Bone Marrow Niche

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Bone Marrow Niche

Takashi Nagasawa
Bone Marrow Niche Book PDF

Author : Takashi Nagasawa
Publisher : Springer Nature
Page : 138 pages
File Size : 44,9 Mb
Release : 2021-12-01
Category : Medical
ISBN : 9783030860165

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Bone Marrow Niche by Takashi Nagasawa Pdf

This volume summarizes recent advances in research on mesenchymal cell populations in the bone marrow. It explores how mesenchymal cells create niches for immune cells in extramedullary organs and it discusses new concepts of lympho-hematopoietic microenvironments. Readers are introduced to the fundamentals of hematopoietic stem cells (HSCs) differentiation to all types of blood cells, including immune cells, in the bone marrow. The book highlights how this process is supported and regulated by the individual microenvironments of stem cells, termed niches. The identity of HSC niches has been subject to longstanding debates. Recent studies identified the population of mesenchymal stem cells as the major cellular component of niches, for hematopoietic stem and progenitor cells (HSPCs) and their candidate developmental origin. Furthermore, candidate cellular niches for immune cells in lymph nodes and adipose and connective tissues were identified. The authors of this volume focus on shared features between those and HSPC niche cells in the bone marrow. Covering latest research results, this book serves as fascinating read for researchers and clinicians in hematology and immunology.

Bone Marrow Niche

Takashi Nagasawa
Bone Marrow Niche Book PDF

Author : Takashi Nagasawa
Publisher : Unknown
Page : 0 pages
File Size : 45,6 Mb
Release : 2021
Category : Electronic
ISBN : 3030860175

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Bone Marrow Niche by Takashi Nagasawa Pdf

This volume summarizes recent advances in research on mesenchymal cell populations in the bone marrow. It explores how mesenchymal cells create niches for immune cells in extramedullary organs and it discusses new concepts of lympho-hematopoietic microenvironments. Readers are introduced to the fundamentals of hematopoietic stem cells (HSCs) differentiation to all types of blood cells, including immune cells, in the bone marrow. The book highlights how this process is supported and regulated by the individual microenvironments of stem cells, termed niches. The identity of HSC niches has been subject to longstanding debates. Recent studies identified the population of mesenchymal stem cells as the major cellular component of niches, for hematopoietic stem and progenitor cells (HSPCs) and their candidate developmental origin. Furthermore, candidate cellular niches for immune cells in lymph nodes and adipose and connective tissues were identified. The authors of this volume focus on shared features between those and HSPC niche cells in the bone marrow. Covering latest research results, this book serves as fascinating read for researchers and clinicians in hematology and immunology.

Hematopoietic Stem Cell Niche

Anonim
Hematopoietic Stem Cell Niche Book PDF

Author : Anonim
Publisher : Elsevier
Page : 186 pages
File Size : 51,6 Mb
Release : 2017-03-10
Category : Science
ISBN : 9780128113769

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Hematopoietic Stem Cell Niche by Anonim Pdf

Hematopoietic Stem Cell Niche focuses on an individual organ, looking at the stem cells in the organ itself (if they exist), their niches, and how to use them alongside relevant methods and protocols. This series addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments in the field, including new data on disease and clinical applications. Video content illustrates such areas as protocols, transplantation techniques, and work with mice. Explores not only reviews of research, but also shares methods, protocols, and transplantation techniques Contains video content to illustrate such areas as protocols, transplantation techniques, and work with mice Each volume concentrates on one organ, making this a unique publication

Adult Stem Cell Niches

Sabine Wislet
Adult Stem Cell Niches Book PDF

Author : Sabine Wislet
Publisher : BoD – Books on Demand
Page : 332 pages
File Size : 45,9 Mb
Release : 2014-08-01
Category : Science
ISBN : 9789535117186

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Adult Stem Cell Niches by Sabine Wislet Pdf

Tissue-specific stem cells have the capacity to self-renew and differentiate into several types of functional cells that replenish lost cells throughout an organism?s lifetime. Studies on stem cells from diverse systems have shown that stem cell function is controlled by extracellular cues from the niche and by intrinsic genetic programs within the stem cell. The objectives of this book would be to review the molecular mechanisms that mediate the balanced response of stem cells to the needs of the organisms. Likewise, niches have also been linked to pathologies, by imposing aberrant function on stem cells or other targets. Therefore, the second objective of this book would be to highligh the molecular dysregulation of niche biology leading to the disease. The third objective would be to review the therapeutical targets described within stem cell niches.

