Biological Robustness

Author : Marta Bertolaso,Silvia Caianiello,Emanuele Serrelli
Publisher : Springer
Page : 258 pages
File Size : 54,8 Mb
Release : 2019-01-04
Category : Philosophy
ISBN : 9783030011987

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Biological Robustness by Marta Bertolaso,Silvia Caianiello,Emanuele Serrelli Pdf

This volume reviews examples and notions of robustness at several levels of biological organization. It tackles many philosophical and conceptual issues and casts an outlook on the future challenges of robustness studies in the context of a practice-oriented philosophy of science. The focus of discussion is on concrete case studies. These highlight the necessity of a level-dependent description of robust biological behaviors.Experts from the neurosciences, biochemistry, ecology, biology, and the history and the philosophy of life sciences provide a multiplex perspective on the topic. Contributions span from protein folding, to cell-level robustness, to organismal and developmental robustness, to sensorimotor systems, up to the robustness of ecological systems.Several chapters detail neurobiological case-studies. The brain, the poster child of plasticity in biology, offers multiple examples of robustness. Neurobiology explores the importance of temporal organization and multiscalarity in making this robustness-with-plasticity possible. The discussion also includes structures well beyond the brain, such as muscles and the complex feedback loops involved in the peculiar robustness of music perception. Overall, the volume grounds general reflections upon concrete case studies, opening to all the life sciences but also to non-biological and bio-inspired fields such as post-modern engineering. It will appeal to researchers, students, as well as non-expert readers.

Author : Andreas Wagner
Publisher : Princeton University Press
Page : 384 pages
File Size : 54,5 Mb
Release : 2013-10-24
Category : Science
ISBN : 9781400849383

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Robustness and Evolvability in Living Systems by Andreas Wagner Pdf

All living things are remarkably complex, yet their DNA is unstable, undergoing countless random mutations over generations. Despite this instability, most animals do not grow two heads or die, plants continue to thrive, and bacteria continue to divide. Robustness and Evolvability in Living Systems tackles this perplexing paradox. The book explores why genetic changes do not cause organisms to fail catastrophically and how evolution shapes organisms' robustness. Andreas Wagner looks at this problem from the ground up, starting with the alphabet of DNA, the genetic code, RNA, and protein molecules, moving on to genetic networks and embryonic development, and working his way up to whole organisms. He then develops an evolutionary explanation for robustness. Wagner shows how evolution by natural selection preferentially finds and favors robust solutions to the problems organisms face in surviving and reproducing. Such robustness, he argues, also enhances the potential for future evolutionary innovation. Wagner also argues that robustness has less to do with organisms having plenty of spare parts (the redundancy theory that has been popular) and more to do with the reality that mutations can change organisms in ways that do not substantively affect their fitness. Unparalleled in its field, this book offers the most detailed analysis available of all facets of robustness within organisms. It will appeal not only to biologists but also to engineers interested in the design of robust systems and to social scientists concerned with robustness in human communities and populations.

Author : Patrick Bateson,Peter Gluckman
Publisher : Cambridge University Press
Page : 167 pages
File Size : 46,5 Mb
Release : 2011-06-30
Category : Science
ISBN : 9781139496285

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Plasticity, Robustness, Development and Evolution by Patrick Bateson,Peter Gluckman Pdf

How do we understand and explain the apparent dichotomy between plasticity and robustness in the context of development? Can we identify these complex processes without resorting to 'either/or' solutions? Written by two leaders in the field, this is the first book to fully unravel the complexity of the subject, explaining that the epigenetic processes generating plasticity and robustness are in fact deeply intertwined. It identifies the different mechanisms that generate robustness and the various forms of plasticity, before considering the functional significance of the integrated mechanisms and how the component processes might have evolved. Finally, it highlights the ways in which epigenetic mechanisms could be instrumental in driving evolutionary change. Essential reading for biologists and psychologists interested in epigenetics and evolution, this book is also a valuable resource for biological anthropologists, sociobiologists, child psychologists and paediatricians.

Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on a New Biology for the 21st Century: Ensuring the United States Leads the Coming Biology Revolution
Publisher : National Academies Press
Page : 113 pages
File Size : 43,6 Mb
Release : 2009-11-20
Category : Science
ISBN : 9780309147866

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A New Biology for the 21st Century by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on a New Biology for the 21st Century: Ensuring the United States Leads the Coming Biology Revolution Pdf

Now more than ever, biology has the potential to contribute practical solutions to many of the major challenges confronting the United States and the world. A New Biology for the 21st Century recommends that a "New Biology" approach-one that depends on greater integration within biology, and closer collaboration with physical, computational, and earth scientists, mathematicians and engineers-be used to find solutions to four key societal needs: sustainable food production, ecosystem restoration, optimized biofuel production, and improvement in human health. The approach calls for a coordinated effort to leverage resources across the federal, private, and academic sectors to help meet challenges and improve the return on life science research in general.

Author : Uri Alon
Publisher : CRC Press
Page : 324 pages
File Size : 40,8 Mb
Release : 2006-07-07
Category : Mathematics
ISBN : 9781584886426

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An Introduction to Systems Biology by Uri Alon Pdf

Thorough and accessible, this book presents the design principles of biological systems, and highlights the recurring circuit elements that make up biological networks. It provides a simple mathematical framework which can be used to understand and even design biological circuits. The textavoids specialist terms, focusing instead on several well-studied biological systems that concisely demonstrate key principles. An Introduction to Systems Biology: Design Principles of Biological Circuits builds a solid foundation for the intuitive understanding of general principles. It encourages the reader to ask why a system is designed in a particular way and then proceeds to answer with simplified models.

Author : Bor-Sen Chen
Publisher : Academic Press
Page : 390 pages
File Size : 43,9 Mb
Release : 2018-02-03
Category : Business & Economics
ISBN : 9780128140734

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Systems Evolutionary Biology by Bor-Sen Chen Pdf

Systems Evolutionary Biology: Biological Network Evolution Theory, Stochastic Evolutionary Game Strategies, and Applications to Systems Synthetic Biology discusses the evolutionary game theory and strategies of nonlinear stochastic biological networks under random genetic variations and environmental disturbances and their application to systematic synthetic biology design. The book provides more realistic stochastic biological system models to mimic the real biological systems in evolutionary process and then introduces network evolvability, stochastic evolutionary game theory and strategy based on nonlinear stochastic networks in evolution. Readers will find remarkable, revolutionary information on genetic evolutionary biology that be applied to economics, engineering and bioscience. Explains network fitness, network evolvability and network robustness of biological networks from the systematic perspective Discusses the evolutionary noncooperative and cooperative game strategies of biological networks Offers detailed diagrams to help readers understand biological networks, their systematic behaviors and the simulational results of evolutionary biological networks Includes examples in every chapter with computational simulation to illustrate the solution procedure of evolutionary theory, strategy and results

Author : Erica Jen
Publisher : Oxford University Press
Page : 318 pages
File Size : 53,5 Mb
Release : 2005-03-03
Category : Science
ISBN : 9780198037026

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Robust Design by Erica Jen Pdf

Robust Design brings together 16 chapters by an eminent group of authors in a wide range of fields presenting aspects of robustness in biological, ecological, and computational systems. The volme is the first to address robustness in biological, ecological, and computational systems. It is an outgrowth of a new research program on robustness at the Sante Fe Institute founded by the David and Lucile Packard Foundation. For those interested in complexity or interdisciplinary science, robustness is seen as currently among the most intellectually active and promising research areas with important applications in all fields of science, business, and economics.

