Biomedical Applications Of Proteomics

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Biomedical Applications of Proteomics

Jean-Charles Sanchez,Garry L. Corthals,Denis F. Hochstrasser
Biomedical Applications of Proteomics Book PDF

Author : Jean-Charles Sanchez,Garry L. Corthals,Denis F. Hochstrasser
Publisher : John Wiley & Sons
Page : 452 pages
File Size : 46,5 Mb
Release : 2006-03-06
Category : Science
ISBN : 9783527605835

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Biomedical Applications of Proteomics by Jean-Charles Sanchez,Garry L. Corthals,Denis F. Hochstrasser Pdf

In this first book to provide an overview of applications of proteomics in the discovery of new diagnostic, prognostic and therapeutic targets, a team of international specialists from research institutions, hospitals and companies contribute with their specific expertise. They cover a wide range of example applications for the most important diseases, such as heart and cardiovascular disorders, cancer, pharmatoxicology, infectious diseases and diseases of the nervous system. Denis Hochstrasser is an eminent scientist in the field of bioinformatics and proteomics and one of the founders of the Swiss Prot Databank as well as of the Swiss biotech company Genebio.

Proteome Research: New Frontiers in Functional Genomics

Marc R. Wilkins,Keith L. Williams,Ron D. Appel,Denis F. Hochstrasser
Proteome Research New Frontiers in Functional Genomics Book PDF

Author : Marc R. Wilkins,Keith L. Williams,Ron D. Appel,Denis F. Hochstrasser
Publisher : Springer Science & Business Media
Page : 256 pages
File Size : 43,5 Mb
Release : 2013-03-14
Category : Science
ISBN : 9783662034934

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Proteome Research: New Frontiers in Functional Genomics by Marc R. Wilkins,Keith L. Williams,Ron D. Appel,Denis F. Hochstrasser Pdf

Recent advances in two-dimensional electrophoresis, protein microanalysis and bioinformatics have made the large-scale, systematic analysis of proteins and their post-translational modifications from any tissue or organism possible. This approach has acquired the name "Proteome Research", and can be considered as the core of functional genomics. The results of proteome analysis show which genes are expressed, how the protein products are modified, and how they interact, making proteome research of fundamental importance for the biologist, clinician, and pharmaceutical industry.

Advancements of Mass Spectrometry in Biomedical Research

Alisa G. Woods,Costel C. Darie
Advancements of Mass Spectrometry in Biomedical Research Book PDF

Author : Alisa G. Woods,Costel C. Darie
Publisher : Springer
Page : 601 pages
File Size : 48,7 Mb
Release : 2014-06-20
Category : Science
ISBN : 9783319060682

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Advancements of Mass Spectrometry in Biomedical Research by Alisa G. Woods,Costel C. Darie Pdf

This volume explores the use of mass spectrometry for biomedical applications. Chapters focus on specific therapeutic areas such as oncology, infectious disease and psychiatry. Additional chapters focus on methodology as well as new technologies and instrumentation. This volume provides readers with a comprehensive and informative manual that will allow them to appreciate mass spectrometry and proteomic research but also to initiate and improve their own work. Thus the book acts as a technical guide but also a conceptual guide to the newest information in this exciting field. Mass spectrometry is the central tool used in proteomic research today and is rapidly becoming indispensable to the biomedical scientist. With the completion of the human genome project and the genomic revolution, the proteomic revolution has followed closely behind. Understanding the human proteome has become critical to basic and clinical biomedical research and holds the promise of providing comprehensive understanding of human physiological processes. In addition, proteomics and mass spectrometry are bringing unprecedented biomarker discovery and are helping to personalize medicine.