Tissue-Specific Stem Cell Niche

Kursad Turksen
Tissue Specific Stem Cell Niche Book PDF

Author : Kursad Turksen
Publisher : Springer
Page : 333 pages
File Size : 42,5 Mb
Release : 2015-10-05
Category : Science
ISBN : 9783319217055

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Tissue-Specific Stem Cell Niche by Kursad Turksen Pdf

This timely volume explores tissue-derived stem cells, summarizing and evaluating the current body of knowledge. Sixteen chapters cover hematopoietic, osteoblast, skeletal, cardiac, pancreatic, epithelial, corneal, hepatic, renal, testicular, ovarian, fingernail, hair follicle and other stem cells- discussing their individual development, functions and pathologies, as well as the commonalities and interdependence between niches. This installment of the popular Stem Cell Biology and Regenerative Medicine series delivers authoritative, international perspectives on this rapidly growing field. Tissue-Specific Stem Cell Niche is an ideal complementary volume to Biology of Stem Cell Niche and Adult Stem Cells, Second Edition and will be invaluable to clinicians and researchers working with stem cells as well as to postgraduate trainees who are studying them.

Stem Cell Microenvironments and Beyond

Alexander Birbrair
Stem Cell Microenvironments and Beyond Book PDF

Author : Alexander Birbrair
Publisher : Springer
Page : 270 pages
File Size : 42,5 Mb
Release : 2017-12-03
Category : Science
ISBN : 9783319691947

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Stem Cell Microenvironments and Beyond by Alexander Birbrair Pdf

This book discusses the main stem cell niches under distinct pathophysiological conditions. The role of tissue microenvironments in stem cell regulation, as well as modern methodologies and new techniques for the identification and characterization of stem cell niches, are discussed by leading experts in the field. Chapters describe the major components of various stem cell microenvironments, such as cellular components, soluble factors, cell-cell interactions, extra-cellular matrix proteins, and physical forces. Stem Cell Microenvironments and Beyond is part of the highly successful Advances in Experimental Medicine and Biology series. It is essential reading for graduate students and researchers in the field of stem cells or cell biology as well as clinicians.

Hematopoietic Stem Cells

Meng Zhao,Pengxu Qian
Hematopoietic Stem Cells Book PDF

Author : Meng Zhao,Pengxu Qian
Publisher : Springer Nature
Page : 218 pages
File Size : 43,6 Mb
Release : 2024-01-17
Category : Medical
ISBN : 9789819974719

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Hematopoietic Stem Cells by Meng Zhao,Pengxu Qian Pdf

This book renders a comprehensive understanding of hematopoietic stem cells (HSCs) from their embryonic development through adult maintenance to aging, in the studies conducted in zebrafish and mammals. Hematopoiesis provides a paradigm for understanding the development, maintenance, regeneration, aging and malignant transformation of mammalian organs. Sitting at the apex of the hematopoiesis hierarchy tree, HSCs orchestrate their proliferation, self-renewal, and differentiation to produce all the blood cell lineages throughout life, which represents the best example for somatic stem cell studies. In this book, key regulatory mechanisms for HSC self-renewal and differentiation are overviewed in an array of fields including epigenetics, metabolism and microenvironment regulation. It also highlights the HSC heterogeneity and clonal dynamics from the recent advanced single-cell technologies. This book elaborates on the research history of HSC studies and reveals how the insights from HSC studies shed light on their clinic application. It presents great value from the bench to the clinic.

Hematopoietic Stem Cells

Louis M. Pelus,Jonathan Hoggatt
Hematopoietic Stem Cells Book PDF

Author : Louis M. Pelus,Jonathan Hoggatt
Publisher : Springer Nature
Page : 284 pages
File Size : 52,6 Mb
Release : 2022-10-18
Category : Science
ISBN : 9781071626795

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Hematopoietic Stem Cells by Louis M. Pelus,Jonathan Hoggatt Pdf

This detailed volume collects updates on the technical advances in hematopoietic stem cell research and incorporates new techniques focused on the molecular/genetic, cellular, and whole organism levels. Exploring methods that apply stress to hematopoiesis, the book also contains chapters focused on better understanding the role of hematopoietic niches and their cellular components, as well as in vivo models that test and quantitate stem cell function and are key to further development of therapeutic applications. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Hematopoietic Stem Cells: Methods and Protocols serves as a valued addition to laboratories focused on understanding hematopoietic stem cell biology and the therapeutic advances that can be derived from it.

