Biologics In Inflammatory Bowel Disease

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Biologics in Inflammatory Bowel Disease

Author : Scott Plevy Associate Professor of Medicine Division of Gastroenterology
Publisher : Oxford University Press, USA
Page : 64 pages
File Size : 49,7 Mb
Release : 2010
Category : Medical
ISBN : 9780199749188

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Biologics in Inflammatory Bowel Disease by Scott Plevy Associate Professor of Medicine Division of Gastroenterology Pdf

SERIES OVERVIEW: The Oxford American Pocket Notes are a series of ultra-concise, small-format books for healthcare professionals on topics related to the diagnosis, treatment and management of various medical conditions. Each title typically features an outline of key points, guidelines and tools such as patient assessments and treatment algorithms, for a specific area of medical diagnosis and/or management. Highly practical in format, content and style, the Pocket Notes serve as a quick, easily accessible point-of-care reference for busy practitioners. In effect, they are miniature versions of the Oxford American Medical Library and Oxford American Handbooks in Medicine, capturing the key essentials needed for appropriate assessment and treatment. Inflammatory bowel disease (IBD) is a gastrointestinal condition which causes inflammation of the lining of the digestive tract. This disease affects an estimated one million Americans, usually in the forms of ulcerative colitis (UC) and Crohn's disease (CD). These two diseases have similar symptoms and are often confused for one another. Crohn's disease can occur anywhere in the digestive tract, often spreading deep into the layers of affected tissues, but ulcerative colitis usually affects only the innermost lining (mucosa) of the large intestine and rectum. IBD patients suffer from severe diarrhea and abdominal pain, and may experience other complications, such as arthritis and kidney stones, that affect the body beyond the intestinal tract. The Oxford American Pocket Notes: Biologics in Inflammatory Bowel Disease is a practical guide to the safe administration of biological agents to treat inflammatory gastrointestinal illnesses. This ultra-concise and practical volume focuses on tumor necrosis factor (TNF) blocking therapy (TNF blocker), an important new class of biologic therapy indicated for the treatment of several rheumatic and other auto-immune disorders, including Crohn's disease and ulcerative colitis. This uniquely compact and affordable book features evidence-based discussion and guidelines on the mechanism of action, dosing, administration and safety considerations for the biologic agents approved to treat CD and UC, thus providing practicing physicians with easily accessible tools and insights on the use of these drugs in a daily practice setting. Culled from the pages of Handbook of Biological Therapy, this portable guide is a valuable resource for gastroenterologists, primary care physicians and other healthcare providers involved in the management of these chronic but treatable diseases.

Treatment of Inflammatory Bowel Disease with Biologics

Author : Adam S. Cheifetz,Joseph D. Feuerstein
Publisher : Springer
Page : 335 pages
File Size : 40,7 Mb
Release : 2017-11-09
Category : Medical
ISBN : 9783319602769

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Treatment of Inflammatory Bowel Disease with Biologics by Adam S. Cheifetz,Joseph D. Feuerstein Pdf

This book is a concise yet comprehensive overview of the use of biologics for the treatment of Crohn’s disease and ulcerative colitis. The volume details how best to utilize these medications in order to optimize their efficacy and safety, as well as how to understand, recognize, and treat complications that may arise from using biologics to treat IBD. The text also focuses on new data, novel biologics, and biosimilars of this rapidly expanding field. Written by experts in the field, Treatment of Inflammatory Bowel Disease with Biologics is a valuable resource for gastroenterologists, allied health professionals, fellows, and trainees who treat patients with inflammatory bowel disease.

Biologics in Inflammatory Bowel Disease, An issue of Gastroenterology Clinics of North America,

Author : Edward V. Loftus, Jr
Publisher : Elsevier Health Sciences
Page : 257 pages
File Size : 41,9 Mb
Release : 2014-08-21
Category : Medical
ISBN : 9780323323260

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Biologics in Inflammatory Bowel Disease, An issue of Gastroenterology Clinics of North America, by Edward V. Loftus, Jr Pdf

By the time this issue of Gastroenterology Clinics of North America is released, it will have been 16 years since infliximab was approved by the US Food and Drug Administration for the treatment of moderate to severe Crohn disease. Not only have we come a long way in understanding the efficacy and safety of infliximab, we are beginning to understand how and when to use the drug. Furthermore, as of this writing, we have five other biologic agents approved for either Crohn disease or ulcerative colitis, and there are many more molecules currently in drug development for these indications. In this issue,the Editors have assembled a collection of experts to provide the most cutting-edge information on the status of biologic therapy for inflammatory bowel disease.

