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Bioprocessing of Viral Vaccines

Amine Kamen,Laura Cervera

Author : Amine Kamen,Laura Cervera
Publisher : CRC Press
Page : 267 pages
File Size : 53,8 Mb
Release : 2022-09-06
Category : Medical
ISBN : 9781000643053

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Bioprocessing of Viral Vaccines by Amine Kamen,Laura Cervera Pdf

This book focuses on cell culture-produced viral vaccines to meet the needs of the rapidly expanding research and development in academia and industry in the field. This book introduces the basic principles of vaccination and the manufacturing of viral vaccines. Bioprocessing of Viral Vaccines, will provide an overview of the advanced strategies needed to respond to the challenges of new and established viral infection diseases. The first few chapters cover the basics of virology and immunology as essential concepts to understand the function and design of viral vaccines. The core of the content is dedicated to process development, including upstream processing and cell culture of viral vaccines, downstream processing, and extensive analytical technologies specific to viral vaccines. Advanced process analytical technologies (PAT) and Quality by Design (QbD) concepts are also introduced in the context of vaccine manufacturing. The case studies included cover inactivated, attenuated vaccines exemplified by influenza vaccines, sub-unit vaccines exemplified by Virus Like Particles (VLPs: HPV vaccines) and sub-unit vaccines (Flublock), vectored vaccines: adenoviruses and Vesicular stomatitis Virus (VSV) vectored vaccines, genomic vaccines (DNA and mRNA) vaccines as developed for COVID-19 response in particular and a review of COVID-19 vaccines approved or in advanced clinical trials. This book is aimed at graduate engineers and professionals in the fields of vaccinology, bioprocessing, and biomanufacturing of viral vaccines.

Opportunities in Biotechnology for Future Army Applications

National Research Council,Division on Engineering and Physical Sciences,Board on Army Science and Technology,Committee on Opportunities in Biotechnology for Future Army Applications

Author : National Research Council,Division on Engineering and Physical Sciences,Board on Army Science and Technology,Committee on Opportunities in Biotechnology for Future Army Applications
Publisher : National Academies Press
Page : 118 pages
File Size : 46,6 Mb
Release : 2001-07-11
Category : Science
ISBN : 9780309075558

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Opportunities in Biotechnology for Future Army Applications by National Research Council,Division on Engineering and Physical Sciences,Board on Army Science and Technology,Committee on Opportunities in Biotechnology for Future Army Applications Pdf

This report surveys opportunities for future Army applications in biotechnology, including sensors, electronics and computers, materials, logistics, and medical therapeutics, by matching commercial trends and developments with enduring Army requirements. Several biotechnology areas are identified as important for the Army to exploit, either by direct funding of research or by indirect influence of commercial sources, to achieve significant gains in combat effectiveness before 2025.

Vaccine Development and Manufacturing

Emily P. Wen,Ronald Ellis,Narahari S. Pujar

Author : Emily P. Wen,Ronald Ellis,Narahari S. Pujar
Publisher : John Wiley & Sons
Page : 456 pages
File Size : 47,5 Mb
Release : 2014-10-06
Category : Technology & Engineering
ISBN : 9781118870907

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Vaccine Development and Manufacturing by Emily P. Wen,Ronald Ellis,Narahari S. Pujar Pdf

Vaccine Manufacturing and Production is an invaluable reference on how to produce a vaccine - from beginning to end - addressing all classes of vaccines from a processing, production, and regulatory viewpoint. It will provide comprehensive information on the various fields involved in the production of vaccines, from fermentation, purification, formulation, to regulatory filing and facility designs. In recent years, there have been tremendous advances in all aspects of vaccine manufacturing. Improved technology and growth media have been developed for the production of cell culture with high cell density or fermentation. Vaccine Manufacturing and Production will serve as a reference on all aspects of vaccine production by providing an in-depth description of the available technologies for making different types of vaccines and the current thinking in facility designs and supply issues. This book will provide insight to the issues scientists face when producing a vaccine, the steps that are involved, and will serve as a reference tool regarding state-of-the-art vaccine manufacturing technologies and facility set-up. Highlights include: Comprehensive coverage of vaccine production : from a process point of view- fermentation to purification to formulation developments; from a production point of view - from facility design to manufacturing; and from a regulatory point of view - requirements from government agencies Authors from different major pharmaceutical and biotechnology companies Describes the challenges and issues involved in vaccine production and manufacturing of the different classes of vaccines, an area not covered by other books currently on the market

