Neurodegenerative Diseases Biomarkers

Author : Philip V. Peplow,Bridget Martinez,Thomas A. Gennarelli
Publisher : Unknown
Page : 565 pages
File Size : 49,5 Mb
Release : 2021
Category : Biochemical markers
ISBN : 1071617125

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Neurodegenerative Diseases Biomarkers by Philip V. Peplow,Bridget Martinez,Thomas A. Gennarelli Pdf

This volume presents recent data on the latest achievements in new and emerging technologies for biomarkers and for innovations in their assessment. The chapters cover topics such as activation of microglia and macrophages in neurodegenerative diseases; oxidative stress and cellular dysfunction in neurodegenerative diseases; TSPO PET imaging as a biomarker of neuroinflammation in neurodegenerative disorders; and imaging biomarkers in Huntington's disease and amyotrophic lateral sclerosis. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and comprehensive, Neurodegenerative Diseases Biomarkers: Towards Translating Research to Clinical Practice is a valuable resource for both experimental and clinical experts in the field of neurodegenerative diseases who are looking to expand their knowledge of novel biomarkers in different types of neurodegenerative diseases.

Author : Philip V. Peplow,Bridget Martinez,Thomas A. Gennarelli
Publisher : Humana
Page : 0 pages
File Size : 52,9 Mb
Release : 2022-10-16
Category : Medical
ISBN : 1071617141

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Neurodegenerative Diseases Biomarkers by Philip V. Peplow,Bridget Martinez,Thomas A. Gennarelli Pdf

This volume presents recent data on the latest achievements in new and emerging technologies for biomarkers and for innovations in their assessment. The chapters cover topics such as activation of microglia and macrophages in neurodegenerative diseases; oxidative stress and cellular dysfunction in neurodegenerative diseases; TSPO PET imaging as a biomarker of neuroinflammation in neurodegenerative disorders; and imaging biomarkers in Huntington's disease and amyotrophic lateral sclerosis. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and comprehensive, Neurodegenerative Diseases Biomarkers: Towards Translating Research to Clinical Practice is a valuable resource for both experimental and clinical experts in the field of neurodegenerative diseases who are looking to expand their knowledge of novel biomarkers in different types of neurodegenerative diseases.

Author : Chaur-Jong Hu,Jean-Noël Octave
Publisher : Frontiers Media SA
Page : 83 pages
File Size : 49,9 Mb
Release : 2019-04-03
Category : Electronic
ISBN : 9782889458028

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Risk Factors and Outcome Predicating Biomarker of Neurodegenerative Diseases by Chaur-Jong Hu,Jean-Noël Octave Pdf

Biomarkers for risk detection and outcome prediction of neurodegenerative diseases become more and more important for the clinical practise and neuroscience research. This eBook presents novel findings in this field, including amyotrophic lateral sclerosis, Alzheimer's disease, Parkinson's disease, Creutzfeldt-Jakob disease and application of neuroimaging, underlying mechanism of oxidative stress. The readers can catch new information about this emerging frontier of neurology with this eBook.

Author : Suman Dutta,Miriam Sklerov,Charlotte Elisabeth Teunissen,Gal Bitan
Publisher : Frontiers Media SA
Page : 273 pages
File Size : 51,9 Mb
Release : 2023-03-23
Category : Science
ISBN : 9782832518007

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Trends in biomarkers for neurodegenerative diseases: Current research and future perspectives by Suman Dutta,Miriam Sklerov,Charlotte Elisabeth Teunissen,Gal Bitan Pdf

Author : Thomas K. Karikari,Nicholas James Ashton,Henrik Zetterberg,Kaj Blennow
Publisher : Frontiers Media SA
Page : 273 pages
File Size : 52,7 Mb
Release : 2022-05-31
Category : Science
ISBN : 9782889762842

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Blood Biomarkers of Neurodegenerative Diseases by Thomas K. Karikari,Nicholas James Ashton,Henrik Zetterberg,Kaj Blennow Pdf

Author : Manuel Menéndez-González
Publisher : Frontiers Media SA
Page : 123 pages
File Size : 40,6 Mb
Release : 2014-12-03
Category : Biochemical markers
ISBN : 9782889194001

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Clinical use of biomarkers for neurodegenerative disorders by Manuel Menéndez-González Pdf

The prevalence of neurodegenerative disorders is increasing dramatically and one of the major challenges today is the need of early and accurate diagnosis, the other is the need of more effective therapies -in turn the development of such therapies also requires early and accurate diagnosis-. The main hope for an earlier and more accurate diagnosis comes from the use of biomarkers. Much research is being done trying to solve the many interrogates related to the role of biomarkers in clinical practice, including the early diagnosis, differential diagnosis and follow-up of neurodegenerative disorders. This is a field where translational research is intense enough to make this topic interesting for basic researchers and clinicians. Indeed, the amount and quality of articles received in response to the call for contributions was very good. This eBook contains a good amount of high quality articles devoted to diverse techniques across several neurodegenerative disorders from different perspectives, including original reports, reviews, methods reports and opinion letters on biochemical biomarkers in biological fluids, neuroimaging techniques and multidimensional approaches linking clinical findings with biomarkers. The disorders covered are also diverse: Alzheimer’s disease, Frontotemporal Dementia, Dementia with Lewy Bodies, Huntington’s disease, Parkinson’s disease among others. As we can learn from articles in this Research Topic, biomarkers are allowing us to expand the knowledge on the biological and anatomical basis of neurodegenerative diseases and to implement diagnostic techniques in clinical practice and clinical trials.

