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Author : Nicholas A. Kefalides
Publisher : Unknown
Page : 648 pages
File Size : 49,7 Mb
Release : 1978
Category : Nature
ISBN : UOM:39015000860273
Author : Nicholas A. Kefalides
Publisher : Unknown
Page : 128 pages
File Size : 40,7 Mb
Release : 1978
Category : Diabetes
ISBN : OCLC:960942905
Author : Anonim
Publisher : Academic Press
Page : 404 pages
File Size : 48,6 Mb
Release : 2015-11-24
Category : Science
ISBN : 9780128040911
Basement Membranes focuses on specialized extracellular matrices that provide the scaffolds used and required by cells to organize themselves into tissues and organs. As basement membranes have been shown to be defective in numerous genetic and acquired diseases and to contribute to the microenvironment of both tumor cells and stem cells, this book presents a view of specific basement membrane components and their roles in development and disease, all written and commented on in chapters written by leaders in the basement membrane field. Written by leading experts in the basement membrane field Contains original material, both textual and illustrative, that should become a very relevant reference material Presents material in a very comprehensive manner Ideal for both researchers in the field and general readers who will find relevant and up-to-date information
Author : David H Rohrbach
Publisher : Academic Press
Page : 471 pages
File Size : 51,6 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323140546
Molecular and Cellular Aspects of Basement Membranes reviews the knowledge about the molecular and cellular aspects of basement membranes. This book focuses on the composition of basement membranes and their organization in extracellular matrices and presents a structural analysis of the various components of the basement membrane. The importance of basement membranes with respect to cell-matrix interactions, differentiation, and pathology is also considered. This text is organized into three sections and is comprised of 20 chapters. It begins with historical perspectives and an overview of the extracellular matrix in general and the basement membrane in particular. The discussion then turns to the organization of basement membrane components into a three-dimensional and functional matrix, along with the unique characteristics of basement membranes in skin, nerve, and kidney. The reader is also introduced to the specificity of particular basement membranes in particular histological sites; the molecular characteristics of basement membrane collagens, laminins, and proteoglycans; and the interaction of specific peptide domains of basement membrane components with cell surface receptors. Finally, the book explains how subtle changes in basement membrane composition or protein structure can cause dramatic pathology. This book will be of value to cell biologists, molecular biologists, biochemists, and pathologists.
Author : Nicholas Kefalides,Jacques Borel
Publisher : Gulf Professional Publishing
Page : 460 pages
File Size : 52,9 Mb
Release : 2005-10-24
Category : Medical
ISBN : 0121533565
Basement Membranes: Cell and Molecular Biology brings together the most important research developments of the past 45 years that have enriched our knowledge and contributed to a better understanding of the biochemistry and cell and molecular biology of basement membranes. It describes the studies that shed light on the ultrastructural organization, the biosynthesis of the macromolecular components, their functions in embryonic development and differentiation, and in the mature state. A major portion of the book is devoted to the description of the genes that regulate the expression of the various structural macromolecules. Reviews the early years of research and the discovery of type IV collagen Presents the diversity of basement membrane morphology Discusses gene structure
Author : Ruth Porter,Julie Whelan
Publisher : John Wiley & Sons
Page : 192 pages
File Size : 53,8 Mb
Release : 2009-09-14
Category : Science
ISBN : 9780470718599
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
Author : CIBA Foundation Symposium
Publisher : Wiley
Page : 296 pages
File Size : 46,6 Mb
Release : 1986-04-17
Category : Science
ISBN : 0471910775
Author : Nicholas Kefalides,Jacques Borel
Publisher : Academic Press
Page : 448 pages
File Size : 42,9 Mb
Release : 2005-11-07
Category : Science
ISBN : 0121533565
Basement Membranes: Cell and Molecular Biology brings together the most important research developments of the past 45 years that have enriched our knowledge and contributed to a better understanding of the biochemistry and cell and molecular biology of basement membranes. It describes the studies that shed light on the ultrastructural organization, the biosynthesis of the macromolecular components, their functions in embryonic development and differentiation, and in the mature state. A major portion of the book is devoted to the description of the genes that regulate the expression of the various structural macromolecules. Reviews the early years of research and the discovery of type IV collagen Presents the diversity of basement membrane morphology Discusses gene structure
Author : Elizabeth D. Hay
Publisher : Springer Science & Business Media
Page : 427 pages
File Size : 40,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461308812
At a recent meeting to discuss the domains of cell biology, I put forth a case for the extracellular matrix, even though my argument ran the risk of falling on deaf ears. After all, the matrix is EXTRAcellular, outside the cells. In this book, however, the authors make a compelling case for the relevance of the matrix to cellular concerns. Not only are numerous cell types, including many epithelia, quite caught up in the business of manufacturing matrix components, but also most of them contain matrix molecules in exoskeletons that are attached to the plasmalemma and that organize or otherwise influence the affairs of the cyto plasm. The idea of this book is to present the extracellular matrix to cell biolo gists of all levels. The authors are active and busy investigators, recognized experts in their fields, but all were enthusiastic about the prospect of writing for this audience. The chapters are not "review" articles in the usual sense, nor are they rehashes of symposium talks; they were written specifically for this book and they present the "state of the art" in engaging style, with ample references to more technical or historical reviews. The book is rich in electron micro graphs and diagrams and for many of the latter, as well as for the design of the cover, we are indebted to Sylvia J. Keene, medical illustrator for the Department of Anatomy at Harvard Medical Scrool. We also owe special thanks to Susan G.
