Medicinal Inorganic Chemistry

Author : Tim Storr
Publisher : John Wiley & Sons
Page : 650 pages
File Size : 42,9 Mb
Release : 2014-06-12
Category : Science
ISBN : 9781118697894

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Ligand Design in Medicinal Inorganic Chemistry by Tim Storr Pdf

Increasing the potency of therapeutic compounds, while limiting side-effects, is a common goal in medicinal chemistry. Ligands that effectively bind metal ions and also include specific features to enhance targeting, reporting, and overall efficacy are driving innovation in areas of disease diagnosis and therapy. Ligand Design in Medicinal Inorganic Chemistry presents the state-of-the-art in ligand design for medicinal inorganic chemistry applications. Each individual chapter describes and explores the application of compounds that either target a disease site, or are activated by a disease-specific biological process. Ligand design is discussed in the following areas: Platinum, Ruthenium, and Gold-containing anticancer agents Emissive metal-based optical probes Metal-based antimalarial agents Metal overload disorders Modulation of metal-protein interactions in neurodegenerative diseases Photoactivatable metal complexes and their use in biology and medicine Radiodiagnostic agents and Magnetic Resonance Imaging (MRI) agents Carbohydrate-containing ligands and Schiff-base ligands in Medicinal Inorganic Chemistry Metalloprotein inhibitors Ligand Design in Medicinal Inorganic Chemistry provides graduate students, industrial chemists and academic researchers with a launching pad for new research in medicinal chemistry.

Author : Katja A. Strohfeldt
Publisher : John Wiley & Sons
Page : 290 pages
File Size : 52,8 Mb
Release : 2015-02-16
Category : Science
ISBN : 9780470665589

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Essentials of Inorganic Chemistry by Katja A. Strohfeldt Pdf

A comprehensive introduction to inorganic chemistry and, specifically, the science of metal-based drugs, Essentials of Inorganic Chemistry describes the basics of inorganic chemistry, including organometallic chemistry and radiochemistry, from a pharmaceutical perspective. Written for students of pharmacy and pharmacology, pharmaceutical sciences, medicinal chemistry and other health-care related subjects, this accessible text introduces chemical principles with relevant pharmaceutical examples rather than as stand-alone concepts, allowing students to see the relevance of this subject for their future professions. It includes exercises and case studies.

Author : Jonathan L. Sessler
Publisher : Unknown
Page : 480 pages
File Size : 43,7 Mb
Release : 2005
Category : Medical
ISBN : UOM:39015062459931

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Medicinal Inorganic Chemistry by Jonathan L. Sessler Pdf

This book reviews the current diagnostic and therapeutic uses of metal-containing compounds in medicine, as well as the role of metals in disease.

Author : Ajay Kumar Goswami,Irena Kostova
Publisher : Walter de Gruyter GmbH & Co KG
Page : 148 pages
File Size : 41,5 Mb
Release : 2022-01-19
Category : Science
ISBN : 9781501516115

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Medicinal and Biological Inorganic Chemistry by Ajay Kumar Goswami,Irena Kostova Pdf

The book provides a detailed state-of-the-art overview of inorganic chemistry applied to medicinal chemistry and biology. It covers the newly emerging field of metals in medicine and the future of medicinal inorganic chemistry. It is an essential reading for every researcher and student in medicinal and bioinorganic chemistry.

Author : Nicholas P Farrell
Publisher : Royal Society of Chemistry
Page : 174 pages
File Size : 54,9 Mb
Release : 2007-10-31
Category : Medical
ISBN : 9781847552242

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Uses of Inorganic Chemistry in Medicine by Nicholas P Farrell Pdf

Metal-based drugs are a commercially important sector of the pharmaceutical business, yet most bioinorganic textbooks lack the space to cover comprehensively the subject of metals in medicine. Uses of Inorganic Chemistry in Medicine approaches an understanding of the topic in a didactic and systematic manner. The field of inorganic chemistry in medicine may usefully be divided into two main categories - drugs which target metal ions in some form, whether free or protein-bound, and secondly, metal-based drugs where the central metal ion is usually the key feature of the mechanism of action. This latter category can further be subdivided into pharmacodynamic and chemotherapeutic applications, as well as those of imaging. The book summarises the chemical and biological studies on clinically used agents of lithium, gold and platinum, as well as highlighting the research on prospective new drugs, including those based on vanadium and manganese. The coverage allows a clear distinction between pharmacodynamic and therapeutic properties of metal-based drugs and focuses not only on those clinical agents in current use, but also on new drugs and uses. This book serves to fill an important niche, bridging bioinorganic and medicinal chemistry and will undoubtedly be of use to senior undergraduates and postgraduates, as well as being an invaluable asset for teachers and researchers in the discipline.

