Cardiac Cell Biology

Author : Elissavet Kardami,Larry Hryshko,Nasrin Mesaeli
Publisher : Springer Science & Business Media
Page : 184 pages
File Size : 43,9 Mb
Release : 2013-06-29
Category : Science
ISBN : 9781475747126

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Cardiac Cell Biology by Elissavet Kardami,Larry Hryshko,Nasrin Mesaeli Pdf

Cardiac cell biology has come of age. Recognition of activated or modified signaling molecules by specific antibodies, new selective inhibitors, and fluorescent fusion tags are but a few of the tools used to dissect signaling pathways and cross-talk mechanisms that may eventually allow rational drug design. Understanding the regulation of cardiac hypertrophy in all its complexity remains a fundamental goal of cardiac research. Since the advancement of adenovirally mediated gene transfer, transfection efficiency is no longer a limiting factor in the study of cardiomyocytes. A limiting factor in considering cell transplantion as a strategy to repair the damaged heart is cell availability at the right time. Cardiac gap junctions, intercellular communication channels that allow electrical and metabolic coupling and play an important role in arrhythmogenesis are now understood to be exquisite sensors of cardiac change. The reports in this volume incLude elegant studies that made use of cutting edge technological advances and many specialized reagents to address these issues.

Author : Anonim
Publisher : Unknown
Page : 198 pages
File Size : 50,7 Mb
Release : 2003
Category : Electronic
ISBN : OCLC:437138223

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Cardiac Cell Biology by Anonim Pdf

Author : Elisabeth Ehler
Publisher : Springer
Page : 309 pages
File Size : 52,7 Mb
Release : 2015-03-03
Category : Science
ISBN : 9783319152639

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Cardiac Cytoarchitecture by Elisabeth Ehler Pdf

This book presents a collection of expert reviews on different subcellular compartments of the cardiomyocyte, addressing fundamental questions such as how these compartments are assembled during development, how they are changed in and by disease and which signaling pathways have been implicated in these processes so far. As such, it offers the first overview of the cell biology of heart disease of its kind, addressing the needs of cell biology students specializing in vascular and cardiac biology, as well as those of cardiologists and researchers in the field of cell biology.

Author : Ira S. Cohen,Glenn R. Gaudette
Publisher : Springer Science & Business Media
Page : 555 pages
File Size : 54,6 Mb
Release : 2011-03-23
Category : Science
ISBN : 9781617790218

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Regenerating the Heart by Ira S. Cohen,Glenn R. Gaudette Pdf

Medical research made huge strides in treating heart disease in the 20th century, from drug-eluding stents to automatic internal defibrillators. Public awareness of the dangers of heart disease has never been more pervasive. Now, though, ten years into a new millennium, scientists are gearing up for the next great challenges in tackling this pervasive condition. Cell therapy is going to be a key weapon in the fight against heart disease. It has the potential to address many cardiovascular conditions. From heart failure to atrioventricular nodal dysfunction, the young but promising field of cell therapy is set to play a significant role in developing the cures that the upcoming decades of hard work will yield. Regenerating the Heart: Stem Cells and the Cardiovascular System organizes the field into a digestible body of knowledge. Its four sections cover mechanical regeneration, electrical regeneration, cardiac tissues and in vivo stem cell therapies. An array of talented researchers share the fruits of their labors, with chapters covering such crucial issues as the cardiogenic potential of varying stem cell types, the ways in which they might be used to tackle arrhythmias, their possible application to biological replacements for cardiac tissues such as valves, and the varying approaches used in the in vivo evaluation of stem cell therapies, including methods of delivering stem cells to the myocardium. This comprehensive survey of an area of research with such exciting potential is an invaluable resource both for veteran stem cell researchers who need to monitor fresh developments, and for newly minted investigators seeking inspirational examples.

Author : Zbigniew Brzozka,Elzbieta Jastrzebska
Publisher : Springer
Page : 245 pages
File Size : 47,7 Mb
Release : 2017-11-21
Category : Technology & Engineering
ISBN : 9783319706856

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Cardiac Cell Culture Technologies by Zbigniew Brzozka,Elzbieta Jastrzebska Pdf

This book provides an introduction to the biological background of heart functioning and analyzes the various materials and technologies used for the development of microfluidic systems dedicated to cell culture, with an emphasis on cardiac cells. The authors describe the characterization of microfluidic systems for cardiac cell culture and center their discussion of the use of stem cell stimulation based on four different types: electrical, biochemical, physical, and mechanical. This book is appropriate for researchers focused on on-chip technologies and heart studies, students in bioengineering and microengineering courses, and a variety of professionals, such as biotechnologists, biomedical engineers, and clinicians working in the cardiac diseases field.