Author : Anonim
Publisher : Unknown
Page : 367 pages
File Size : 52,9 Mb
Release : 2005
Category : Molecular evolution
ISBN : OCLC:489012299

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Robustness and Evolvability in Living Systems by Anonim Pdf

Author : Toru Ohira,Tohru Uzawa
Publisher : Springer
Page : 166 pages
File Size : 44,5 Mb
Release : 2015-03-18
Category : Science
ISBN : 9784431554448

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Mathematical Approaches to Biological Systems by Toru Ohira,Tohru Uzawa Pdf

This book presents the most recent mathematical approaches to the growing research area of networks, oscillations, and collective motions in the context of biological systems. Bringing together the results of multiple studies of different biological systems, this book sheds light on the relations among these research themes. Included in this book are the following topics: feedback systems with time delay and threshold of sensing (dead zone), robustness of biological networks from the point of view of dynamical systems, the hardware-oriented neuron modeling approach, a universal mechanism governing the entrainment limit under weak forcing, the robustness mechanism of open complex systems, situation-dependent switching of the cues primarily relied on by foraging ants, and group chase and escape. Research on different biological systems is presented together, not separated by specializations or by model systems. Therefore, the book provides diverse perspectives at the forefront of current mathematical research on biological systems, especially focused on networks, oscillations, and collective motions. This work is aimed at advanced undergraduate, graduate, and postdoctoral students, as well as scientists and engineers. It will also be of great use for professionals in industries and service sectors owing to the applicability of topics such as networks and synchronizations.

Author : Hidefumi Sawai
Publisher : Springer
Page : 226 pages
File Size : 44,9 Mb
Release : 2011-01-11
Category : Technology & Engineering
ISBN : 9783642151026

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Biological Functions for Information and Communication Technologies by Hidefumi Sawai Pdf

By incorporating biologically-inspired functions into ICT, various types of new-generation information and communication systems can be created. Just some example of areas already benefiting from such design inspiration are network architectures, information processing, molecular communication, and complex network modeling for solving real world-problems. This book provides the theoretical basis for understanding these developments and explains their practical applications. Highlighted inserts appears throughout to help readers to understand the very latest topics in these emerging research fields. The book ends with a more philosophical discussion on how new ICT solutions can be found by looking at analogous systems in biology. This new way of thinking may help researchers and practitioners to apply innovative ideas in developing next-generation technologies.

Author : Clara B. Jones
Publisher : Springer Science & Business Media
Page : 108 pages
File Size : 50,7 Mb
Release : 2012-06-06
Category : Science
ISBN : 9781461438854

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Robustness, Plasticity, and Evolvability in Mammals by Clara B. Jones Pdf

Among the unresolved topics in evolutionary biology and behavioral ecology are the origins, mechanisms, evolution, and consequences of developmental and phenotypic diversity. In an attempt to address these challenges, plasticity has been investigated empirically and theoretically at all levels of biological organization—from biochemical to whole organism and beyond to the population, community, and ecosystem levels. Less commonly explored are constraints (e.g., ecological), costs (e.g., increased response error), perturbations (e.g., alterations in selection intensity), and stressors (e.g., resource limitation) influencing not only selective values of heritable phenotypic components but, also, decisions and choices (not necessarily conscious ones) available to individuals in populations. Treating extant mammals, the primary purpose of the proposed work is to provide new perspectives on common themes in the literature on robustness (“functional diversity”; differential resistance to “deconstraint” of conserved elements) and weak robustness (the potential to restrict plasticity and evolvability), plasticity (variation expressed throughout the lifetimes of individuals in a population setting “evolvability potential”), and evolvability (non-lethal phenotypic novelties induced by endogenous and/or exogenous stimuli). The proposed project will place particular emphasis upon the adaptive complex in relation to endogenous (e.g., genomes, neurophysiology) and exogenous (abiotic and biotic, including social environments) organismal features discussed as regulatory and environmental perturbations with the potential to induce, and, often, constrain variability and novelty of form and function

Author : Chris Voigt
Publisher : Academic Press
Page : 714 pages
File Size : 48,7 Mb
Release : 2011-07-08
Category : Science
ISBN : 9780123850768