Author : Shahid Ul-Islam,Athar Adil Hashmi,Salman Ahmad Khan
Publisher : John Wiley & Sons
Page : 432 pages
File Size : 42,9 Mb
Release : 2020-07-08
Category : Science
ISBN : 9781119640424

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Advances in Metallodrugs by Shahid Ul-Islam,Athar Adil Hashmi,Salman Ahmad Khan Pdf

This book is organized into 12 important chapters that focus on the progress made by metal-based drugs as anticancer, antibacterial, antiviral, anti-inflammatory, and anti-neurodegenerative agents, as well as highlights the application areas of newly discovered metallodrugs. It can prove beneficial for researchers, investigators and scientists whose work involves inorganic and coordination chemistry, medical science, pharmacy, biotechnology and biomedical engineering.

Author : John H. Block
Publisher : Unknown
Page : 494 pages
File Size : 44,9 Mb
Release : 1974
Category : Science
ISBN : UOM:39015000813751

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Inorganic Medicinal and Pharmaceutical Chemistry by John H. Block Pdf

Author : Enzo Alessio
Publisher : John Wiley & Sons
Page : 625 pages
File Size : 55,6 Mb
Release : 2011-02-25
Category : Science
ISBN : 9783527633128

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Bioinorganic Medicinal Chemistry by Enzo Alessio Pdf

This book gives a comprehensive overview about medicinal inorganic chemistry. Topics like targeting strategies, mechanism of action, Pt-based antitumor drugs, radiopharmaceuticals are covered in detail and offer the reader an in-depth overview about this important topic.

Author : Gérard Jaouen,Nils Metzler-Nolte
Publisher : Springer Science & Business Media
Page : 305 pages
File Size : 48,9 Mb
Release : 2010-09-14
Category : Science
ISBN : 9783642131844

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Medicinal Organometallic Chemistry by Gérard Jaouen,Nils Metzler-Nolte Pdf

Contents: Gérard Jaouen, Nils Metzler-Nolte : Introduction ; Stéphane GIBAUD and Gérard JAOUEN: Arsenic - based drugs: from Fowler’s solution to modern anticancer chemotherapy; Ana M. Pizarro, Abraha Habtemariam and Peter J. Sadler : Activation Mechanisms for Organometallic Anticancer Complexes; Angela Casini, Christian G. Hartinger, Alexey A. Nazarov, Paul J. Dyson : Organometallic antitumour agents with alternative modes of action; Elizabeth A. Hillard, Anne Vessières, Gerard Jaouen : Ferrocene functionalized endocrine modulators for the treatment of cancer; Megan Hogan and Matthias Tacke : Titanocenes – Cytotoxic and Anti-Angiogenic Chemotherapy Against Advanced Renal-Cell Cancer; Seann P. Mulcahy and Eric Meggers : Organometallics as Structural Scaffolds for Enzyme Inhibitor Design; Christophe Biot and Daniel Dive : Bioorganometallic Chemistry and Malaria; Nils Metzler-Nolte : Biomedical applications of organometal-peptide conjugates; Roger Alberto : Organometallic Radiopharmaceuticals; Brian E. Mann : Carbon Monoxide – an essential signaling molecule.

Author : James C. Dabrowiak
Publisher : John Wiley & Sons
Page : 484 pages
File Size : 42,7 Mb
Release : 2017-07-11
Category : Science
ISBN : 9781119191308

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Metals in Medicine by James C. Dabrowiak Pdf

Working from basic chemical principles, Metals in Medicine, 2nd Edition describes a wide range of metal-based agents for treating and diagnosing disease. Thoroughly revised and restructured to reflect significant research activity and advances, this new edition contains extensive updates and new pedagogical features while retaining the popular feature boxes and end-of-chapter problems of the first edition. Topics include: Metallo-Drugs and their action Platinum drugs for treating cancer Anticancer agents beyond cisplatin including ruthenium, gold, titanium and gallium Responsive Metal Complexes Treating arthritis and diabetes with metal complexes Metal complexes for killing bacteria, parasites and viruses Metal ion imbalance and its links to diseases including Alzheimer's, Wilson's and Menkes disease Metal complexes for detecting disease Nanotechnology in medicine Now in full colour, Metals in Medicine, 2nd Edition employs real-life applications and chapter-end summaries alongside feature boxes and problems. It provides a complete and methodical examination of the use of metal complexes in medicine for advanced undergraduate and postgraduate students in medicinal inorganic chemistry, bioinorganic chemistry, biochemistry, pharmacology, biophysics, biology and bioengineering. It is also an invaluable resource for academic researchers and industrial scientists in inorganic chemistry, medicinal chemistry and drug development.

