Mimicking The Extracellular Matrix

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Mimicking the Extracellular Matrix

Gregory A Hudalla,William L Murphy
Mimicking the Extracellular Matrix Book PDF

Author : Gregory A Hudalla,William L Murphy
Publisher : Royal Society of Chemistry
Page : 422 pages
File Size : 47,7 Mb
Release : 2019-03-15
Category : Technology & Engineering
ISBN : 9781788018159

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Mimicking the Extracellular Matrix by Gregory A Hudalla,William L Murphy Pdf

The extracellular matrix (ECM) is the focus of much interest in biology and bioengineering. Increasing understanding of the influence of the ECM on cell behaviour has led to the exciting possibilities of tissue engineering. Aside from new therapeutic tools, understanding the ECM is of course fundamental to basic cell biology research. Mimicking the Extracellular Matrix approaches this topic from both basic science and practical engineering perspectives. Seven topics are approached each in a pair of chapters, one with a biological approach and its partner with a bioengineering approach. Topics include the mechanical properties of the ECM, which outlines current knowledge of the ECM physical structure and reviewing state-of-the-art strategies to mimic its native microenvironments. The organisational characteristics of the ECM form the focus of another pair of chapters, where the collagen triple helix is discussed, followed by a review of advances in artificial reproduction of well-ordered systems using self-assembling peptides, or peptide amphiphiles. The balanced approach of this text gives it a broad appeal to those interested in the ECM from a range of backgrounds and disciplines. Suitable for undergraduates, postgraduates, and academics, this text aims to unify the current knowledge of ECM biology and matrix-mimicking biomaterials.

Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair

Mario Barbosa,M Cristina L Martins
Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair Book PDF

Author : Mario Barbosa,M Cristina L Martins
Publisher : Woodhead Publishing
Page : 390 pages
File Size : 53,6 Mb
Release : 2017-09-25
Category : Technology & Engineering
ISBN : 9780081008522

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Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair by Mario Barbosa,M Cristina L Martins Pdf

Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair highlights the various important considerations that go into biomaterial development, both in terms of fundamentals and applications. After covering a general introduction to protein and cell interactions with biomaterials, the book discusses proteins in biomaterials that mimic the extracellular matrix (ECM). The properties, fabrication and application of peptide biomaterials and protein-based biomaterials are discussed in addition to in vivo and in vitro studies. This book is a valuable resource for researchers, scientists and advanced students interested in biomaterials science, chemistry, molecular biology and nanotechnology. Presents an all-inclusive and authoritative coverage of the important role which protein and peptides play as biomaterials for tissue regeneration Explores protein and peptides from the fundamentals, to processing and applications Written by an international group of leading biomaterials researchers

Composition and Function of the Extracellular Matrix in the Human Body

Francesco Travascio
Composition and Function of the Extracellular Matrix in the Human Body Book PDF

Author : Francesco Travascio
Publisher : BoD – Books on Demand
Page : 376 pages
File Size : 45,6 Mb
Release : 2016-06-15
Category : Science
ISBN : 9789535124153

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Composition and Function of the Extracellular Matrix in the Human Body by Francesco Travascio Pdf

The extracellular matrix (ECM) is an ensemble of non-cellular components present within all tissues and organs of the human body. The ECM provides structural support for scaffolding cellular constituents and biochemical and biomechanical support for those events leading to tissue morphogenesis, differentiation and homeostasis. Essential components of all ECMs are water, proteins and polysaccharides. However, their composition, architecture and bioactivity greatly vary from tissue to tissue in relation to the specific role the ECM is required to assume. This book overviews the role of the ECM in different tissues and organs of the human body.

