Biomarkers Of Neuroinflammation

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Page : 89 pages
File Size : 42,7 Mb
Release : 2018-03-16
Category : Medical
ISBN : 9780309463652

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Biomarkers of Neuroinflammation by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders Pdf

Neuroinflammation is a burgeoning area of interest in academia and biopharma, with a broadly acknowledged role in many central nervous system (CNS) disorders. However, there is little agreement on the pathophysiological mechanisms that underlie the manifestations of neuroinflammation in the CNS compartment and how neuroinflammation operates as a driver and also as a consequence of disease in the brain. Moreover, another unclear area is how to translate increased understanding of the mechanisms that underlie neuroinflammation and its manifestations in the CNS to therapeutics. To address these gaps in understanding mechanisms and how to translate that understanding into therapeutics, the Forum on Neuroscience and Nervous System Disorders of the National Academies of Sciences, Engineering, and Medicine convened a workshop on March 20-21, 2017, bringing together key leaders in the field from industry, academia, and governmental agencies to explore the role and mechanisms of neuroinflammation in a variety of CNS diseases. The workshop also considered strategies to advance the identification and validation of biomarkers of neuroinflammation that could accelerate development of therapies, bringing much-needed treatments to patients with disorders ranging from neuroinflammatory diseases such as multiple sclerosis (MS) to neuropsychiatric disorders such as depression. This publication summarizes the presentations and discussions from the workshop.

Author : Mohamed Mosaad Salama,Stefania Mondello,Firas H. Kobeissy,Wael M. Y. Mohamed
Publisher : Frontiers Media SA
Page : 173 pages
File Size : 41,8 Mb
Release : 2020-05-12
Category : Electronic
ISBN : 9782889636938

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Biomarkers in Neurology by Mohamed Mosaad Salama,Stefania Mondello,Firas H. Kobeissy,Wael M. Y. Mohamed Pdf

Author : Issam A. Awad,Daniel L. Barrow
Publisher : Thieme
Page : 250 pages
File Size : 55,6 Mb
Release : 1993
Category : Medical
ISBN : 1879284073

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Cavernous Malformations by Issam A. Awad,Daniel L. Barrow Pdf

The massive convergence of information about cavernous malformations has been synthesized in this volume by experts in the field of pathology, neuroradiology and neurosurgery. Cavernous Malformations represents state-of-the-art knowledge about this lesion and the spectrum of opinion about its nature, clinical behavior and management strategies. Highlights of Cavernous Malformations: Definition and pathologic features Epidemiology Diagnostic imaging Epilepsy Hemorrhage Conservative management Surgical intervention Microsurgical treatments Spinal cavernous malformations Pediatrics Radiotherapy (Distributed by Thieme for the American Association of Neurological Surgeons)

Author : Paola Patrignani,Bernhard Brüne,Dieter Steinhilber
Publisher : Frontiers Media SA
Page : 192 pages
File Size : 40,8 Mb
Release : 2022-02-01
Category : Science
ISBN : 9782889742561

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Resolution of Inflammation: Mechanisms, Mediators & Biomarkers by Paola Patrignani,Bernhard Brüne,Dieter Steinhilber Pdf

Author : Chiara Villa
Publisher : MDPI
Page : 442 pages
File Size : 47,6 Mb
Release : 2021-02-05
Category : Science
ISBN : 9783039439034

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Novel Biomarkers in Alzheimer’s Disease by Chiara Villa Pdf

Alzheimer’s disease (AD) represents the most common form of dementia in the elderly population worldwide. AD is characterized by progressive neurodegeneration that leads to a gradual deterioration of memory and other cognitive functions. Given the global prevalence and impact of AD, there is a critical need to establish biomarkers that can be used to detect AD in individuals before the onset of clinical signs and provide mitigating therapeutics. The aim of this Special Issue is to discuss the current knowledge as well as future perspectives on the role of biomarkers in the screening, diagnosis, treatment and follow-up of AD.

