Biometals In Neurodegenerative Diseases

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Biometals in Neurodegenerative Diseases

Anthony R. White,Michael Aschner,Lucio G. Costa,Ashley I. Bush
Biometals in Neurodegenerative Diseases Book PDF

Author : Anthony R. White,Michael Aschner,Lucio G. Costa,Ashley I. Bush
Publisher : Academic Press
Page : 462 pages
File Size : 40,9 Mb
Release : 2017-04-28
Category : Medical
ISBN : 9780128045633

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Biometals in Neurodegenerative Diseases by Anthony R. White,Michael Aschner,Lucio G. Costa,Ashley I. Bush Pdf

Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics is an authoritative and timely resource bringing together the major findings in the field for ease of access to those working in the field or with an interest in metals and their role in brain function, disease, and as therapeutic targets. Chapters cover metals in Alzheimer’s Disease, Parkinson’s Disease, Motor Neuron Disease, Autism and lysosomal storage disorders. This book is written for academic researchers, clinicians and advanced graduate students studying or treating patients in neurodegeneration, neurochemistry, neurology and neurotoxicology. The scientific literature in this field is advancing rapidly, with approximately 300 publications per year adding to our knowledge of how biometals contribute to neurodegenerative diseases. Despite this rapid increase in our understanding of biometals in brain disease, the fields of biomedicine and neuroscience have often overlooked this information. The need to bring the research on biometals in neurodegeneration to the forefront of biomedical research is essential in order to understand neurodegenerative disease processes and develop effective therapeutics. Authoritative and timely resource bringing together the major findings in the field for those with an interest in metals and their role in the brain function, disease, and as therapeutic targets Written for academic researchers, clinicians and advanced graduate students studying, or treating, patients in neurodegeneration, neurochemistry, neurology and neurotoxicology Edited by international leaders in the field who have contributed greatly to the study of metals in neurodegenerative diseases

Metals and Neurodegeneration: Restoring the Balance

Anthony R. White,Katja M. Kanninen,Peter J. Crouch
Metals and Neurodegeneration Restoring the Balance Book PDF

Author : Anthony R. White,Katja M. Kanninen,Peter J. Crouch
Publisher : Frontiers Media SA
Page : 134 pages
File Size : 50,8 Mb
Release : 2016-02-02
Category : Electronic book
ISBN : 9782889197392

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Metals and Neurodegeneration: Restoring the Balance by Anthony R. White,Katja M. Kanninen,Peter J. Crouch Pdf

Biometals such as copper, zinc and iron have key biological functions, however, aberrant metabolism can lead to detrimental effects on cell function and survival. These biometals have important roles in the brain, driving cellular respiration, antioxidant activity, intracellular signaling and many additional structural and enzymatic functions. There is now considerable evidence that abnormal biometal homeostasis is a key feature of many neurodegenerative diseases and may have an important role in the onset and progression of disorders such as Alzheimer’s, Parkinson’s, prion and motor neuron diseases. Recent studies also support biometal roles in a number of less common neurodegenerative disorders. The role of biometals in a growing list of brain disorders is supported by evidence from a wide range of sources including molecular genetics, biochemical studies and biometal imaging. These studies have spurred a growing interest in understanding the role of biometals in brain function and disease as well as the development of therapeutic approaches that may be able to restore the altered biometal chemistry of the brain. These approaches range from genetic manipulation of biometal transport to chelation of excess metals or delivery of metals where levels are deficient. A number of these approaches are offering promising results in cellular and animal models of neurodegeneration with successful translation to pre-clinical and clinical trials. At a time of aging populations and slow progress in development of neurotherapeutics to treat age-related neurodegenerative diseases, there is now a critical need to further our understanding of biometals in neurodegeneration. This issue covers a broad range of topics related to biometals and their role in neurodegeneration. It is hoped that this will inspire greater discussion and exchange of ideas in this crucial area of research and lead to positive outcomes for sufferers of these neurodegenerative diseases.

