Cancer Vaccines And Immunotherapy

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Vaccines for Cancer Immunotherapy

Nima Rezaei,Mahsa Keshavarz-Fathi
Vaccines for Cancer Immunotherapy Book PDF

Author : Nima Rezaei,Mahsa Keshavarz-Fathi
Publisher : Academic Press
Page : 198 pages
File Size : 44,8 Mb
Release : 2018-10-17
Category : Medical
ISBN : 9780128140406

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Vaccines for Cancer Immunotherapy by Nima Rezaei,Mahsa Keshavarz-Fathi Pdf

Therapeutic cancer vaccines represent a type of active cancer immunotherapy. Clinicians, scientists, and researchers working on cancer treatment require evidence-based and up-to-date resources relating to therapeutic cancer vaccines. Vaccines for Cancer Immunotherapy provides a reference for cancer treatment for clinicians and presents a well-organized resource for determining high-potential research areas. The book considers that this promising modality can be made more feasible as a treatment for cancer. Chapters cover cancer immunology, general approaches to cancer immunotherapy, vaccines, tumor antigens, the strategy of allogeneic and autologous cancer vaccines, personalized vaccines, whole-tumor antigen vaccines, protein and peptide vaccines, dendritic cell vaccines, genetic vaccines, candidate cancers for vaccination, obstacles to developing therapeutic cancer vaccines, combination therapy, future perspectives and concluding remarks on therapeutic cancer vaccines. Introduces the feasible immunotherapeutic vaccines for patients with different types of cancer Presents the status of past and current vaccines for cancer treatment Considers advantages and disadvantages of different therapeutic cancer vaccines Looks at the combination of vaccines and other modalities, including immunotherapeutic and conventional methods Analyzes obstacles to development of therapeutic cancer vaccines Gives a view on future perspectives in the application of therapeutic cancer vaccines

Vaccines for Cancer Immunotherapy

Nima Rezaei,Mahsa Keshavarz-Fathi
Vaccines for Cancer Immunotherapy Book PDF

Author : Nima Rezaei,Mahsa Keshavarz-Fathi
Publisher : Academic Press
Page : 0 pages
File Size : 54,5 Mb
Release : 2018-10-22
Category : Medical
ISBN : 0128140399

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Vaccines for Cancer Immunotherapy by Nima Rezaei,Mahsa Keshavarz-Fathi Pdf

Therapeutic cancer vaccines represent a type of active cancer immunotherapy. Clinicians, scientists, and researchers working on cancer treatment require evidence-based and up-to-date resources relating to therapeutic cancer vaccines. Vaccines for Cancer Immunotherapy provides a reference for cancer treatment for clinicians and presents a well-organized resource for determining high-potential research areas. The book considers that this promising modality can be made more feasible as a treatment for cancer. Chapters cover cancer immunology, general approaches to cancer immunotherapy, vaccines, tumor antigens, the strategy of allogeneic and autologous cancer vaccines, personalized vaccines, whole-tumor antigen vaccines, protein and peptide vaccines, dendritic cell vaccines, genetic vaccines, candidate cancers for vaccination, obstacles to developing therapeutic cancer vaccines, combination therapy, future perspectives and concluding remarks on therapeutic cancer vaccines.

Cancer Vaccines and Immunotherapy

Peter L. Stern,Peter C. L. Beverley,Miles Carroll
Cancer Vaccines and Immunotherapy Book PDF

Author : Peter L. Stern,Peter C. L. Beverley,Miles Carroll
Publisher : Cambridge University Press
Page : 304 pages
File Size : 51,9 Mb
Release : 2000-08-17
Category : Medical
ISBN : 0521622638

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Cancer Vaccines and Immunotherapy by Peter L. Stern,Peter C. L. Beverley,Miles Carroll Pdf

Rapid progress in the definition of tumor antigens, and improved immunization methods, bring effective cancer vaccines within reach. In this wide-ranging survey, leading clinicians and scientists review therapeutic cancer vaccine strategies against a variety of diseases and molecular targets. Intended for an interdisciplinary readership, their contributions cover the rationale, development, and implementation of vaccines in human cancer treatment, with specific reference to cancer of the cervix, breast, colon, bladder, and prostate, and to melanoma and lymphoma. They review target identification, delivery vectors and clinical trial design. The book begins and ends with lucid overviews from the editors, that discuss the most recent developments.

