Biological Membrane Ion Channels

Author : Shin-Ho Chung,Olaf S. Anderson,Vikram V. Krishnamurthy
Publisher : Springer Science & Business Media
Page : 658 pages
File Size : 47,5 Mb
Release : 2007-11-13
Category : Science
ISBN : 9780387689197

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Biological Membrane Ion Channels by Shin-Ho Chung,Olaf S. Anderson,Vikram V. Krishnamurthy Pdf

This book deals with recent breakthroughs in ion-channel research that have been brought about by the combined effort of experimental biophysicists and computational physicists, who together are beginning to unravel the story of these exquisitely designed biomolecules. With chapters by leading experts, the book is aimed at researchers in nanodevices and biosensors, as well as advanced undergraduate and graduate students in biology and the physical sciences.

Author : Shin-Ho Chung,Olaf S. Anderson,Vikram V. Krishnamurthy
Publisher : Springer
Page : 658 pages
File Size : 54,6 Mb
Release : 2006-11-17
Category : Science
ISBN : 0387333231

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Biological Membrane Ion Channels by Shin-Ho Chung,Olaf S. Anderson,Vikram V. Krishnamurthy Pdf

This book deals with recent breakthroughs in ion-channel research that have been brought about by the combined effort of experimental biophysicists and computational physicists, who together are beginning to unravel the story of these exquisitely designed biomolecules. With chapters by leading experts, the book is aimed at researchers in nanodevices and biosensors, as well as advanced undergraduate and graduate students in biology and the physical sciences.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 54,6 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : David J. Aidley,Peter R. Stanfield
Publisher : Cambridge University Press
Page : 324 pages
File Size : 42,5 Mb
Release : 1996-08-13
Category : Medical
ISBN : 0521498821

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Ion Channels by David J. Aidley,Peter R. Stanfield Pdf

Ion channels are crucial components of living cells. Situated in the cell's membranes. they allow particular ions to pass from one side of the membrane to the other. In recent years the patch clamp technique has allowed the activity of individual channels to be measured, and recombinant DNA technology has led to fascinating detail on their structure. Together, these technical advances have produced a great flowering of knowledge and understanding about the subject, itself leading to further breakthroughs in science and medicine. Ion Channels provides an introduction to this scientific endeavour. It emphasises the molecular structure of channels as determined by gene cloning technology. This knowledge illuminates discussions of the permeability and selectivity of channels, their gating and modulation, their responses to drugs and toxins and the human diseases caused when they do not function properly.

Author : Nikita Gamper
Publisher : Humana Press
Page : 456 pages
File Size : 50,9 Mb
Release : 2016-05-01
Category : Science
ISBN : 1493960091

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Ion Channels by Nikita Gamper Pdf

This Methods in Molecular Biology book offers strategies and protocols for studying a large group of proteins that form ionic channels in the plasma membrane and intracellular membranes of cells. Includes step-by-step protocols, materials lists, tips and more."

Author : Jie Zheng,Matthew C. Trudeau
Publisher : CRC Press
Page : 682 pages
File Size : 54,6 Mb
Release : 2015-02-25
Category : Medical
ISBN : 9781466551428

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Handbook of Ion Channels by Jie Zheng,Matthew C. Trudeau Pdf

The New Benchmark for Understanding the Latest Developments of Ion ChannelsIon channels control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli, and regulate the response to physical stimuli. They can often interact with the cellular environment due to their location at the surface of ce

Author : Julita Kulbacka,Saulius Satkauskas
Publisher : Springer
Page : 140 pages
File Size : 51,7 Mb
Release : 2017-10-04
Category : Medical
ISBN : 9783319568959

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Transport Across Natural and Modified Biological Membranes and its Implications in Physiology and Therapy by Julita Kulbacka,Saulius Satkauskas Pdf

This book elucidates the mechanisms involved in biological membrane functions. It describes the new modalities and characterization for basic in vitro as well as computer models of biological membranes. Biological membranes are analyzed in terms of advances in molecular dynamics. The individual chapters provide an in depth analysis of images from various biological models. The potential of membrane models in the context of treatment trials is discussed. The authors present new insights and current concepts for treatment procedures (nanocarriers, electroporation, channel blockers).