Author : Kevin K. W. Wang,Zhiqun Zhang,Firas H. Kobeissy
Publisher : CRC Press
Page : 652 pages
File Size : 44,5 Mb
Release : 2014-10-28
Category : Medical
ISBN : 9781482239829

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Biomarkers of Brain Injury and Neurological Disorders by Kevin K. W. Wang,Zhiqun Zhang,Firas H. Kobeissy Pdf

This book explores the recent advances in the techniques and platforms used in biomarker research that have revolutionized the way we study, diagnose, and treat brain injury conditions. The contributors describe different biomarker studies pertaining to brain injury and other neurological disorders and analyze the different models and technologies used to identify these biological markers. The book includes findings from "Omics research" that have been utilized to decipher and identify such biomarkers. It discusses protein, microRNA, and altered gene profiles and reviews neurological disorders such as multiple sclerosis, Charcot-Marie-Tooth disease, and prion and Alzheimer’s disease.

Author : Tabish Qidwai
Publisher : Bentham Science Publishers
Page : 306 pages
File Size : 46,5 Mb
Release : 2022-08-10
Category : Medical
ISBN : 9789815040920

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Neurodegenerative Diseases: Multifactorial Degenerative Processes, Biomarkers and Therapeutic Approaches (First Edition) by Tabish Qidwai Pdf

This reference is the definitive guide to common neurodegenerative diseases that affect humans. The book covers mechanisms of some of the most well-known neurodegenerative diseases, their biomarkers, neuropharmacology, and emerging treatment strategies. The book introduces the subject of neurodegeneration by outlining the biochemistry, pathophysiology and multifactorial neurological mechanisms (the role of genetics, environmental factors and mitochondrial damage, for example). Next, it explains some of the most studied diseases, namely, Parkinson’s Disease, Alzheimer’s Disease, Huntington’s Disease, and Multiple Sclerosis. Subsequent chapters delve into current knowledge about diagnostic and immunological biomarkers, followed by a summary of novel therapeutic strategies. Special attention has been given to the role of medicinal plants in attempting to treat neurodegenerative diseases, as well as the public health burden posed by these conditions. Key Features - give readers an overview of multifactorial disease mechanisms in neurodegeneration - covers some major neurodegenerative diseases in detail - covers diagnostic and immunological biomarkers - explores current therapeutic strategies and drug targets in common neurodegenerative diseases - offers a simple presentation with references for advanced readers The book is a suitable reference for all readers, including students, research scholars, and physicians who are interested in the mechanisms and treatment of neurodegenerative diseases.

Author : Daniela Galimberti,Elio Scarpini
Publisher : Springer
Page : 407 pages
File Size : 55,9 Mb
Release : 2018-03-15
Category : Medical
ISBN : 9783319729381

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Neurodegenerative Diseases by Daniela Galimberti,Elio Scarpini Pdf

This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer’s disease, frontotemporal lobar degeneration, Lewy body dementia,Parkinson’s disease, amyotrophic lateral sclerosis, and additional less common neurodegenerative diseases. Both clinical and basic aspects of each disease are treated, including novel diagnostic criteria, old and new treatments, basic discoveries (genetics, epigenetics and molecular biology), and translation of basic research into biomarkers for early diagnosis, particularly to identify peripheral biomarkers. In addition, emerging data indicate that neurodegeneration seems to also be present in classically non-degenerative disorders. Therefore, a chapter about overlapping mechanisms between dementias and psychiatric disorders is included, as well as a description of the role of neurodegeneration in multiple sclerosis. Neurodegenerative Diseases is aimed at clinicians, particularly those working in academic hospitals. This multidisciplinary book will also be of interest to basic researchers in medical fields.

Author : Lars Lannfelt,Martin Ingelsson
Publisher : Unknown
Page : 289 pages
File Size : 52,9 Mb
Release : 2016
Category : Biochemical markers
ISBN : 1493935607

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Immunotherapy and Biomarkers in Neurodegenerative Disorders by Lars Lannfelt,Martin Ingelsson Pdf

Author : Sylvain Lehmann,Charlotte Elisabeth Teunissen
Publisher : Frontiers Media SA
Page : 220 pages
File Size : 42,5 Mb
Release : 2016-11-10
Category : Electronic book
ISBN : 9782889450411

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Biomarkers of Alzheimer's Disease: The Present and the Future by Sylvain Lehmann,Charlotte Elisabeth Teunissen Pdf