The Application of Viruses to Biotechnology

Carla Varanda,Patrick Materatski

Author : Carla Varanda,Patrick Materatski
Publisher : Mdpi AG
Page : 306 pages
File Size : 44,8 Mb
Release : 2021-12-21
Category : Science
ISBN : 3036525394

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The Application of Viruses to Biotechnology by Carla Varanda,Patrick Materatski Pdf

Viruses are microscopic agents that exist worldwide and are present in humans, animals, plants, and other living organisms in which they can cause devastating diseases. However, the advances of biotechnology and next-generation sequencing technologies have accelerated novel virus discovery, identification, sequencing, and manipulation, showing that they present unique characteristics that place them as valuable tools for a wide variety of biotechnological applications. Many applications of viruses have been used for agricultural purposes, namely concerning plant breeding and plant protection. Nevertheless, it is interesting to mention that plants have also many advantages to be used in vaccine production, such as the low cost and low risks they entail, showing once more the versatility of the use of viruses in biotechnology. Although it will obviously never be ignored that viruses are responsible for devastating diseases, it is clear that the more they are studied, the more possibilities they offer to us. They are now on the front line of the most revolutionizing techniques in several fields, providing advances that would not be possible without their existence. In this book there are presented studies that demonstrate the work developed using viruses in biotechnology. These studies were brought by experts that focus on the development and applications of many viruses in several fields, such as agriculture, the pharmaceutical industry, and medicine.

Bioprocess and Analytics Development for Virus-based Advanced Therapeutics and Medicinal Products (ATMPs)

Saurabh Gautam,Abhilash I. Chiramel,Roland Pach

Author : Saurabh Gautam,Abhilash I. Chiramel,Roland Pach
Publisher : Springer Nature
Page : 448 pages
File Size : 42,8 Mb
Release : 2023-08-10
Category : Medical
ISBN : 9783031284892

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Bioprocess and Analytics Development for Virus-based Advanced Therapeutics and Medicinal Products (ATMPs) by Saurabh Gautam,Abhilash I. Chiramel,Roland Pach Pdf

This book reviews the knowledge, methods and available techniques in the rapidly advancing field of virus based vaccines and gene therapeutics. It also highlights new innovative tools and interdisciplinary techniques for bioprocess development and analytics of viruses and viral vectors. As such, it provides a timely and highly relevant resource, since current advances in pharmaceutical research have seen the rise of vaccines and advanced therapeutics and medicinal products (ATMPs), that rely on the power of viruses. However, developing bioprocesses and analytics required to create this often called “magic bullet” (i.e. gene therapy) remains an extremely challenging and costly task. This book offers strategies for overcoming hurdles and difficulties within in all the necessary steps of viral vector development - from scalability to purification methods and quality control. The book is intended for researchers working in academia or industry, as well as graduate students pursuing a career in virology.

Adenoviral Vectors for Gene Therapy

David T. Curiel

Author : David T. Curiel
Publisher : Academic Press
Page : 868 pages
File Size : 55,7 Mb
Release : 2016-03-10
Category : Science
ISBN : 9780128005101

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Adenoviral Vectors for Gene Therapy by David T. Curiel Pdf

Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research. This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models, with final consideration of the regulatory issues surrounding human clinical gene therapy trials. This broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors. Provides complete coverage of the basic biology of adenoviruses, as well as their construction, propagation, and purification of adenoviral vectors Introduces common strategies for the development of adenoviral vectors, along with cutting-edge methods for their improvement Demonstrates noninvasive imaging of adenovirus-mediated gene transfer Discusses utility of adenoviral vectors in animal disease models Considers Federal Drug Administration regulations for human clinical trials

Genetically Engineered Plants as a Source of Vaccines Against Wide Spread Diseases

Sergio Rosales-Mendoza

Author : Sergio Rosales-Mendoza
Publisher : Springer
Page : 0 pages
File Size : 42,5 Mb
Release : 2016-09-03
Category : Science
ISBN : 1493954253

