Biomarkers For Antioxidant Defense And Oxidative Damage

Author : Giancarlo Aldini,Kyung-Jin Yeum,Etsuo Niki,Robert M. Russell
Publisher : John Wiley & Sons
Page : 380 pages
File Size : 40,8 Mb
Release : 2011-06-09
Category : Medical
ISBN : 9780470961759

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Biomarkers for Antioxidant Defense and Oxidative Damage by Giancarlo Aldini,Kyung-Jin Yeum,Etsuo Niki,Robert M. Russell Pdf

Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications critically evaluates the basic concepts and methodologies of conventional biomarkers as well as current state-of-the-art assays for measuring antioxidant activity/oxidative stress and their practical applications. . Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications will be of a great interest to scientists who are involved in basic research on oxidation, applied scientists evaluating the effects of nutraceuticals or pharmaceutical compounds on antioxidant activity/oxidative stress, and physicians who want to understand the degree of oxidative damage in patients with certain chronic diseases. Discovering sensitive and specific biomarkers for systemic oxidative damage is essential to understand the role of oxidative stress in human disease. Once these roles are clearly understood, we are able to identify novel drug and nutraceutical targets. This volume goes beyond conventional analytical methods of measuring overall antioxidant activity and provides insight to the discovery of biomarkers that reveal information on specific areas of oxidative stress. Contributed by an international list of experts, Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications describes both conventional biomarkers and recent developments in this area. Special Features: Discusses conventional biomarkers as well as recent advances for measuring antioxidants and oxidative stress Biomarkers for lipid peroxidation: isoprostane, hydroxyloctadecaenoic acid, oxysterols, and reactive carbonyl species from lipid peroxidation Biomarkers for protein oxidation: carbonylation, tyrosine oxidation, ubiquitin-conjugation Biomarkers for DNA oxidative damage: comet assay, hydroxylated nucleotides, and exocylcic DNA adducts Recently developed biomarkers from cutting-edge technology

Author : Donald Armstrong,Robert D. Stratton
Publisher : John Wiley & Sons
Page : 600 pages
File Size : 41,6 Mb
Release : 2016-01-14
Category : Science
ISBN : 9781118832400

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Oxidative Stress and Antioxidant Protection by Donald Armstrong,Robert D. Stratton Pdf

Oxidative Stress and Antioxidant Protection: The Science of Free Radical Biology and Disease Oxidative Stress and Antioxidant Protection begins with a historical perspective of pioneers in oxidative stress with an introductory section that explains the basic principles related to oxidative stress in biochemistry and molecular biology, demonstrating both pathways and biomarkers. This section also covers diagnostic imaging and differential diagnostics. The following section covers psychological, physiologic, pharmacologic and pathologic correlates. This section addresses inheritance, gender, nutrition, obesity, family history, behavior modification, natural herbal-botanical products, and supplementation in the treatment of disease. Clinical trials are also summarized for major medical disorders and efficacy of treatment, with particular focus on inflammation, immune response, recycling, disease progression, outcomes and interventions. Each of the chapters describes what biomarker(s) and physiological functions may be relevant to a concept of specific disease and potential alternative therapy. The chapters cover medical terminology, developmental change, effects of aging, senescence, lifespan, and wound healing, and also illustrates cross-over exposure to other fields. The final chapter covers how and when to interpret appropriate data used in entry level biostatistics and epidemiology. Authored and edited by leaders in the field, Oxidative Stress and Antioxidant Protection will be an invaluable resource for students and researchers studying cell biology, molecular biology, and biochemistry, as well professionals in various health science fields.