Alzheimer disease (AD) is a neurodegenerative disorder characterized by significant cognitive deficits, behavioral changes, sleep disorders and loss of functional autonomy. AD represents the main cause of dementia and has become a major public health issue. In addition, the number of patients suffering from AD is growing rapidly as the population ages worldwide. Memory impairment is usually the earliest clinical and core symptom of this disease. The diagnosis at a late clinical stage is relatively easy. However, a delay in the diagnosis is damageable for the handling of patients in terms of optimal medical and social care. The actual interest of the scientific head-ways is to optimize the diagnosis in prodromal stage of the disease and to propose personalized therapeutic solutions to individual patients. New revised AD diagnostic criteria include early alteration of cerebrospinal fluid (CSF) biomarkers: decrease of amyloïd peptides (Aβ42), and increase in tau and phosphorylated-tau (p-tau) protein concentration. This recognition of CSF biological biomarkers for the diagnosis of AD is a major step towards the “molecular” diagnosis and follow-up of the disease. Many issues are however still subject of debate. This e-book provides a comprehensive overview of the state of the art of fluid biomarkers for AD, e.g. which novel biomarkers should be implemented in clinical practice for diagnosis or for monitoring treatment or side effects, which ones are new for AD or related dementias or what is the potential of peripheral blood markers. Moreover, the e-Book provides practical guidelines how to optimally and efficiently develop and validate novel biomarker assays, and to document and control pre-analytical variation.

Author : Paul C. Guest
Publisher : Springer
Page : 328 pages
File Size : 49,8 Mb
Release : 2019-02-12
Category : Science
ISBN : 9783030055424

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Reviews on Biomarker Studies in Psychiatric and Neurodegenerative Disorders by Paul C. Guest Pdf

This book includes a series of reviews on general aspects of biomarker use in the study of psychiatric and neurodegenerative diseases and the development of medications involved in their treatment. It describes the pros and cons of the various approaches and covers the successes and failures in this research field. It is only by a thorough understanding of the shortcomings that progress can be made. The overall goal is to facilitate the understanding and treatment of these disorders, by providing a viable mechanism of catching up with other areas of modern medicine, such as diabetes and heart disease. Finally, it is anticipated that the development and application of valid biomarker tests and the leveraging of novel drug targets will help the fields of psychiatry on neurodegenerative disorders move into the area of personalized medicine where the right patients can receive the right medication at the right time for the best possible outcome.

Author : Megha Agrawal,William C. Cho
Publisher : Frontiers Media SA
Page : 92 pages
File Size : 45,6 Mb
Release : 2017-07-04
Category : Electronic book
ISBN : 9782889451944

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Molecular Diagnostics in the Detection of Neurodegenerative Disorders by Megha Agrawal,William C. Cho Pdf

Neurodegeneration is characterized by the progressive loss of neural tissue that result in various neurodegeneration-initiated cerebral failures and complex diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease. All these medical conditions are accompanied by the disruption of blood-brain barrier (BBB). The BBB is an interface, separating the brain from the circulatory system and protecting the central nervous system from potentially harmful chemicals while regulating transport of essential molecules and maintaining a stable environment. Owing to the inability of the neurons to regenerate on their own after neurodegeneration or severe damage to the neural tissue, neurodegenerative disorders do not have natural cures on their own. Neuroregeneration is a viable way to curb neurodegeneration. One of the current approaches is stem cell-based therapy that has been shown to be potentially helpful for the application of neuronal cell replacement for neuroregeneration. It is vital that the neurodegenerative disorder being detected at an early stage as it can provide a chance for treatment that may be helpful to prevent further progression of the fatal disease. Thus, research has focused on developing effective non-invasive diagnostic methods for early detection of these disorders. Molecular diagnostics can provide a powerful method to detect and diagnose various neurological disorders. Such diagnosis can enhance early detection, provide subsequent medical counsel based on medical pathway, as well as to gain better insight of neurogenesis and hopefully eventual cure of the neurodegenerative diseases. With research reports, reviews, mini-reviews and commentary, this research topic covers a wide range of areas in neurodegeneration research, including diagnosis and prognosis; regulating central nervous system; biomarkers and brain injury induced neurobehavioral outcomes among other timely reports on neurodegeneration.

Author : Yuzhen Xu,Jun Xu,Shenfeng Qiu,Wen-Jun Tu
Publisher : Frontiers Media SA
Page : 298 pages
File Size : 40,8 Mb
Release : 2023-07-06
Category : Science
ISBN : 9782832527863

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Molecular Biomarkers in the Prediction, Diagnosis, and Prognosis of Neurodegenerative Diseases by Yuzhen Xu,Jun Xu,Shenfeng Qiu,Wen-Jun Tu Pdf

Author : Mohamed Mosaad Salama,Stefania Mondello,Firas H. Kobeissy,Wael M. Y. Mohamed
Publisher : Frontiers Media SA
Page : 173 pages
File Size : 45,6 Mb
Release : 2020-05-12
Category : Electronic
ISBN : 9782889636938

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Biomarkers in Neurology by Mohamed Mosaad Salama,Stefania Mondello,Firas H. Kobeissy,Wael M. Y. Mohamed Pdf