Brain Glycogen Metabolism

Author : Mauro DiNuzzo,Arne Schousboe
Publisher : Springer Nature
Page : 443 pages
File Size : 47,6 Mb
Release : 2019-10-31
Category : Medical
ISBN : 9783030274801

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Brain Glycogen Metabolism by Mauro DiNuzzo,Arne Schousboe Pdf

This book aims to provide a state-of-the-art summary of what is currently known about brain glycogen metabolism, detailing the recent advances in our understanding of why glycogen is so critical for normal brain function. The role of glycogen in cellular neurophysiology remains largely unclear and its specific contribution to the energy demand of brain cells is still elusive.Glycogen is the sole cerebral glucose reserve and is emerging as a fundamental component of brain energy metabolism. Pharmacological or genetic manipulation of glycogen metabolism in the brain impairs memory formation and increases susceptibility to epileptic seizures and cortical spreading depression. Glycogen is also directly implicated in abnormal neuronal excitability and mental retardation that characterize brain disorders like Lafora disease and Pompe disease.

Author : M.Z.M. Ibrahim
Publisher : Springer Science & Business Media
Page : 144 pages
File Size : 46,6 Mb
Release : 2013-12-11
Category : Medical
ISBN : 9783642868757

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Glycogen and its Related Enzymes of Metabolism in the Central Nervous System by M.Z.M. Ibrahim Pdf

The glycogen content of normal mammalian CNS is small when compared with that of some other mammalian tissues such as liver and muscle. Nevertheless, this glycogen content normally comprises at least one quarter of its total reserve of energy, the rest being adenosine triphosphate (ATP), phosphocreatine and glucose. Since this glycogen undergoes a turnover 50-100 times that of brain lipids, and exceeds by several orders of magnitude that of liver glycogen, it most likely plays a dynamic role in the metabolism of brain, Gatfield et al. (1966), Prasannan and Subrahmanyam (1968b), Brunner et al. (1971), Edwards and Rogers (1972) and Watanabe and Passonneau (1973). Glycogen also has an unequal distribution in the normal mammalian brain and spinal cord (Shimizu and Kumamoto, 1952; Shimizu and Okada, 1957; Friede, 1966; Shanthaveerappa et al., 1966; Ibrahim etal., 1970a), and it is possible that areas showing more glycogen "are inherently vulnerable and that their extra glycogen is an added protective mechanism" (Ibrahim, 1972). However, this is probably not the only explanation for the unequal distribution of glycogen since it is suggested for instance that neuronal glycogen may be normally impli cated in the process of synaptic transmission (Shanthaveerappa et al., 1966; Drummond and Bellward, 1970) and that retinal glycogen plays a role in the normal dark-light adaptation sequence (Shimizu and Maeda, 1953). Also, a wide variety of physiological, pathological and experimental conditions leads to a common response in the CNS, namely, accumulation of glycogen

Author : Johannes Hirrlinger,Helle S. Waagepetersen
Publisher : Humana Press
Page : 0 pages
File Size : 42,7 Mb
Release : 2014-09-16
Category : Medical
ISBN : 1493910582

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Brain Energy Metabolism by Johannes Hirrlinger,Helle S. Waagepetersen Pdf

Brain Energy Metabolism addresses its challenging subject by presenting diverse technologies allowing for the investigation of brain energy metabolism on different levels of complexity. Model systems are discussed, starting from the reductionist approach like primary cell cultures which allow assessing of the properties and functions of a single brain cell type with many different types of analysis, however, at the expense of neglecting the interaction between cell types in the brain. On the other end, analysis in animals and humans in vivo is discussed, maintaining the full complexity of the tissue and the organism but making high demands on the methods of analysis. Written for the popular Neuromethods series, chapters include the kind of detailed description and key implementation advice that aims to support reproducible results in the lab. Meticulous and authoritative, Brain Energy Metabolism provides an ideal guide for researchers interested in brain energy metabolism with the hope of stimulating more research in this exciting and very important field.

