Biomarkers Of Brain Injury And Neurological Disorders

Author : Kevin K. W. Wang,Zhiqun Zhang,Firas H. Kobeissy
Publisher : CRC Press
Page : 652 pages
File Size : 48,8 Mb
Release : 2014-10-28
Category : Medical
ISBN : 9781482239829

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Biomarkers of Brain Injury and Neurological Disorders by Kevin K. W. Wang,Zhiqun Zhang,Firas H. Kobeissy Pdf

This book explores the recent advances in the techniques and platforms used in biomarker research that have revolutionized the way we study, diagnose, and treat brain injury conditions. The contributors describe different biomarker studies pertaining to brain injury and other neurological disorders and analyze the different models and technologies used to identify these biological markers. The book includes findings from "Omics research" that have been utilized to decipher and identify such biomarkers. It discusses protein, microRNA, and altered gene profiles and reviews neurological disorders such as multiple sclerosis, Charcot-Marie-Tooth disease, and prion and Alzheimer’s disease.

Author : Olli Tenovuo,Jean-charles Sanchez,Damir Janigro,Johan Undén
Publisher : Frontiers Media SA
Page : 152 pages
File Size : 48,9 Mb
Release : 2021-05-10
Category : Medical
ISBN : 9782889667543

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Biomarkers of Brain Damage – A Complex Challenge with Great Potential by Olli Tenovuo,Jean-charles Sanchez,Damir Janigro,Johan Undén Pdf

Olli Tenovuo is consultant and member of SAB for NeuroTrauma Sciences LLC (Georgia, USA) and ABCDx SA (Geneva, Switzerland). Jean-Charles Sanchez has a research grant to disclose from ABCDx SA, (Geneva, Switzerland). Damir Janigro is the CEO of FloTBI Inc. (Cleveland, USA), a company interested in biomarkers of neurological diseases.

Author : Svetlana Dambinova,Ronald L. Hayes,Kevin K. W. Wang
Publisher : Royal Society of Chemistry
Page : 247 pages
File Size : 43,8 Mb
Release : 2012
Category : Medical
ISBN : 9781849733892

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Biomarkers for Traumatic Brain Injury by Svetlana Dambinova,Ronald L. Hayes,Kevin K. W. Wang Pdf

Due to injuries sustained in sports and in combat, interest in traumatic brain injury (TBI) has never been greater. This book will fulfill a gap in understanding of what is occurring in the brain following injury that can subsequently be detected in biological fluids and imaging.

Author : Firas H. Kobeissy
Publisher : CRC Press
Page : 725 pages
File Size : 43,6 Mb
Release : 2015-02-25
Category : Science
ISBN : 9781466565999

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Brain Neurotrauma by Firas H. Kobeissy Pdf

Every year, an estimated 1.7 million Americans sustain brain injury. Long-term disabilities impact nearly half of moderate brain injury survivors and nearly 50,000 of these cases result in death. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma, including brain injury pathophysiology, biomarker research, experimental models of CNS injury, diagnostic methods, and neurotherapeutic interventions as well as neurorehabilitation strategies in the field of neurotraum research. The book includes several sections on neurotrauma mechanisms, biomarker discovery, neurocognitive/neurobehavioral deficits, and neurorehabilitation and treatment approaches. It also contains a section devoted to models of mild CNS injury, including blast and sport-related injuries. Over the last decade, the field of neurotrauma has witnessed significant advances, especially at the molecular, cellular, and behavioral levels. This progress is largely due to the introduction of novel techniques, as well as the development of new animal models of central nervous system (CNS) injury. This book, with its diverse coherent content, gives you insight into the diverse and heterogeneous aspects of CNS pathology and/or rehabilitation needs.