Cancer Vaccines as Immunotherapy of Cancer

Luigi Buonaguro,Sjoerd Van Der Burg
Cancer Vaccines as Immunotherapy of Cancer Book PDF

Author : Luigi Buonaguro,Sjoerd Van Der Burg
Publisher : Academic Press
Page : 273 pages
File Size : 48,5 Mb
Release : 2022-03-04
Category : Science
ISBN : 9780128239025

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Cancer Vaccines as Immunotherapy of Cancer by Luigi Buonaguro,Sjoerd Van Der Burg Pdf

Cancer Vaccines as Immunotherapy of Cancer provides extensive and state-of-the-art information about the meaning, relevance and limitation of therapeutic cancer vaccines. It covers all the aspects involved in the vaccine research and development (identification of optimal target antigens, formulations, delivery strategies, adjuvants among others) as well as their use in combination with other immunomodulatory approaches. The book discusses topics such as identification of tumor associated and specific antigens, proteogenomic for identification of novel target tumor antigens, antigen-specific T cells, and Peptide and RNA based vaccines. Additionally, it covers oncolytic viruses for antigen delivery, cancer vaccine targeting viral antigens and combinatorial immunotherapy strategies. Written by leading experts worldwide, this is a valuable resource for cancer researchers, oncologists and members of biomedical field who wants to understand in depth the recent findings in the field of cancer vaccines. Describes the state-of-the-art of the research and development of therapeutic cancer vaccines Presents detailed diagrams to help the reader understand the functionality of each type of vaccine discussed Encompasses recent findings in the field through chapters written by leading experts worldwide

Cancer Vaccines and Tumor Immunity

Rimas Orentas,James W. Hodge,Bryon D. Johnson
Cancer Vaccines and Tumor Immunity Book PDF

Author : Rimas Orentas,James W. Hodge,Bryon D. Johnson
Publisher : John Wiley & Sons
Page : 352 pages
File Size : 55,7 Mb
Release : 2007-10-26
Category : Medical
ISBN : 9780470170106

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Cancer Vaccines and Tumor Immunity by Rimas Orentas,James W. Hodge,Bryon D. Johnson Pdf

Cancer Vaccines and Tumor Immunity offers a review of the basic scientific discoveries that have moved forward into clinical trials. Presented in the context of real-world human research and experimentation, these major scientific advances demonstrate how our understanding of immune activation, T-regulatory cells, and autoimmunity will impact cancer vaccine design. The authors also explain how vaccination in the context of bone marrow transplantation will open new avenues for clinical study in the future.

Cancer Vaccines

Adrian Bot,Mihail Obrocea,Francesco M. Marincola
Cancer Vaccines Book PDF

Author : Adrian Bot,Mihail Obrocea,Francesco M. Marincola
Publisher : CRC Press
Page : 280 pages
File Size : 43,5 Mb
Release : 2015-05-06
Category : Medical
ISBN : 9781841848303

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Cancer Vaccines by Adrian Bot,Mihail Obrocea,Francesco M. Marincola Pdf

Recent advances in immunology and biology have opened new horizons in cancer therapy, included in the expanding array of cancer treatment options, which are immunotherapies, or cancer vaccines, for both solid and blood borne cancers. Cancer Vaccines: From Research to Clinical Practice is the first text in the field to bring immunotherapy treatments from the laboratory trial to the bedside for the practicing oncologist. Cancer Vaccines: From Research to Clinical Practice: Analyzes the most promising classes of investigational immunotherapies, integrating their scientific rationale and clinical potential Discusses "theranostics" as pertaining to immunotherapy, i.e., using molecular diagnostics to identify patients that would most likely benefit from a therapy Presents the new paradigm of biomarker guided R&D and clinical development in immunotherapy of cancer Reviews bottlenecks in translational process of immunotherapies and offers strategies to resolve them

Approaches to Advance Cancer Vaccines to Clinical Utility

An M. T. Van Nuffel,Caroline Boudousquié,Sandra Tuyaerts
Approaches to Advance Cancer Vaccines to Clinical Utility Book PDF

Author : An M. T. Van Nuffel,Caroline Boudousquié,Sandra Tuyaerts
Publisher : Frontiers Media SA
Page : 196 pages
File Size : 45,9 Mb
Release : 2019-12-27
Category : Electronic
ISBN : 9782889631605

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Approaches to Advance Cancer Vaccines to Clinical Utility by An M. T. Van Nuffel,Caroline Boudousquié,Sandra Tuyaerts Pdf

Although cancer vaccines have yielded promising results both in vitro and in animal models, their translation into clinical application has not been very successful so far. Through the success of immune checkpoint inhibitors, the tumor immunotherapy field revived and led to important new insights. A better understanding of the functional capacity of different dendritic cell (DC) subsets and the immunogenicity of tumor antigens, more particularly of neoantigens, have important implications for the improvement of cancer vaccines. These insights can guide the development of novel strategies, to enhance the clinical utility of cancer vaccines. The aim of this Research Topic is therefore to provide a comprehensive overview of current issues regarding cancer vaccine development with an emphasis on novel approaches toward enhancing their efficacy.

