Brain Receptor Methodologies Pt A

Author : Paul J. Marangos
Publisher : Elsevier
Page : 384 pages
File Size : 49,9 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323152808

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Brain Receptor Methodologies Pt A by Paul J. Marangos Pdf

Brain Receptor Methodologies, Part A, General Methods and Concepts: Amines and Acetylcholine provides information pertinent to neurotransmitter and neuromodulator receptors in brain. This book explores the methodologies that can used to address several basic and clinical problems. Organized into two sections encompassing 18 chapters, this book starts with an overview of the receptor concept, which can be validated from indirect evidence obtained in studies of the quantitative aspects of drug antagonism. This text then examines the radioligand–receptor binding interactions. Other chapters consider immunocytochemistry, which has a primary role in determining the precise distribution of regulatory peptides to neural and endocrine elements of the diffuse neuroendocrine system. The final chapter discusses the use of the radioligand binding procedure for the study of muscarinic receptors, which has expanded the area of muscarinic receptor pharmacology. Biochemists, pharmacologists, physiologists, and researchers engaged in the fields of neurobiology and neuroscience will find this book extremely useful.

Author : Paul J. Marangos,Robert M. Cohen,Iain C. Campbell
Publisher : Unknown
Page : 392 pages
File Size : 52,8 Mb
Release : 1984
Category : Brain chemistry
ISBN : UOM:39015007102760

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Brain Receptor Methodologies by Paul J. Marangos,Robert M. Cohen,Iain C. Campbell Pdf

Brain Receptor Methodologies, Part A, General Methods and Concepts: Amines and Acetylcholine provides information pertinent to neurotransmitter and neuromodulator receptors in brain. This book explores the methodologies that can used to address several basic and clinical problems. Organized into two sections encompassing 18 chapters, this book starts with an overview of the receptor concept, which can be validated from indirect evidence obtained in studies of the quantitative aspects of drug antagonism. This text then examines the radioligand-receptor binding interactions. Other chapters consi ...

Author : Paul J. Marangos,Iain C. Campbell,Robert M. Cohen
Publisher : Academic Press
Page : 357 pages
File Size : 46,7 Mb
Release : 2013-10-22
Category : Nature
ISBN : 9781483269597

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Brain Receptor Methodologies by Paul J. Marangos,Iain C. Campbell,Robert M. Cohen Pdf

Brain Receptor Methodologies: Part B Amino Acids. Peptides. Psychoactive Drugs is the second of the two-part first volume of the Neurobiological Research series, which provides a comprehensive view of various subdisciplines within neurobiology. The first volume (Parts A and B) deals with the area of neurotransmitter and neuromodulator receptors in brain; future volumes will cover the subdisciplines of neuroanatomy, neurophysiology, brain-specific macromolecules, neurochemistry, and behavioral neurobiology. It is hoped that the series will be of equal value for both basic as well as clinical scientists Part B continues from Part A with the remainder of Section II, specific receptor binding methodologies. Subsection II,B deals with receptors for amino acids and neuropeptides and covers areas including GABA, glycine, carnosine, opiates, bombesin, CCK, TRH, and substance P. Amino acids probably represent the majority of brain neurotransmitter substances, at least relative to the amines and acetylcholine, although with the exception of GABA, the amino acids remain relatively uncharacterized in brain. Their further study should receive high priority.

Author : Rafael Luján,Francisco Ciruela
Publisher : Humana Press
Page : 475 pages
File Size : 45,9 Mb
Release : 2018-03-31
Category : Medical
ISBN : 1493979833

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Receptor and Ion Channel Detection in the Brain by Rafael Luján,Francisco Ciruela Pdf

Receptor and Ion Channel Detection in the Brain provides state-of-the-art and up-to-date methodological information on molecular, neuroanatomical and functional techniques that are currently used to study neurotransmitter receptors and ion channels in the brain. The chapters have been contributed by world-wide recognized neuroscientists who explain in an easy and detailed way well established and tested protocols embracing molecular, cellular, subcellular, anatomical and electrophysiological aspects of the brain. This comprehensive and practical manual is presented in a simple, step-by-step manner for laboratory use, and also offers unambiguous detail and key implementation advice that proves essential for successful results and facilitate choosing the best method for the target proteins under study. This work serves as a useful guide for young researchers and students in training as well as for neurologists and established scientists who wish to extend their repertoire of techniques.