Treatment of Inflammatory Bowel Disease with Biologics

Author : Adam S. Cheifetz,Joseph D. Feuerstein
Publisher : Springer
Page : 0 pages
File Size : 43,6 Mb
Release : 2017-11-22
Category : Medical
ISBN : 3319602756

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Treatment of Inflammatory Bowel Disease with Biologics by Adam S. Cheifetz,Joseph D. Feuerstein Pdf

This book is a concise yet comprehensive overview of the use of biologics for the treatment of Crohn’s disease and ulcerative colitis. The volume details how best to utilize these medications in order to optimize their efficacy and safety, as well as how to understand, recognize, and treat complications that may arise from using biologics to treat IBD. The text also focuses on new data, novel biologics, and biosimilars of this rapidly expanding field. Written by experts in the field, Treatment of Inflammatory Bowel Disease with Biologics is a valuable resource for gastroenterologists, allied health professionals, fellows, and trainees who treat patients with inflammatory bowel disease.

Biologics in Inflammatory Bowel Disease

Author : Scott Plevy
Publisher : OUP USA
Page : 56 pages
File Size : 40,6 Mb
Release : 2012-10
Category : Medical
ISBN : 0195391187

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Biologics in Inflammatory Bowel Disease by Scott Plevy Pdf

Biologics in Inflammatory Bowel Disease is a practical guide to the safe administration of biological agents to treat inflammatory gastrointestinal illnesses. This ultraconcise and practical volume focuses on tumour necrosis factor (TNF) blocking therapy (TNF blocker), and important new class of biologic therapy indicated for the treatment of several rheumatic and other auto-immune disorders, including Crohn's disease and ulcerative colitis.

Biological Therapy for Inflammatory Bowel Disease

Author : Raquel Franco Leal,Tristan Torriani
Publisher : BoD – Books on Demand
Page : 142 pages
File Size : 54,5 Mb
Release : 2020-03-11
Category : Medical
ISBN : 9781838802639

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Biological Therapy for Inflammatory Bowel Disease by Raquel Franco Leal,Tristan Torriani Pdf

The treatment of inflammatory bowel disease (IBD) has posed a major challenge since its appearance. Biomedical researchers, physicians, gastroenterologists, and surgeons have struggled to improve the quality of life of their patients and have sought, above all else, to keep the disease under remission for as long as possible. Blockers for tumoral necrosis factor alpha (TNF-alpha) were the first biological drugs to be discovered and for this reason they played a crucial role in the subsequent evolution of IBD treatment. The aim of this book is to provide an overview of such drugs and the latest developments in IBD immunopathology. Our contributors discuss the main indications, efficacy, and possible side effects of the different types of drugs available today for IBD treatment.

Biologic Therapy for Inflammatory Bowel Diseases

Author : Daniel C. Baumgart
Publisher : Unknown
Page : 0 pages
File Size : 53,8 Mb
Release : 2010
Category : Electronic books
ISBN : 3837452522

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Biologic Therapy for Inflammatory Bowel Diseases by Daniel C. Baumgart Pdf

Harrison's Principles of Internal Medicine

Author : Tinsley Randolph Harrison
Publisher : McGraw-Hill Companies
Page : 2569 pages
File Size : 41,5 Mb
Release : 1998
Category : Medical
ISBN : 0070202915

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Harrison's Principles of Internal Medicine by Tinsley Randolph Harrison Pdf

Classic text for practitioners, residents, and students.

New Frontiers in Therapeutic Drug Monitoring of Biologics in Inflammatory Bowel Disease and Other Immune-Mediated Inflammatory Diseases

Author : Konstantinos Papamichael
Publisher : Mdpi AG
Page : 0 pages
File Size : 50,9 Mb
Release : 2023-12-26
Category : Medical
ISBN : 303659843X

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New Frontiers in Therapeutic Drug Monitoring of Biologics in Inflammatory Bowel Disease and Other Immune-Mediated Inflammatory Diseases by Konstantinos Papamichael Pdf