Author : Pawan Kumar Maurya,Pranjal Chandra
Publisher : Springer
Page : 168 pages
File Size : 44,9 Mb
Release : 2017-10-24
Category : Science
ISBN : 9789811047114

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Oxidative Stress: Diagnostic Methods and Applications in Medical Science by Pawan Kumar Maurya,Pranjal Chandra Pdf

This book discusses the importance of oxidative stress, related biomarkers, and its diagnostic methods including bio-analytical and advanced detection systems. Oxidative stress is associated with diminished capacity of a biological system to overcome the overproduction of reactive oxygen species. Since oxidative stress has been suggested as a causative factor in many diseases, its prevention is vital, and there is an urgent need for oxidative stress monitoring using in vitro and in vivo models. Interdisciplinary approaches have lead to the development of various oxidative stress monitoring models for real-world clinical and biomedical applications. The development of such methods requires a broad understanding of biology, chemistry, molecular biology, immunology and microbiology. As such, the book is a valuable resource for students, researchers and clinicians interested in the fundamental as well as applied aspects of oxidative stress associated diseases.

Author : Donald Armstrong
Publisher : Springer Science & Business Media
Page : 320 pages
File Size : 53,8 Mb
Release : 2008-02-04
Category : Science
ISBN : 9781592591732

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Oxidative Stress Biomarkers and Antioxidant Protocols by Donald Armstrong Pdf

The first protocols book, Free Radical and Antioxidant Protocols (1) was published in late 1998. Sections were divided into three parts, covering selected biochemical techniques for measuring oxidative stress, antioxidant (AOX) activity, and combined applications. In choosing the 40 methods to be included in that book, I realized there were considerably more of equal value than that which we could have presented in a single volume. To produce a comprehensive resource, this book and a third are being compiled to expand coverage of the field. A summary of papers (2) published on this important subject emphasizes the continuing rapid growth in oxidative stress investigations relating to our understanding of biochemical reactions, their relevance to pathophysiological mechanisms, how disease may arise, and how therapeutic intervention may be achieved(3). Although there is some overlap between the categories, the ana- sis shown below illustrates where current studies are concentrated and are almost evenly distributed between free radicals and AOX. Over the last 4 yr, there has been a 55% increase in the number of papers published in the area.

Author : Helaine M. Alessio,Ann E. Hagerman
Publisher : World Scientific
Page : 185 pages
File Size : 40,6 Mb
Release : 2006
Category : Medical
ISBN : 9781860946196

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Oxidative Stress, Exercise and Aging by Helaine M. Alessio,Ann E. Hagerman Pdf

Examines oxidative stress in a variety of models, at rest and after exercise. This book presents key concepts of oxidative stress, exercise and aging; explains oxidative stress in different types of exercises; and includes knowledge of the underlying mechanisms influencing health and disease processes associated with oxidative stress.

Author : Volodymyr Lushchak
Publisher : BoD – Books on Demand
Page : 406 pages
File Size : 50,6 Mb
Release : 2012-05-02
Category : Science
ISBN : 9789535105534

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Oxidative Stress by Volodymyr Lushchak Pdf

This book focuses on the numerous applications of oxidative stress theory in effects of environmental factors on biological systems. The topics reviewed cover induction of oxidative stress by physical, chemical, and biological factors in humans, animals, plants and fungi. The physical factors include temperature, light and exercise. Chemical induction is related to metal ions and pesticides, whereas the biological one highlights host-pathogen interaction and stress effects on secretory systems. Antioxidants, represented by a large range of individual compounds and their mixtures of natural origin and those chemically synthesized to prevent or fix negative effects of reactive species are also described in the book. This volume will be a useful source of information on induction and effects of oxidative stress on living organisms for graduate and postgraduate students, researchers, physicians, and environmentalists.

Author : Bo Akerstrom,Magnus Gram
Publisher : Frontiers Media SA
Page : 132 pages
File Size : 53,5 Mb
Release : 2020-06-15
Category : Electronic
ISBN : 9782889637843

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Biomarkers of Oxidative Stress by Bo Akerstrom,Magnus Gram Pdf

Author : W.A. Pryor
Publisher : Elsevier
Page : 296 pages
File Size : 50,9 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780080929927

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Bio-Assays for Oxidative Stress Status by W.A. Pryor Pdf