Author : Rafael Lujan,Francisco Ciruela
Publisher : Humana
Page : 554 pages
File Size : 50,6 Mb
Release : 2022-08-10
Category : Medical
ISBN : 1071615246

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Receptor and Ion Channel Detection in the Brain by Rafael Lujan,Francisco Ciruela Pdf

This second edition volume expands on the previous edition with new information on the latest developments in the field, and the most up-to-date representative methodological information on molecular neuroanatomical and functional techniques that are currently used to study neurotransmitter receptors and ion channels in the brain. The chapters in this book are organized into three parts. Part One discusses molecular immunological and pharmacological aspects related to the detection of receptors and ion channels in the brain. Part Two explores the neuroanatomical techniques devoted to localizing receptors and ion channels within the central nervous system. Part Three looks at functional approaches devoted to ascertaining receptors and ion channels functionality in the brain. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and comprehensive, Receptor and Ion Channels Detection in the Brain, Second Edition is a valuable resource that contains detailed molecular, cellular, neuroanatomical, and electrophysiological methods that will help researchers study neurotransmitter receptor and ion channel in any region of neuron of the brain.

Author : Paul J. Marangos,Iain C. Campbell,Robert M. Cohen
Publisher : Unknown
Page : 128 pages
File Size : 45,6 Mb
Release : 1984
Category : Electronic
ISBN : 012470350X

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Brain Receptor Methodologies by Paul J. Marangos,Iain C. Campbell,Robert M. Cohen Pdf

Author : John P. Perkins
Publisher : Springer Science & Business Media
Page : 410 pages
File Size : 50,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461204633

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The Beta-Adrenergic Receptors by John P. Perkins Pdf

Author : Jr. Ruffolo
Publisher : Springer Science & Business Media
Page : 548 pages
File Size : 42,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461245827

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The alpha-1 Adrenergic Receptors by Jr. Ruffolo Pdf

During the past decade, great strides have been made in our un derstanding of the biochemistry and pharmacology of the alpha-l adrenergic receptor. The alpha-l adrenergic receptor plays a key role in biological function. This is evidenced by the fact that the alpha-l adrenergic receptor plays a prominent functional role in most organs of the body and in the key systems responsible for survival of the organism and maintenance of optimum biological activity. This is most apparent in the cardiovascular system, in which alpha-l adrenergic receptors are the single most important receptor involved in the maintenance of blood pressure and circu latory function. It is appropriate, therefore, that recent findings related to the pharmacology and biochemistry of the alpha-l adrenergic receptor be compiled, since this subject has not been reviewed in detail in recent years. It is the purpose of this book to present a series of reviews of key experimental findings that shed new light on the alpha-l adrenergic receptor and the manner in which it functions. Classically, most receptors have been characterized based on structure-activity relationships obtained for selective agonists and antagonists interacting with the receptor. Although there are many newer and more sophisticated approaches to receptor char acterization, structure-activity relationships still provide impor tant information regarding the chemical requirements made by the receptor for its occupation by ligands and its subsequent acti vation by those ligands possessing intrinsic efficacy and, there fore, agonist activity.