Author : Irwin B. Levitan,Leonard K. Kaczmarek
Publisher : Oxford University Press, USA
Page : 640 pages
File Size : 55,9 Mb
Release : 2002
Category : Molecular neurobiology
ISBN : 0195145232

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The Neuron by Irwin B. Levitan,Leonard K. Kaczmarek Pdf

Intended for use by advanced undergraduate, graduate and medical students, this book presents a study of the unique biochemical and physiological properties of neurons, emphasising the molecular mechanisms that generate and regulate their activity.

Author : Ramón Latorre,Juan Carlos Sáez
Publisher : Springer Science & Business Media
Page : 515 pages
File Size : 54,9 Mb
Release : 2013-11-21
Category : Medical
ISBN : 9781489917959

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From Ion Channels to Cell-to-Cell Conversations by Ramón Latorre,Juan Carlos Sáez Pdf

Ion channels allow us to see nature in all its magnificence, to hear a Bach suite, to smell the aroma of grandmother's cooking, and, in this regard, they put us in contact with the external world. These ion channels are protein molecules located in the cell membrane. In complex organisms, cells need to communicate in order to know about their metabolic status and to act in a coordinate manner. The latter is also accomplished by a class of ion channels able to pierce the lipid bilayer membranes of two adjacent cells. These intercellular channels are the functional subunits of gap junctions. Accordingly, the book is divided in two parts: the first part is dedicated to ion channels that look to the external world, and the second part is dedicated to gap junctions found at cell interfaces. This book is based on a series of symposia for a meeting on ion channels and gap junctions held in Santiago, Chile, on November 28-30, 1995. The book should be useful to graduate students taking the first steps in this field as well as a reference for the aficionado. The aim of the meeting was mainly to show the impact of various modern techniques, including cell biology, molecular biology, biophysics, and molecular genetics techniques in the study of these ubiquitous intrinsic membrane proteins. Molecular-genetics techniques paved the road to the manipulation of the channel forming molecules.

Author : Bertil Hille
Publisher : Sinauer Associates, Incorporated
Page : 632 pages
File Size : 52,7 Mb
Release : 1992
Category : Excitable membranes
ISBN : UOM:39015024124383

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Ionic Channels of Excitable Membranes by Bertil Hille Pdf

This new, fully revised and expanded edition of Ionic Channels of Excitable Membranes includes new chapters on fast chemical synapses, modulation through G protein coupled receptors and second messenger systems, molecules cloning, site directed mutagenesis, and cell biology. It begins with the classical biophysical work of Hodgkin and Huxley and then weaves a description of the known ionic channels together with their biological functions. The book continues by developing the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. Ionic Channels of Excitable Membranes is written to be accessible and interesting to biological and physical scientists of all kinds.

Author : Anonim
Publisher : Academic Press
Page : 454 pages
File Size : 40,9 Mb
Release : 2021-06-12
Category : Science
ISBN : 9780128239254

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Ion Channels: Channel Chemical Biology, Engineering, and Physiological Function by Anonim Pdf

Ion Channels, Part C, Volume 653 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of topics, including Nonsense suppression in ion channels, Engineering Ion Channels Using Protein Trans-splicing, Probing Ion Channel Neighborhoods Using APEX, STX based probes for NaVs, ANAP: a versatile, fluorescent probe of ion channel gating and regulation, High Throughput Screens for Small Molecule Ion Channel Modulators, Using toxins to study ion channels, Re/de-constructing ubiquitin regulation of ion channels, Tethered Peptide Toxins for Ion Channels, Voltage-Sensing Phosphatase Molecular Engineering, and more. Additional chapters cover Engineering excitable cells, Stretch and Poke Stimulation of Mechanically-Activated Ion Channels, Optical Control of STIM Channels, High Throughput Electrophysiological Evaluation of Mutant Ion Channels, Evaluating BEST1 Mutations in RPE Stem Cells, Long Read Transcript Profiling of Ion Channel Splice Variants, Permeation of Connexin Channels, Ratiometric pH indicator for melanosomes and lysosomes, and Ion channels in the epithelial cells of the choroid plexus. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series