This work contains over thirty chapters by leading researchers in the field of oxidative biology, originally presented as articles in an extended Forum in the highly-cited journal, Free Radical Biology & Medicine. The papers in this Forum (or Symposium-in-print) spanned seven issues of the journal, over many months. This is the first time that all of these expert contributions are presented in one place. Reliable methods for measuring OSS in organisms are essential. These would, amongst other things, offer applications as early warning signals for cancer and heart disease - eventually giving a range of measurable oxidation products best related to any given disease state. Additional observations relevant to OSS include: how much do measures of OSS vary in a group of humans? Does OSS decrease as a result of life-change factors and does it increase with age? With disease? With stress? Can a non-invasive, reliable, reputable measure of OSS be identified? This informative book provides the reader with the latest status of studies into OSS, currently used examples of BOSS, and answers to at least some of the questions posed above.

Author : Anonim
Publisher : BoD – Books on Demand
Page : 232 pages
File Size : 44,6 Mb
Release : 2023-05-31
Category : Science
ISBN : 9781803563299

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Importance of Oxidative Stress and Antioxidant System in Health and Disease by Anonim Pdf

Oxidative stress is a major contributor to the etiology of chronic disorders like cancer, diabetes, neurodegenerative diseases, and cardiovascular diseases. Long-term exposure to elevated levels of pro-oxidant substances can lead to structural damage in mitochondrial DNA as well as functional changes in a number of enzymes and cellular components, which can lead to abnormalities in gene expression. Modern lifestyles, which include eating processed food, exposure to a variety of chemicals, and not exercising, are significant factors in the development of oxidative stress. However, the ability of medicinal plants with antioxidant capabilities to cure or prevent a number of human illnesses in which oxidative stress appears to be a contributing factor has been demonstrated. A growing body of research links free radicals to the etiology of many diseases, supporting the use of antioxidants as a promising therapeutic strategy for the management of pathologies caused by free radicals. Despite these remarkable advances, there is still much to learn about the relationship between free radicals and antioxidants. Understanding the principles behind pathological and physiological disorders caused by free radicals is crucial. Importance of Oxidative Stress and Antioxidant System in Health and Disease contributes to understanding the fundamental principles of oxidative stress and the effects of antioxidants on disease and health.

Author : Tahira Farooqui,Akhlaq A. Farooqui
Publisher : John Wiley & Sons
Page : 433 pages
File Size : 47,8 Mb
Release : 2011-10-24
Category : Science
ISBN : 9781118148112

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Oxidative Stress in Vertebrates and Invertebrates by Tahira Farooqui,Akhlaq A. Farooqui Pdf

This volume presents a unique comparative treatment of the role oxidative stress plays in vertebrates and invertebrates in multiple organ systems with regards to cell death, development, aging, and human diseases, and anti-oxidant therapy. It offers comprehensive reviews of the current understanding of oxidative stress-mediated physiology and pathology as well as directions for future research. It also provides current information on the role of oxidative stress in neurodegenerative diseases, cardiovascular diseases, and various types of cancer mediated by oxidative stress.

Author : Tilman Grune
Publisher : Springer Science & Business Media
Page : 268 pages
File Size : 45,5 Mb
Release : 2005-01-18
Category : Medical
ISBN : 3540224238

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Oxidants and Antioxidant Defense Systems by Tilman Grune Pdf

Oxidative stress is one of the major symptoms accompanying physiological functions and numerous diseases. Oxidants and free radicals are connected with diseases such as cancer, diabetes, infectious, cardiovascular and neurodegenerative diseases and also in the aging process itself. Therefore, comprehensive knowledge of the underlying mechanisms of oxidant and free radical production and the defence against this permanent threat to cells is important for the understanding of many physiological and pathophysiological processes. This book overviews the basic mechanisms of oxidant formation and antioxidant defences. In addition, the formation of oxidants and their detoxification, the damage of macromolecules and the major repair and removal systems will be highlighted.