Proteomics: Biomedical and Pharmaceutical Applications

Hubert Hondermarck
Proteomics Biomedical and Pharmaceutical Applications Book PDF

Author : Hubert Hondermarck
Publisher : Springer Science & Business Media
Page : 396 pages
File Size : 45,5 Mb
Release : 2007-05-08
Category : Medical
ISBN : 9781402023231

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Proteomics: Biomedical and Pharmaceutical Applications by Hubert Hondermarck Pdf

Human biology has now entered into a phase of post-genomics and it might not be an exaggeration to say that the major outcome of the human genome sequencing has finally been to open the way to the exploration of the proteome-proteomics. Proteins are the functional output of genes and there are two main expected outcomes from human proteomics. The first is to discover new molecular markers for early diagnosis and profiling of pathologies. The second is to decipher the intracellular signaling pathways leading to the initiation and progression of pathologies, for the identification of new targets and the development of innovative therapeutic strategies. This is clearly a promising challenge that this book explores through a series of ongoing experiences and projects representative of the new era in which biology and medicine have now entered.

Proteome Research

Marc R. Wilkins
Proteome Research Book PDF

Author : Marc R. Wilkins
Publisher : Springer Science & Business Media
Page : 270 pages
File Size : 45,7 Mb
Release : 1997
Category : Medical
ISBN : 3540627537

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Proteome Research by Marc R. Wilkins Pdf

Introduction to the proteome (K. L. Williams, D. F. Hochstrasser). Two-dimensional electrophoresis: the state of the art and future directions (B. R. Herbert, J.-C. Sanchez, L. Bini). large-scale comparative protein modeling ( M. C. Peitsch, N. Guex); Clinical and biomedical applications of proteomics (D. F. Hochstrasser). Biological applications of proteomics (K. L. Williams, V. Pallini). Conclusions (D. F. Hochstrasser, L. Williams). Index.

Biomedical Applications of Natural Proteins

Dhiraj Kumar,Rajesh R. Kundapur
Biomedical Applications of Natural Proteins Book PDF

Author : Dhiraj Kumar,Rajesh R. Kundapur
Publisher : Springer
Page : 148 pages
File Size : 44,8 Mb
Release : 2015-08-07
Category : Science
ISBN : 9788132224914

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Biomedical Applications of Natural Proteins by Dhiraj Kumar,Rajesh R. Kundapur Pdf

This book is intended as a reference guide for graduate students, postgraduate students and researchers with a basic knowledge of protein chemistry who would like to know more about the biomedical applications of natural proteins to promote healthier lives. The book is divided into ten chapters, each of which explains different natural proteins and their established biomedical applications. The first chapter extensively deals with protein based natural fibers and provides an overview of all protein based fibers currently available. In turn, chapter two mainly focuses on the biomedical applications of a special class of proteins called Heat Shock Proteins; the biomedical applications of silkworm pupae proteins are dealt in chapter three. Chapter four examines an interesting use of Eri silk fibroin as a biomaterial for Tissue Engineering, while chapter five discusses the key experimental details involved in converting Tasar silk sericin into self-assembled nanoparticles. Chapter six offers brief descriptions of bioactive proteins with respect to their sources, synthesis and applications. Chapter seven is dedicated to Interleukine-8 and its role in human life, while chapter eight addresses the importance of natural proteins in infectious diseases. Chapter nine explores the issue of excess intake of dietary proteins and its adverse effects, and finally, chapter ten discusses the efficiency of drug delivery systems made up of gelatin nanocomposites. The book is above all intended as a valuable resource for students and researchers alike, sparking their curiosity with regard to the applications of natural proteins and motivating them to focus their own energies on the discovery or identification of additional natural proteins for diverse biomedical uses.