Author : Anonim
Publisher : Unknown
Page : 252 pages
File Size : 55,9 Mb
Release : 1993
Category : Drug receptors
ISBN : MINN:31951D009489860

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Sigma, PCP, and NMDA Receptors by Anonim Pdf

Author : National Institutes of Health (U.S.)
Publisher : Unknown
Page : 628 pages
File Size : 43,6 Mb
Release : 1985
Category : Biochemistry
ISBN : UOM:39015052211151

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Scientific Directory and Annual Bibliography by National Institutes of Health (U.S.) Pdf

Each issue lists papers published during the preceding year.

Author : D.G. Grahame-Smith
Publisher : Elsevier
Page : 484 pages
File Size : 43,7 Mb
Release : 2016-01-22
Category : Medical
ISBN : 9781483275338

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Preclinical Psychopharmacology by D.G. Grahame-Smith Pdf

Psychopharmacology, Volume 2: Preclinical Psychopharmacology presents the mechanism of action of antidepressant drugs and neuroleptics. This book discusses the significance of the interaction between various neurotransmitter system in both biochemical and functional consequences of repeated drug administration. Organized into 12 chapters, this volume begins with an overview of the effects of antidepressant drugs on norepinephrine metabolism. This text then discusses the different aspects of monoamine oxidase and its inhibitors. Other chapters consider the mechanism of action of lithium, which requires consideration of some of the general characteristics of periodic behavior. This book discusses as well the preclinical aspects of tranquilizers, particularly those dealing with benzodiazepines and non-benzodiazepines acting through the benzodiazepine receptor. The final chapter deals with the various behavioral and electrophysiological effects of cocaine in animals, which presumably reflect both local anesthetic properties and action on monoamine mechanisms. This book is a valuable resource for neuropharmacologists and practicing psychiatrists.

Author : Anonim
Publisher : Unknown
Page : 260 pages
File Size : 55,7 Mb
Release : 1976
Category : Drug abuse
ISBN : COLUMBIA:HR01752260

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NIDA Research Monograph by Anonim Pdf

Author : National Academy of Sciences,Institute of Medicine,Sandra Ackerman
Publisher : National Academies Press
Page : 195 pages
File Size : 41,5 Mb
Release : 1992-01-01
Category : Medical
ISBN : 9780309045292

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Discovering the Brain by National Academy of Sciences,Institute of Medicine,Sandra Ackerman Pdf

The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brainâ€"an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines: How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attentionâ€"and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniquesâ€"what various technologies can and cannot tell usâ€"and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakersâ€"and many scientists as wellâ€"with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."

Author : Amitabha Chattopadhyay
Publisher : CRC Press
Page : 230 pages
File Size : 44,8 Mb
Release : 2007-05-17
Category : Medical
ISBN : 9781420005752

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Serotonin Receptors in Neurobiology by Amitabha Chattopadhyay Pdf

A number of developments spanning a multitude of techniques makes this an exciting time for research in serotonin receptors. A comprehensive review of the subject from a multidisciplinary perspective, Serotonin Receptors in Neurobiology is among the first books to include information on serotonin receptor knockout studies. With contributions from l

Author : Rafael Luján,Francisco Ciruela
Publisher : Humana
Page : 0 pages
File Size : 44,6 Mb
Release : 2016-02-02
Category : Medical
ISBN : 149393063X

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Receptor and Ion Channel Detection in the Brain by Rafael Luján,Francisco Ciruela Pdf

Receptor and Ion Channel Detection in the Brain provides state-of-the-art and up-to-date methodological information on molecular, neuroanatomical and functional techniques that are currently used to study neurotransmitter receptors and ion channels in the brain. The chapters have been contributed by world-wide recognized neuroscientists who explain in an easy and detailed way well established and tested protocols embracing molecular, cellular, subcellular, anatomical and electrophysiological aspects of the brain. This comprehensive and practical manual is presented in a simple, step-by-step manner for laboratory use, and also offers unambiguous detail and key implementation advice that proves essential for successful results and facilitate choosing the best method for the target proteins under study. This work serves as a useful guide for young researchers and students in training as well as for neurologists and established scientists who wish to extend their repertoire of techniques.