Metal Ions and Neurodegenerative Disorders

Paolo Zatta
Metal Ions and Neurodegenerative Disorders Book PDF

Author : Paolo Zatta
Publisher : World Scientific
Page : 538 pages
File Size : 53,6 Mb
Release : 2003
Category : Medical
ISBN : 9789812383983

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Metal Ions and Neurodegenerative Disorders by Paolo Zatta Pdf

Numerous studies have established a clear connection between neuronal oxidative stress and several neurodegenerative diseases, with consequential damages to lipids, proteins, nucleic acids, etc. In addition, several modifications indicative of oxidative stress have been described in association with neurons, neurofibrillary tangles and senile plaques in Alzheimer's disease, including advanced glycation end products and free carbonyl oxidation.Oxidative damage and antioxidant responses are now well characterized, but sources of damaging free radicals are yet to be fully understood. Evidences of alteration in metal ions metabolism have been reported in various diseases like Alzheimer's, Wilson, Menkes, Prion, Pick, Huntington disease, epilepsy and other pathological events. Thus, metal ions play a pivotal role in neurodegenerative phenomena.Chelation therapy is still in the early days of its development, but research in this area could lead to new products that could revolutionize treatment. Two international conferences on ?Metals and the Brain: From Neurochemistry to Neurodegeneration? (Padova, Italy, 2000 and Fez, Morocco, 2002) were recently held to discuss the role of metal ions in neurophysiopathology. A third will be held in 2005 in Johannesburg, South Africa.This book follows the same train of thought as those conferences, in order to highlight the unquestionable importance of metal ions in the research on the neurophysiopathology of neurodegenerative diseases. The excellent reputation of the scientists who have contributed to this project ensures the quality of the chapters presented here, and hopefully this will help spur new research initiatives in the field, which is still in its infancy.

Neurodegenerative Diseases and Metal Ions

Astrid Sigel,Helmut Sigel,Roland K. O. Sigel
Neurodegenerative Diseases and Metal Ions Book PDF

Author : Astrid Sigel,Helmut Sigel,Roland K. O. Sigel
Publisher : John Wiley & Sons
Page : 488 pages
File Size : 40,5 Mb
Release : 2006-07-11
Category : Science
ISBN : 9780470028100

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Neurodegenerative Diseases and Metal Ions by Astrid Sigel,Helmut Sigel,Roland K. O. Sigel Pdf

About the Series... Metal Ions in Life Sciences links coordination chemistry and biochemistry in their widest sense and thus increases our understanding of the relationship between the chemistry of metals and life processes. The series reflects the interdisciplinary nature of Biological Inorganic Chemistry and coordinates the efforts of scientists in fields like biochemistry, inorganic chemistry, coordination chemistry, molecular and structural biology, enzymology, environmental chemistry, physiology, toxicology, biophysics, pharmacy, and medicine. Consequently, the volumes are an essential source for researchers active in these and related fields as well as teachers preparing courses, e.g., in Bioinorganic Chemistry. About this Book... Volume 1, devoted solely to the vital research area concerning the role of metal ions in neurodegenerative diseases, offers in 15 stimulating chapters an authoritative and timely view of this fascinating subject. Written by 41 internationally recognized experts, Neurodegenerative Diseases and Metal Ions highlights, supported by 130 illustrations, the recent progress made in understanding the role metal ions play in diseases like transmissible spongiform encephalopathies (Creutzfeldt-Jakob and related diseases), Alzheimer's, Parkinson's, Huntington's, Wilson's and Menkes' diseases, as well as in familial amyotrophic lateral sclerosis and others. The interplay between metal ions, catecholamines and the formation of reactive oxygen species resulting in oxidative stress is considered, as is the metalloneurochemistry of zinc and the neurotoxicity of aluminum, cadmium, lead, and mercury. The need for novel drugs which manipulate metal-centered neuropathology is emphasized.