Decellularized Materials

Xiaoming Li,Huiqi Xie
Decellularized Materials Book PDF

Author : Xiaoming Li,Huiqi Xie
Publisher : Springer Nature
Page : 517 pages
File Size : 47,6 Mb
Release : 2021-04-28
Category : Medical
ISBN : 9789813369627

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Decellularized Materials by Xiaoming Li,Huiqi Xie Pdf

This book will consist of 8 chapters, in which important issues regarding decellularized materials (DMs) will be discussed. This book will provide special knowledge of materials for the persons with biomedical background, and special biomedical knowledge for the persons with the background of materials, which will hopefully become a valuable informative read for the researchers and students of biomedical engineering major.

Decellularized Extracellular Matrix

Takashi Hoshiba,Tetsuji Yamaoka
Decellularized Extracellular Matrix Book PDF

Author : Takashi Hoshiba,Tetsuji Yamaoka
Publisher : Royal Society of Chemistry
Page : 368 pages
File Size : 46,6 Mb
Release : 2019-12-05
Category : Science
ISBN : 9781788014670

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Decellularized Extracellular Matrix by Takashi Hoshiba,Tetsuji Yamaoka Pdf

Using this book, the reader will gain a good foundation to the field complemented with a broad overview of characterisation, microfabrication and applications.

Decellularized Scaffolds and Organogenesis

Kursad Turksen
Decellularized Scaffolds and Organogenesis Book PDF

Author : Kursad Turksen
Publisher : Humana Press
Page : 128 pages
File Size : 50,9 Mb
Release : 2018-07-21
Category : Science
ISBN : 1493976559

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Decellularized Scaffolds and Organogenesis by Kursad Turksen Pdf

This practical, hands-on volume examines the use of decellularized tissues and organs as biologically-active scaffolds by providing numerous approaches from experts in the field. While knowledge of how to grow and differentiate cells in culture has dramatically improved over time, the book addresses the challenges of how to instruct particular cells of interest to recognize and respond to their environment so as to proliferate, differentiate, and function for restoration of original tissue and organ form and function. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, Decellularized Scaffolds and Organogenesis: Methods and Protocols share novel approaches and insights that will provide new opportunities for those already in the field or moving to enter the field.

Mimicked Tissue Engineering Scaffolds for Maxillofacial and Articular Cartilage Surgery

Jirut Meesane
Mimicked Tissue Engineering Scaffolds for Maxillofacial and Articular Cartilage Surgery Book PDF

Author : Jirut Meesane
Publisher : Springer Nature
Page : 192 pages
File Size : 43,9 Mb
Release : 2022-12-16
Category : Technology & Engineering
ISBN : 9789811978302

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Mimicked Tissue Engineering Scaffolds for Maxillofacial and Articular Cartilage Surgery by Jirut Meesane Pdf

This book outlines the latest research on the design and fabrication of the biomaterials used in mimicked scaffolds for tissue engineering for maxillofacial and orthopedic applications. The book is written based on integration and optimized concepts of 3 main parts 1) principle of tissue engineering; 2) mimicking of structure and function of scaffolds which is similar to extracellular matrix (ECM); and 3) mimicked scaffolds for tissue engineering in maxillofacial and orthopedic surgery. The content of this book which is interdisciplinary in nature caters to medical product designers, materials scientists and engineers, biologists, and surgeons who have interest in the field of bone tissue engineering.

Tumor Organoids

Shay Soker,Aleksander Skardal
Tumor Organoids Book PDF

Author : Shay Soker,Aleksander Skardal
Publisher : Humana Press
Page : 213 pages
File Size : 53,5 Mb
Release : 2017-10-20
Category : Medical
ISBN : 9783319605111

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Tumor Organoids by Shay Soker,Aleksander Skardal Pdf

Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.

