Biology Of Human Aging

Author : Caleb E. Finch
Publisher : Elsevier
Page : 640 pages
File Size : 49,6 Mb
Release : 2010-07-28
Category : Medical
ISBN : 0080545947

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The Biology of Human Longevity by Caleb E. Finch Pdf

Written by Caleb Finch, one of the leading scientists of our time, The Biology of Human Longevity: Inflammation, Nutrition, and Aging in the Evolution of Lifespans synthesizes several decades of top research on the topic of human aging and longevity particularly on the recent theories of inflammation and its effects on human health. The book expands a number of existing major theories, including the Barker theory of fetal origins of adult disease to consider the role of inflammation and Harmon's free radical theory of aging to include inflammatory damage. Future increases in lifespan are challenged by the obesity epidemic and spreading global infections which may reverse the gains made in lowering inflammatory exposure. This timely and topical book will be of interest to anyone studying aging from any scientific angle. Author Caleb Finch is a highly influential and respected scientist, ranked in the top half of the 1% most cited scientists Provides a novel synthesis of existing ideas about the biology of longevity and aging Incorporates important research findings from several disciplines, including Gerontology, Genomics, Neuroscience, Immunology, Nutrition

Author : Alexander P. Spence
Publisher : Unknown
Page : 285 pages
File Size : 48,8 Mb
Release : 1989
Category : Aging
ISBN : 0130801852

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Biology of Human Aging by Alexander P. Spence Pdf

Author : Calogero Caruso,Giuseppina Candore
Publisher : Academic Press
Page : 382 pages
File Size : 49,9 Mb
Release : 2021-05-11
Category : Science
ISBN : 9780128227374

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Human Aging by Calogero Caruso,Giuseppina Candore Pdf

Human Aging: From Cellular Mechanisms to Therapeutic Strategies offers an exhaustive picture of all the biological aspects of human aging by describing the key mechanisms associated with human aging and covering events that could disrupt the normal course of aging. Each chapter includes a summary of the salient points covered, along with futures prospects. The book provides readers with the information they need to gain or deepen the skills needed to evaluate the mechanisms of aging and age-related diseases and to monitor the effectiveness of therapies aimed at slowing aging. The book encourages PhD and Postdoc students, researchers, health professionals and others interested in the biology of aging to explore the fascinating and challenging questions about why and how we age as well as what can and cannot be done about it. Concentrates on different processes, e.g., oxidative stress, cellular senescence and Inflammaging Offers the ability to access cross-sectional knowledge more easily Written by expert researchers in biogerontology who are actively involved in various fields within aging research

Author : John K. Hampton, Jr.
Publisher : Unknown
Page : 200 pages
File Size : 48,8 Mb
Release : 1989-01
Category : Electronic
ISBN : 0922506000

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The Biology of Human Aging by John K. Hampton, Jr. Pdf

Author : Matt Kaeberlein,George Martin
Publisher : Academic Press
Page : 576 pages
File Size : 47,6 Mb
Release : 2015-08-20
Category : Medical
ISBN : 9780124116207

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Handbook of the Biology of Aging by Matt Kaeberlein,George Martin Pdf

Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems. The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others. Covers the key areas in biological gerontology research in one volume, with an 80% update from the previous edition Edited by Matt Kaeberlein and George Martin, highly respected voices and researchers within the biology of aging discipline Assists basic researchers in keeping abreast of research and clinical findings outside their subdiscipline Presents information that will help medical, behavioral, and social gerontologists in understanding what basic scientists and clinicians are discovering New chapters on genetics, evolutionary biology, bone aging, and epigenetic control Provides a close examination of the diverse research being conducted today in the study of the biology of aging, detailing recent breakthroughs and potential new directions

Author : John K. Hampton,Ruth F. Craven,Margaret M. Heitkemper
Publisher : McGraw-Hill Science, Engineering & Mathematics
Page : 340 pages
File Size : 42,9 Mb
Release : 1997
Category : Aging
ISBN : CORNELL:31924073942785

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The Biology of Human Aging by John K. Hampton,Ruth F. Craven,Margaret M. Heitkemper Pdf

Presenting up-to-date information about the biology of human ageing, this second edition of the text includes background biological material, numerous illustrations and end-of-chapter review questions.