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Synthetic Biology, Part A by Chris Voigt Pdf

Synthetic biology encompasses a variety of different approaches, methodologies and disciplines, and many different definitions exist. This Volume of Methods in Enzymology has been split into 2 Parts and covers topics such as Measuring and Engineering Central Dogma Processes, Mathematical and Computational Methods and Next-Generation DNA Assembly and Manipulation. Encompasses a variety of different approaches, methodologies and disciplines Split into 2 parts and covers topics such as measuring and engineering central dogma processes, mathematical and computational methods and next-generation DNA assembly and manipulation

Author : Uri Alon
Publisher : CRC Press
Page : 324 pages
File Size : 52,7 Mb
Release : 2019-07-12
Category : Mathematics
ISBN : 9781000001327

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An Introduction to Systems Biology by Uri Alon Pdf

Praise for the first edition: ... superb, beautifully written and organized work that takes an engineering approach to systems biology. Alon provides nicely written appendices to explain the basic mathematical and biological concepts clearly and succinctly without interfering with the main text. He starts with a mathematical description of transcriptional activation and then describes some basic transcription-network motifs (patterns) that can be combined to form larger networks. – Nature [This text deserves] serious attention from any quantitative scientist who hopes to learn about modern biology ... It assumes no prior knowledge of or even interest in biology ... One final aspect that must be mentioned is the wonderful set of exercises that accompany each chapter. ... Alon’s book should become a standard part of the training of graduate students. – Physics Today Written for students and researchers, the second edition of this best-selling textbook continues to offer a clear presentation of design principles that govern the structure and behavior of biological systems. It highlights simple, recurring circuit elements that make up the regulation of cells and tissues. Rigorously classroom-tested, this edition includes new chapters on exciting advances made in the last decade. Features: Includes seven new chapters The new edition has 189 exercises, the previous edition had 66 Offers new examples relevant to human physiology and disease

Author : M.M.W.B. Hendriks,J.H. de Boer,A.K. Smilde
Publisher : Elsevier
Page : 345 pages
File Size : 46,6 Mb
Release : 1996-12-11
Category : Technology & Engineering
ISBN : 0080540635

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Robustness of Analytical Chemical Methods and Pharmaceutical Technological Products by M.M.W.B. Hendriks,J.H. de Boer,A.K. Smilde Pdf

In analytical chemistry and pharmaceutical technology attention is increasingly focussed on improving the quality of methods and products. This book aims at fostering the awareness of the potential of existing mathematical and statistical methods to improve this quality. It provides procedures and ideas on how to make a product or a method less sensitive to small variations in influencing factors. Major issues covered are robustness and stability improvement and ruggedness testing. General strategies and a theoretical introduction to these methods are described, and thorough overviews of methods used in both application areas and descriptions of practical applications are given. Features of this book: • Gives a good overview of mathematical and statistical methods used in two application areas, i.e. pharmaceutical technology and analytical chemistry • Illustrates the different approaches available to attain robustness • Gives ideas on how to use methods in practical situations. The book is intended for those who develop and optimize, and are responsible for the overall quality of, analytical methods and pharmaceutical technological products and procedures.

Author : Orkun S. Soyer
Publisher : Springer Science & Business Media
Page : 459 pages
File Size : 53,9 Mb
Release : 2012-07-23
Category : Science
ISBN : 9781461435679

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Evolutionary Systems Biology by Orkun S. Soyer Pdf

The book aims to introduce the reader to the emerging field of Evolutionary Systems Biology, which approaches classical systems biology questions within an evolutionary framework. An evolutionary approach might allow understanding the significance of observed diversity, uncover “evolutionary design principles” and extend predictions made in model organisms to others. In addition, evolutionary systems biology can generate new insights into the adaptive landscape by combining molecular systems biology models and evolutionary simulations. This insight can enable the development of more detailed mechanistic evolutionary hypotheses.