Cancer Diagnostics With Dna Microarrays

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Cancer Diagnostics with DNA Microarrays

Steen Knudsen
Cancer Diagnostics with DNA Microarrays Book PDF

Author : Steen Knudsen
Publisher : John Wiley & Sons
Page : 272 pages
File Size : 47,6 Mb
Release : 2006-11-03
Category : Science
ISBN : 9780470041093

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Cancer Diagnostics with DNA Microarrays by Steen Knudsen Pdf

Authored by an international authority in the field,Cancer Diagnostics with DNA Microarrays is a complete reference work on the rapidly growing use of DNA microarray data in the diagnosis of and treatment planning for a large number of human cancers. Uniquely deals with direct clinical application of microarray data to oncology diagnosis, leading to more effective diagnosis of and clearer treatment regimens for a wide range of human cancers Offers clinicians summary presentation of state-of-the-art science of DNA microarrays Each chapter includes bibliographic and further reading suggestions Easily accessible, assuming no special training in statistics or bioinformatics Replete with examples and mini-cases, Cancer Diagnostics with DNA Microarrays offers cancer researchers in private, pharmacologic, and governmental institutions, biomedical statisticians, and practicing oncologists concise, thoughtfully authored guidance on the use of microarray data and analysis as clinical tools. The text carefully addresses the needs of end users – researchers and physicians – using microarrays as a tool to be applied in common clinical situations, and is of interest for students in medicine and biology and professionals in health care as well.

Microarray Technology and Cancer Gene Profiling

Simone Mocellin
Microarray Technology and Cancer Gene Profiling Book PDF

Author : Simone Mocellin
Publisher : Springer Science & Business Media
Page : 176 pages
File Size : 45,8 Mb
Release : 2007-08-28
Category : Medical
ISBN : 9780387399782

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Microarray Technology and Cancer Gene Profiling by Simone Mocellin Pdf

Given the revolutionary implications that the use of this technology might have in the clinical management of cancer patients, the principles of DNA array-based tumor gene profiling must be clearly understood for the data to be correctly interpreted and appreciated. This book, written by leading experts, discusses the technical features characterizing the powerful laboratory tool of microarray technology, and reviews applications in the field of oncology.

DNA Microarray Technology and Data Analysis in Cancer Research

Shaoguang Li
DNA Microarray Technology and Data Analysis in Cancer Research Book PDF

Author : Shaoguang Li
Publisher : World Scientific
Page : 131 pages
File Size : 48,8 Mb
Release : 2008
Category : Science
ISBN : 9789812790460

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DNA Microarray Technology and Data Analysis in Cancer Research by Shaoguang Li Pdf

DNA microarray technology has become a useful technique in gene expression analysis for the development of new diagnostic tools and for the identification of disease genes and therapeutic targets for human cancers. Appropriate control for DNA microarray experiment and reliable analysis of the array data are key to performing the assay and utilizing the data correctly. The most difficult challenge has been the lack of a powerful method to analyze the data for all genes (more than 30,000 genes) simultaneously and to use the microarray data in a decision-making process. In this book, the authors describe DNA microarray technology and data analysis by pointing out current advantages and disadvantages of the technique and available analytical methods. Crucially, new ideas and analytical methods based on the authors'' own experience in DNA microarray study and analysis are introduced. It is believed that this new way of interpreting and analyzing microarray data will bring us closer to success in decision-making using the information obtained through the DNA microarray technology.

High-dimensional Microarray Data Analysis

Shuichi Shinmura
High dimensional Microarray Data Analysis Book PDF

Author : Shuichi Shinmura
Publisher : Springer
Page : 419 pages
File Size : 44,5 Mb
Release : 2019-05-14
Category : Medical
ISBN : 9789811359989

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High-dimensional Microarray Data Analysis by Shuichi Shinmura Pdf