Activity-Based Proteomics

Herman S. Overkleeft,Bogdan I. Florea
Activity Based Proteomics Book PDF

Author : Herman S. Overkleeft,Bogdan I. Florea
Publisher : Humana
Page : 0 pages
File Size : 52,7 Mb
Release : 2016-10-25
Category : Science
ISBN : 1493964372

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Activity-Based Proteomics by Herman S. Overkleeft,Bogdan I. Florea Pdf

This volume focuses on explorative activity-based proteomics, biomedical applications of activity-based proteomics, and chemical strategies in activity-based proteomics providing a concise overview of activity-based protein profiling. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Activity-Based Proteomics: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Proteomics for Biological Discovery

Timothy D. Veenstra,John R. Yates, III
Proteomics for Biological Discovery Book PDF

Author : Timothy D. Veenstra,John R. Yates, III
Publisher : John Wiley & Sons
Page : 363 pages
File Size : 41,6 Mb
Release : 2019-07-18
Category : Science
ISBN : 9781118279243

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Proteomics for Biological Discovery by Timothy D. Veenstra,John R. Yates, III Pdf

An update to the popular guide to proteomics technology applications in biomedical research Building on the strength of the original edition, this book presents the state of the art in the field of proteomics and offers students and scientists new tools and techniques to advance their own research. Written by leading experts in the field, it provides readers with an understanding of new and emerging directions for proteomics research and applications. Proteomics for Biological Discovery begins by discussing the emergence of proteomics technologies and summarizing the potential insights to be gained from proteome-level research. The tools of proteomics, from conventional to novel techniques, are thoroughly covered, from underlying concepts to limitations and future directions. Later chapters provide an overview of the current developments in post-translational modification studies, structural proteomics, biochemical proteomics, applied proteomics, and bioinformatics relevant to proteomics. Chapters cover: Quantitative Proteomics for Differential Protein Expression Profiling; Protein Microarrays; Protein Biomarker Discovery; Biomarker Discovery using Mass Spectrometry Imaging; Protein-Protein Interactions; Mass Spectrometry Of Intact Protein Complexes; Crosslinking Applications in Structural Proteomics; Functional Proteomics; High Resolution Interrogation of Biological Systems via Mass Cytometry; Characterization of Drug-Protein Interactions by Chemoproteomics; Phosphorylation; Large-Scale Phosphoproteomics; and Probing Glycoforms of Individual Proteins Using Antibody-Lectin Sandwich Arrays. Presents a comprehensive and coherent review of the major issues in proteomic technology development, bioinformatics, strategic approaches, and applications Chapters offer a rigorous overview with summary of limitations, emerging approaches, questions, and realistic future industry and basic science applications Features new coverage of mass spectrometry for high throughput proteomic measurements, and novel quantitation strategies such as spectral counting and stable isotope labeling Discusses higher level integrative aspects, including technical challenges and applications for drug discovery Offers new chapters on biomarker discovery, global phosphorylation analysis, proteomic profiling using antibodies, and single cell mass spectrometry Proteomics for Biological Discovery is an excellent advanced resource for graduate students, postdoctoral fellows, and scientists across all the major fields of biomedical science.

Proteome Analysis

David W Speicher
Proteome Analysis Book PDF

Author : David W Speicher
Publisher : Elsevier
Page : 394 pages
File Size : 46,6 Mb
Release : 2004-05-18
Category : Science
ISBN : 9780080515304

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Proteome Analysis by David W Speicher Pdf

This book explores the current status of proteomics, an exciting new discipline, which is less than 10 years old. This new field has rapidly grown into a major commercial and research enterprise with great prospects for dramatically advancing our knowledge of basic biological and disease processes. The contributors to this book are an international panel of proteomics experts, who review and discuss the current status of specific technologies and approaches. Proteomics represents an exciting new way to pursue biological and biomedical science at an unprecedented pace. Proteomics takes a broad, comprehensive, systematic approach to understanding biology that is generally unbiased and not dependent upon existing knowledge. The major components of proteomics from basic discovery using a range of alternative analytical methods to discovery validation and use for clinical applications are discussed. State-of-the-art protein profiling methods include high resolution two-dimensional gels, two-dimensional differential in-gel electrophoresis, LC-MS and LC-MS/MS using accurate mass tags, and protein identifications of proteins from gels using mass spectrometry methods are discussed in depth. Other chapters describe comprehensive characterization of proteomes using electrophoretic prefractionation and analyses of sub-proteomes based on specific posttranslational modifications including the phospho-proteome, the glyco-proteome, and nitrated proteins. These conventional proteome analysis chapters are complemented by discussion of emerging technologies and approaches such as affinity based biosensor proteomics as well as the use of protein microarrays, microfluidics and nanotechnology. Strategies for improving throughput by automation are also discussed. Additional chapters address the application of current proteome techniques to clinical problems and the availability of protein expression library resources for proteome studies. · Authored by international experts in the field · Covers a wide range of topics including 2-D gels, global proteomics using accurate mass tags, global proteomics using electrophoretic prefractionation, microfluidics, and nanotechnology · Includes state-of-the-art protein profiling methods, and emerging technologies