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Genetically Engineered Plants as a Source of Vaccines Against Wide Spread Diseases by Sergio Rosales-Mendoza Pdf

Genetically Engineered Plants as a Source of Vaccines Against Wide Spread Diseases: An Integrated View provides an integrated outlook of the disciplines involved in the development of plant-based vaccines as well as an updated compilation of the successful developments in the field. The volume covers immunological aspects of mucosal vaccine design, molecular approaches to attain high levels of the recombinant antigens, the rationale of using bioreactor to expand plant biomass, and pharmaceutical technology approaches that have been applied to the development of plant-based vaccine formulations. Practical figures and tables are presented to facilitate reading and identification of key points. Perspectives for this field are also discussed. Written by authorities in the field, Genetically Engineered Plants as a Source of Vaccines Against Wide Spread Diseases: An Integrated View is a comprehensive resource for researchers and students interested in plant genetics and breeding, immunology, and genetic engineering.

Animal Cell Biotechnology

Ralf Pörtner

Author : Ralf Pörtner
Publisher : Humana
Page : 0 pages
File Size : 50,9 Mb
Release : 2016-08-23
Category : Science
ISBN : 149396318X

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Animal Cell Biotechnology by Ralf Pörtner Pdf

Animal Cell Biotechnology: Methods and Protocols, Third Edition constitutes a comprehensive manual of state-of-the-art and new techniques for setting up mammalian cell lines for production of biopharmaceuticals, and for optimizing critical parameters for cell culture from lab to final production. The volume is divided into five parts that reflect the processes required for different stages of production. In Part I, basic techniques for establishment of production cell lines are addressed, especially high-throughput synchronization, insect cell lines, transient gene and protein expression, DNA Profiling and Characterisation. Part II addresses tools for process and medium optimization as well as microcarrier technology while Part III covers monitoring of cell growth, viability and apoptosis, metabolic flux estimation, quenching methods as well as NMR-based techniques. Part IV details cultivation techniques, and Part V describes special applications, including vaccine production, baculovirus protein expression, chromatographic techniques for downstream as well as membrane techniques for virus separation. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Animal Cell Biotechnology: Methods and Protocols, Third Edition provides a compendium of techniques for scientists in industrial and research laboratories that use mammalian cells for biotechnology purposes.

Industrial Scale Suspension Culture of Living Cells

Hans-Peter Meyer,Diego Schmidhalter

Author : Hans-Peter Meyer,Diego Schmidhalter
Publisher : John Wiley & Sons
Page : 642 pages
File Size : 55,8 Mb
Release : 2014-08-04
Category : Science
ISBN : 9783527335473

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Industrial Scale Suspension Culture of Living Cells by Hans-Peter Meyer,Diego Schmidhalter Pdf

The submersed cultivation of organisms in sterile containments or fermenters has become the standard manufacturing procedure, and will remain the gold standard for some time to come. This book thus addresses submersed cell culture and fermentation and its importance for the manufacturing industry. It goes beyond expression systems and integrally investigates all those factors relevant for manufacturing using suspension cultures. In so doing, the contributions cover all industrial cultivation methods in a comprehensive and comparative manner, with most of the authors coming from the industry itself. Depending on the maturity of the technology, the chapters address in turn the expression system, basic process design, key factors affecting process economics, plant and bioreactor design, and regulatory aspects.

Putting Biotechnology to Work

National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Bioprocess Engineering

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Bioprocess Engineering
Publisher : National Academies Press
Page : 133 pages
File Size : 51,5 Mb
Release : 1992-02-01
Category : Science
ISBN : 9780309047852

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Putting Biotechnology to Work by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Bioprocess Engineering Pdf

The ability of the United States to sustain a dominant global position in biotechnology lies in maintaining its primacy in basic life-science research and developing a strong resource base for bioprocess engineering and bioproduct manufacturing. This book examines the status of bioprocessing and biotechnology in the United States; current bioprocess technology, products, and opportunities; and challenges of the future and what must be done to meet those challenges. It gives recommendations for action to provide suitable incentives to establish a national program in bioprocess-engineering research, development, education, and technology transfer.

