Biomarkers In Autoimmune Diseases Of The Central Nervous System

Author : Mei-Ping Ding,Long-Jun Wu,Shougang Guo,Honghao Wang,Yin-Xi Zhang
Publisher : Frontiers Media SA
Page : 219 pages
File Size : 54,8 Mb
Release : 2023-09-25
Category : Medical
ISBN : 9782832534090

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Biomarkers in Autoimmune Diseases of the Central Nervous System by Mei-Ping Ding,Long-Jun Wu,Shougang Guo,Honghao Wang,Yin-Xi Zhang Pdf

Autoimmune diseases of the central nervous system (CNS) are a group of complex and disabling disorders characterized by the immune system mistakenly attacking the CNS. During the last 2 decades, we have witnessed a rapidly evolving spectrum of CNS autoimmune diseases, which has become a research hotspot in neurology. These include CNS inflammatory demyelinating diseases such as multiple sclerosis and neuromyelitis optical spectrum disorders, paraneoplastic, and other autoimmune encephalomyelitis and CNS involvement in systemic autoimmune diseases. Recently, although remarkable discoveries have accumulated more understanding of the autoimmune basis behind the physiopathologic mechanism, the exact pathogenic processes are still unclear. Patients may present with a variety of manifestations, posing a great challenge to diagnosis and management. The determination of biomarkers plays a significant role in CNS autoimmune diseases. Biomarkers can reflect the presence, nature, and intensity of certain immune responses triggered by both genetic and environmental processes, and bear great importance in guiding clinical diagnosis, estimating disease risk or prognosis, evaluating disease severity, and monitoring progression or response to therapy. For instance, the detection of disease-specific antibodies can contribute to the accurate diagnosis and precise treatment. Moreover, identifying the diverse biomarkers could further help to achieve the ultimate goal of personalized medicine.

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Page : 89 pages
File Size : 50,6 Mb
Release : 2018-03-16
Category : Medical
ISBN : 9780309463652

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Biomarkers of Neuroinflammation by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders Pdf

Neuroinflammation is a burgeoning area of interest in academia and biopharma, with a broadly acknowledged role in many central nervous system (CNS) disorders. However, there is little agreement on the pathophysiological mechanisms that underlie the manifestations of neuroinflammation in the CNS compartment and how neuroinflammation operates as a driver and also as a consequence of disease in the brain. Moreover, another unclear area is how to translate increased understanding of the mechanisms that underlie neuroinflammation and its manifestations in the CNS to therapeutics. To address these gaps in understanding mechanisms and how to translate that understanding into therapeutics, the Forum on Neuroscience and Nervous System Disorders of the National Academies of Sciences, Engineering, and Medicine convened a workshop on March 20-21, 2017, bringing together key leaders in the field from industry, academia, and governmental agencies to explore the role and mechanisms of neuroinflammation in a variety of CNS diseases. The workshop also considered strategies to advance the identification and validation of biomarkers of neuroinflammation that could accelerate development of therapies, bringing much-needed treatments to patients with disorders ranging from neuroinflammatory diseases such as multiple sclerosis (MS) to neuropsychiatric disorders such as depression. This publication summarizes the presentations and discussions from the workshop.

Author : Firas H. Kobeissy
Publisher : CRC Press
Page : 725 pages
File Size : 42,8 Mb
Release : 2015-02-25
Category : Science
ISBN : 9781466565999

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Brain Neurotrauma by Firas H. Kobeissy Pdf

Every year, an estimated 1.7 million Americans sustain brain injury. Long-term disabilities impact nearly half of moderate brain injury survivors and nearly 50,000 of these cases result in death. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma, including brain injury pathophysiology, biomarker research, experimental models of CNS injury, diagnostic methods, and neurotherapeutic interventions as well as neurorehabilitation strategies in the field of neurotraum research. The book includes several sections on neurotrauma mechanisms, biomarker discovery, neurocognitive/neurobehavioral deficits, and neurorehabilitation and treatment approaches. It also contains a section devoted to models of mild CNS injury, including blast and sport-related injuries. Over the last decade, the field of neurotrauma has witnessed significant advances, especially at the molecular, cellular, and behavioral levels. This progress is largely due to the introduction of novel techniques, as well as the development of new animal models of central nervous system (CNS) injury. This book, with its diverse coherent content, gives you insight into the diverse and heterogeneous aspects of CNS pathology and/or rehabilitation needs.