This book shows how to decompose high-dimensional microarrays into small subspaces (Small Matryoshkas, SMs), statistically analyze them, and perform cancer gene diagnosis. The information is useful for genetic experts, anyone who analyzes genetic data, and students to use as practical textbooks. Discriminant analysis is the best approach for microarray consisting of normal and cancer classes. Microarrays are linearly separable data (LSD, Fact 3). However, because most linear discriminant function (LDF) cannot discriminate LSD theoretically and error rates are high, no one had discovered Fact 3 until now. Hard-margin SVM (H-SVM) and Revised IP-OLDF (RIP) can find Fact3 easily. LSD has the Matryoshka structure and is easily decomposed into many SMs (Fact 4). Because all SMs are small samples and LSD, statistical methods analyze SMs easily. However, useful results cannot be obtained. On the other hand, H-SVM and RIP can discriminate two classes in SM entirely. RatioSV is the ratio of SV distance and discriminant range. The maximum RatioSVs of six microarrays is over 11.67%. This fact shows that SV separates two classes by window width (11.67%). Such easy discrimination has been unresolved since 1970. The reason is revealed by facts presented here, so this book can be read and enjoyed like a mystery novel. Many studies point out that it is difficult to separate signal and noise in a high-dimensional gene space. However, the definition of the signal is not clear. Convincing evidence is presented that LSD is a signal. Statistical analysis of the genes contained in the SM cannot provide useful information, but it shows that the discriminant score (DS) discriminated by RIP or H-SVM is easily LSD. For example, the Alon microarray has 2,000 genes which can be divided into 66 SMs. If 66 DSs are used as variables, the result is a 66-dimensional data. These signal data can be analyzed to find malignancy indicators by principal component analysis and cluster analysis.

Microarrays in Diagnostics and Biomarker Development

Bertrand Jordan
Microarrays in Diagnostics and Biomarker Development Book PDF

Author : Bertrand Jordan
Publisher : Springer Science & Business Media
Page : 241 pages
File Size : 54,7 Mb
Release : 2012-04-23
Category : Medical
ISBN : 9783642282034

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Microarrays in Diagnostics and Biomarker Development by Bertrand Jordan Pdf

Microarray technology has made strong progress over the past decade, and there have also been significant changes in application areas, from nucleic acids to proteomics and from research to clinical applications. This book provides a comprehensive overview of microarrays in diagnostics and biomarker development, covering DNA, peptide, protein and tissue arrays. The focus is on entities that are in actual clinical use, or quite close, and on recent developments, such as peptide and aptamer arrays. A further topic is the miniaturisation towards “nanoarrays”, which is expected to have great potential in clinical applications. Relevant issues of bioinformatics and statistical analysis of array data are discussed in detail, as well as the barriers to the commercialisation of array-based tests and the vexing IP issues involved. Thus, the book should be very useful tor active array users as well as to newcomers seeking to make the best choice between different technologies.

DNA Microarrays

Mark Schena
DNA Microarrays Book PDF

Author : Mark Schena
Publisher : Scion Publishing Ltd
Page : 289 pages
File Size : 46,5 Mb
Release : 2007-10-01
Category : Science
ISBN : 9781907904394

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DNA Microarrays by Mark Schena Pdf

DNA Microarrays: Methods Express covers the very latest in DNA microarray technology, with a clear focus on how these techniques can be used in the lab to gain the very best results. The authors are from some of the leading laboratories in the field and write with real authority on the latest methodology. Every chapter provides detailed step-by-step protocols with valuable hints and tips for success, as well as giving typical experimental results and selected literature citations. This book is a 'must have' manual for researchers in all fields of biology, medicine and agriculture.

Microarray Technology and Cancer Gene Profiling

Simone Mocellin
Microarray Technology and Cancer Gene Profiling Book PDF

Author : Simone Mocellin
Publisher : Springer
Page : 0 pages
File Size : 47,9 Mb
Release : 2008-11-01
Category : Medical
ISBN : 038751600X

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Microarray Technology and Cancer Gene Profiling by Simone Mocellin Pdf

Given the revolutionary implications that the use of this technology might have in the clinical management of cancer patients, the principles of DNA array-based tumor gene profiling must be clearly understood for the data to be correctly interpreted and appreciated. This book, written by leading experts, discusses the technical features characterizing the powerful laboratory tool of microarray technology, and reviews applications in the field of oncology.