Cell Culture Bioprocess Engineering, Second Edition

Wei-Shou Hu

Author : Wei-Shou Hu
Publisher : CRC Press
Page : 466 pages
File Size : 48,6 Mb
Release : 2020-03-06
Category : Science
ISBN : 9781498762861

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Cell Culture Bioprocess Engineering, Second Edition by Wei-Shou Hu Pdf

This book is the culmination of three decades of accumulated experience in teaching biotechnology professionals. It distills the fundamental principles and essential knowledge of cell culture processes from across many different disciplines and presents them in a series of easy-to-follow, comprehensive chapters. Practicality, including technological advances and best practices, is emphasized. This second edition consists of major updates to all relevant topics contained within this work. The previous edition has been successfully used in training courses on cell culture bioprocessing over the past seven years. The format of the book is well-suited to fast-paced learning, such as is found in the intensive short course, since the key take-home messages are prominently highlighted in panels. The book is also well-suited to act as a reference guide for experienced industrial practitioners of mammalian cell cultivation for the production of biologics.

Biological Safety

Dawn P. Wooley,Karen B. Byers

Author : Dawn P. Wooley,Karen B. Byers
Publisher : John Wiley & Sons
Page : 953 pages
File Size : 48,7 Mb
Release : 2017-02-01
Category : Science
ISBN : 9781683673132

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Biological Safety by Dawn P. Wooley,Karen B. Byers Pdf

Biological safety and biosecurity protocols are essential to the reputation and responsibility of every scientific institution, whether research, academic, or production. Every risk—no matter how small—must be considered, assessed, and properly mitigated. If the science isn't safe, it isn't good. Now in its fifth edition, Biological safety: Principles and Practices remains the most comprehensive biosafety reference. Led by editors Karen Byers and Dawn Wooley, a team of expert contributors have outlined the technical nuts and bolts of biosafety and biosecurity within these pages. This book presents the guiding principles of laboratory safety, including: the identification, assessment, and control of the broad variety of risks encountered in the lab; the production facility; and, the classroom. Specifically, Biological Safety covers protection and control elements—from biosafety level cabinets and personal protection systems to strategies and decontamination methods administrative concerns in biorisk management, including regulations, guidelines, and compliance various aspects of risk assessment covering bacterial pathogens, viral agents, mycotic agents, protozoa and helminths, gene transfer vectors, zooonotic agents, allergens, toxins, and molecular agents as well as decontamination, aerobiology, occupational medicine, and training A resource for biosafety professionals, instructors, and those who work with pathogenic agents in any capacity, Biological safety is also a critical reference for laboratory managers, and those responsible for managing biohazards in a range of settings, including basic and agricultural research, clinical laboratories, the vivarium, field study, insectories, and greenhouses.

Biological Threats and Terrorism

Institute of Medicine,Board on Global Health,Forum on Emerging Infections

Author : Institute of Medicine,Board on Global Health,Forum on Emerging Infections
Publisher : National Academies Press
Page : 335 pages
File Size : 47,8 Mb
Release : 2002-03-07
Category : Political Science
ISBN : 9780309169950

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Biological Threats and Terrorism by Institute of Medicine,Board on Global Health,Forum on Emerging Infections Pdf

In the wake of September 11th and recent anthrax events, our nation's bioterrorism response capability has become an imminent priority for policymakers, researchers, public health officials, academia, and the private sector. In a three-day workshop, convened by the Institute of Medicine's Forum on Emerging Infections, experts from each of these communities came together to identify, clarify, and prioritize the next steps that need to be taken in order to prepare and strengthen bioterrorism response capabilities. From the discussions, it became clear that of utmost urgency is the need to cast the issue of a response in an appropriate framework in order to attract the attention of Congress and the public in order to garner sufficient and sustainable support for such initiatives. No matter how the issue is cast, numerous workshop participants agreed that there are many gaps in the public health infrastructure and countermeasure capabilities that must be prioritized and addressed in order to assure a rapid and effective response to another bioterrorist attack.

