Myc And The Pathway To Cancer

Author : Chi V. Dang,Robert N. Eisenman
Publisher : Cold Spring Harbor Perspective
Page : 0 pages
File Size : 44,6 Mb
Release : 2014
Category : Medical
ISBN : 1621820084

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MYC and the Pathway to Cancer by Chi V. Dang,Robert N. Eisenman Pdf

The MYC gene family plays essential roles in normal development and in multiple cellular functions. Moreover aberrant MYC gene activation is profoundly involved in the etiology of a wide range of cancers. MYC encodes a transcriptional regulator that modulates expression of genes controlling cell growth, proliferation, metabolism, differentiation, and death. Deregulation of these expression programs has been linked to MYC's function in tumor initiation, progression, and survival. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers all aspects of MYC biology. The contributors discuss its normal functions in the control of cell growth, cell competition, pluripotency, and development, as well as the molecular basis for the effects of the MYC protein on transcription. In addition, they examine how MYC interacts with other proteins, induces apoptosis, and impacts metabolism, genomic stability, and microRNA expression. The authors also provide a detailed analysis of the role of MYC in tumor initiation and progression. Its involvement in cancers such as medulloblastoma, neuroblastoma, and Burkitt's lymphoma is examined, as are the prospects for anti-MYC therapies in cancer treatment. This book is essential reading for all cancer biologists, as well as researchers studying the regulation of gene expression.

Author : C.V. Dang,Linda A. Lee
Publisher : Springer Science & Business Media
Page : 208 pages
File Size : 42,7 Mb
Release : 2013-11-21
Category : Medical
ISBN : 9783662226810

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c-Myc Function in Neoplasia by C.V. Dang,Linda A. Lee Pdf

1. 1 SCOPE OF BOOK n explosion of novel findings in the past decade has contrib A uted to the great progress toward understanding the biology of human cancers. Much of this progress can be attributed to our abil ity to dissect many biological processes at the molecular level. Most spectacular is the technology of molecular biology that allows identi fication and characterization of genes that participate in the genesis of human cancers. Three major groups of genes appear to play out the drama of cancer development: tumor suppressor genes, mis match repair genes, and oncogenes. The tumor suppressor genes 1 encode products that are inhibitory to cell proliferation. The loss of these inhibitors, by mutation or deletion, can unleash cells from their restraints to proliferate. Mutations in the mismatch repair 2 10 genes also have been implicated in tumorigenesis. - The inability of cells to repair spontaneously occurring mutations leads to genom ic instability and could potentially result in the accumulation of car cinogenic DNA lesions. Finally, activation of proto-oncogenes, which are normal cellular genes, into oncogenes could accelerate the 11 processes of cell proliferation. c-myc was one of the very first proto oncogenes to be identified and because it normally plays pivotal roles in both cell proliferation and cell death has enticed many to investigate the molecular mechanisms by which it transforms cells.

Author : Robert Clarke
Publisher : Springer
Page : 220 pages
File Size : 43,9 Mb
Release : 2019-03-01
Category : Medical
ISBN : 9783030050672

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The Unfolded Protein Response in Cancer by Robert Clarke Pdf

This volume presents state-of-the-art information on each of the arms of the unfolded protein response (UPR), how their activation/repression are regulated, integrated, and coordinated, how UPR components affect cancer cell biology and responsiveness to therapeutic interventions, and how UPR components/activities offer potentially novel targets for drug discovery, repurposing, and development. The volume will provide the most recent information on the signaling and regulation of the UPR, explore examples of how the UPR and/or specific components contribute to cancer biology, and identify and explore specific examples of potently new actionable targets for drug discovery and development from within the UPR and its regulation. Unique to the volume will be a specific focus on the UPR and its role in cancer biology, as well as a discussion of the role of the UPR in drug responses and resistance in cancer.

Author : Anne Le
Publisher : Springer
Page : 186 pages
File Size : 49,8 Mb
Release : 2018-06-26
Category : Medical
ISBN : 9783319777368

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The Heterogeneity of Cancer Metabolism by Anne Le Pdf

Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Author : Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Publisher : John Wiley & Sons
Page : 2008 pages
File Size : 53,9 Mb
Release : 2017-03-10
Category : Medical
ISBN : 9781119000846

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Holland-Frei Cancer Medicine by Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland Pdf

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Author : Manfred Schwab
Publisher : Springer Science & Business Media
Page : 3307 pages
File Size : 52,6 Mb
Release : 2008-09-23
Category : Medical
ISBN : 9783540368472

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Encyclopedia of Cancer by Manfred Schwab Pdf

This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.