Proteomics

Tsz Kwong Man,Ricardo Flores
Proteomics Book PDF

Author : Tsz Kwong Man,Ricardo Flores
Publisher : BoD – Books on Demand
Page : 454 pages
File Size : 47,6 Mb
Release : 2012-02-10
Category : Science
ISBN : 9789533078328

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Proteomics by Tsz Kwong Man,Ricardo Flores Pdf

Biomedical research has entered a new era of characterizing a disease or a protein on a global scale. In the post-genomic era, Proteomics now plays an increasingly important role in dissecting molecular functions of proteins and discovering biomarkers in human diseases. Mass spectrometry, two-dimensional gel electrophoresis, and high-density antibody and protein arrays are some of the most commonly used methods in the Proteomics field. This book covers four important and diverse areas of current proteomic research: Proteomic Discovery of Disease Biomarkers, Proteomic Analysis of Protein Functions, Proteomic Approaches to Dissecting Disease Processes, and Organelles and Secretome Proteomics. We believe that clinicians, students and laboratory researchers who are interested in Proteomics and its applications in the biomedical field will find this book useful and enlightening. The use of proteomic methods in studying proteins in various human diseases has become an essential part of biomedical research.

Proteomics for Biological Discovery

Timothy D. Veenstra,John R. Yates, III
Proteomics for Biological Discovery Book PDF

Author : Timothy D. Veenstra,John R. Yates, III
Publisher : John Wiley & Sons
Page : 361 pages
File Size : 49,7 Mb
Release : 2006-06-12
Category : Science
ISBN : 9780470007730

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Proteomics for Biological Discovery by Timothy D. Veenstra,John R. Yates, III Pdf

Written by recognized experts in the study of proteins, Proteomics for Biological Discovery begins by discussing the emergence of proteomics from genome sequencing projects and a summary of potential answers to be gained from proteome-level research. The tools of proteomics, from conventional to novel techniques, are then dealt with in terms of underlying concepts, limitations and future directions. An invaluable source of information, this title also provides a thorough overview of the current developments in post-translational modification studies, structural proteomics, biochemical proteomics, microfabrication, applied proteomics, and bioinformatics relevant to proteomics. Presents a comprehensive and coherent review of the major issues faced in terms of technology development, bioinformatics, strategic approaches, and applications Chapters offer a rigorous overview with summary of limitations, emerging approaches, questions, and realistic future industry and basic science applications Discusses higher level integrative aspects, including technical challenges and applications for drug discovery Accessible to the novice while providing experienced investigators essential information Proteomics for Biological Discovery is an essential resource for students, postdoctoral fellows, and researchers across all fields of biomedical research, including biochemistry, protein chemistry, molecular genetics, cell/developmental biology, and bioinformatics.