Author : Philip V. Peplow,Bridget Martinez,Thomas A. Gennarelli
Publisher : Unknown
Page : 565 pages
File Size : 42,9 Mb
Release : 2021
Category : Biochemical markers
ISBN : 1071617125

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Neurodegenerative Diseases Biomarkers by Philip V. Peplow,Bridget Martinez,Thomas A. Gennarelli Pdf

This volume presents recent data on the latest achievements in new and emerging technologies for biomarkers and for innovations in their assessment. The chapters cover topics such as activation of microglia and macrophages in neurodegenerative diseases; oxidative stress and cellular dysfunction in neurodegenerative diseases; TSPO PET imaging as a biomarker of neuroinflammation in neurodegenerative disorders; and imaging biomarkers in Huntington's disease and amyotrophic lateral sclerosis. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and comprehensive, Neurodegenerative Diseases Biomarkers: Towards Translating Research to Clinical Practice is a valuable resource for both experimental and clinical experts in the field of neurodegenerative diseases who are looking to expand their knowledge of novel biomarkers in different types of neurodegenerative diseases.

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Page : 89 pages
File Size : 43,8 Mb
Release : 2018-02-16
Category : Medical
ISBN : 9780309463683

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Biomarkers of Neuroinflammation by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders Pdf

Neuroinflammation is a burgeoning area of interest in academia and biopharma, with a broadly acknowledged role in many central nervous system (CNS) disorders. However, there is little agreement on the pathophysiological mechanisms that underlie the manifestations of neuroinflammation in the CNS compartment and how neuroinflammation operates as a driver and also as a consequence of disease in the brain. Moreover, another unclear area is how to translate increased understanding of the mechanisms that underlie neuroinflammation and its manifestations in the CNS to therapeutics. To address these gaps in understanding mechanisms and how to translate that understanding into therapeutics, the Forum on Neuroscience and Nervous System Disorders of the National Academies of Sciences, Engineering, and Medicine convened a workshop on March 20-21, 2017, bringing together key leaders in the field from industry, academia, and governmental agencies to explore the role and mechanisms of neuroinflammation in a variety of CNS diseases. The workshop also considered strategies to advance the identification and validation of biomarkers of neuroinflammation that could accelerate development of therapies, bringing much-needed treatments to patients with disorders ranging from neuroinflammatory diseases such as multiple sclerosis (MS) to neuropsychiatric disorders such as depression. This publication summarizes the presentations and discussions from the workshop.

Author : Philip V. Peplow,Bridget Martinez,Thomas A. Gennarelli
Publisher : Humana
Page : 0 pages
File Size : 50,7 Mb
Release : 2022-10-16
Category : Medical
ISBN : 1071617141

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Neurodegenerative Diseases Biomarkers by Philip V. Peplow,Bridget Martinez,Thomas A. Gennarelli Pdf

This volume presents recent data on the latest achievements in new and emerging technologies for biomarkers and for innovations in their assessment. The chapters cover topics such as activation of microglia and macrophages in neurodegenerative diseases; oxidative stress and cellular dysfunction in neurodegenerative diseases; TSPO PET imaging as a biomarker of neuroinflammation in neurodegenerative disorders; and imaging biomarkers in Huntington's disease and amyotrophic lateral sclerosis. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and comprehensive, Neurodegenerative Diseases Biomarkers: Towards Translating Research to Clinical Practice is a valuable resource for both experimental and clinical experts in the field of neurodegenerative diseases who are looking to expand their knowledge of novel biomarkers in different types of neurodegenerative diseases.

Author : Svetlana Dambinova,Ronald L. Hayes,Kevin K. W. Wang
Publisher : Royal Society of Chemistry
Page : 247 pages
File Size : 48,5 Mb
Release : 2012
Category : Medical
ISBN : 9781849733892

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Biomarkers for Traumatic Brain Injury by Svetlana Dambinova,Ronald L. Hayes,Kevin K. W. Wang Pdf

Due to injuries sustained in sports and in combat, interest in traumatic brain injury (TBI) has never been greater. This book will fulfill a gap in understanding of what is occurring in the brain following injury that can subsequently be detected in biological fluids and imaging.

Author : Waliza Ansar,Shyamasree Ghosh
Publisher : Springer
Page : 301 pages
File Size : 52,7 Mb
Release : 2016-03-23
Category : Medical
ISBN : 9788132226802

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Biology of C Reactive Protein in Health and Disease by Waliza Ansar,Shyamasree Ghosh Pdf

This book offers a comprehensive study of C-reactive protein (CRP) belonging to the pentraxin family, including a brief history of CRP, its structure, synthesis and evolution. Focusing on the emerging role of CRP and its clinical application in the field of disease biology, it details the pathophysiological role of CRP in a host of diseases such as cardiovascular disease, diabetes, cancers, rheumatoid arthritis and infectious diseases and others. It also discusses the role of innate immunity and acute phase response (APR) and their key mediators in the host body in response to tissue injury, infection, trauma or surgery, immunological disorders or neoplastic growth. CRP’s significance in inflammation is highlighted, and its importance as a clinical marker in cardiovascular disease, its functional significance in Leishmania and Plasmodium infections, its association with the development of insulin resistance in type 2 diabetes mellitus, and its role in cancer are discussed in detail. The book also includes clinical data studies and presents the latest research advances to further readers’ understanding of CRP.