Vaccine Development and Manufacturing

Emily P. Wen,Ronald Ellis,Narahari S. Pujar

Author : Emily P. Wen,Ronald Ellis,Narahari S. Pujar
Publisher : John Wiley & Sons
Page : 452 pages
File Size : 46,6 Mb
Release : 2014-11-17
Category : Technology & Engineering
ISBN : 9780470261941

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Vaccine Development and Manufacturing by Emily P. Wen,Ronald Ellis,Narahari S. Pujar Pdf

Vaccine Manufacturing and Production is an invaluable reference on how to produce a vaccine - from beginning to end - addressing all classes of vaccines from a processing, production, and regulatory viewpoint. It will provide comprehensive information on the various fields involved in the production of vaccines, from fermentation, purification, formulation, to regulatory filing and facility designs. In recent years, there have been tremendous advances in all aspects of vaccine manufacturing. Improved technology and growth media have been developed for the production of cell culture with high cell density or fermentation. Vaccine Manufacturing and Production will serve as a reference on all aspects of vaccine production by providing an in-depth description of the available technologies for making different types of vaccines and the current thinking in facility designs and supply issues. This book will provide insight to the issues scientists face when producing a vaccine, the steps that are involved, and will serve as a reference tool regarding state-of-the-art vaccine manufacturing technologies and facility set-up. Highlights include: Comprehensive coverage of vaccine production : from a process point of view- fermentation to purification to formulation developments; from a production point of view - from facility design to manufacturing; and from a regulatory point of view - requirements from government agencies Authors from different major pharmaceutical and biotechnology companies Describes the challenges and issues involved in vaccine production and manufacturing of the different classes of vaccines, an area not covered by other books currently on the market

Bioprocess Technology

P T Kalaichelvan,I Arul Pandi

Author : P T Kalaichelvan,I Arul Pandi
Publisher : MJP Publisher
Page : 692 pages
File Size : 49,7 Mb
Release : 2019-06-07
Category : Science
ISBN : 8210379456XXX

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Bioprocess Technology by P T Kalaichelvan,I Arul Pandi Pdf

Overview of BioprocessingTypes of FermentationStructure and Anatomy of FermenterTypes of FermenterIsolation and Screening of Industrially Important MicrobesMedia for Industrial FermentationProcess Control in FermentationDownstream ProcessingMicrobial Contamination and Spoilage of FoodGeneral Methods of Preserving FoodProduction of Milk ProductsProduction of Bakery ProductsProduction of Fermented BeveragesSingle Cell ProteinsMushroomVaccinesAntibiotic ProductionIndustrial EnzymesImmobilizationEnzyme KineticsOrganic AcidsVitaminsMicrobial PolysaccharidesBiofertilizersBiopesticidesBioremediation and TransformationBiological Waste TreatmentBiogas ProductionBiofuelsEthanolBiodieselGlossaryReferencesIndex

Bioprocessing Of Viral Vaccines

Bioprocessing of Viral Vaccines by Amine Kamen,Laura Cervera Pdf

Opportunities in Biotechnology for Future Army Applications by National Research Council,Division on Engineering and Physical Sciences,Board on Army Science and Technology,Committee on Opportunities in Biotechnology for Future Army Applications Pdf

Vaccine Development and Manufacturing by Emily P. Wen,Ronald Ellis,Narahari S. Pujar Pdf

The Application of Viruses to Biotechnology by Carla Varanda,Patrick Materatski Pdf

Bioprocess and Analytics Development for Virus-based Advanced Therapeutics and Medicinal Products (ATMPs) by Saurabh Gautam,Abhilash I. Chiramel,Roland Pach Pdf

Adenoviral Vectors for Gene Therapy by David T. Curiel Pdf

Genetically Engineered Plants as a Source of Vaccines Against Wide Spread Diseases by Sergio Rosales-Mendoza Pdf

Animal Cell Biotechnology by Ralf Pörtner Pdf

Industrial Scale Suspension Culture of Living Cells by Hans-Peter Meyer,Diego Schmidhalter Pdf

Putting Biotechnology to Work by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Bioprocess Engineering Pdf

Cell Culture Bioprocess Engineering, Second Edition by Wei-Shou Hu Pdf

Biological Safety by Dawn P. Wooley,Karen B. Byers Pdf

Biological Threats and Terrorism by Institute of Medicine,Board on Global Health,Forum on Emerging Infections Pdf

Vaccine Development and Manufacturing by Emily P. Wen,Ronald Ellis,Narahari S. Pujar Pdf

Bioprocess Technology by P T Kalaichelvan,I Arul Pandi Pdf

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