Introduction to Molecular Biology, Genomics and Proteomics for Biomedical Engineers

Robert B. Northrop,Anne N. Connor
Introduction to Molecular Biology Genomics and Proteomics for Biomedical Engineers Book PDF

Author : Robert B. Northrop,Anne N. Connor
Publisher : CRC Press
Page : 492 pages
File Size : 47,9 Mb
Release : 2008-10-28
Category : Medical
ISBN : 9781420061215

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Introduction to Molecular Biology, Genomics and Proteomics for Biomedical Engineers by Robert B. Northrop,Anne N. Connor Pdf

Illustrates the Complex Biochemical Relations that Permit Life to ExistIt can be argued that the dawn of the 21st century has emerged as the age focused on molecular biology, which includes all the regulatory mechanisms that make cellular biochemical reaction pathways stable and life possible. For biomedical engineers, this concept is essential to

Proteomics

Manuel Fuentes,Joshua LaBaer
Proteomics Book PDF

Author : Manuel Fuentes,Joshua LaBaer
Publisher : Caister Academic Press Limited
Page : 0 pages
File Size : 49,9 Mb
Release : 2014
Category : Science
ISBN : 1908230460

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Proteomics by Manuel Fuentes,Joshua LaBaer Pdf

Targeted proteomics is a technology for detecting proteins of interest with high sensitivity, quantitative accuracy, and reproducibility. The analysis of a pre-defined group of proteins provides precise, quantitative, and sensitive data to scientists and clinicians and can provide information on a subset of proteins important for their biological function. In this volume, a panel of high-profile contributors provides an overview of targeted proteomics in biomedical science. The book is focused on current state-of-the-art technology and applications, and it will be a valuable source of information for everyone working in this field. The first part of the book provides detailed examples of the application of targeted proteomics in biomarker discovery and pathogenesis. The second part is focused on the various tools used in targeted proteomics, including bioinformatics approaches, while the final section is dedicated to biobanks, a vital aspect of targeted proteomics. The book is highly recommended for anyone interested in proteomics, disease pathogenesis, clinical protein science, and biomarker discovery. [Subject: Microbiology, Protein Science, Life Science, Biomedical Science]

Neuroproteomics

Oscar Alzate
Neuroproteomics Book PDF

Author : Oscar Alzate
Publisher : CRC Press
Page : 356 pages
File Size : 43,7 Mb
Release : 2009-10-26
Category : Medical
ISBN : 9781420076264

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Neuroproteomics by Oscar Alzate Pdf

In this, the post-genomic age, our knowledge of biological systems continues to expand and progress. As the research becomes more focused, so too does the data. Genomic research progresses to proteomics and brings us to a deeper understanding of the behavior and function of protein clusters. And now proteomics gives way to neuroproteomics as we beg

Cancer Biomarkers

Mahmoud H. Hamdan
Cancer Biomarkers Book PDF

Author : Mahmoud H. Hamdan
Publisher : John Wiley & Sons
Page : 408 pages
File Size : 46,7 Mb
Release : 2007-04-23
Category : Science
ISBN : 9780470113110

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Cancer Biomarkers by Mahmoud H. Hamdan Pdf

Tools, techniques, and progress in cancer biomarkers discovery The completion of a number of gene sequencing projects, recent advances in genomic and proteomic technologies, and the availability of powerful bioinformatics tools have led to promising new avenues and approaches in the search for cancer biomarkers. This book provides a comprehensive overview of current methodologies and technologies. It discusses biomarker discovery as a whole, rather than focusing on one specific marker or cancer. With information on both existing and potential biomarkers, Cancer Biomarkers: Analytical Techniques for Discovery: * Provides insights into the current technological platforms for biomarker discovery, including mass spectrometry combined with multidimensional chromatography, DIGE, and various chip technologies * Includes a detailed discussion of protein networks and protein phosphorylation in cancer * Details the use of imaging mass spectrometry, laser capture microdissection, serial analysis of gene expression, enzyme-linked immunosorbent assays, protein microarrays, antibody-based microarrays, and bioinformatics * Covers the emerging role of surface-enhanced laser desorption ionization (SELDI) and various tagging and labeling strategies * Discusses related regulatory and ethical issues With a wealth of information that can be applied to a broad spectrum of biomarker research projects, this is a core reference for biomarker researchers, scientists working in proteomics and bioinformatics, pharmaceutical scientists, oncologists, biochemists, biologists, and chemists.