The Applications of Bioinformatics in Cancer Detection

Asad Umar,Izet Kapetanovic,Javed Khan (M.D.)
The Applications of Bioinformatics in Cancer Detection Book PDF

Author : Asad Umar,Izet Kapetanovic,Javed Khan (M.D.)
Publisher : Unknown
Page : 296 pages
File Size : 52,9 Mb
Release : 2004
Category : Cancer
ISBN : UVA:X004793340

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The Applications of Bioinformatics in Cancer Detection by Asad Umar,Izet Kapetanovic,Javed Khan (M.D.) Pdf

The state of the science of bioinformatics - that is, application of computer processes to solving biological problems - and its potential for assisting early cancer detection, risk assessment, and risk reduction form the focus of this volume.

Bioarrays

Krishnarao Appasani
Bioarrays Book PDF

Author : Krishnarao Appasani
Publisher : Springer Science & Business Media
Page : 269 pages
File Size : 43,7 Mb
Release : 2007-10-04
Category : Science
ISBN : 9781597453288

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Bioarrays by Krishnarao Appasani Pdf

This book provides an integrated collection of timely articles on the use of bioarray techniques in the fields of biotechnology and molecular medicine. It is the first book to comprehensively integrate molecular diagnostics and molecular pathology. This book serves as an indispensable reference for graduate students, post-docs, and professors as well as an explanatory analysis for executives and scientists in biotechnology and pharmaceutical companies.

Developing Biomarker-Based Tools for Cancer Screening, Diagnosis, and Treatment

Institute of Medicine,National Cancer Policy Forum
Developing Biomarker Based Tools for Cancer Screening Diagnosis and Treatment Book PDF

Author : Institute of Medicine,National Cancer Policy Forum
Publisher : National Academies Press
Page : 112 pages
File Size : 51,7 Mb
Release : 2006-11-18
Category : Medical
ISBN : 9780309101349

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Developing Biomarker-Based Tools for Cancer Screening, Diagnosis, and Treatment by Institute of Medicine,National Cancer Policy Forum Pdf

Research has long sought to identify biomarkers that could detect cancer at an early stage, or predict the optimal cancer therapy for specific patients. Fueling interest in this research are recent technological advances in genomics, proteomics, and metabolomics that can enable researchers to capture the molecular fingerprints of specific cancers and fine-tune their classification according to the molecular defects they harbor. The discovery and development of new markers of cancer could potentially improve cancer screening, diagnosis, and treatment. Given the potential impact cancer biomarkers could have on the cost effectiveness of cancer detection and treatment, they could profoundly alter the economic burden of cancer as well. Despite the promise of cancer biomarkers, few biomarker-based cancer tests have entered the market, and the translation of research findings on cancer biomarkers into clinically useful tests seems to be lagging. This is perhaps not surprising given the technical, financial, regulatory, and social challenges linked to the discovery, development, validation, and incorporation of biomarker tests into clinical practice. To explore those challenges and ways to overcome them, the National Cancer Policy Forum held the conference "Developing Biomarker-Based Tools for Cancer Screening, Diagnosis and Treatment: The State of the Science, Evaluation, Implementation, and Economics" in Washington, D.C., from March 20 to 22, 2006. At this conference, experts gave presentations in one of six sessions. In addition, seven small group discussions explored the policy implications surrounding biomarker development and adoption into clinical practice. Developing Biomarker-based Tools for Developing Cancer Screening, Diagnosis, and Treatment: The State of the Science, Evaluation, Implementation, and Economics-Workshop Summary presents the conference proceedings and will be used by an Institute of Medicine (IOM) committee to develop consensus-based recommendations for moving the field of cancer biomarkers forward.