Author : Marianne J. Legato
Publisher : Springer Science & Business Media
Page : 292 pages
File Size : 51,8 Mb
Release : 1985
Category : Gardening
ISBN : UCAL:B4513774

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The Developing Heart by Marianne J. Legato Pdf

Heart disease, despite recent improvements, continues to be the single most im portant cause of death and disability in the United States. It is estimated that the direct cost of medical care for cardiovascular disease is $6 billion dollars per year. Data compiled by the National Center for Health Statistics reveal a dramatic de cline in deaths from cardiovascular disease in the United States (greater than 20% since 1968). This phenomenon has been the subject of in-depth study. It is clear that the decline is real and not a statistical artifact. The decrease in mortality has been noted in all sections of the country, though the onset and rate of decline varies in different regions of the country. Both primary prevention, through changes in risk factors, and basic and applied research leading to earlier recognition and im proved treatment have contributed to the decline. They do not fully explain the decline. Further research is needed to clarify this issue. Clinical cardiologists have been exposed to a veritable explosion of new knowl edge of mechanisms of cardiovascular disease, development of new improved non-invasive diagnostic techniques, and the pharmacodynamics of agents affect ing the cardiovascular system. This new knowledge results from contributions made by individuals from diverse disciplines including cellular and molecular bi ologists, geneticists, hematologists, cardiologists, and cardiovascular surgeons.

Author : Howard E. Morgan
Publisher : Unknown
Page : 146 pages
File Size : 40,5 Mb
Release : 1982-01
Category : Medical
ISBN : 012506960X

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Cellular Biology of the Heart by Howard E. Morgan Pdf

Author : Richard A. Walsh
Publisher : CRC Press
Page : 812 pages
File Size : 49,5 Mb
Release : 2005-11-29
Category : Medical
ISBN : 9780203503249

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Molecular Mechanisms of Cardiac Hypertrophy and Failure by Richard A. Walsh Pdf

This title reviews current knowledge of the mechanisms contributing to heart failure. Editor Richard Walsh and an internationally renowned team of contributors discuss key advances in molecular and cell biology, biochemistry, and pharmacology, focusing on advances that have a direct bearing on current clinical studies. It highlights developments across a broad range of disciplines, with in-depth coverage of each topic providing background and perspective on current literature. By setting new advances in a broader context, this text allows readers to compare different ideas and evaluate their importance in their own areas of research or clinical practice.

Author : Emerson Perin,James T. Willerson
Publisher : CRC Press
Page : 210 pages
File Size : 44,5 Mb
Release : 2006-09-15
Category : Medical
ISBN : 9781841844718

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An Essential Guide to Cardiac Cell Therapy by Emerson Perin,James T. Willerson Pdf

Sparked by a new understanding that the development of tissues is not restricted to the embryonic phase of development and thus that regeneration of tissues can occur in adults, the emerging field of stem cell therapy has grown exponentially in the last several years. Crucially, the research and findings associated with stem cell research overlap into many other areas, such as basic cell biology, molecular biology and hematology, and the proliferation of clinical studies involving stem cell research is gradually crossing over into the practice of medicine as many patients may become candidates for such novel treatments. As a response to this, Guide to Cardiac Cell Therapy is a comprehensive but understandable resource that makes this exciting field accessible to clinical practitioners. Bridging the gap between basic science and practice, it is a useful introduction to the area as well as a cutting-edge update of the developments in stem cell therapy as applied to cardiovascular disease.