Advances in Stem Cells and their Niches

Susie Nilsson
Advances in Stem Cells and their Niches Book PDF

Author : Susie Nilsson
Publisher : Elsevier
Page : 100 pages
File Size : 48,6 Mb
Release : 2023-12-01
Category : Science
ISBN : 9780443193538

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Advances in Stem Cells and their Niches by Susie Nilsson Pdf

Advances in Stem Cells and their Niches, Volume Seven highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Stem Cells and their Niches series

Molecular Basis of Hematopoiesis

Amittha Wickrema,Barbara Kee
Molecular Basis of Hematopoiesis Book PDF

Author : Amittha Wickrema,Barbara Kee
Publisher : Springer Science & Business Media
Page : 260 pages
File Size : 41,9 Mb
Release : 2008-12-26
Category : Medical
ISBN : 9780387858166

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Molecular Basis of Hematopoiesis by Amittha Wickrema,Barbara Kee Pdf

Although much is known with respect to blood cell formation and function, many new concepts in the areas of the regulation of hematopoietic stem cell commitment and the subsequent survival, proliferation, and differentiation of progenitors have been elucidated in the last five years. Our understanding of the microenvironment where stem cells reside and commit to distinct blood types (the niche) has grown significantly in recent years. Furthermore, blood cells have been used as the key model system to study microRNA function and the role of microRNAs in the transformation of normal cells into cancer cells. The current volume Molecular Basis of Hematopoiesis, edited by Amittha Wickrema & Barbara Kee, provides the most recent developments in the area in addition to a chapter on the utilization of basic science knowledge for the treatment of blood diseases. Each chapter in this book has been written and edited by faculty in major academic and research institutions around the world, who are pushing the frontiers of research in this important area.

Biology and Engineering of Stem Cell Niches

Ajaykumar Vishwakarma,Jeffrey M Karp
Biology and Engineering of Stem Cell Niches Book PDF

Author : Ajaykumar Vishwakarma,Jeffrey M Karp
Publisher : Academic Press
Page : 642 pages
File Size : 53,5 Mb
Release : 2017-03-22
Category : Science
ISBN : 9780128027561

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Biology and Engineering of Stem Cell Niches by Ajaykumar Vishwakarma,Jeffrey M Karp Pdf

Biology and Engineering of Stem Cell Niches covers a wide spectrum of research and current knowledge on embryonic and adult stem cell niches, focusing on the understanding of stem cell niche molecules and signaling mechanisms, including cell-cell/cell-matrix interactions. The book comprehensively reviews factors regulating stem cell behavior and the corresponding approaches for understanding the subsequent effect of providing the proper matrix molecules, mechanical cues, and/or chemical cues. It encompasses a variety of tools and techniques for developing biomaterials-based methods to model synthetic stem cell niches in vivo, or to enhance and direct stem cell fate in vitro. A final section of the book discusses stem cell niche bioengineering strategies and current advances in each tissue type. Includes the importance of Cell-Cell and Cell Matrix Interactions in each specific tissue and system Authored and edited by authorities in this emerging and multidisciplinary field Includes valuable links to 5-10 minute YouTube© author videos that describe main points

Myeloma Bone Disease

G. David Roodman
Myeloma Bone Disease Book PDF

Author : G. David Roodman
Publisher : Springer Science & Business Media
Page : 257 pages
File Size : 48,7 Mb
Release : 2010-04-28
Category : Medical
ISBN : 9781607615545

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Myeloma Bone Disease by G. David Roodman Pdf

This book presents the forefront in the science and clinical management of myeloma bone disease. Coverage begins with sections on clinical presentation, imaging, and biochemical markers and goes on to discuss radiation, surgical, and medical therapies.

Handbook of Benign Hematology

Martha Pritchett Mims, MD, PhD,Courtney Miller-Chism, MD,Iberia Romina Sosa, MD, PhD
Handbook of Benign Hematology Book PDF

Author : Martha Pritchett Mims, MD, PhD,Courtney Miller-Chism, MD,Iberia Romina Sosa, MD, PhD
Publisher : Springer Publishing Company
Page : 555 pages
File Size : 49,8 Mb
Release : 2019-12-11
Category : Medical
ISBN : 9780826149879

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Handbook of Benign Hematology by Martha Pritchett Mims, MD, PhD,Courtney Miller-Chism, MD,Iberia Romina Sosa, MD, PhD Pdf