Author : Meyer B. Jackson
Publisher : CRC Press
Page : 454 pages
File Size : 52,5 Mb
Release : 1992-11-18
Category : Science
ISBN : 0849369088

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Thermodynamics of Membrane Receptors and Channels by Meyer B. Jackson Pdf

Thermodynamics of Membrane Receptors and Channels synthesizes a wealth of new information regarding the biophysics of membrane proteins. New insights provided by molecular genetics, single channel recording, and high resolution structural techniques are discussed from a conceptual perspective. Basic theoretical topics are introduced, developed, and then extensively illustrated with recent results from the literature or data from the authors' own laboratories. Theoretical and experimental information is incorporated into in-depth discussions of ion permeation mechanisms, ion channel and receptor conformational changes, aggregate activity of complexes of lipids and proteins, and how coupling is achieved between different energy modes in the many transduction systems residing in biomembranes. Thermodynamics of Membrane Receptors and Channels will be valuable both as a learning aid and a reference for biophysicists, neuroscientists, cell biologists, physiologists, and other researchers investigating any aspects of biomembranes.

Author : T. Narahashi
Publisher : Springer Science & Business Media
Page : 361 pages
File Size : 42,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461533283

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Ion Channels by T. Narahashi Pdf

In the past few years, the scientific community has witnessed significant progress in the study of ion channels. Technological advancement in biophysics, molecular biology, and immunology has been greatly ac celerated, making it possible to conduct experiments which were deemed very difficult if not impossible in the past. For example, patch-clamp techniques can now be used to measure ionic currents generated by almost every type of cell, thereby allowing us to analyze whole-cell and single channel events. It is now possible to incorporate purified ion channel components into lipid bilayers to reconstitute an "excitable membrane." Gene cloning and monoclonal antibody techniques provide us with new approaches to the study of the molecular structure of ion channels. A variety of chemicals have now been found to interact with ion channels. One of the classical examples is represented by tetrodotoxin, a puffer fish poison, which was shown in the early 1960s to block the voltage-activated sodium channel in a highly specific and potent manner.

Author : Piero P. Foa,Mary F. Walsh
Publisher : Springer Science & Business Media
Page : 605 pages
File Size : 50,7 Mb
Release : 2013-03-07
Category : Science
ISBN : 9781461225966

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Ion Channels and Ion Pumps by Piero P. Foa,Mary F. Walsh Pdf

Omnis cellula e cellula, "every cell from a cell," was dogma to the 19th century cellular physiologist and the cornerstone of Virchow's Cellular pathologie. "Spread out a cell into a layer and you will find that, in ceasing to be a cell, it has ceased to act as such," wrote the British 1 physiologist G . R. Lewes more than a century age. "The cell remains vital as long as its wall remains intact . . . " keeping its content "pure and clear" and thus preserving the "vital principle" within, echoed Claude 2 Bernard a few years later. The notion of the cell membrane as a pro tecting envelope held sway until it became clear that it could not account for the "coalescence" of poorly differentiated embryonic "vesicles" and for their transformation into "cell-like structures" capable of auto regulation and yet subject to what the grandfather of one of us defined as the "federal obligations imposed by the whole organism. ,,3 A new concept was needed, and soon the membrane was described as a structure capable of uniting as well as separating adjacent cells. Morphologic evidence for this dual function was obtained several years later when the electron microscope revealed the existence of tight and gap junc tions which, acting as intercellular bonds and channels, allowed the cells to communicate with one another and thus coordinate their biologic activities.

Author : Anonim
Publisher : Academic Press
Page : 358 pages
File Size : 51,9 Mb
Release : 2021-05-29
Category : Science
ISBN : 9780323853750

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Ion Channels: Channel Biochemistry, Reconstitution, and Function by Anonim Pdf

Ion Channels Part A, Volume 651 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of new developments on the topic. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series