Therapeutic drug monitoring (TDM) has emerged as a useful tool for optimizing biological treatment in patients with inflammatory bowel disease (IBD) and other immune-mediated inflammatory diseases (IMID). Reactive TDM has rationalized the management of primary non-response and secondary loss of response to biologics, while cumulative evidence suggests that proactive TDM is efficacious for optimizing anti-tumour necrosis factor (anti-TNF) therapy in patients with IBD. Proactive TDM can be very useful for optimizing biological therapy in specific IBD populations, such as pregnant women as well as patients with perianal fistulizing Crohn's disease and acute severe ulcerative colitis who are characterized by high drug clearance. Preliminary data suggest that proactive TDM may also have a role in de-escalating anti-TNF therapy in patients in clinical remission including stopping the immunomodulator when combined with anti-TNF therapy. However, several knowledge gaps and limitations hinder the wide implementation of TDM in clinical practice, including the optimal drug concentration to target the lag time between sampling and results and the lack of harmonization of TDM assays. Recent advances regarding the role of TDM include the use of rapid point-of-care assays and the incorporation of model-informed precision dosing. The aim of this Special Issue is to highlight the clinical utility of TDM and discuss the barriers and recent advances of TDM of biologics in IBD and other IMID.

Interventional Inflammatory Bowel Disease: Endoscopic Management and Treatment of Complications

Author : Bo Shen
Publisher : Academic Press
Page : 380 pages
File Size : 50,9 Mb
Release : 2018-01-16
Category : Medical
ISBN : 9780128113899

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Interventional Inflammatory Bowel Disease: Endoscopic Management and Treatment of Complications by Bo Shen Pdf

Interventional Inflammatory Bowel Diseases: Endoscopic Management and Treatment of Complications covers the preparation, principle, techniques, and damage control of complications in endoscopic therapy, providing the ultimate guidance in endoscopic management of IBD. With contributions from a panel of international leading experts in the field, perspectives are included from GI pathologists, GI radiologists, gastroenterologists, advanced endoscopists, IBD specialists and colorectal surgeons. Recommendations from experts are also included within each chapter. By bridging medical and surgical treatment modalities for IBD, this is the perfect reference for GI researchers, medical students, therapeutic GI endoscopists, IBD specialists, surgeons and advanced health care providers. Incorporates state-of-the-art of research in the area of therapeutic endoscopy in Crohn’s Disease and Ulcerative Colitis Makes the connection between the understanding of the complex nature and disease course of IBD with corresponding advanced endoscopic procedures Explores endoscopic treatment as the missing link between medical and surgical treatment for complex Crohn’s Disease and Ulcerative Colitis Contains access to videos demonstrating important procedural concepts

Advances in Inflammatory Bowel Diseases

Author : P. Rutgeerts,J-F. Colombel,S.B. Hanauer,J. Schölmerich,Guido Tytgat,A. van Gossum
Publisher : Springer Science & Business Media
Page : 340 pages
File Size : 47,7 Mb
Release : 1998-12-31
Category : Medical
ISBN : 0792387503

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Advances in Inflammatory Bowel Diseases by P. Rutgeerts,J-F. Colombel,S.B. Hanauer,J. Schölmerich,Guido Tytgat,A. van Gossum Pdf

Ulcerative colitis and Crohn's disease remain a great therapeutic challenge to the medical community. In recent years knowledge about the pathogenesis of these diseases has progressed rapidly but the cause of the diseases remains completely unknown. It has become clear that dysregulation of the mucosal immune system is the basis for the chronic evolution of the diseases in a genetically susceptible population. Exciting new therapeutic approaches have been attempted in the last couple of years and cytokine and anti-cytokine treatments in particular seem very promising, especially in intractable disease. The format of the Falk Symposium 106 on `Advances in Inflammatory Bowel Diseases', held in Brussels, Belgium, June 18-20, 1998, was somewhat innovative as each session attempted to link the new insights into pathogenetic mechanisms with new therapeutic approaches, resulting in optimal information transfer. The classic therapeutic schemes were updated with a special focus on step-wise build-up of therapy.

Pediatric Inflammatory Bowel Disease

Author : Petar Mamula,Jonathan E. Markowitz,Robert N. Baldassano
Publisher : Springer Science & Business Media
Page : 573 pages
File Size : 49,6 Mb
Release : 2012-12-14
Category : Medical
ISBN : 9781461450610

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Pediatric Inflammatory Bowel Disease by Petar Mamula,Jonathan E. Markowitz,Robert N. Baldassano Pdf

Pediatric Inflammatory Bowel Disease, Second Edition provides an essential reference with an emphasis on the unique pediatric issues of IBD. Chapters focus on complications of IBD specific to children and adolescents. Treatment recommendations are based on the latest clinical research available. The textbook also presents sections dedicated to the aspects of participation in clinical research unique to children and adolescents and the complicated yet vital process of successfully transitioning a patient from a pediatric to adult specialist. Controversies in pediatric IBD care such as the off-label use of medications are also covered. The format incorporates multiple tables, graphs, and figures to improve readability and make for an efficient reference for clinicians to use. Thoroughly revised and updated from the first edition, the volumes includes new therapies that are currently being used or tested for treatment of IBD, important areas regarding incidence and prevalence, immunization and response to vaccine administration as well as advancements in our understanding of growth and development with particular to the use of growth hormone therapy. Other new areas covered include important topics of complementary and alternative medicine use in IBD, immunization, and liver disease in IBD. Pediatric Inflammatory Bowel Disease, Second Edition is a valuable resource for pediatric gastroenterologists as well as adult gastroenterologists.