Handbook of Benign Hematology is a practical guide to the diagnosis and management of benign hematologic conditions. The book begins with a chapter on normal hematopoiesis and follows with chapters devoted to groups of blood disorders and syndromes including neutrophil disorders, nonmalignant myeloid disorders, bone marrow failure syndromes, myeloproliferative disorders, anemias, iron metabolism disorders, platelet disorders, hemostasis and coagulation defects, and thrombosis. Each disorder subtype covered features a clinical case, an introduction to the condition, details on diagnosis including applicable criteria and lab work needed, key diagnostic dilemmas, prognosis, treatment options, details on clinical trials and emerging clinical strategies, and bulleted key points to highlight clinical pearls and common pitfalls. The final chapters provide best practices for transfusion medicine and a guide to pharmacologic agents and their uses in clinical practice for adult and pediatric patients. The handbook is filled with tables and illustrations which highlight FDA-approved drug information, clinical trials data, hematopathologic characteristics of different disorders, important management criteria and more, making it the ideal handbook for those in practice or for review. The Editors and chapter authors are experienced academic practitioners in the fields of adult and pediatric hematology, pathology, blood banking, and pharmacology. Emphasizing best practices for patient management, this handbook is essential for oncologists, hematologists, trainees, and other practitioners who regularly or increasingly receive referrals to diagnose and treat adults or children with nonmalignant hematologic conditions. Key Features: Includes dozens of clinical cases covering all nonmalignant blood disorders Emphasizes patient management and best practices for disorders seen in adults and children Contains over 30 color images and numerous tables for quick reference Presents important details of all pharmacologic agents used to treat or manage hematologic disorders and their complications Purchase includes access to the ebook for use on most mobile devices or computers

The Cancer Stem Cell Niche

Susie Nilsson
The Cancer Stem Cell Niche Book PDF

Author : Susie Nilsson
Publisher : Academic Press
Page : 248 pages
File Size : 44,7 Mb
Release : 2021-01-23
Category : Science
ISBN : 9780323853262

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The Cancer Stem Cell Niche by Susie Nilsson Pdf

The Cancer Stem Cell Niche, Volume Five in the Advances in Stem Cells and their Niches series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Acute lymphoblastic leukemia and the bone marrow microenvironment, Stem cell niches in bone and their roles in cancer metastasis, The role of vasculature in cancer stem cell niches, The lung cancer stem cell niche, The prostate cancer stem cell niche: Genetic drivers and therapeutic approaches, Impact of prostate cancer stem cell niches on prostate cancer tumorigenesis and progression, The testicular cancer stem cell niche. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Stem Cells and their Niches series Includes the latest information on the Cancer Stem Cell Niche

Metastatic Cancer: Clinical and Biological Perspectives

Rahul Jandial
Metastatic Cancer Clinical and Biological Perspectives Book PDF

Author : Rahul Jandial
Publisher : CRC Press
Page : 312 pages
File Size : 40,6 Mb
Release : 2013-08-08
Category : Medical
ISBN : 1587066599

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Metastatic Cancer: Clinical and Biological Perspectives by Rahul Jandial Pdf

Most cancer deaths are a result of metastasis. The spread of a primary tumor to colonize neighboring and distant organs is the relentless endgame that defines the neoplastic process. Patients who have been diagnosed with cancer are treated to prevent both the recurrence of the tumor at the site of origin and metastasis that would re-stage them as advanced stage IV cancer. Historically and still with some types of cancer, stage IV is perceived by patients as “terminal.” Fortunately, recent molecular therapies have extended the lives of patients with advanced cancer and reassuringly people living with metastatic disease increasingly visit our clinics. What is the path forward? Given that the consilience of science and medicine is a dynamic art from which therapies arise, it would be misguided to consider any single work adequate at capturing the horizon for research. So with humility we constructed this text as primer for scientists. It begins with a broad introduction to the clinical management of common cancers. This is intended to serve as a foundation for investigators to consider when developing basic science hypotheses. Unquestionably, medical and surgical care of cancer patients reveals biology and dictates how novel therapeutics will ultimately be evaluated in clinical trials. The second section of this text offers provocative and evolving insights that underscore the breadth of science involved in the elucidation of cancer metastasis biology. The text concludes with information that integrates scientific and clinical foundations to highlight translational research. This book serves as a framework for scientists to conceptualize clinical and translational knowledge on the complexity of disease that is metastatic cancer.