Author : Anne Le
Publisher : Springer
Page : 186 pages
File Size : 48,6 Mb
Release : 2018-06-26
Category : Medical
ISBN : 9783319777368

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The Heterogeneity of Cancer Metabolism by Anne Le Pdf

Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Author : Bo K. Siesjö
Publisher : John Wiley & Sons
Page : 636 pages
File Size : 40,5 Mb
Release : 1978
Category : Brain chemistry
ISBN : UCLA:L0067145169

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Brain Energy Metabolism by Bo K. Siesjö Pdf

Author : Marshall D. McCue
Publisher : Springer Science & Business Media
Page : 431 pages
File Size : 52,7 Mb
Release : 2012-05-17
Category : Science
ISBN : 9783642290565

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Comparative Physiology of Fasting, Starvation, and Food Limitation by Marshall D. McCue Pdf

All animals face the possibility of food limitation and ultimately starvation-induced mortality. This book summarizes state of the art of starvation biology from the ecological causes of food limitation to the physiological and evolutionary consequences of prolonged fasting. It is written for an audience with an understanding of general principles in animal physiology, yet offers a level of analysis and interpretation that will engage seasoned scientists. Each chapter is written by active researchers in the field of comparative physiology and draws on the primary literature of starvation both in nature and the laboratory. The chapters are organized among broad taxonomic categories, such as protists, arthropods, fishes, reptiles, birds, and flying, aquatic, and terrestrial mammals including humans; particularly well-studied animal models, e.g. endotherms are further organized by experimental approaches, such as analyses of blood metabolites, stable isotopes, thermobiology, and modeling of body composition.

Author : Romano Piras,Horacio G. Pontis
Publisher : Unknown
Page : 824 pages
File Size : 54,7 Mb
Release : 1972
Category : Science
ISBN : UOM:39015000836141

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Biochemistry of the Glycosidic Linkage by Romano Piras,Horacio G. Pontis Pdf

Biochemistry of the Glycosidic Linkage: An Integrated View is a collection of papers presented at The Pan-American Association of Biochemical Societies Symposium, held in San Carlos de Bariloche, Argentina on November 8-11, 1971. This symposium is organized as a tribute to Luis F. Leloir and his contributions in the field glycosidic linkage. This book is divided into six sessions encompassing 57 chapters. The opening session discusses the role of biochemical mechanisms in the glycosidic linkage formation. The following sessions examine the metabolic functions of some disaccharides, such as tre ...

Author : Javier T. Gonzalez
Publisher : MDPI
Page : 267 pages
File Size : 51,8 Mb
Release : 2018-07-04
Category : Electronic
ISBN : 9783038429999

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Carbohydrate Metabolism in Health and Disease by Javier T. Gonzalez Pdf

This book is a printed edition of the Special Issue "Carbohydrate Metabolism in Health and Disease" that was published in Nutrients

Author : Abraham M. Rudolph
Publisher : McGraw-Hill/Appleton & Lange
Page : 2337 pages
File Size : 45,5 Mb
Release : 1996
Category : Medical
ISBN : 0838584926

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Rudolph's Pediatrics by Abraham M. Rudolph Pdf

Provides descriptions of the clinical features of diseases of childhood, and of therapeutic approaches, and also to review biological principles underlying etiology, diagnosis, and treatment.

Author : Juan M. Pascual
Publisher : Cambridge University Press
Page : 507 pages
File Size : 47,9 Mb
Release : 2017-04-20
Category : Medical
ISBN : 9781107042056

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Progressive Brain Disorders in Childhood by Juan M. Pascual Pdf

A review of childhood neurodegenerative and other progressive but non-degenerative disorders to guide their diagnosis and management.

Author : Institute of Medicine,Food and Nutrition Board,Committee on Military Nutrition Research
Publisher : National Academies Press
Page : 172 pages
File Size : 41,5 Mb
Release : 2002-01-07
Category : Medical
ISBN : 9780309082587

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Caffeine for the Sustainment of Mental Task Performance by Institute of Medicine,Food and Nutrition Board,Committee on Military Nutrition Research Pdf