Author : John Mendelsohn,Peter M. Howley,Mark A. Israel,Joe W. Gray,Craig B. Thompson
Publisher : Elsevier Health Sciences
Page : 1948 pages
File Size : 53,9 Mb
Release : 2008-04-01
Category : Medical
ISBN : 9781437710991

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The Molecular Basis of Cancer by John Mendelsohn,Peter M. Howley,Mark A. Israel,Joe W. Gray,Craig B. Thompson Pdf

Successfully fighting cancer starts with understanding how it begins. This thoroughly revised 3rd Edition explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of cancer. A team of leading experts thoroughly explain the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Incorporating cutting-edge advances and the newest research, the book provides thorough descriptions of everything from molecular abnormalities in common cancers to new approaches for cancer therapy. Features sweeping updates throughout, including molecular targets for the development of anti-cancer drugs, gene therapy, and vaccines...keeping you on the cutting edge of your specialty. Offers a new, more user-friendly full-color format so the information that you need is easier to find. Presents abundant figures-all redrawn in full color-illustrating major concepts for easier comprehension. Features numerous descriptions of the latest clinical strategies-helping you to understand and take advantage of today’s state-of-the-art biotechnology advances.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 52,8 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Sam Thiagalingam
Publisher : Cambridge University Press
Page : 597 pages
File Size : 40,6 Mb
Release : 2015-04-09
Category : Mathematics
ISBN : 9780521493390

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Systems Biology of Cancer by Sam Thiagalingam Pdf

An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.

Author : Anonim
Publisher : Unknown
Page : 4 pages
File Size : 49,7 Mb
Release : 1986
Category : Cells
ISBN : MINN:30000010710451

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Cellular Transforming Genes by Anonim Pdf

Author : Laura Soucek,Jonathan Whitfield
Publisher : Humana
Page : 349 pages
File Size : 53,5 Mb
Release : 2021-05-23
Category : Science
ISBN : 1071614789

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The Myc Gene by Laura Soucek,Jonathan Whitfield Pdf

This second edition provides new and updated chapters detailing recent advances in MYC research and current techniques. Chapters guide readers through protocols on how to express and purify MYC protein, X-ray crystallography, NMR, techniques to study how MYC is modified, apoptosis, senescence, proliferation, metabolic changes, translation, tumorigenesis,reprogramming, and clinical application of MYC studies.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, The Myc Gene: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field.

Author : M. A. Hayat
Publisher : Academic Press
Page : 430 pages
File Size : 48,7 Mb
Release : 2016-12-28
Category : Medical
ISBN : 9780128094273

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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging by M. A. Hayat Pdf

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections. Presents the most advanced information regarding the role of the autophagic system in life and death Examines whether autophagy acts fundamentally as a cell survivor or cell death pathway or both Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation Features recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, including atherosclerosis and CNS tumors, and their development and treatment Includes chapters authored by leaders in the field around the globe—the broadest, most expert coverage available

Author : David A. Frank
Publisher : Springer Science & Business Media
Page : 358 pages
File Size : 53,6 Mb
Release : 2002-12-31
Category : Medical
ISBN : 9781402073403

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Signal Transduction in Cancer by David A. Frank Pdf

One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."

Author : Theodor Boveri
Publisher : Unknown
Page : 108 pages
File Size : 51,5 Mb
Release : 2008
Category : Medical
ISBN : STANFORD:36105131699378

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Concerning the Origin of Malignant Tumours by Theodor Boveri Pdf

An English translation of Boveri's famous monograph which was first published in Germany in 1914. Written almost a hundred years ago, Theodor Boveri's Zur Frage der Entstehung maligner Tumoren has had a momentous impact on cancer research. In it he argues that malignancy arises as a consequence of chromosomal abnormalities and that multiplication is an inherent property of cells. With astonishing prescience, Boveri predicts in this monograph the existence of tumor suppressor mechanisms and is perhaps the first to suggest that hereditary factors (genes) are linearly arranged along chromosomes. This new translation by Sir Henry Harris, Regius Professor of Medicine Emeritus at Oxford University and former Editor-in-Chief of Journal of Cell Science, includes extensive annotations in which he discusses the relevance of Boveri's views today. It is essential reading for all cancer researchers, as well as those interested in the history of cytogenetics and cell biology.

Author : Robert N. Eisenman
Publisher : Springer
Page : 0 pages
File Size : 54,8 Mb
Release : 2014-09-23
Category : Medical
ISBN : 3642421415

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The Myc/Max/Mad Transcription Factor Network by Robert N. Eisenman Pdf

Scientists often look askance at their colleagues whose research appears too strongly focused on a single gene or gene product. We are supposed to be interested in the “big picture” and excessive zeal in pursuit of a single pixel might seem to border on an obsession that is likely to yield only details. However as this volume of Current Topics in Microbiology and Immunology demonstrates, this is certainly not the case for myc. Intense study of this en- matic proto-oncogene over the last twenty years has only broadened our view of its functions and led to insights into mechanisms relating to transcriptional regulation as well as to cell growth, proliferation, differentiation, apoptosis and organismal development. The myc gene originally came to light as a retroviral oncogene (v-myc) associated with a wide range of acute neoplasms. It was later shown to be a virally transduced cellular gene (c-myc) which is a member of family of on- genes (c-myc,N-myc,L-myc). These family members are themselves subject to a bewildering assortment of genetic rearrangements associated with many different types of tumors derived from many different types of cells. These rearrangements (including chromosomal translocation, viral integration, and gene ampli?cation) act to uncouple expression of the myc family genes from their normal physiological regulators. The chapter by LIU and LEVENS - scribes the key pathways leading to regulation of myc expression, showing that such regulation occurs at several different levels and through multiple mechanisms.