Human and Animal Models for Translational Research on Neurodegeneration: Challenges and Opportunities From South America

Agustín Ibáñez,Lucas Sedeño,Adolfo M. García,Robert M.J. Deacon,Patricia Cogram
Human and Animal Models for Translational Research on Neurodegeneration Challenges and Opportunities From South America Book PDF

Author : Agustín Ibáñez,Lucas Sedeño,Adolfo M. García,Robert M.J. Deacon,Patricia Cogram
Publisher : Frontiers Media SA
Page : 217 pages
File Size : 50,5 Mb
Release : 2018-06-21
Category : Electronic
ISBN : 9782889454945

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Human and Animal Models for Translational Research on Neurodegeneration: Challenges and Opportunities From South America by Agustín Ibáñez,Lucas Sedeño,Adolfo M. García,Robert M.J. Deacon,Patricia Cogram Pdf

Neurodegenerative diseases are the most frequent cause of dementia, representing a burden for public health systems (especially in middle and middle-high income countries). Although most research on this issue is concentrated in first-world centers, growing efforts in South America are affording important breakthroughs. This emerging agenda poses new challenges for the region but also new opportunities for the field. This book aims to integrate the community of experts across the globe and the region, and to establish new challenges and developments for future investigation. We present research focused on neurodegenerative research in South America. We introduce studies assessing the interplay among genetic, neural, and behavioral dimensions of these diseases, as well as articles on vulnerability factors, comparisons of findings from various countries, and works promoting multicenter and collaborative networking. More generally, our book covers a broad scope of human-research approaches (behavioral assessment, neuroimaging, electromagnetic techniques, brain connectivity, peripheral measures), animal methodologies (genetics, epigenetics, proteomics, metabolomics, other molecular biology tools), species (all human and non-human animals, sporadic, and genetic versions), and article types (original research, review, and opinion papers). Through this wide-ranging proposal, we hope to introduce a fresh approach to the challenges and opportunities of research on neurodegeneration in South America.

Neurodegeneration

Anthony Schapira,Zbigniew K. Wszolek,Ted M. Dawson,Nicholas Wood
Neurodegeneration Book PDF

Author : Anthony Schapira,Zbigniew K. Wszolek,Ted M. Dawson,Nicholas Wood
Publisher : John Wiley & Sons
Page : 344 pages
File Size : 53,7 Mb
Release : 2017-04-24
Category : Medical
ISBN : 9780470672686

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Neurodegeneration by Anthony Schapira,Zbigniew K. Wszolek,Ted M. Dawson,Nicholas Wood Pdf

This book unites the diverse range of complex neurodegenerative diseases into a textbook designed for clinical practice, edited by globally leading authorities on the subject. Presents a clinically oriented guide to the diseases caused by neurodegeneration Templated chapters combine clinical and research information on neurodegenerative diseases beginning with the common elements before treating each disease individually Diseases are grouped by anatomical regions of degeneration and include common disorders such as Parkinson’s Disease, Alzheimer’s Disease, Amyotrophic Lateral Sclerosis/Motor Neuron Disease, and Multiple Sclerosis as well as less common diseases Edited by globally leading authorities on the subject, and written by expert contributing authors

Toxicological Risk Assessment and Multi-System Health Impacts from Exposure

Aristidis M. Tsatsakis
Toxicological Risk Assessment and Multi System Health Impacts from Exposure Book PDF

Author : Aristidis M. Tsatsakis
Publisher : Elsevier
Page : 684 pages
File Size : 49,7 Mb
Release : 2021-08-01
Category : Medical
ISBN : 9780323853583

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Toxicological Risk Assessment and Multi-System Health Impacts from Exposure by Aristidis M. Tsatsakis Pdf

Toxicological Risk Assessment and Multisystem Health Impacts From Exposure highlights the emerging problems of human and environmental health attributable to cumulative and multiple sources of long-term exposure to environmental toxicants. The book describes the cellular, biological, immunological, endocrinologic, genetic, and epigenetic effects of long-term exposure. It examines how the combined exposure to nanomaterials, metals, pharmaceuticals, multifrequency radiation, dietary mycotoxins, and pesticides accelerates ecotoxicity in humans, animals, plants, and the larger environment. The book goes on to also offer insights into mixture risk assessments, protocols for evaluating the risks, and how this information can serve the regulatory agencies in setting safer exposure limits. The book is a go-to resource for scientists and professionals in the field tackling the current and emerging trends in modern toxicology and risk assessment. • Bridges basic research with clinical, epidemiological, regulatory, and translational research, conveying both an introductory understanding and the latest developments in the field • Evaluates real-life human health risk assessment for long-term exposures to xenobiotic mixtures and the role they play in contributing to chronic disease • Discusses advances in predictive (in silico) toxicology tools and the benefits of using omics technologies in toxicology research