Crohn's Disease and Ulcerative Colitis

Author : Daniel C. Baumgart
Publisher : Springer
Page : 695 pages
File Size : 43,7 Mb
Release : 2017-03-01
Category : Medical
ISBN : 9783319337036

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Crohn's Disease and Ulcerative Colitis by Daniel C. Baumgart Pdf

This new edition is a unique combined resource for physicians and scientists addressing the needs of both groups. In addition to stimulating exchange and collaboration and shortening the path between discovery and application of new knowledge, the book helps clinicians understand new therapeutic concepts from their origins. The volume serves as a comprehensive guide to the current diagnostic modalities, including enhanced imaging techniques such as MRI and CT enterography, virtual colonoscopy, ultrasound, and endomicroscopy, as well as conventional and complex immunomodulatory principles. The latest edition also includes revised chapters from the previous edition, as well as new chapters reflecting current developments in the field. Written by experts in their field, Crohn’s Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach, Second Edition is of great value to gastroenterologists, surgeons, internists, pediatricians and gynecologists trainees, as well as all those involved in Crohn’s disease, ulcerative colitis, and related autoimmune disorders.

Curbside Consultation in IBD

Author : David T. Rubin,Sonia Friedman,Francis A. Farraye
Publisher : SLACK Incorporated
Page : 244 pages
File Size : 55,9 Mb
Release : 2009
Category : Inflammatory bowel diseases
ISBN : 1556428561

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Curbside Consultation in IBD by David T. Rubin,Sonia Friedman,Francis A. Farraye Pdf

Are you looking for concise, practical answers to questions that are often left unanswered by traditional IBD references? Are you seeking brief, evidence-based advice for complicated cases or complications? Curbside Consultation in IBD: 49 Clinical Questions provides quick and direct answers to the thorny questions commonly posed during a "curbside consultation" between colleagues. Dr. David Rubin, Dr. Sonia Friedman and Dr. Francis A. Farraye have designed this unique reference, which offers expert advice, preferences, and opinions on tough clinical questions commonly associated with IBD. The unique Q&A format provides quick access to current information related to IBD with the simplicity of a conversation between two colleagues. Numerous images, diagrams, and references are included to enhance the text and to illustrate IBD. Curbside Consultation in IBD: 49 Clinical Questions provides information that high-volume clinicians will appreciate, and yet is basic enough for residents. Gastroenterologists, fellows and residents in training, surgical attendings, and surgical residents will benefit from the user-friendly and casual format and the expert advice contained within. Some of the questions that are answered: - Which patients might be better for a "top down" approach (using anti-TNF therapy before steroids or proven failure of oral thiopurines)? What clinical behavior or serological markers might you use to identify these patients? - When is it appropriate to switch to another biologic therapy? - Should I be using chromoendoscopy in my surveillance colonoscopy in IBD? How and which agent? Would narrow band imaging be an alternative for this? - Can we follow flat low-grade dysplasia? Is any dysplasia really flat or just a spectrum of depth and size? - If women continue infliximab therapy during pregnancy, what are the implications for the baby? What should we be telling our patients about vaccinations?

Intestinal Immune System

Author : Soichiro Miura,Ryota Hokari,Shunsuke Komoto
Publisher : Morgan & Claypool Publishers
Page : 125 pages
File Size : 50,7 Mb
Release : 2011
Category : Medical
ISBN : 9781615041442

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Intestinal Immune System by Soichiro Miura,Ryota Hokari,Shunsuke Komoto Pdf

These negative regulatory mechanisms of the intestinal immune system are disturbed in certain disease conditions, causing the immunocompetent cells to respond to food components and commensal bacteria by becoming activated and to overproduce inflammatory cytokines and chemokines. These disease conditions include food allergies, such as celiac disease, and the inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease, although their exact etiological mechanisms remain to be revealed. --Book Jacket.