basic science students in pharmacology, biochemistry, nutrition and nursing studies, to pre-clinical medical students and to under graduate and post-graduate students in toxicology. Therefore, it is our inten tion that this text will serve as a primer in drug metabolism to a variety of students in the life sciences taking courses in this subject. The term 'drug metabolism' in its broadest sense may be considered as the absorption, distribution, biotransformation and excretion of drugs. To cover all these facets of drug metabolism in a single text is a voluminous task and therefore we have focused primarily on the biotransformation aspects of the subject.

Metabolism of Drugs and Other Xenobiotics

Pavel Anzenbacher,Ulrich M. Zanger
Metabolism of Drugs and Other Xenobiotics Book PDF

Author : Pavel Anzenbacher,Ulrich M. Zanger
Publisher : John Wiley & Sons
Page : 755 pages
File Size : 50,5 Mb
Release : 2012-05-29
Category : Medical
ISBN : 9783527329038

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Metabolism of Drugs and Other Xenobiotics by Pavel Anzenbacher,Ulrich M. Zanger Pdf

A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook provides systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body. The first part comprehensively reviews the main enzyme systems involved in biotransformation and how they are orchestrated in the body, while parts two to four cover the three main classes of xenobiotics: drugs, natural products, environmental pollutants. The part on drugs includes more than 300 substances from five major therapeutic groups (central nervous system, cardiovascular system, cancer, infection, and pain) as well as most drugs of abuse including nicotine, alcohol and "designer" drugs. Selected, well-documented case studies from the most important xenobiotics classes illustrate general principles of metabolism, making this equally useful for teaching courses on pharmacology, drug metabolism or molecular toxicology. Of particular interest, and unique to this volume is the inclusion of a wide range of additional xenobiotic compounds, including food supplements, herbal preparations, and agrochemicals.

Drug Metabolism

Corina Ionescu,Mino R. Caira
Drug Metabolism Book PDF

Author : Corina Ionescu,Mino R. Caira
Publisher : Springer Science & Business Media
Page : 444 pages
File Size : 51,8 Mb
Release : 2006-02-28
Category : Medical
ISBN : 1402041411

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Drug Metabolism by Corina Ionescu,Mino R. Caira Pdf

Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.

A Handbook of Bioanalysis and Drug Metabolism

Gary Evans
A Handbook of Bioanalysis and Drug Metabolism Book PDF

Author : Gary Evans
Publisher : CRC Press
Page : 490 pages
File Size : 40,9 Mb
Release : 2021-10-15
Category : Medical
ISBN : 9781134477364

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A Handbook of Bioanalysis and Drug Metabolism by Gary Evans Pdf

Recent years have seen a greater industrial emphasis in undergraduate and postgraduate courses in the pharmaceutical and chemical sciences. However, textbooks have been slow to adapt, leaving the field without a text/reference that is both instructional and practical in the industrial setting – until now. A Handbook of Bioanalysis and Drug Metabolismis a stimulating new text that examines the techniques, methodology, and theory of bioanalysis, pharmacokinetics, and metabolism from the perspective of scientists with extensive professional experience in drug discovery and development. These three areas of research help drug developers to optimize the active component within potential drugs thereby increasing their effectiveness, and to provide safety and efficacy information required by regulators when granting a drug license. Professionals with extensive experience in drug discovery and development as well as specialized knowledge of the individual topics contributed to each chapter to create a current and well-credentialed text. It covers topics such as high performance liquid chromatography, protein binding, pharmacokinetics and drug–drug interactions. The unique industrial perspective helps to reinforce theory and develop valuable analytical and interpreting skills. This text is an invaluable guide to students in courses such as pharmaceutical science, pharmacology, chemistry, physiology and toxicology, as well as professionals in the biotechnology industry.