Metal Related Neurodegenerative Disease

Anonim
Metal Related Neurodegenerative Disease Book PDF

Author : Anonim
Publisher : Academic Press
Page : 434 pages
File Size : 40,6 Mb
Release : 2013-11-07
Category : Medical
ISBN : 9780124105355

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Metal Related Neurodegenerative Disease by Anonim Pdf

This issue reviews the role of metals in neurodegenerative diseases; including Parkinson’s and Huntington’s disease; restless leg syndrome and NBIA disorders; and Wilson’s disease and manganese and calcium accumulation disorders. An update on advances in neuroimaging and pathology of metal related disease is also presented. This volume of International Review of Neurobiology brings together cutting-edge research on metal related neurodegenerative disease It reviews the role of metals in neurodegenerative diseases, including Parkinson’s and Huntington’s disease; restless leg syndrome and NBIA disorders; and Wilson’s disease and manganese and calcium accumulation disorders An update on advances in neuroimaging and pathology of metal related disease is also presented

Magnesium in the Central Nervous System

Robert Vink,Mihai Nechifor
Magnesium in the Central Nervous System Book PDF

Author : Robert Vink,Mihai Nechifor
Publisher : University of Adelaide Press
Page : 354 pages
File Size : 47,8 Mb
Release : 2011
Category : Medical
ISBN : 9780987073051

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Magnesium in the Central Nervous System by Robert Vink,Mihai Nechifor Pdf

The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.

Manganese in Health and Disease

Lucio G Costa,Michael Aschner
Manganese in Health and Disease Book PDF

Author : Lucio G Costa,Michael Aschner
Publisher : Royal Society of Chemistry
Page : 654 pages
File Size : 46,7 Mb
Release : 2014-11-27
Category : Medical
ISBN : 9781782622383

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Manganese in Health and Disease by Lucio G Costa,Michael Aschner Pdf

Manganese in the diet is nutritionally essential for normal physiologic functioning. However, excessive exposure to manganese has been associated with developmental, neurodegenerative and other disorders. The book comprehensively covers the toxicology of manganese. Leading investigators provide perspectives from toxicology, neuroscience, nutrition, molecular biology and risk assessment disciplines and chapters cover the toxicokinetics, toxicodynamic interactions and health effects of manganese, as well as its potential role in neurodegenerative diseases. A large section devoted to health effects presents the latest research that associates manganese exposure to potential human diseases. Any scientists, health professional or regulator involved with metal exposure and toxicology should find this volume essential reading. Students and researchers in neurotoxicology will also find this book a useful reference.

Protein Misfolding, Aggregation and Conformational Diseases

Vladimir N. Uversky,Anthony Fink
Protein Misfolding Aggregation and Conformational Diseases Book PDF

Author : Vladimir N. Uversky,Anthony Fink
Publisher : Springer Science & Business Media
Page : 538 pages
File Size : 42,8 Mb
Release : 2007-05-26
Category : Medical
ISBN : 9780387365343

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Protein Misfolding, Aggregation and Conformational Diseases by Vladimir N. Uversky,Anthony Fink Pdf

The second volume continues to fill the gap in protein review and protocol literature. It does this while summarizing recent achievements in the understanding of the relationships between protein misfoldings, aggregation, and development of protein deposition disorders. The focus of Part B is the molecular basis of differential disorders.