Author : Monte Willis,Jonathon W. Homeister,James R. Stone
Publisher : Academic Press
Page : 339 pages
File Size : 55,5 Mb
Release : 2013-12-23
Category : Medical
ISBN : 9780124055254

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Cellular and Molecular Pathobiology of Cardiovascular Disease by Monte Willis,Jonathon W. Homeister,James R. Stone Pdf

Cellular and Molecular Pathobiology of Cardiovascular Disease focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine. No other single text-reference combines clinical cardiology and cardiovascular pathology with enough molecular content for graduate students in both biomedical research and clinical departments. The text is complemented and supported by a rich variety of photomicrographs, diagrams of molecular relationships, and tables. It is uniquely useful to a wide audience of graduate students and post-doctoral fellows in areas from pathology to physiology, genetics, pharmacology, and more, as well as medical residents in pathology, laboratory medicine, internal medicine, cardiovascular surgery, and cardiology. Explains how to identify cardiovascular pathologies and compare with normal physiology to aid research Gives concise explanations of key issues and background reading suggestions Covers molecular bases of diseases for better understanding of molecular events that precede or accompany the development of pathology

Author : Paul J.R. Barton,Kenneth R. Boheler,Nigel J. Brand,Penny S. Thomas
Publisher : Springer Science & Business Media
Page : 280 pages
File Size : 42,6 Mb
Release : 2013-11-21
Category : Science
ISBN : 9783662221921

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Molecular Biology of Cardiac Development and Growth by Paul J.R. Barton,Kenneth R. Boheler,Nigel J. Brand,Penny S. Thomas Pdf

This is the only book to specifically combine basic information on molecular biology with current thinking in cardiac development. The authors clearly illustrate that molecular biology has already provided a wealth of new approaches to the investigation of cellular processes at the molecular level and is now making a significant contribution to the understanding of the role played by such mechanisms in cardiac development. Furthermore, it is shown that this rapidly-expanding field provides an insight into the molecular events underlying cardiac malformation and disease.

Author : Margaret E. Buckingham,Kenneth R. Chien,Christine L. Mummery
Publisher : Cold Spring Harbor Perspective
Page : 0 pages
File Size : 42,8 Mb
Release : 2014
Category : Medical
ISBN : 1936113864

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The Biology of Heart Disease by Margaret E. Buckingham,Kenneth R. Chien,Christine L. Mummery Pdf

"A subject collection from Cold Spring Harbor perspectives in medicine."

Author : Paul J.R. Barton,Kenneth R. Boheler,Nigel J. Brand,Penny S. Thomas
Publisher : Springer
Page : 273 pages
File Size : 50,9 Mb
Release : 2013-10-03
Category : Science
ISBN : 3662221942

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Molecular Biology of Cardiac Development and Growth by Paul J.R. Barton,Kenneth R. Boheler,Nigel J. Brand,Penny S. Thomas Pdf

This is the only book to specifically combine basic information on molecular biology with current thinking in cardiac development. The authors clearly illustrate that molecular biology has already provided a wealth of new approaches to the investigation of cellular processes at the molecular level and is now making a significant contribution to the understanding of the role played by such mechanisms in cardiac development. Furthermore, it is shown that this rapidly-expanding field provides an insight into the molecular events underlying cardiac malformation and disease.

Author : Masaki Ieda,Wolfram-Hubertus Zimmermann
Publisher : Springer
Page : 274 pages
File Size : 43,9 Mb
Release : 2017-10-27
Category : Medical
ISBN : 9783319561066

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Cardiac Regeneration by Masaki Ieda,Wolfram-Hubertus Zimmermann Pdf

This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration.

Author : Lars Kaestner,Peter Lipp
Publisher : Springer
Page : 132 pages
File Size : 54,9 Mb
Release : 2018-12-07
Category : Science
ISBN : 9783319953045

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Microscopy of the Heart by Lars Kaestner,Peter Lipp Pdf

This book provides in depths information on different microscopy approaches and supplies the reader with methods how to untangle highly complex processes involved in physiological and pathophysiological cardiac signaling. Microscopy approaches have established themselves as the quasi gold standard that enables us to appreciate the underlying mechanisms of physiological and pathophysiological cardiac signaling. This book presents the most important microscopy techniques from the level of individual molecule e.g. Förster-Resonance Energy Transfer (FRET), up to cellular and tissue imaging, e.g. electron microscopy (TEM) or light sheet microscopy. The book is intended for graduate students and postdocs in cardiovascular research, imaging and cell biology, pre-clinical and clinical researchers in cardiovascular sciences as well as decision makers of the pharmaceutical industry.