Author : Suman Bala,Ioannis L. Liakos
Publisher : Unknown
Page : 299 pages
File Size : 51,9 Mb
Release : 2018-06
Category : Electronic
ISBN : 1642230707

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Pharmaceutical Inorganic Chemistry by Suman Bala,Ioannis L. Liakos Pdf

The idea of creating new drugs is now moving from serendipity to rational design.Drug discovery and development process is intended to make available medicines that are safe and effective in cultivating the length and quality of life and relieving pain and suffering. However, the process is very complex, time consuming, and resource intensive, needing multi-disciplinary expertise and innovative approaches. The area of pharmaceutical chemistry is varied and contains many areas of expertise. Natural-product and analytical chemists separate and recognize active components from plant and other natural sources. Theoretical chemists create molecular models of existing drugs to evaluate their properties. These computational studies assist medicinal chemists and bioengineers design and synthesize compounds with enhanced biological activity. Emerging trends in medicinal chemistry efforts are moving towards the more targeted approach and this is being revolutionized and enhanced by genomics and proteomics. Target identification and validation are the first key stages in this process. Pharmaceutical Inorganic Chemistry is devoted to scientific and technical research on the developments of new drugs and the advances of manufacturing technology of drugs and intermediates. The worldwide contributions by eminent researchers and authors cover the comprehensive coverage of new drug research, methods of synthesis; complexing and cheiating agents, results of pharmacological, toxicological, and biochemical studies; investigation of structure; and impurities in pharmaceutical substances with the development of ecologically safe and economically feasible methods of industrial production. It is very important for scientists all over the globe to enhance drug discovery research for better human health.

Author : Anonim
Publisher : Academic Press
Page : 510 pages
File Size : 47,9 Mb
Release : 2020-02-10
Category : Science
ISBN : 9780128191972

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Medicinal Chemistry by Anonim Pdf

Medicinal Chemistry, Volume 75, the latest release in the Advances in Inorganic Chemistry series, presents timely and informative summaries on current progress in a variety of subject areas. This acclaimed serial features reviews written by experts in the field, serving as an indispensable reference to advanced researchers that empowers readers to pursue new developments in each field. Users will find this to be a comprehensive overview of recent findings and trends from the last decade that covers various kinds of inorganic topics, from theoretical oriented supramolecular chemistry, to the quest for accurate calculations of spin states in transition metals. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Inorganic Chemistry series Includes the latest information on medicinal chemistry

Author : Clarence A. Discher,Thomas Medwick,Leonard C. Bailey
Publisher : Unknown
Page : 658 pages
File Size : 48,5 Mb
Release : 1985
Category : Science
ISBN : UOM:39015014467370

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Modern Inorganic Pharmaceutical Chemistry by Clarence A. Discher,Thomas Medwick,Leonard C. Bailey Pdf

Inorganic pharmaceutical chemistry text geared to actual practice in the profession of pharmacy & the health sciences. Provides theoretical & practical background to students. Compendial references.

Author : Kaza Somasekhara Rao,Chennupati venkata Suresh
Publisher : Pharmamed Press
Page : 566 pages
File Size : 49,5 Mb
Release : 2019-10-29
Category : Science
ISBN : 9385433253

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Pharmaceutical Inorganic Chemistry by Kaza Somasekhara Rao,Chennupati venkata Suresh Pdf

Features - Every inorganic compound has been discussed under definition, preparation, test for identity, tests for purity, assay method and uses - In practical Manual, qualitative, quantitative analysis, limit tests and some of the preparations are discussed

Author : Thomas Nogrady,Donald F. Weaver
Publisher : Oxford University Press
Page : 649 pages
File Size : 46,8 Mb
Release : 2005-08-11
Category : Medical
ISBN : 9780190282967

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Medicinal Chemistry by Thomas Nogrady,Donald F. Weaver Pdf

Fully updated and rewritten by a basic scientist who is also a practicing physician, the third edition of this popular textbook remains comprehensive, authoritative and readable. Taking a receptor-based, target-centered approach, it presents the concepts central to the study of drug action in a logical, mechanistic way grounded on molecular and principles. Students of pharmacy, chemistry and pharmacology, as well as researchers interested in a better understanding of drug design, will find this book an invaluable resource. Starting with an overview of basic principles, Medicinal Chemistry examines the properties of drug molecules, the characteristics of drug receptors, and the nature of drug-receptor interactions. Then it systematically examines the various families of receptors involved in human disease and drug design. The first three classes of receptors are related to endogenous molecules: neurotransmitters, hormones and immunomodulators. Next, receptors associated with cellular organelles (mitochondria, cell nucleus), endogenous macromolecules (membrane proteins, cytoplasmic enzymes) and pathogens (viruses, bacteria) are examined. Through this evaluation of receptors, all the main types of human disease and all major categories of drugs are considered. There have been many changes in the third edition, including a new chapter on the immune system. Because of their increasingly prominent role in drug discovery, molecular modeling techniques, high throughput screening, neuropharmacology and genetics/genomics are given much more attention. The chapter on hormonal therapies has been thoroughly updated and re-organized. Emerging enzyme targets in drug design (e.g. kinases, caspases) are discussed, and recent information on voltage-gated and ligand-gated ion channels has been incorporated. The sections on antihypertensive, antiviral, antibacterial, anti-inflammatory, antiarrhythmic, and anticancer drugs, as well as treatments for hyperlipidemia and peptic ulcer, have been substantially expanded. One new feature will enhance the book's appeal to all readers: clinical-molecular interface sections that facilitate understanding of the treatment of human disease at a molecular level.