Cardiac Ischemia From Injury To Protection

Author : Bohuslav Ost'ádal,Frantisek Kolár
Publisher : Springer Science & Business Media
Page : 198 pages
File Size : 48,6 Mb
Release : 2013-03-09
Category : Medical
ISBN : 9781475730258

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Cardiac Ischemia: From Injury to Protection by Bohuslav Ost'ádal,Frantisek Kolár Pdf

Cardiac Ischemia: From Injury to Protection has been divided into six parts. The first part describes the differences between hypoxia and ischemia, animal models, the effects of ischemia on myocardial function and metabolism, and the electrophysiological consequences of ischemia. The second part deals with the mechanisms of cardiomyocyte death in ischemia, structural aspects of irreversible ischemic injury, necrosis and apoptosis of cardiac cells, the role of calcium, and the concept of calcium antagonism. The third chapter is a brief description of reperfusion injury, its clinical relevance, and possible prevention. The fourth part summarizes changes in myocardial vasculature during ischemia and reperfusion. The fifth part is the survey of two main possibilities for increasing cardiac resistance to ischemia and hypoxia, i.e. long-lasting adaptation to chronic hypoxia and short-lasting preconditioning. The last part of the book deals with comparative and ontogenetic aspects of cardiac sensitivity to oxygen deprivation; this chapter also summarizes the ontogenetic differences and limitations in endogenous and exogenous protection of the ischemic/hypoxic heart.

Author : Bohuslav Ost'ádal,Frantisek Kolár
Publisher : Springer
Page : 173 pages
File Size : 49,6 Mb
Release : 2010-12-02
Category : Medical
ISBN : 1441951059

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Cardiac Ischemia: From Injury to Protection by Bohuslav Ost'ádal,Frantisek Kolár Pdf

Cardiac Ischemia: From Injury to Protection has been divided into six parts. The first part describes the differences between hypoxia and ischemia, animal models, the effects of ischemia on myocardial function and metabolism, and the electrophysiological consequences of ischemia. The second part deals with the mechanisms of cardiomyocyte death in ischemia, structural aspects of irreversible ischemic injury, necrosis and apoptosis of cardiac cells, the role of calcium, and the concept of calcium antagonism. The third chapter is a brief description of reperfusion injury, its clinical relevance, and possible prevention. The fourth part summarizes changes in myocardial vasculature during ischemia and reperfusion. The fifth part is the survey of two main possibilities for increasing cardiac resistance to ischemia and hypoxia, i.e. long-lasting adaptation to chronic hypoxia and short-lasting preconditioning. The last part of the book deals with comparative and ontogenetic aspects of cardiac sensitivity to oxygen deprivation; this chapter also summarizes the ontogenetic differences and limitations in endogenous and exogenous protection of the ischemic/hypoxic heart.

Author : Naranjan S. Dhalla,Nobuakira Takeda,Manjeet Singh,Anton Lukas
Publisher : Springer Science & Business Media
Page : 541 pages
File Size : 47,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461503552

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Myocardial Ischemia and Preconditioning by Naranjan S. Dhalla,Nobuakira Takeda,Manjeet Singh,Anton Lukas Pdf

Current evidence suggests that the ischemic preconditioning response is a multi-factorial process consisting of an initial early trigger, an intermediate mediator, and an end effector. Each of these steps in is now its own intense area of investigation. The need to render the heart ischemic for a brief period to invoke the preconditioning response is currently the major factor limiting clinical application of this powerful cardioprotective strategy. Recent research efforts have utilized brief exposures to pharmacological agents, in lieu of a brief preconditioning ischemia, to trigger/mimic the ischemic preconditioning-induced response. The World Heart Congress held in Winnipeg in July 2001 provided a forum for the presentation of new insights into the basic mechanisms of ischemia and reperfusion injury, as well as novel strategies to protect the heart from cell death, ventricular arrhythmias, and contractile dysfunction. Many pioneers in the fields of ischemia-reperfusion injury and preconditioning-induced protection presented there and the chapters in this book represent selected papers from these symposia.