Author : Anonim
Publisher : BoD – Books on Demand
Page : 140 pages
File Size : 43,8 Mb
Release : 2020-08-26
Category : Science
ISBN : 9781838801250

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Glutathione System and Oxidative Stress in Health and Disease by Anonim Pdf

The imbalance between the production of reactive oxygen species (ROS) and antioxidant defenses determines a state known as oxidative stress. Higher levels of pro-oxidants compared to antioxidant defenses may generate oxidative damage, which, in turn, may lead to modifications in cellular proteins, lipids, and DNA, reducing functional capacity and increasing the risk of diseases. Nevertheless, the clearance of harmful reactive chemical species is achieved by the antioxidant defense systems. These protection systems are referred to as the first and second lines of defense and comprise the classic antioxidants, enzymatic and nonenzymatic defenses, including glutathione. This book presents and discusses the advancement of research on health and diseases and their underlying mechanisms, exploring mainly aspects related to the glutathione antioxidant system.

Author : Sami Ahmad
Publisher : Springer Science & Business Media
Page : 478 pages
File Size : 42,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461596899

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Oxidative Stress and Antioxidant Defenses in Biology by Sami Ahmad Pdf

This volume provides a comprehensive treatment of the latest research on oxidative stress and antioxidant defenses in all types of aerobic organisms. This book investigates oxidative stress in prokaryotes, protists, plants, fungi, vertebrates, and invertebrates, stimulating cross-fertilization among diverse fields. In addition, it explains the basic science of oxygen activation and oxidative stress as a foundation for more advanced material, making this book useful as a resource for both specialists and non-specialists.

Author : Victor R. Preedy,Vinood B. Patel
Publisher : Springer
Page : 0 pages
File Size : 45,8 Mb
Release : 2015-08-14
Category : Medical
ISBN : 9400776950

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General Methods in Biomarker Research and their Applications by Victor R. Preedy,Vinood B. Patel Pdf

In the past decade there has been a major sea change in the way disease is diagnosed and investigated due to the advent of high throughput technologies, such as microarrays, lab on a chip, proteomics, genomics, lipomics, metabolomics etc. These advances have enabled the discovery of new and novel markers of disease relating to autoimmune disorders, cancers, endocrine diseases, genetic disorders, sensory damage, intestinal diseases etc. In many instances these developments have gone hand in hand with the discovery of biomarkers elucidated via traditional or conventional methods, such as histopathology or clinical biochemistry. Together with microprocessor-based data analysis, advanced statistics and bioinformatics these markers have been used to identify individuals with active disease or pathology as well as those who are refractory or have distinguishing pathologies. New analytical methods that have been used to identify markers of disease and is suggested that there may be as many as 40 different platforms. Unfortunately techniques and methods have not been readily transferable to other disease states and sometimes diagnosis still relies on single analytes rather than a cohort of markers. There is thus a demand for a comprehensive and focused evidenced-based text and scientific literature that addresses these issues. Hence the formulation of Biomarkers in Disease. The series covers a wide number of areas including for example, nutrition, cancer, endocrinology, cardiology, addictions, immunology, birth defects, genetics and so on. The chapters are written by national or international experts and specialists.

Author : Isaias Dichi,José Wander Breganó,Andréa Name Colado Simão,Rubens Cecchini
Publisher : CRC Press
Page : 720 pages
File Size : 49,7 Mb
Release : 2014-03-14
Category : Medical
ISBN : 9781482216820

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Role of Oxidative Stress in Chronic Diseases by Isaias Dichi,José Wander Breganó,Andréa Name Colado Simão,Rubens Cecchini Pdf

This book presents recent findings on the role of oxidative stress in chronic diseases. Understanding the mechanisms behind it enables readers to comprehend the rationale which underlies intervention in such conditions. The book places special emphasis on genetic polymorphism—an important issue related to this field of study. It covers the role of oxidative stress in transmissible disorders as well as non-transmissible chronic conditions with chapters on metabolic diseases, autoimmune and neurodegenerative diseases, and cancer and cachexia. Each chapter covers a different disorder and the efficacy of interventional procedures.