C Myc Function In Neoplasia

Author : C.V. Dang,Linda A. Lee
Publisher : Springer Science & Business Media
Page : 208 pages
File Size : 47,7 Mb
Release : 2013-11-21
Category : Medical
ISBN : 9783662226810

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c-Myc Function in Neoplasia by C.V. Dang,Linda A. Lee Pdf

1. 1 SCOPE OF BOOK n explosion of novel findings in the past decade has contrib A uted to the great progress toward understanding the biology of human cancers. Much of this progress can be attributed to our abil ity to dissect many biological processes at the molecular level. Most spectacular is the technology of molecular biology that allows identi fication and characterization of genes that participate in the genesis of human cancers. Three major groups of genes appear to play out the drama of cancer development: tumor suppressor genes, mis match repair genes, and oncogenes. The tumor suppressor genes 1 encode products that are inhibitory to cell proliferation. The loss of these inhibitors, by mutation or deletion, can unleash cells from their restraints to proliferate. Mutations in the mismatch repair 2 10 genes also have been implicated in tumorigenesis. - The inability of cells to repair spontaneously occurring mutations leads to genom ic instability and could potentially result in the accumulation of car cinogenic DNA lesions. Finally, activation of proto-oncogenes, which are normal cellular genes, into oncogenes could accelerate the 11 processes of cell proliferation. c-myc was one of the very first proto oncogenes to be identified and because it normally plays pivotal roles in both cell proliferation and cell death has enticed many to investigate the molecular mechanisms by which it transforms cells.

Author : Chi V. Dang,Linda A. Lee
Publisher : R G Landes Company
Page : 196 pages
File Size : 46,7 Mb
Release : 1995
Category : Medical
ISBN : 1570593124

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C-Myc Function in Neoplasia by Chi V. Dang,Linda A. Lee Pdf

Author : Chi V. Dang,Robert N. Eisenman
Publisher : Cold Spring Harbor Perspective
Page : 0 pages
File Size : 52,5 Mb
Release : 2014
Category : Medical
ISBN : 1621820084

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MYC and the Pathway to Cancer by Chi V. Dang,Robert N. Eisenman Pdf

The MYC gene family plays essential roles in normal development and in multiple cellular functions. Moreover aberrant MYC gene activation is profoundly involved in the etiology of a wide range of cancers. MYC encodes a transcriptional regulator that modulates expression of genes controlling cell growth, proliferation, metabolism, differentiation, and death. Deregulation of these expression programs has been linked to MYC's function in tumor initiation, progression, and survival. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers all aspects of MYC biology. The contributors discuss its normal functions in the control of cell growth, cell competition, pluripotency, and development, as well as the molecular basis for the effects of the MYC protein on transcription. In addition, they examine how MYC interacts with other proteins, induces apoptosis, and impacts metabolism, genomic stability, and microRNA expression. The authors also provide a detailed analysis of the role of MYC in tumor initiation and progression. Its involvement in cancers such as medulloblastoma, neuroblastoma, and Burkitt's lymphoma is examined, as are the prospects for anti-MYC therapies in cancer treatment. This book is essential reading for all cancer biologists, as well as researchers studying the regulation of gene expression.

Author : Michael Potter,Fritz Melchers
Publisher : Springer Science & Business Media
Page : 288 pages
File Size : 47,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642608018

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C-Myc in B-Cell Neoplasia by Michael Potter,Fritz Melchers Pdf

The papers in this book were presented at the 14th Mechanisms in B-cell Neoplasia meeting that was held in Bethesda, Maryland October 21-23, 1996. In 1995 the organizers decided that the format of the meeting would be changed and that specific topics relevant to B-cell neoplasia would be discussed. This year's topic is on the c-myc oncogene in B-cell neoplasia which has been discussed in virtually every previous meeting. Some of the presentations announced for the first time dramatic advances in our understanding of c-myc and because this subject has become highly complex it was thought that devoting the whole meeting to this theme would be appropriate. The book, therefore, repre sents a review of many aspects of the myc problem but by no means is truly comprehensive. In a recent Medline search there were 8,505 references to myc, fully illustrating the magnitude of the interest and depth of this field. The organizers of the meeting have each contributed review chapters that summarize different aspects of the meeting. We thank the National Cancer Institute for sponsoring this workshop and the staff of Cygnus, Inc. , for their outstanding organizational assistance. The organizers are most grateful to Vickie Rogers for assembling the book and dealing with the edi torialization of the manuscripts. MICHAEL POlTER FRITZ MELCHERS Table of Contents M. POlTER and K. B. MARCU The c-myc Story: Where We've Been, Where We Seem to be Going. With 2 Figures . . . . . . . . . . . . . . . . . . . . . . . . I F.