Author : E.D. Hay
Publisher : Springer Science & Business Media
Page : 478 pages
File Size : 51,8 Mb
Release : 2013-11-11
Category : Science
ISBN : 9781461537700
In the ten-year interval since the first edition of this volume went to press, our knowledge of extracellular matrix (ECM) function and structure has enor mously increased. Extracellular matrix and cell-matrix interaction are now routine topics in the meetings and annual reviews sponsored by cell biology societies. Research in molecular biology has so advanced the number of known matrix molecules and the topic of gene structure and regulation that we won dered how best to incorporate the new material. For example, we deliberated over the inclusion of chapters on molecular genetics. We decided that with judicious editing we could present the recent findings in molecular biology within the same cell biology framework that was used for the first edition, using three broad headings: what is extracellular matrix, how is it made, and what does it do for cells? Maintaining control over the review of literature on the subject of ECM was not always an easy task, but we felt it was essential to production of a highly readable volume, one compact enough to serve the the student as an introduction and the investigator as a quick update on graduate the important recent discoveries. The first edition of this volume enjoyed con hope the reader finds this edition equally useful. siderable success; we D. Hay Elizabeth vii Contents Introductory Remarks 1 Elizabeth D. Hay PART I. WHAT IS EXTRACELLULAR MATRIX? Chapter 1 Collagen T. F. Linsenmayer 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 2. The Collagen Molecule . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 2. 1. Triple-Helical Domain(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Author : Gregory A Hudalla,William L Murphy
Publisher : Royal Society of Chemistry
Page : 422 pages
File Size : 43,5 Mb
Release : 2019-03-15
Category : Technology & Engineering
ISBN : 9781788018159
The extracellular matrix (ECM) is the focus of much interest in biology and bioengineering. Increasing understanding of the influence of the ECM on cell behaviour has led to the exciting possibilities of tissue engineering. Aside from new therapeutic tools, understanding the ECM is of course fundamental to basic cell biology research. Mimicking the Extracellular Matrix approaches this topic from both basic science and practical engineering perspectives. Seven topics are approached each in a pair of chapters, one with a biological approach and its partner with a bioengineering approach. Topics include the mechanical properties of the ECM, which outlines current knowledge of the ECM physical structure and reviewing state-of-the-art strategies to mimic its native microenvironments. The organisational characteristics of the ECM form the focus of another pair of chapters, where the collagen triple helix is discussed, followed by a review of advances in artificial reproduction of well-ordered systems using self-assembling peptides, or peptide amphiphiles. The balanced approach of this text gives it a broad appeal to those interested in the ECM from a range of backgrounds and disciplines. Suitable for undergraduates, postgraduates, and academics, this text aims to unify the current knowledge of ECM biology and matrix-mimicking biomaterials.
Author : Richard Effros
Publisher : Elsevier
Page : 334 pages
File Size : 45,5 Mb
Release : 2012-12-02
Category : Nature
ISBN : 9780323155496
Microcirculation: Current Physiologic, Medical, and Surgical Concepts is based primarily on a course and a series of lectures presented at a congress on microcirculation held at the University of California in August 1979. The book gives an overview of the concepts regarding the structure and properties of small vessels, a topic mostly read only in specialized journals. The primary focus of the text is on the function and dysfunction of small blood vessels. Three major parts comprise the text. Part I discusses the morphology, physiology, and pharmacology of circulation, and Part II presents the dynamics or role of the microcirculation in the study of diabetes. Finally, Part III discusses also the role of microcirculation in disease states, particularly hemoconcentration. The book will provide much information to researchers and students in the fields of biology, medicine, physiology, and pharmacology.
Author : P. Motta,A. Ruggeri
Publisher : Springer Science & Business Media
Page : 224 pages
File Size : 43,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461328315
In recent years, the techniques of electron microscopy have developed so widely and rapidly that they now cover the fields of research once the unique ll:panage of sister research techniques such as biochemistry, physiology, immunology, X-ray diffraction, etc. It is now possible to reach molecular and submolecular levels, making this technique indispensable in every type of research. Electron microscopy alone often provides enough information to solve given problems. In the field of the connective tissue matrix, knowledge of the molecular structure of collagen, pro teoglycans and elastin and their interaction has been to a large extent elucidated by electron microscopy. The field over which electron microscopy ranges in the investigation of the connective tissue matrix is so wide that the aim of this volume is to collect the main ultrastructural acquisitions disseminated in various journals and monographs in one book. The intent ofthis volume is to: (a) integrate different and new microscopic methods and review the results of such an integrative approach; (b) present a comprehensive ultrastructural account of selected aspects of the field; (c) point out gaps or controversial topics in our knowledge; (d) outline pertinent future research and expansion of the subject.
Author : David A. Hall,D. S. Jackson
Publisher : Elsevier
Page : 342 pages
File Size : 52,7 Mb
Release : 2016-04-20
Category : Science
ISBN : 9781483191683
International Review of Connective Tissue Research, Volume 6 presents the relationship between structure and function in connective tissue. This book deals with articular cartilage, a connective tissue that depends for its function on the integrity of its surface. Organized into six chapters, this volume begins with an overview of the structure, biology, chemistry, and biochemistry of collagen. This text then summarizes the data on the construction and application of collagen products to medicine and surgery. Other chapters consider the characteristic of the amino acid composition of basement membranes and the structural features of the synovial joint. This book discusses as well the functional properties of collagenous tissues with emphasis on their behavior when internal or external mechanical stresses are applied. The final chapter deals with the structure of fresh connective tissue based on conventional histological procedures such as dehydration, fixation, embedding, and staining. This book is a valuable resource for biochemists, rheologists, and physicists.
Author : Nancy Cummings
Publisher : Springer Science & Business Media
Page : 572 pages
File Size : 47,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461346258