Cancer Vaccines

Natalia Savelyeva,Christian Ottensmeier
Cancer Vaccines Book PDF

Author : Natalia Savelyeva,Christian Ottensmeier
Publisher : Springer
Page : 210 pages
File Size : 41,6 Mb
Release : 2017-07-10
Category : Medical
ISBN : 9783319239101

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Cancer Vaccines by Natalia Savelyeva,Christian Ottensmeier Pdf

This volume focuses on the laboratory and clinical experience with targeting viral onco-antigens, while also reviewing the approaches to targeting self-cancer antigens in cancers of non-viral origin, where self-tolerance has been a challenge. It emphasizes the importance of selecting the right vaccine platform to induce a successful immune response against cancer antigens. In addition, the volume discusses the advances made with genetic vaccines, including recent advances with DNA vaccines and the rapid transition of mRNA vaccines from the laboratory to bedside. The new avenues opening up for cancer immunotherapy underline the importance of combinational approaches using cancer vaccines with costimulatory antibodies, which may dramatically improve cancer treatment. This book is intended for all translational researchers and clinicians who aspire to develop novel vaccination approaches for cancer patients with unmet clinical needs.

Immunotherapy of Cancer

Yoshiyuki Yamaguchi
Immunotherapy of Cancer Book PDF

Author : Yoshiyuki Yamaguchi
Publisher : Springer
Page : 358 pages
File Size : 45,8 Mb
Release : 2016-02-22
Category : Medical
ISBN : 9784431550310

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Immunotherapy of Cancer by Yoshiyuki Yamaguchi Pdf

This timely book, published just as cancer immunotherapy comes of age, summarizes the rationale, present status, and future perspective for cancer immunotherapy. Included are explanations of the constitution of the immune system and immunocheckpoints, the mechanism of antigen presentation and recognition, valuable modalities, clinical trials and guidance, personalization, and biomarkers, all of which are essential for understanding the success of cancer immunotherapy. This innovative therapy has been investigated worldwide as the fourth line of cancer treatment after the standard treatments of surgery, chemotherapy, and radiotherapy. The progress in fundamental understanding of tumor immunology and the recent advances in clinical trials have opened new avenues with a cancer vaccine in 2010 and immunocheckpoint modulation in 2011, with their approval already granted in the United States. Today, there are no doubts, even among experts in cancer chemotherapy and radiotherapy, that the immune system plays a vital role in tumor eradication. Following American approval, many clinical trials of cancer immunotherapy are being conducted. With this book the reader will readily understand the paradigm shift in cancer treatment and will realize the importance of cancer immunotherapy. The great value of immunotherapy will be obvious, not only for tumor shrinkage but for prolonging patient survival.

Advancements in Tumor Immunotherapy and Cancer Vaccines

Hilal Arnouk
Advancements in Tumor Immunotherapy and Cancer Vaccines Book PDF

Author : Hilal Arnouk
Publisher : BoD – Books on Demand
Page : 232 pages
File Size : 53,6 Mb
Release : 2012-02-03
Category : Medical
ISBN : 9789533079981

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Advancements in Tumor Immunotherapy and Cancer Vaccines by Hilal Arnouk Pdf

Harnessing the potential of the human body's own immune system to attack malignant tumor cells has been the goal of many scientific investigators in recent years, with advances in cancer biology and immunology enabling cancer immunotherapy to become a reality. World-class bench and clinical researchers have joined forces to collaborate and review current developments and trends in cancer immunology for the purposes of this book, and the result is a promising review of contemporary clinical treatments. In each chapter the authors present the scientific basis behind such therapeutic approaches, including cancer vaccines with special focus on prostate cancer, melanoma and novel approaches utilizing both innate and adaptive immune responses.

Cancer Immunotherapy

Claire Hearnden,Ed C. Lavelle
Cancer Immunotherapy Book PDF

Author : Claire Hearnden,Ed C. Lavelle
Publisher : Elsevier Inc. Chapters
Page : 684 pages
File Size : 47,6 Mb
Release : 2013-06-04
Category : Medical
ISBN : 9780128059173

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Cancer Immunotherapy by Claire Hearnden,Ed C. Lavelle Pdf

This chapter describes the types of adjuvants that are being investigated as potential cancer adjuvant candidates and those that are currently being used in vaccines against certain cancers.