Author : Alireza Minagar
Publisher : Elsevier
Page : 540 pages
File Size : 55,6 Mb
Release : 2010-12-17
Category : Science
ISBN : 0123849144

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Neuroinflammation by Alireza Minagar Pdf

Inflammation is a central mechanism in many neurological diseases, including stroke, multiple sclerosis, and brain trauma as well as meningitis and contributes to the generation of pain. We are now beginning to understand the impact of the immune system on different nervous system functions and diseases, ranging from damage through tolerance to modulation and repair. This book discusses some of the more common neuro-inflammatory diseases. Topics covered include multiple sclerosis, optic neuritis and Susac syndrome. Comprehensive review of the latest developments in neuroinflammation Includes contributions from leading authorities

Author : Kevin K. W. Wang,Zhiqun Zhang,Firas H. Kobeissy
Publisher : CRC Press
Page : 652 pages
File Size : 43,9 Mb
Release : 2014-10-28
Category : Medical
ISBN : 9781482239829

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Biomarkers of Brain Injury and Neurological Disorders by Kevin K. W. Wang,Zhiqun Zhang,Firas H. Kobeissy Pdf

This book explores the recent advances in the techniques and platforms used in biomarker research that have revolutionized the way we study, diagnose, and treat brain injury conditions. The contributors describe different biomarker studies pertaining to brain injury and other neurological disorders and analyze the different models and technologies used to identify these biological markers. The book includes findings from "Omics research" that have been utilized to decipher and identify such biomarkers. It discusses protein, microRNA, and altered gene profiles and reviews neurological disorders such as multiple sclerosis, Charcot-Marie-Tooth disease, and prion and Alzheimer’s disease.

Author : Ulrich Dirnagl,Bernd Elger
Publisher : Springer Science & Business Media
Page : 248 pages
File Size : 44,7 Mb
Release : 2013-04-17
Category : Medical
ISBN : 9783662054260

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Neuroinflammation in Stroke by Ulrich Dirnagl,Bernd Elger Pdf

The successful treatment of acute stroke remains one of the major challenges in clinical medicine. Over the last decades, the understanding of stroke pathophysiology has greatly improved, while the therapeutic options in stroke therapy remain very limited. Today, hyperacute mechanisms of damage, such as excitotoxicity, can be discriminated from delayed ones, such as inflammation and apoptosis. Targeting of inflammation has already been successfully applied in various stroke models, but translation into a clinically efficacious strategy has not been achieved so far. In this book, leading experts in basic cerebrovascular research as well as stroke treatment review the current evidence for and against an important role for inflammation in stroke, and explore the potential of treating or modulating inflammation in stroke therapy.

Author : Panayiotis Vlamos
Publisher : Springer Nature
Page : 391 pages
File Size : 43,5 Mb
Release : 2022-01-01
Category : Medical
ISBN : 9783030787714

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GeNeDis 2020 by Panayiotis Vlamos Pdf

The 4th World Congress on Genetics, Geriatrics and Neurodegenerative Diseases Research (GeNeDis 2020) focuses on the latest major challenges in scientific research, new drug targets, the development of novel biomarkers, new imaging techniques, novel protocols for early diagnosis of neurodegenerative diseases, and several other scientific advances, with the aim of better, safer, and healthier aging. The increase in the average length of life leads to the development of various diseases in the elderly population. This volume focuses on the sessions from the conference on Geriatrics.

Author : Andrea Bernasconi,Neda Bernasconi,Matthias Koepp
Publisher : Cambridge University Press
Page : 263 pages
File Size : 48,6 Mb
Release : 2019-01-10
Category : Medical
ISBN : 9781107108356

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Imaging Biomarkers in Epilepsy by Andrea Bernasconi,Neda Bernasconi,Matthias Koepp Pdf

Assembles world-class expertise on clinical and molecular imaging-derived biomarkers, presenting neuroimaging in epilepsy in a broad neuroscientific context.