Author : Alexey Moskalev
Publisher : Unknown
Page : 421 pages
File Size : 52,9 Mb
Release : 2019
Category : Aging
ISBN : 3030249727

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Biomarkers of Human Aging by Alexey Moskalev Pdf

This book collects and reviews, for the first time, a wide range of advances in the area of human aging biomarkers. This accumulated data allows researchers to assess the rate of aging processes in various organs and systems, and to individually monitor the effectiveness of therapies intended to slow aging. In an introductory chapter, the editor defines biomarkers of aging as molecular, cellular and physiological parameters that demonstrate reproducible changes - quantitative or qualitative - with age. The introduction recounts a study which aimed to create a universal model of biological age, whose most predictive parameters were albumin and alkaline phosphatase (indication liver function), glucose (metabolic syndrome), erythrocytes (respiratory function) and urea (renal function). The book goes on to describe DNA methylation, known as the "epigenetic clock," as currently the most comprehensive predictor of total mortality. It is also useful for predicting mortality from cancer and cardiovascular diseases, and for analyzing the effects of lifestyle factors including diet, exercise, and education. Individual contributions draw additional insight from research on genetics and epigenetic aging markers, and immunosenescence and inflammaging markers. A concluding chapter outlines the challenge of integrating of biological and clinical markers of aging. Biomarkers of Human Aging is written for professionals and practitioners engaged in the study of aging, and will be useful to both advanced students and researchers.

Author : Society for the Study of Human Biology
Publisher : Cambridge University Press
Page : 298 pages
File Size : 54,6 Mb
Release : 1986-03-20
Category : Medical
ISBN : 0521304857

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The Biology of Human Ageing by Society for the Study of Human Biology Pdf

This book discusses the findings of a joint symposium held in 1984 to consider human ageing and longevity from an interdisciplinary point of view.

Author : Alvaro Macieira-Coelho
Publisher : Springer Science & Business Media
Page : 198 pages
File Size : 49,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642189944

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Biology of Aging by Alvaro Macieira-Coelho Pdf

The survival of the human species has improved significantly in modern times. During the last century, the mean survival of human populations in developed countries has increased more than during the preceding 5000 years. This improvement in survival was accompanied by an increase in the number of active years. In other words, the increase in mean life span was accompanied by an increase in health span. This is now accentuated by progress in medicine reducing the impact of physiologic events such as menopause and of patho logical processes such as atherosclerosis. Up to now,research on aging, whether theoretical or experimental, has not contributed to improvement in human survival. Actually, there is a striking contrast between these significant modifications in survival and the present knowledge of the mechanisms of human aging. Revealed by this state of affairs are the profound disagreements between gerontologists in regard to the way oflooking at the aging process. The definition of aging itself is difficult to begin with because of the variability of how it occurs in different organisms.

Author : Roger B. McDonald
Publisher : Garland Science
Page : 432 pages
File Size : 52,8 Mb
Release : 2019-06-07
Category : Science
ISBN : 9780429641367

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Biology of Aging by Roger B. McDonald Pdf

Biology of Aging, Second Edition presents the biological principles that have led to a new understanding of the causes of aging and describes how these basic principles help one to understand the human experience of biological aging, longevity, and age-related disease. Intended for undergraduate biology students, it describes how the rate of biological aging is measured; explores the mechanisms underlying cellular aging; discusses the genetic pathways that affect longevity in various organisms; outlines the normal age-related changes and the functional decline that occurs in physiological systems over the lifespan; and considers the implications of modulating the rate of aging and longevity. The book also includes end-of-chapter discussion questions to help students assess their knowledge of the material. Roger McDonald received his Ph.D. from the University of Southern California and is Professor Emeritus in the Department of Nutrition at the University of California, Davis. Dr. McDonald’s research focused on mechanisms of cellular aging and the interaction between nutrition and aging. His research addressed two key topics in the field: the relationship between dietary restriction and lifespan, and the effect of aging on circadian rhythms and hypothalamic regulation. You can contact Dr. McDonald at [email protected]. Related Titles Ahmad, S. I., ed. Aging: Exploring a Complex Phenomenon (ISBN 978-1-1381-9697-1) Moody, H. R. & J. Sasser. Gerontology: The Basics (ISBN 978-1-1387-7582-4) Timiras, P. S. Physiological Basis of Aging and Geriatrics (ISBN 978-0-8493-7305-3)