Tumor Immunology

A. G. Dalgleish,M. J. Browning
Tumor Immunology Book PDF

Author : A. G. Dalgleish,M. J. Browning
Publisher : Cambridge University Press
Page : 382 pages
File Size : 43,8 Mb
Release : 1996-06-13
Category : Medical
ISBN : 0521472377

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Tumor Immunology by A. G. Dalgleish,M. J. Browning Pdf

This 1996 volume reviewed advances in the field of human tumour immunology for an audience of clinicians and researchers.

Cancer Immunotherapy

Jeffrey Schlom,James W. Hodge,Claudia Palena,John W. Greiner,Kwong-Yok Tsang,Benedetto Farsaci,Ravi A. Madan,James L. Gulley
Cancer Immunotherapy Book PDF

Author : Jeffrey Schlom,James W. Hodge,Claudia Palena,John W. Greiner,Kwong-Yok Tsang,Benedetto Farsaci,Ravi A. Madan,James L. Gulley
Publisher : Elsevier Inc. Chapters
Page : 684 pages
File Size : 50,6 Mb
Release : 2013-06-04
Category : Medical
ISBN : 9780128059166

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Cancer Immunotherapy by Jeffrey Schlom,James W. Hodge,Claudia Palena,John W. Greiner,Kwong-Yok Tsang,Benedetto Farsaci,Ravi A. Madan,James L. Gulley Pdf

This article reviews progress made in the design and development of recombinant poxviral-based vaccines that express transgenes for tumor-associated antigens (TAAs) and human T-cell co-stimulatory molecules (designated TRICOM). The TRICOM vaccine platform consists of priming with a recombinant vaccinia (rV-) vector and multiple boosts with a replication defective fowlpox (rF-) vector. The rV, rF-PSA-TRICOM (PROSTVAC) has demonstrated survival benefit in randomized trials. rV, rF-CEA-MUC1-TRICOM (PANVAC) has demonstrated evidence of benefit in patients with colorectal, breast and ovarian cancers. Preclinical studies with TRICOM-based vaccines have demonstrated their ability to be used in combination with anti-CTLA4 monoclonal antibody, radiation, chemotherapeutics, and small molecule targeted therapies to enhance vaccine-mediated immune responses and antitumor activity. Randomized clinical studies have been completed, are ongoing, and are planned employing several of these TRICOM vaccine combination therapies. The importance of trial design in terms of patient population and clinical trial endpoint has been demonstrated in these studies.

Immunotherapy of Cancer

Mary L. Disis
Immunotherapy of Cancer Book PDF

Author : Mary L. Disis
Publisher : Springer Science & Business Media
Page : 516 pages
File Size : 48,9 Mb
Release : 2007-10-28
Category : Medical
ISBN : 9781597450119

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Immunotherapy of Cancer by Mary L. Disis Pdf

Expert bench and clinical scientists join forces to concurrently review both the state-of-the-art in tumor immunology and its clinical translation into promising practical treatments. The authors explain in each chapter the scientific basis behind such therapeutic agents as monoclonal antibodies, cytokines, vaccines, and T-cells, and illustrate their clinical manipulation to combat cancer. Additional chapters address statistical analysis-both of clinical trials and assay evaluations-methods for the discovery of antigens, adoptive T cell therapy, and adaptive and innate immunity. The challenges in clinical trial design, the need for biomarkers of response-such as novel imaging techniques and immunologic monitoring-and the new advances and directions in cancer immunotherapy are also fully examined.

Handbook of Cancer Vaccines

Michael A. Morse,Timothy M. Clay,H. Kim Lyerly
Handbook of Cancer Vaccines Book PDF

Author : Michael A. Morse,Timothy M. Clay,H. Kim Lyerly
Publisher : Springer Science & Business Media
Page : 585 pages
File Size : 42,6 Mb
Release : 2004-01-28
Category : Medical
ISBN : 9781592596805

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Handbook of Cancer Vaccines by Michael A. Morse,Timothy M. Clay,H. Kim Lyerly Pdf

An authoritative survey of the scientific background for therapeutic cancer vaccines, the challenges to their development, and their current uses in treating cancer. The authors examine the basic issues that effect all vaccines (such as immune adjuvants and prime-boost strategies), describe the methods for antigen discovery, and review the preclinical development phases for each major vaccine strategy. They also spell out the clinical results for cancer vaccines now beginning to be used in the treatment of many common cancers.