Antioxidants and Functional Foods for Neurodegenerative Disorders

Abhai Kumar,Debasis Bagchi
Antioxidants and Functional Foods for Neurodegenerative Disorders Book PDF

Author : Abhai Kumar,Debasis Bagchi
Publisher : CRC Press
Page : 473 pages
File Size : 46,8 Mb
Release : 2021-01-07
Category : Health & Fitness
ISBN : 9781000282665

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Antioxidants and Functional Foods for Neurodegenerative Disorders by Abhai Kumar,Debasis Bagchi Pdf

Neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are a growing problem across the world’s aging population. Oxidative stress in the brain plays a central role in a common pathophysiology of these diseases. This book presents scientific research on the potential of antioxidant therapy in the prevention and treatment of neurodegenerative disorders. This book outlines the roles of oxidative stress and diabetes mellitus in neurodegeneration, describes the molecular mechanisms of neurodegenerative disorders including the roles of environmental pollutants and inflammatory responses, and explores mitochondrial dysfunction. It then describes the protective abilities of antioxidants – including vitamin D, tocotrienol and coenzyme Q10 – against neurodegeneration. The book demonstrates the therapeutic potential of ketogenic diets, and highlights the roles of medicinal plants, phytopharmaceuticals, traditional medicines and food nutrients in neuroprotection. Key Features: Explains damage caused by numerous neurodegenerative disorders and the possible protection offered by antioxidants and functional foods. Describes molecular mechanisms of neurodegeneration by oxidative stress, advancing age, diabetes and mitochondrial dysfunctions. Demonstrates protection offered by nutraceuticals, antioxidants, botanical extracts and functional foods. The book contains twenty-three chapters divided into six sections written by leading researchers. This book is essential reading for health professionals, dietitians, food and nutrition scientists and anyone wanting to improve their knowledge of etiology of neurodegenerative diseases.

Nervous System Diseases—Advances in Research and Treatment: 2013 Edition

Anonim
Nervous System Diseases Advances in Research and Treatment 2013 Edition Book PDF

Author : Anonim
Publisher : ScholarlyEditions
Page : 491 pages
File Size : 42,7 Mb
Release : 2013-06-21
Category : Medical
ISBN : 9781481678001

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Nervous System Diseases—Advances in Research and Treatment: 2013 Edition by Anonim Pdf

Nervous System Diseases—Advances in Research and Treatment: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Neuromuscular Diseases. The editors have built Nervous System Diseases—Advances in Research and Treatment: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Neuromuscular Diseases in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Nervous System Diseases—Advances in Research and Treatment: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Medicinal Inorganic Chemistry

Jonathan L. Sessler
Medicinal Inorganic Chemistry Book PDF

Author : Jonathan L. Sessler
Publisher : Unknown
Page : 480 pages
File Size : 46,8 Mb
Release : 2005
Category : Medical
ISBN : UOM:39015062459931

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Medicinal Inorganic Chemistry by Jonathan L. Sessler Pdf

This book reviews the current diagnostic and therapeutic uses of metal-containing compounds in medicine, as well as the role of metals in disease.

Trace Elements and Minerals in Health and Longevity

Marco Malavolta,Eugenio Mocchegiani
Trace Elements and Minerals in Health and Longevity Book PDF

Author : Marco Malavolta,Eugenio Mocchegiani
Publisher : Springer
Page : 328 pages
File Size : 44,7 Mb
Release : 2018-11-13
Category : Medical
ISBN : 9783030037420

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Trace Elements and Minerals in Health and Longevity by Marco Malavolta,Eugenio Mocchegiani Pdf

This book describes the role of trace elements in health and longevity, pursuing a biogerontological approach. It offers essential information on the impact of trace elements on molecular and physiological processes of aging, and on their impact on health in connection with aging. The major topics covered in its 11 chapters, each dedicated to a specific trace element or mineral, are: a) Role of the element in species longevity, b) Recommended intake for longevity in animal species and in the elderly, c) Deficiency and age-related disease, d) Excess/toxicity and age-related disease, and e) Interactions with drugs prescribed in the elderly. Clinical, animal and other laboratory models of interest in aging are included, which enable a more in-depth analysis to be made. The respective chapters are a mixture of overviews and more in-depth reviews in which the mechanisms of aging are described from the point of view of their specific interactions with trace elements and minerals.