Author : Francisco Javier Quintana
Publisher : Elsevier
Page : 0 pages
File Size : 43,5 Mb
Release : 2024-03-23
Category : Medical
ISBN : 9780128238493

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23/03/2024 by Francisco Javier Quintana Pdf

Mechanisms of Disease Pathogenesis in Multiple Sclerosis summarizes our current understanding on MS and its clinical features and monitoring with available biomarkers, focusing on mechanisms that drive disease pathogenesis and their control by genetic, environmental factors and novel therapies for disease management. The book is written for neurologists, neuroimmunologists and clinical, translational and basic researchers interested in mechanisms of neurodegeneration. Multiple Sclerosis (MS) is an autoimmune disease which targets the central nervous system (CNS). It is the most common cause of non-traumatic neurological disability in young adults with a prevalence of 1 in 1000 and increasing, hence the importance of this book. Summarizes our current understanding of Multiple Sclerosis Discusses clinical features and available biomarker monitoring Focuses on mechanisms that drive disease pathogenesis

Author : Svetlana Dambinova,Ronald L. Hayes,Kevin K. W. Wang
Publisher : Royal Society of Chemistry
Page : 247 pages
File Size : 46,8 Mb
Release : 2012
Category : Medical
ISBN : 9781849733892

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Biomarkers for Traumatic Brain Injury by Svetlana Dambinova,Ronald L. Hayes,Kevin K. W. Wang Pdf

Due to injuries sustained in sports and in combat, interest in traumatic brain injury (TBI) has never been greater. This book will fulfill a gap in understanding of what is occurring in the brain following injury that can subsequently be detected in biological fluids and imaging.

Author : Kevin Wang
Publisher : Oxford University Press, USA
Page : 529 pages
File Size : 54,8 Mb
Release : 2018-11-16
Category : Medical
ISBN : 9780190279431

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Neurotrauma by Kevin Wang Pdf

Neurotrauma: A Comprehensive Textbook on Traumatic Brain Injury and Spinal Cord Injury aims to bring together the latest clinical practice and research in the filed of two forms of trauma to the central nervous system: namely traumatic brain injury (TBI) and spinal cord injury (SCI). Nationally, more 1.9 million Americans sustain a traumatic brain injury annually. In parallel, there are an estimate of 12,000 new cases of SCI in the United States annually. In addition, approximately 1.2 million people live with paralysis due to SCI. In recent years, dramatic advancements in the field have resulted in much improved outcomes for patients and higher standards of care. This volume details the latest research and clinical practice in the treatment of neurotrauma, in a comprehensive but easy-to-follow format. Neurotrauma is a valuable resource for any clinician involved in caring for TBI and SCI patients, clinical research professionals, researchers, medical and graduate students, and nurse specialists.

Author : Maria Teresa Cencioni,Roberta Magliozzi,Luisa María Villar
Publisher : Frontiers Media SA
Page : 220 pages
File Size : 48,6 Mb
Release : 2023-04-10
Category : Medical
ISBN : 9782832520147

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Reassessing the immune system contribution in multiple sclerosis: Therapeutic target, biomarkers of disease and immune pathogenesis by Maria Teresa Cencioni,Roberta Magliozzi,Luisa María Villar Pdf

Author : Anonim
Publisher : Elsevier
Page : 568 pages
File Size : 41,6 Mb
Release : 2016-03-11
Category : Science
ISBN : 9780444634467

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Autoimmune Neurology by Anonim Pdf

Autoimmune Neurology presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists, neuroscientists, and any medical professional working with autoimmune disease and disorders. Includes comprehensive coverage of autoimmune neurology Details the latest techniques for the study, diagnosis, and treatment of diseases and disorders, including dementia, neuromuscular disease, epilepsy, and sleep disorders Presents a focused reference for clinical practitioners and the clinical neurology and neurology research communities

Author : António Salgado
Publisher : Elsevier
Page : 712 pages
File Size : 53,8 Mb
Release : 2020-06-10
Category : Medical
ISBN : 9780128180853

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Handbook of Innovations in Central Nervous System Regenerative Medicine by António Salgado Pdf

Handbook of Innovations in CNS Regenerative Medicine provides a comprehensive overview of the CNS regenerative medicine field. The book describes the basic biology and anatomy of the CNS and how injury and disease affect its balance and the limitations of the present therapies used in the clinics. It also introduces recent trends in different fields of CNS regenerative medicine, including cell transplantation, bio and neuro-engineering, molecular/pharmacotherapy therapies and enabling technologies. Finally, the book presents successful cases of translation of basic research to first-in-human trials and the steps needed to follow this path. Areas such as cell transplantation approaches, bio and neuro-engineering, molecular/pharmacotherapy therapies and enabling technologies are key in regenerative medicine are covered in the book, along with regulatory and ethical issues. Describes the basic biology and anatomy of the CNS and how injury and disease affect its balance Discusses the limitations of present therapies used in the clinics Introduces the recent trends in different fields of CNS regenerative medicine, including cell transplantation, bio and neuro-engineering, molecular/pharmacotherapy therapies, and enabling technologies Presents successful cases of translation of basic research to first-in-human trials, along with the steps needed to follow this path

Author : Jinzhou Feng,Philippe Monnier,Shougang Guo,Cong-Cong Wang
Publisher : Frontiers Media SA
Page : 119 pages
File Size : 54,7 Mb
Release : 2024-05-28
Category : Medical
ISBN : 9782832549551