Author : Svetlana Dambinova,Ronald L Hayes,Kevin K.W. Wang
Publisher : Royal Society of Chemistry
Page : 246 pages
File Size : 50,6 Mb
Release : 2012-05-24
Category : Science
ISBN : 9781849734745

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Biomarkers for Traumatic Brain Injury by Svetlana Dambinova,Ronald L Hayes,Kevin K.W. Wang Pdf

Due to injuries sustained in sports and in combat, interest in TBI has never been greater. Biomarkers for Traumatic Brain Injury will fulfil a gap in our understanding of what is occurring in the brain following injury that can subsequently be detected in biological fluids and imaging. This knowledge will be useful for all researchers and clinicians interested in the biochemical and structural sequelae underpinning clinical manifestations of TBI and help guide appropriate patient management. Current and prospective biomarkers for the assessment of traumatic brain injury (TBI), particularly mild TBI, are examined using a multidisciplinary approach involving biochemistry, molecular biology, and clinical chemistry. The book incorporates presentations from outstanding researchers and clinicians in the area and describes advanced proteomic and degradomic technologies in the development of novel biomarker assays. For practical purposes, the focus of this volume is on detection of blood-based biomarkers to improve diagnostic certainty of mild TBI in conjunction with radiological and clinical findings. It represents contributions from internationally-recognized researchers at the forefront of traumatic brain injury many of whom are recipients of grants and contracts from the United States Department of Defense for research specifically on developing diagnostic tests for TBI. The book will be essential reading for scientists, pharmacologists, chemists, medical and graduate students.

Author : Mohamed Mosaad Salama,Stefania Mondello,Firas H. Kobeissy,Wael M. Y. Mohamed
Publisher : Frontiers Media SA
Page : 173 pages
File Size : 47,6 Mb
Release : 2020-05-12
Category : Electronic
ISBN : 9782889636938

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Biomarkers in Neurology by Mohamed Mosaad Salama,Stefania Mondello,Firas H. Kobeissy,Wael M. Y. Mohamed Pdf

Author : Daniel Laskowitz,Gerald Grant
Publisher : CRC Press
Page : 412 pages
File Size : 46,7 Mb
Release : 2015-12-01
Category : Medical
ISBN : 9781498766579

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Translational Research in Traumatic Brain Injury by Daniel Laskowitz,Gerald Grant Pdf

Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Page : 89 pages
File Size : 49,5 Mb
Release : 2018-02-16
Category : Medical
ISBN : 9780309463683

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Biomarkers of Neuroinflammation by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders Pdf

Neuroinflammation is a burgeoning area of interest in academia and biopharma, with a broadly acknowledged role in many central nervous system (CNS) disorders. However, there is little agreement on the pathophysiological mechanisms that underlie the manifestations of neuroinflammation in the CNS compartment and how neuroinflammation operates as a driver and also as a consequence of disease in the brain. Moreover, another unclear area is how to translate increased understanding of the mechanisms that underlie neuroinflammation and its manifestations in the CNS to therapeutics. To address these gaps in understanding mechanisms and how to translate that understanding into therapeutics, the Forum on Neuroscience and Nervous System Disorders of the National Academies of Sciences, Engineering, and Medicine convened a workshop on March 20-21, 2017, bringing together key leaders in the field from industry, academia, and governmental agencies to explore the role and mechanisms of neuroinflammation in a variety of CNS diseases. The workshop also considered strategies to advance the identification and validation of biomarkers of neuroinflammation that could accelerate development of therapies, bringing much-needed treatments to patients with disorders ranging from neuroinflammatory diseases such as multiple sclerosis (MS) to neuropsychiatric disorders such as depression. This publication summarizes the presentations and discussions from the workshop.

Author : Tobias Ruck,Marcello Moccia,Tobias Warnecke,Stefan Bittner
Publisher : Frontiers Media SA
Page : 340 pages
File Size : 42,9 Mb
Release : 2020-04-01
Category : Electronic
ISBN : 9782889636433

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Pathophysiologic Insights from Biomarker Studies in Neurological Disorders by Tobias Ruck,Marcello Moccia,Tobias Warnecke,Stefan Bittner Pdf

Author : ConferenceSeries
Publisher : ConferenceSeries
Page : 60 pages
File Size : 41,7 Mb
Release : 2024-06-28
Category : Electronic
ISBN : 8210379456XXX

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Proceedings of 3rd International Conference on Neurological Disorders and Brain Injury 2017 by ConferenceSeries Pdf