Tissue Regeneration

Qing Liu,Hongjun Wang
Tissue Regeneration Book PDF

Author : Qing Liu,Hongjun Wang
Publisher : World Scientific
Page : 546 pages
File Size : 42,8 Mb
Release : 2014
Category : Science
ISBN : 9789814494847

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Tissue Regeneration by Qing Liu,Hongjun Wang Pdf

This unique volume presents the recent advances in tissue regeneration. The authors are all active researchers in their respective fields with extensive experiences. The focus of the book is on the use of stem cells and nano-structured biomaterials for tissue regeneration/tissue engineering. It includes the use of stem cells, naturally derived extracellular matrix (ECM), synthetic biomimetic nano-fibers, synthetic nano-structured ceramics and synthetic nano-structured polymer/ceramic composites that can help/promote tissue regeneration. Methods on how to produce these nano-structured biomaterials are also discussed in several chapters. Future challenges and perspectives in the field of regenerative medicine (tissue regeneration) are also discussed.

Biological Soft Matter

Corinne Nardin,Helmut Schlaad
Biological Soft Matter Book PDF

Author : Corinne Nardin,Helmut Schlaad
Publisher : John Wiley & Sons
Page : 288 pages
File Size : 51,9 Mb
Release : 2021-04-06
Category : Technology & Engineering
ISBN : 9783527810994

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Biological Soft Matter by Corinne Nardin,Helmut Schlaad Pdf

Biological Soft Matter Explore a comprehensive, one-stop reference on biological soft matter written and edited by leading voices in the field Biological Soft Matter: Fundamentals, Properties and Applications delivers a unique and indispensable compilation of up-to-date knowledge and material on biological soft matter. The book presents a thorough overview about biological soft matter, beginning with different substance classes, including proteins, nucleic acids, lipids, and polysaccharides. It goes on to describe a variety of superstructures and aggregated and how they are formed by self-assembly processes like protein folding or crystallization. The distinguished editors have included materials with a special emphasis on macromolecular assembly, including how it applies to lipid membranes, and proteins fibrillization. Biological Soft Matter is a crucial resource for anyone working in the field, compiling information about all important substance classes and their respective roles in forming superstructures. The book is ideal for beginners and experts alike and makes the perfect guide for chemists, physicists, and life scientists with an interest in the area. Readers will also benefit from the inclusion of: An introduction to DNA nano-engineering and DNA-driven nanoparticle assembly Explorations of polysaccharides and glycoproteins, engineered biopolymers, and engineered hydrogels Discussions of macromolecular assemblies, including liquid membranes and small molecule inhibitors for amyloid aggregation A treatment of inorganic nanomaterials as promoters and inhibitors of amyloid fibril formation An examination of a wide variety of natural and artificial polymers Perfect for materials scientists, biochemists, polymer chemists, and protein chemists, Biological Soft Matter: Fundamentals, Properties and Applications will also earn a place in the libraries of biophysicists and physical chemists seeking a one-stop reference summarizing the rapidly evolving topic of biological soft matter.

Engineered Bone

Herve Petite
Engineered Bone Book PDF

Author : Herve Petite
Publisher : CRC Press
Page : 250 pages
File Size : 48,5 Mb
Release : 2005-08-15
Category : Medical
ISBN : UCLA:L0097714547

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Engineered Bone by Herve Petite Pdf

This book addresses relevant issues that tissue-engineering researchers must consider when planning new strategies, especially in the bone and cartilage field. It describes transcription factors that are essential in bone development, and deals with bone healing.

Bio-inspired Materials for Biomedical Engineering

Anthony B. Brennan,Chelsea M. Kirschner
Bio inspired Materials for Biomedical Engineering Book PDF

Author : Anthony B. Brennan,Chelsea M. Kirschner
Publisher : John Wiley & Sons
Page : 414 pages
File Size : 45,8 Mb
Release : 2014-04-14
Category : Science
ISBN : 9781118369364

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Bio-inspired Materials for Biomedical Engineering by Anthony B. Brennan,Chelsea M. Kirschner Pdf

This book covers the latest bio-inspired materials synthesis techniques and biomedical applications that are advancing the field of tissue engineering. Bio-inspired concepts for biomedical engineering are at the forefront of tissue engineering and regenerative medicine. Scientists, engineers and physicians are working together to replicate the sophisticated hierarchical organization and adaptability found in nature and selected by evolution to recapitulate the cellular microenvironment. This book demonstrates the dramatic clinical breakthroughs that have been made in engineering all four of the major tissue types and modulating the immune system. Part I (Engineering Bio-inspired Material Microenvironments) covers Bio-inspired Presentation of Chemical Cues, Bio-inspired Presentation of Physical Cues, and Bio-inspired Integration of Natural Materials. Part II (Bio-inspired Tissue Engineering) addresses tissue engineering in epithelial tissue, muscle tissue, connective tissue, and the immune system.