Molecular Pathology in Cancer Research

Sunil R. Lakhani,Stephen B. Fox
Molecular Pathology in Cancer Research Book PDF

Author : Sunil R. Lakhani,Stephen B. Fox
Publisher : Springer
Page : 369 pages
File Size : 54,7 Mb
Release : 2017-01-20
Category : Medical
ISBN : 9781493966431

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Molecular Pathology in Cancer Research by Sunil R. Lakhani,Stephen B. Fox Pdf

The aim of the book is to discuss the application of molecular pathology in cancer research, and its contribution in the classification of different tumors and identification of potential molecular targets, as well as how this knowledge may be translated into clinical practice, and the huge impact this field is likely to have in the next 5 to 10 years.

Microarrays in Clinical Diagnostics

Thomas O. Joos,Paolo Fortina
Microarrays in Clinical Diagnostics Book PDF

Author : Thomas O. Joos,Paolo Fortina
Publisher : Springer Science & Business Media
Page : 283 pages
File Size : 40,9 Mb
Release : 2008-02-02
Category : Medical
ISBN : 9781592599233

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Microarrays in Clinical Diagnostics by Thomas O. Joos,Paolo Fortina Pdf

Leading academic and industrial investigators surveys the world of microarray technology, describing in step-by-step detail diverse DNA and protein assays in clinical laboratories using state-of-the-art technologies. The advanced tools and methods described are designed for mRNA expression analysis, SNP analysis, identification, and quantification of proteins, and for studies of protein-protein interactions. The protocols follow the successful Methods in Molecular BiologyTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.

DNA Microarrays

Ulrike Nuber
DNA Microarrays Book PDF

Author : Ulrike Nuber
Publisher : Taylor & Francis
Page : 320 pages
File Size : 53,9 Mb
Release : 2007-01-24
Category : Science
ISBN : 9781134243990

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DNA Microarrays by Ulrike Nuber Pdf

"DNA Microarrays" introduces the reader to the different types of DNA microarrays and their various applications. Furthermore, several data analysis methods are described. It is written for scientists who are entering the field of DNA microarrays, as well as for those already familiar with the technology, but interested in new applications and methods.

Expression Profiling of Human Tumors

Marc Ladanyi,William L. Gerald
Expression Profiling of Human Tumors Book PDF

Author : Marc Ladanyi,William L. Gerald
Publisher : Springer Science & Business Media
Page : 419 pages
File Size : 45,5 Mb
Release : 2003-05-01
Category : Medical
ISBN : 9781592593866

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Expression Profiling of Human Tumors by Marc Ladanyi,William L. Gerald Pdf

A comprehensive review of the use of global gene expression profiling to understand human tumors. The authors focus on the analysis of human tissue samples for a variety of cancers, including breast, colorectal, lung, renal, ovarian, bone, and brain tumors, among others. A primer on the technology and its novel analytical methods. Contains over 40 color images. Explains both the theory and practice of comprehensive gene expression profiling. Timely and topical, Expression Profiling of Human Tumors: Diagnostic and Research Applications offers every oncologist, pathologists, and cancer surgeons an essential introduction to the most promising new high-throughput investigative approaches in molecular biology-technology that is already dramatically reshaping the future of cancer research, diagnostic pathology, and clinical oncology.

Microarray Technology in Practice

Steven Russell,Lisa Ann Meadows,Roslin R. Russell
Microarray Technology in Practice Book PDF

Author : Steven Russell,Lisa Ann Meadows,Roslin R. Russell
Publisher : Academic Press
Page : 449 pages
File Size : 47,5 Mb
Release : 2009
Category : Medical
ISBN : 012372516X

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Microarray Technology in Practice by Steven Russell,Lisa Ann Meadows,Roslin R. Russell Pdf

"Microarray Technology is a volume presenting cutting-edge research on DNA microarray technology. As with other large-scale genomics approaches, microarray technologies are broadly applicable across disciplines of life and biomedical sciences, but remain daunting to many researchers. This comprehensive volume is a guide designed to demystify the technology and inform biologists about this critically important experimental technique. Expert authors highlight the utility of the technology using examples from human health and disease, such as malaria and cancer diagnostics. Microarray Technology in Practice provides the reader with an understanding of the rationale behind each of the analysis techniques and experimental methods used rather than focusing on complex underlying mathematics." --Book Jacket.