April 18- 19, 2017 London, UK Key Topics : Neurology of Brain, Neurodegenerative diseases, Cerebro Spinal Complications, Brain Disorder: Pathophysiology, Brain Disorders, Brain Stem Stroke, Brain Surgery, Clinical Management of Brain Injury, Diagnosis/Assessment of Brain Injury, Brain Injury Biomarkers, Brain Therapeutics, Animal models in Brain Research, Case Reports and Case Management of Brain Injuries, Neurological Disorders, Brain Injury Medicine, Brain Injury Mental Retardation, Brain Injury Treatment, Fatal & Neonatal Brain Injury, Neurobehavioral Disorders, Neurosurgery, Pediatric Brain Injury, Traumatic Brain Injury,

Author : Megha Agrawal,William C. Cho
Publisher : Frontiers Media SA
Page : 92 pages
File Size : 43,9 Mb
Release : 2017-07-04
Category : Electronic book
ISBN : 9782889451944

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Molecular Diagnostics in the Detection of Neurodegenerative Disorders by Megha Agrawal,William C. Cho Pdf

Neurodegeneration is characterized by the progressive loss of neural tissue that result in various neurodegeneration-initiated cerebral failures and complex diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease. All these medical conditions are accompanied by the disruption of blood-brain barrier (BBB). The BBB is an interface, separating the brain from the circulatory system and protecting the central nervous system from potentially harmful chemicals while regulating transport of essential molecules and maintaining a stable environment. Owing to the inability of the neurons to regenerate on their own after neurodegeneration or severe damage to the neural tissue, neurodegenerative disorders do not have natural cures on their own. Neuroregeneration is a viable way to curb neurodegeneration. One of the current approaches is stem cell-based therapy that has been shown to be potentially helpful for the application of neuronal cell replacement for neuroregeneration. It is vital that the neurodegenerative disorder being detected at an early stage as it can provide a chance for treatment that may be helpful to prevent further progression of the fatal disease. Thus, research has focused on developing effective non-invasive diagnostic methods for early detection of these disorders. Molecular diagnostics can provide a powerful method to detect and diagnose various neurological disorders. Such diagnosis can enhance early detection, provide subsequent medical counsel based on medical pathway, as well as to gain better insight of neurogenesis and hopefully eventual cure of the neurodegenerative diseases. With research reports, reviews, mini-reviews and commentary, this research topic covers a wide range of areas in neurodegeneration research, including diagnosis and prognosis; regulating central nervous system; biomarkers and brain injury induced neurobehavioral outcomes among other timely reports on neurodegeneration.

Author : Yongxia Zhou
Publisher : BoD – Books on Demand
Page : 167 pages
File Size : 46,9 Mb
Release : 2019-09-11
Category : Medical
ISBN : 9781789842951

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Traumatic Brain Injury by Yongxia Zhou Pdf

Traumatic brain injury (TBI) is a significant public health problem. There are several advanced techniques available for the investigation of disease neurobiology, diagnosis, and treatment. This book covers many topics in the active TBI research field such as cumulative mild head injury review, brain changes, and risk factors, as well as post-concussion syndrome (PCS) definition, classification, and association with brain dysfunction. Brain changes, including blood flow, intracranial pressure, and neuroinflammation, the neurobiological basis of neuroprotective activation, as well as correlation with PCS, including sleep, are illustrated further. Furthermore, multiple biomarkers, including S-100?, UCH-L1, and GFAP for blood-brain barrier breakdown and neuronal injury, are reviewed thoroughly. Lastly, well-evaluated neuroprotective agents, hypothermia as a neuroprotective effect in TBI, and effects investigation, as well as sedation in TBI as a neurocritical and therapeutic strategy with different assessments, are reported. This book introduces readers to a number of perspectives, including TBI disease pathophysiology and post-concussion syndrome classification, associated brain changes, imaging diagnosis, and several useful biomarkers with high sensitivities, as well as multiple therapeutic strategies. Various advanced technical developments, upfront neuroimaging, and clinical data are presented together with comprehensive, up-to-date, and interesting examples. Detailed reviews and accurate illustrations together with objective and informative discussions of several challenging problems such as PCS and neuroprotective treatments are the advantages of this book. Finally, this book will hopefully convey the clinical aspects of TBI and help guide diagnosis and therapeutic research in this field.