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Multiple Sclerosis and Related Disorders: Challenges and Approaches to Mechanisms, Biomarkers, and Therapeutic Targets by Jinzhou Feng,Philippe Monnier,Shougang Guo,Cong-Cong Wang Pdf

Multiple sclerosis (MS) is an autoimmune condition that causes inflammatory damage to the central nervous system. The pathologic features are diffuse and focal inflammation, demyelination, gliosis, and neuronal damage in the optic nerves, brain, and spinal cord. Multiple sclerosis remains a challenging and disabling disease. There is a greater understanding of the underlying genetic and environmental factors driving the disorder, including low vitamin D levels, smoking, and obesity. Early and accurate diagnosis is essential and needs to be supported by diagnostic criteria, including imaging and spinal fluid abnormalities in patients with clinically isolated syndromes. Other demyelinating diseases are neuromyelitis optica spectrum disorders (NMOSD), anti-myelin oligodendrocyte glycoprotein antibody disease (MOGAD), and acute disseminated encephalomyelitis (ADEM).

Author : Robert Weissert,Fabienne Brilot
Publisher : Frontiers Media SA
Page : 143 pages
File Size : 48,8 Mb
Release : 2017-11-23
Category : Electronic book
ISBN : 9782889453474

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Induction of Central Nervous System Disease by the Adaptive Immune Response by Robert Weissert,Fabienne Brilot Pdf

Over the last years it has become evident that many neurological diseases of the central nervous system (CNS) are induced by a specific adaptive immune response directed against molecules expressed on CNS-resident cells. Well-recognized examples are anti-N-Methyl-D-Aspartate Receptor (NMDAR) encephalitis which is characterized by the presence of antibodies against neuron-expressed NMDAR, or neuromyelitis optica (NMO), induced by antibodies to astrocyte-expressed aquaporin-4. Many more examples exist, and antibodies, and T or/and B cells have increasingly been associated with CNS disease. Often the symptoms of these diseases have not been typically reported to have an immune aetiology. Beside classical neurological symptoms like ataxia, vision disturbance, and motor or sensory symptoms, these can include cognitive disturbances, behavioral abnormalities, or/and epileptic seizures. Although much has been learned regarding the pathophysiology of prototypic examples of these disorders, there are still major gaps in our understanding of their biology. This may be due to the fact that they are rare diseases, and their therapies are still very limited. This research topic includes contributions addressing the analysis of the adaptive immune response driving disease including target antigens, molecular epitope mapping, and factors involved in the disease pathogenesis such as complement activation cascades, genetic and genomic regulation, as well as environmental triggers. Diagnostic criteria and methods, and treatment are also discussed. The overall aim of the volume is to review progress in our pathophysiological understanding of immune-mediated CNS disorders in order to advance diagnostic and therapeutic approaches, and ultimately improve outcomes for patients.

Author : Tobias Ruck,Marcello Moccia,Tobias Warnecke,Stefan Bittner
Publisher : Frontiers Media SA
Page : 340 pages
File Size : 48,7 Mb
Release : 2020-04-01
Category : Electronic
ISBN : 9782889636433

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Pathophysiologic Insights from Biomarker Studies in Neurological Disorders by Tobias Ruck,Marcello Moccia,Tobias Warnecke,Stefan Bittner Pdf

Author : Anonim
Publisher : ScholarlyEditions
Page : 115 pages
File Size : 45,5 Mb
Release : 2012-01-09
Category : Medical
ISBN : 9781464929021

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Advances in Autoimmune Diseases of the Nervous System Research and Treatment: 2011 Edition by Anonim Pdf

Advances in Autoimmune Diseases of the Nervous System Research and Treatment: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Autoimmune Diseases of the Nervous System. The editors have built Advances in Autoimmune Diseases of the Nervous System Research and Treatment: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Autoimmune Diseases of the Nervous System in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Autoimmune Diseases of the Nervous System Research and Treatment: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Anonim
Publisher : ScholarlyEditions
Page : 533 pages
File Size : 55,5 Mb
Release : 2013-07-22
Category : Medical
ISBN : 9781481657129

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Autoimmune Diseases: New Insights for the Healthcare Professional: 2013 Edition by Anonim Pdf

Autoimmune Diseases: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Genetics. The editors have built Autoimmune Diseases: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Genetics in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Autoimmune Diseases: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Alastair Compston,Douglas McAlpine
Publisher : Unknown
Page : 620 pages
File Size : 40,7 Mb
Release : 1998
Category : Multiple sclerosis
ISBN : UOM:39015046891498

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McAlpine's Multiple Sclerosis by Alastair Compston,Douglas McAlpine Pdf

This is the latest edition of the classic book on the subject of multiple sclerosis. An international group of authors has been involved in updating this edition which features more information on imaging and investigations, and a new chapter on neurobiology and glial development.