Tissue Engineering

W. Mark Saltzman
Tissue Engineering Book PDF

Author : W. Mark Saltzman
Publisher : Oxford University Press
Page : 544 pages
File Size : 50,8 Mb
Release : 2004-07-15
Category : Medical
ISBN : 0198032404

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Tissue Engineering by W. Mark Saltzman Pdf

Tissue or organ transplantation are among the few options available for patients with excessive skin loss, heart or liver failure, and many common ailments, and the demand for replacement tissue greatly exceeds the supply, even before one considers the serious constraints of immunological tissue type matching to avoid immune rejection. Tissue engineering promises to help sidestep constraints on availability and overcome the scientific challenges, with huge medical benefits. This book lays out the principles of tissue engineering. It will be a useful reference work for those associated with this field and as a textbook for specialized courses in the subject. It is a companion volume to Saltzman's OUP book on drug delivery.

The Extracellular Matrix: an Overview

Robert Mecham
The Extracellular Matrix an Overview Book PDF

Author : Robert Mecham
Publisher : Springer Science & Business Media
Page : 429 pages
File Size : 41,9 Mb
Release : 2011-02-16
Category : Science
ISBN : 9783642165559

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The Extracellular Matrix: an Overview by Robert Mecham Pdf

Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.

Extracellular Matrix: Pathobiology and Signaling

Nikos Karamanos
Extracellular Matrix Pathobiology and Signaling Book PDF

Author : Nikos Karamanos
Publisher : Walter de Gruyter
Page : 940 pages
File Size : 55,5 Mb
Release : 2012-08-31
Category : Science
ISBN : 9783110258776

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Extracellular Matrix: Pathobiology and Signaling by Nikos Karamanos Pdf

Over the last decades cell biology and biological chemistry have increasingly turned their attention to the space between cells and revealed an elaborate network of macromolecules essential for structural support, cell adhesion and signaling. This comprehensive handbook of the extracellular matrix will give an overview of the current state of knowledge of matrix components (structure and function), their role in heath and disease (matrix pathobiology) and new aspects related to pharmacological targeting. It will provide an introduction to the extracellular matrix and detailed sections and chapters on: Importance of extracellular matrix in health and disease Matrix proteoglycans (aggrecan, versican, perlecan, SLRPs, syndecans, glypicans, serglycin) Matrix proteinases (remodeling, would healing, regulatory roles in health and disease, metalloproteinases, cystein proteases, plasmin and plasminogen activator system) Glycobiology (hyaluronan and sulfated glycosaminoglycans in cancer, inflammation and metabolic control) Collagens (supramolecular assembly, proteins binding collagen, scaffolds, bacterial and mutated collagens, procollagen proteinases) Cell surface receptors (integrins, syndecans, mechanical strain and TGFb, CD44 and DDR). Biotechnological and pharmacological outlook (matrix regulation by growth factors, hyaluronidases, pathobiology, disease targeting, delivery systems, EMT and proteomics). "The book Extracellular Matrix: Pathobiology and Signaling provides a comprehensive and up to date collection of very relevant topics for understanding the various facets of extracellular matrix and its interactions with cells in normal tissue as well as in disease. It represents the current front-line and will serve as a reference for extracellular matrix and posttranslational modifications." Dick Heinegård, Department of Clinical Sciences Lund, Section Rheumatology, Lund University, Sweden