Author : Amit Agrawal
Publisher : BoD – Books on Demand
Page : 538 pages
File Size : 48,8 Mb
Release : 2012-03-23
Category : Medical
ISBN : 9789535102656

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Brain Injury by Amit Agrawal Pdf

The present two volume book "Brain Injury" is distinctive in its presentation and includes a wealth of updated information on many aspects in the field of brain injury. The Book is devoted to the pathogenesis of brain injury, concepts in cerebral blood flow and metabolism, investigative approaches and monitoring of brain injured, different protective mechanisms and recovery and management approach to these individuals, functional and endocrine aspects of brain injuries, approaches to rehabilitation of brain injured and preventive aspects of traumatic brain injuries. The collective contribution from experts in brain injury research area would be successfully conveyed to the readers and readers will find this book to be a valuable guide to further develop their understanding about brain injury.

Author : Anonim
Publisher : Elsevier
Page : 320 pages
File Size : 49,9 Mb
Release : 2017-11-17
Category : Medical
ISBN : 9780128043240

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Cerebrospinal Fluid in Neurologic Disorders by Anonim Pdf

Cerebrospinal Fluid in Neurologic Disorders, Volume 146 provides a brief overview on the current use of CSF in clinical routine, the physiology of CSF, and its usefulness and potential as a biomarker. The second part addresses the main purpose of the volume, describing CSF from a research perspective in context with the most important diagnostic entities in neurology. The book's authors provide insight into the current understanding of CSF changes in these various conditions and what it tells us about the nature of neurological diseases. Furthermore, methodological aspects are discussed, as are shortcomings that need to be addressed. Finally, the book provides an outlook for potential directions that can be explored to improve the various aspects of CSF research with the ultimate goal of being incorporated in clinical practice. Provides a brief overview on the current use of CSF in clinical routine, the physiology of CSF, and its usefulness and potential as a biomarker Addresses relevant research in context with the most important diagnostic entities in neurology Edited by leading authors in CSF research from around the globe, presenting the broadest, most expert coverage available

Author : National Research Council,Institute of Medicine,Board on Children, Youth, and Families,Committee on Sports-Related Concussions in Youth
Publisher : National Academies Press
Page : 215 pages
File Size : 40,7 Mb
Release : 2014-02-04
Category : Medical
ISBN : 9780309288033

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Sports-Related Concussions in Youth by National Research Council,Institute of Medicine,Board on Children, Youth, and Families,Committee on Sports-Related Concussions in Youth Pdf

In the past decade, few subjects at the intersection of medicine and sports have generated as much public interest as sports-related concussions - especially among youth. Despite growing awareness of sports-related concussions and campaigns to educate athletes, coaches, physicians, and parents of young athletes about concussion recognition and management, confusion and controversy persist in many areas. Currently, diagnosis is based primarily on the symptoms reported by the individual rather than on objective diagnostic markers, and there is little empirical evidence for the optimal degree and duration of physical rest needed to promote recovery or the best timing and approach for returning to full physical activity. Sports-Related Concussions in Youth: Improving the Science, Changing the Culture reviews the science of sports-related concussions in youth from elementary school through young adulthood, as well as in military personnel and their dependents. This report recommends actions that can be taken by a range of audiences - including research funding agencies, legislatures, state and school superintendents and athletic directors, military organizations, and equipment manufacturers, as well as youth who participate in sports and their parents - to improve what is known about concussions and to reduce their occurrence. Sports-Related Concussions in Youth finds that while some studies provide useful information, much remains unknown about the extent of concussions in youth; how to diagnose, manage, and prevent concussions; and the short- and long-term consequences of concussions as well as repetitive head impacts that do not result in concussion symptoms. The culture of sports negatively influences athletes' self-reporting of concussion symptoms and their adherence to return-to-play guidance. Athletes, their teammates, and, in some cases, coaches and parents may not fully appreciate the health threats posed by concussions. Similarly, military recruits are immersed in a culture that includes devotion to duty and service before self, and the critical nature of concussions may often go unheeded. According to Sports-Related Concussions in Youth, if the youth sports community can adopt the belief that concussions are serious injuries and emphasize care for players with concussions until they are fully recovered, then the culture in which these athletes perform and compete will become much safer. Improving understanding of the extent, causes, effects, and prevention of sports-related concussions is vitally important for the health and well-being of youth athletes. The findings and recommendations in this report set a direction for research to reach this goal.