This report from the Committee on Military Nutrition Research reviews the history of caffeine usage, the metabolism of caffeine, and its physiological effects. The effects of caffeine on physical performance, cognitive function and alertness, and alleviation of sleep deprivation impairments are discussed in light of recent scientific literature. The impact of caffeine consumption on various aspects of health, including cardiovascular disease, reproduction, bone mineral density, and fluid homeostasis are reviewed. The behavioral effects of caffeine are also discussed, including the effect of caffeine on reaction to stress, withdrawal effects, and detrimental effects of high intakes. The amounts of caffeine found to enhance vigilance and reaction time consistently are reviewed and recommendations are made with respect to amounts of caffeine appropriate for maintaining alertness of military personnel during field operations. Recommendations are also provided on the need for appropriate labeling of caffeine-containing supplements, and education of military personnel on the use of these supplements. A brief review of some alternatives to caffeine is also provided.

Author : Chris D. Geddes,Joseph R. Lakowicz
Publisher : Springer Science & Business Media
Page : 460 pages
File Size : 44,6 Mb
Release : 2007-12-29
Category : Science
ISBN : 9780387330150

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Glucose Sensing by Chris D. Geddes,Joseph R. Lakowicz Pdf

An essential reference for any laboratory working in the analytical fluorescence glucose sensing field. The increasing importance of these techniques is typified in one emerging area by developing non-invasive and continuous approaches for physiological glucose monitoring. This volume incorporates analytical fluorescence-based glucose sensing reviews, specialized enough to be attractive to professional researchers, yet appealing to a wider audience of scientists in related disciplines of fluorescence.

Author : Anonim
Publisher : Elsevier
Page : 555 pages
File Size : 53,5 Mb
Release : 2002-11-04
Category : Medical
ISBN : 9780080491592

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Glucose Metabolism in the Brain by Anonim Pdf

Regulation of glucose at the biochemical level affects every area of the brain, and has impact from cellular to behavioral brain function. It plays an important role in diseases such as diabetes, stroke, schizophrenia and drug abuse as well as in normal and dysfunctional memory and cognition. This volume represents a thorough examination of all the major issues that are relevant to glucose metabolism by brain cells in relation to disease, combining basic research and clinical findings in a single, indispensable reference. Serves as an essential reference on glucose metabolism in the brain Presents authoritative accounts by leading researchers in the field Includes thorough reviews with provocative sections on future directions

Author : Jesmine Khan,Po-Shiuan Hsieh
Publisher : BoD – Books on Demand
Page : 230 pages
File Size : 49,5 Mb
Release : 2020-07-15
Category : Science
ISBN : 9781838801816

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Cellular Metabolism and Related Disorders by Jesmine Khan,Po-Shiuan Hsieh Pdf

This book deals with a vital topic: metabolism in the cells of the body and various disorders due to its imbalance and/or diseases that disrupt the metabolism of the body. The objective of this book was to collect and compile up-to-date information from reputed researchers in their respective fields to disseminate the latest information about topics that have profound effects on the metabolic processes in the body including insulin resistance, diabetes mellitus, hypothyroidism, metabolic syndrome, glycogen storage disease, and the urea cycle disorder. In total, there are 12 chapters in this book in which the authors have shared their research findings and real-life experiences in managing their patients.

Author : Hans-Peter Landolt,Derk-Jan Dijk
Publisher : Springer Nature
Page : 481 pages
File Size : 40,8 Mb
Release : 2019-09-03
Category : Medical
ISBN : 9783030112721

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Sleep-Wake Neurobiology and Pharmacology by Hans-Peter Landolt,Derk-Jan Dijk Pdf

This volume connects current ideas and concepts about sleep functions and circadian rhythms with the search for novel target-selective sleep-wake therapeutics. To do so, it provides a timely, state-of-the-art overview of sleep-wake mechanisms in health and disease, ongoing developments in drug discovery, and their prospects for the clinical treatment of sleep-disordered patients. It particularly focuses on the concept that sleep and wakefulness mutually affect each other, and the future therapeutic interventions with either sleep- or wake-promoting agents that are expected to not only improve the quality of sleep but also the waking behavior, cognition, mood and other sleep-associated physiological functions. The chapter 'Sleep Physiology, Circadian Rhythms, Waking Performance and the Development of Sleep-Wake Therapeutics' available open access under a CC BY 4.0 license at link.springer.com