Author : Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Publisher : John Wiley & Sons
Page : 2008 pages
File Size : 44,7 Mb
Release : 2017-03-10
Category : Medical
ISBN : 9781119000846

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Holland-Frei Cancer Medicine by Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland Pdf

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Author : Anne Le
Publisher : Springer
Page : 186 pages
File Size : 54,7 Mb
Release : 2018-06-26
Category : Medical
ISBN : 9783319777368

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The Heterogeneity of Cancer Metabolism by Anne Le Pdf

Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Author : R.S. Verma
Publisher : Elsevier
Page : 445 pages
File Size : 49,8 Mb
Release : 1995-09-25
Category : Medical
ISBN : 0080526160

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Genetics of Human Neoplasia by R.S. Verma Pdf

The underlying idea that cancer is a genetic disease at the cellular level was postulated over 75 years ago when Boveri hypothesised that the malignant cell was one that had obtained an abnormal chromatin content. However, it has been only the last decade where enormous strides have been made toward understanding neoplastic development. Explosive growth in the discipline of cancer genetics is so rapid that any attempt to review this subject becomes rapidly outdated and continuous revisions are warranted. Conclusive evidence has been reached associating specific chromosomal abnormalities to various cancers. We have just begun to characterise the genes, which are involved in these consistent chromosomal rearrangements resulting in the elucidation of the mechanisms of neoplastic transformation at a molecular level. The identification of over 50 oncogenes has led to a better understanding of the physiological process. Tumor suppresser genes, which were discovered through inheritance mechanisms, have further shed some light towards understanding the loss of heterozygosity during carcinogenesis. The message emerging with increasing clarity concerning specific pathways which regulate the fundamental process of cell division and uncontrolled growth. The advances in molecular biology have led to a major insight in establishing precise diagnosis and treatment of many cancers resulting in prevention of death. The field is expanding so rapidly that a complete account of all aspects of genetics of cancer could not be accommodated within the scope of a single volume format. Nevertheless, a few very specific topics have been chosen, which readers may find of great interest in hopes that their interest may be rejuvenated concerning the bewildering nature of this deadly disease. The contributors to Volume 3 have provided up-to-date accounts of their fields of expertise. Although the contributors have kept their chapters brief, they include an extensive bibliography for those who wish to understand a particular topic in depth. For more than a century, cancer has been diagnosed on the enigmatic basis of morphological features. Establishing a diagnosis based on DNA, RNA, and proteins, which is done routinely now, was once inconceivable. Cloning a gene of hematopoietic origin is no longer a fantasy. The approach has shifted over the past 15 years from identification of chromosomal abnormalities toward zeroing in on cancer genes.

Author : John Mendelsohn,Peter M. Howley,Mark A. Israel,Joe W. Gray,Craig B. Thompson
Publisher : Elsevier Health Sciences
Page : 1948 pages
File Size : 52,9 Mb
Release : 2008-04-01
Category : Medical
ISBN : 9781437710991

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The Molecular Basis of Cancer by John Mendelsohn,Peter M. Howley,Mark A. Israel,Joe W. Gray,Craig B. Thompson Pdf

Successfully fighting cancer starts with understanding how it begins. This thoroughly revised 3rd Edition explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of cancer. A team of leading experts thoroughly explain the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Incorporating cutting-edge advances and the newest research, the book provides thorough descriptions of everything from molecular abnormalities in common cancers to new approaches for cancer therapy. Features sweeping updates throughout, including molecular targets for the development of anti-cancer drugs, gene therapy, and vaccines...keeping you on the cutting edge of your specialty. Offers a new, more user-friendly full-color format so the information that you need is easier to find. Presents abundant figures-all redrawn in full color-illustrating major concepts for easier comprehension. Features numerous descriptions of the latest clinical strategies-helping you to understand and take advantage of today’s state-of-the-art biotechnology advances.

Author : Walter R. Paukovits
Publisher : CRC Press
Page : 326 pages
File Size : 48,6 Mb
Release : 2018-01-18
Category : Science
ISBN : 9781351089227

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Growth Regulation and Carcinogenesis by Walter R. Paukovits Pdf

Growth Regulation and Carcinogenesis discusses topics such as growth factors, including stimulators and inhibitors of proliferation; networks in proliferation regulation; differentiation-inducing factors; origins of neoplasia and their relationship to growth control; genetic alterations in cellular regulatory machinery; extrachromosomal phenomena; non-genotoxic carcinogens; immortalization and transformation of cells; and the role of cell production, cell function, and cell elimination in physiological growth control.