Author : John A. Behnke
Publisher : Springer Science & Business Media
Page : 388 pages
File Size : 52,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461339946

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The Biology of Aging by John A. Behnke Pdf

Egocentricity is characteristically human. It is natural for our prime in terest to be ourselves and for one of our major concerns to be what affects us personally. Aging and death - universal and inevitable have always been of compelling concern. Mystical explanations were invented when scientific answers were lacking. and gross physiologi As scientific knowledge developed, anatomy cal processes were explained, and the roles of the endocrine glands were revealed. Since the sex hormones obviously lose some of their potency with age, it was logical to assume that they played the major role in declining general well-being. The puzzle of aging would now be solved. The Ponce de Leon quest would soon be fulfilled. Pseudoscientists and quacks rushed in where most scientists feared to tread. By the time the glowing promises of perpetual youth through gland transplants and injections had proved illusory, serious study of the aging process had been set back for years. The field had lost "respect ability," and most capable scientists shunned it. Those who did con tinue to seek answers to its tough questions deserve special recognition.

Author : Augustine Gaspar DiGiovanna
Publisher : McGraw-Hill Companies
Page : 356 pages
File Size : 52,6 Mb
Release : 1994
Category : Family & Relationships
ISBN : UOM:39015029979385

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Human Aging by Augustine Gaspar DiGiovanna Pdf

This text provides comprehensive coverage of biological aspects of human ageing at a level accessible to students with little or no science background. It is aimed at students pursuing a career working with, or for, the elderly. Each system is covered in its own chapter. Individual chapters present the structure and function of each body system, followed by natural age changes, and conclude with abnormal changes or diseased conditions of the elderly. Homeostasis is a unifying theme throughout the text: systems are presented relative to the body's ability to maintain homeostasis and good health is the main theme.

Author : P. Michael Conn
Publisher : Elsevier
Page : 1075 pages
File Size : 53,8 Mb
Release : 2011-04-28
Category : Medical
ISBN : 0080460062

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Handbook of Models for Human Aging by P. Michael Conn Pdf

The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues. Utilizes a multidisciplinary approach Shows tricks and approaches not available in primary publications First volume of its kind to combine both methods of study for human aging and animal models Over 200 illustrations

Author : Avril D. Woodhead,Anthony D. Blackett,Alexander Hollaender
Publisher : Springer Science & Business Media
Page : 485 pages
File Size : 49,9 Mb
Release : 2013-11-22
Category : Psychology
ISBN : 9781489922182

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Molecular Biology of Aging by Avril D. Woodhead,Anthony D. Blackett,Alexander Hollaender Pdf

It is delightful but humbling to find my face at the start of these Proceedings--there are innumerable other faces which could equally weIl stand there, from among the band who have fore gathered at every gerontology conference since the subject was launched in its present form; but I deeply appreciate being there. Gerontology d. id not grow by accident. Its present standing is the fruit of careful planning, undertaken by European and American scientists back in the 1950's. In those days it was still a "fringe" science, and the conspirators had much the standing of the 1920's Interplanetary Society. The United States itself is the offspring of conspiracy, for when the results of conspiracy are beneficent, the conspirators become Founding Fathers. This has been the case with gerontology. The present meeting is especially gratifying because the papers have been recitals of normal, hard-science investigation. We had to get through the rigors of a long period of semantic argument and a long period of one-shot general theories before this kind of meeting, normal in all other research fields, could take place. It was also necesssary to breed in the menagerie a generation of excellent investigators aware of the theoretical background but unintimidated by it, who share our conviction that human aging is comprehensible and probably controllable, and who go into the laboratory to attack specifics.

Author : Caleb Finch,Edward L. Schneider
Publisher : Van Nostrand Reinhold Company
Page : 1064 pages
File Size : 45,9 Mb
Release : 1985
Category : Medical
ISBN : UOM:39015009553549

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Handbook of the Biology of Aging by Caleb Finch,Edward L. Schneider Pdf