Author : George F. Vande Woude,George Klein
Publisher : Elsevier
Page : 437 pages
File Size : 50,7 Mb
Release : 2007-12-17
Category : Medical
ISBN : 9780080556512

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Advances in Cancer Research by George F. Vande Woude,George Klein Pdf

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics including RUNX Genes in Development and Cancer; The RNA Continent; The c-myc Promoter; Designer Self-Assembling Peptide Nanofiber Scaffolds for Study of 3-D Cell Biology and Beyond; and Dendritic Cells in Cancer. Immunotherapy

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 49,8 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Walter R. Paukovits
Publisher : CRC Press
Page : 338 pages
File Size : 40,8 Mb
Release : 1990-12-19
Category : Medical
ISBN : UOM:39015019565541

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Growth Regulation & Carcinogenesis by Walter R. Paukovits Pdf

Growth Regulation and Carcinogenesis discusses topics such as growth factors, including stimulators and inhibitors of proliferation; networks in proliferation regulation; differentiation-inducing factors; origins of neoplasia and their relationship to growth control; genetic alterations in cellular regulatory machinery; extrachromosomal phenomena; non-genotoxic carcinogens; immortalization and transformation of cells; and the role of cell production, cell function, and cell elimination in physiological growth control.

Author : Kathy B. Burck,Edison T. Liu,James W. Larrick
Publisher : Springer Science & Business Media
Page : 312 pages
File Size : 43,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461237181

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Oncogenes by Kathy B. Burck,Edison T. Liu,James W. Larrick Pdf

"Cancer viruses" have played a paradoxical role in the history of cancer research. Discovered in 1911 by Peyton Rous (1) at the Rockefeller Institute, they were largely ignored for several decades. Witness his eventual recognition for a Nobel Prize, but not until 1966-setting an all time record for latency, and testimony to one more advantage of longevity. In the 1950s, another Rockefeller Nobelist, Wendell Stanley, spearheaded a campaign to focus attention on viruses as etiological agents in cancer, his plat form having been the chemical characterization of the tobacco mosaic virus as a pure protein-correction, ribonucleoprotein-in 1935 (2). This doctrine was a centerpiece of the U.S. National Cancer Crusade of 1971: if human cancers were caused by viruses, the central task was to isolate them and prepare vaccines for immunization. At that point, many observers felt that perhaps too much attention was being devoted to cancer viruses. It was problematic whether viruses played an etiological role in more than a handful of human cancers.

Author : Yahwardiah Siregar
Publisher : Inst za onkologiju i radiol
Page : 497 pages
File Size : 45,6 Mb
Release : 2013-01-24
Category : Medical
ISBN : 9789535108580

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Oncogene and Cancer by Yahwardiah Siregar Pdf

This book describes a course of cancer growth starting from normal cells to cancerous form and the genomic instability, the cancer treatment as well as its prevention in form of the invention of a vaccine. Some diseases are also discussed in detail, such as breast cancer, leucaemia, cervical cancer, and glioma. Understanding cancer through its molecular mechanism is needed to reduce the cancer incidence. How to treat cancer more effectively and the problems like drug resistance and metastasis are very clearly illustrated in this publication as well as some research result that could be used to treat the cancer patients in the very near future. The book was divided into six main sections: 1. HER2 Carcinogenesis: Etiology, Treatment and Prevention; 2. DNA Repair Mechanism and Cancer; 3. New Approach to Cancer Mechanism; 4. New Role of Oncogenes and Tumor Suppressor Genes; 5. Non Coding RNA and Micro RNA in Tumorigenesis; 6. Oncogenes for Transcription Factors

Author : Laura Soucek,Jonathan Whitfield
Publisher : Humana
Page : 349 pages
File Size : 47,7 Mb
Release : 2021-05-23
Category : Science
ISBN : 1071614789

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The Myc Gene by Laura Soucek,Jonathan Whitfield Pdf

This second edition provides new and updated chapters detailing recent advances in MYC research and current techniques. Chapters guide readers through protocols on how to express and purify MYC protein, X-ray crystallography, NMR, techniques to study how MYC is modified, apoptosis, senescence, proliferation, metabolic changes, translation, tumorigenesis,reprogramming, and clinical application of MYC studies.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, The Myc Gene: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field.