Author : Seibu Mochizuki,Nobuakira Takeda,Makoto Nagano,Naranjan S. Dhalla
Publisher : Springer
Page : 601 pages
File Size : 55,8 Mb
Release : 2007-11-23
Category : Medical
ISBN : 9780585398440

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The Ischemic Heart by Seibu Mochizuki,Nobuakira Takeda,Makoto Nagano,Naranjan S. Dhalla Pdf

Over the past three decades, impressive progress in the field of pathogenesis, prevention and therapy of ischemic heart disease has resulted in a marked decline in mortality in the Western World. However, the incidence of this devastating disease is on the rise in developing countries. The Ischemic Heart is based upon a recent symposium in Tokyo on the subject. This volume is organized into two sections: (i) Pathophysiologic Mechanisms of Ischemia-Reperfusion Injury and (ii) Preconditioning and Protection of Ischemia-Reperfusion Injury, and contains up-to-date information concerning the current concepts of ischemia-reperfusion injury, the sequence of events resulting in the loss of contractile dysfunction, and mechanisms of cardioprotection by several drugs as well as the role of ischemic preconditioning in attenuating problems associated with ischemia-reperfusion injury.

Author : Morris Karmazyn
Publisher : Birkhäuser
Page : 508 pages
File Size : 55,9 Mb
Release : 2013-03-12
Category : Medical
ISBN : 9783034889889

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Myocardial Ischemia: Mechanisms, Reperfusion, Protection by Morris Karmazyn Pdf

Myocardial ischemia and subsequent reperfusion of the ischemic myocardium represent complex phenomena encompassing numerous physiological processes. This book aims at enhancing our understanding of these processes and stresses recent important developments in this very active area of research. The concise, state-of-the-art reviews cover recent advances in many fields important to the area of myocardial ischemia and reperfusion including physiology, pathology, pharmacology, biochemistry and molecular biology with reference to clinical relevance and applicability of these findings. Major areas which are highlighted include vascular mechanisms resulting in myocardial ischemia, cellular events in the ischemic, postinfarcted and reperfused myocardium as well as new exciting developments in cardiac protection that involve both novel pharmacological approaches as well as endogenous cardioprotective mechanisms such as preconditioning. Aimed at both the basic and clinical cardiovascular investigator, the book comprehensively reviews the rapid progress made in recent years in understanding the etiology of myocardial ischemia and reperfusion. It will further serve as an authoritative reference for all those interested in learning about the important developments in the treatment of myocardial ischemic and reperfusion disorders.

Author : Hui Gong,Hongmei Tan,Yaoliang Tang
Publisher : Frontiers Media SA
Page : 155 pages
File Size : 41,5 Mb
Release : 2022-06-07
Category : Medical
ISBN : 9782889763580

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Ischemic Myocardial Injury and Protection: From Bench to Bedside by Hui Gong,Hongmei Tan,Yaoliang Tang Pdf

Author : Tomas A. Salerno,Marco Ricci
Publisher : John Wiley & Sons
Page : 344 pages
File Size : 48,8 Mb
Release : 2008-04-15
Category : Medical
ISBN : 9781405178433

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Myocardial Protection by Tomas A. Salerno,Marco Ricci Pdf

Myocardial protection is regarded as one of the most important, yet also most controversial aspects of cardiac surgery. There has been considerable improvement in myocardial protection strategies over recent years, utilising a variety of new approaches to treat cardiac diseases, and this text is intended to embrace the state of the art in this field. The book summarises the state of knowledge on all aspects of myocardial protection, including the latest in the treatment of cardiac diseases, robotics, pediatric surgery and the treatment of cardiac failure. Robotic surgery, valvular surgery, pediatric surgery and coronary surgery are all covered by renowned experts, producing a comprehensive, forward-looking view of the field of myocardial protection. This book should function to update physicians and surgeons interested in the field of cardiac surgery on the current state of knowledge on myocardial protection.

Author : Paul A. Iaizzo
Publisher : Springer
Page : 817 pages
File Size : 42,9 Mb
Release : 2015-11-13
Category : Medical
ISBN : 9783319194646

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Handbook of Cardiac Anatomy, Physiology, and Devices by Paul A. Iaizzo Pdf

This book covers the latest information on the anatomic features, underlying physiologic mechanisms, and treatments for diseases of the heart. Key chapters address animal models for cardiac research, cardiac mapping systems, heart-valve disease and genomics-based tools and technology. Once again, a companion of supplementary videos offer unique insights into the working heart that enhance the understanding of key points within the text. Comprehensive and state-of-the art, the Handbook of Cardiac Anatomy, Physiology and Devices, Third Edition provides clinicians and biomedical engineers alike with the authoritative information and background they need to work on and implement tomorrow’s generation of life-saving cardiac devices.

Author : Derek M. Yellon,Robert B. Jennings
Publisher : Unknown
Page : 232 pages
File Size : 50,6 Mb
Release : 1992
Category : Medical
ISBN : UOM:39015024926126

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Myocardial Protection by Derek M. Yellon,Robert B. Jennings Pdf

An insight into the theories and controversies regarding myocardial reperfusion and reperfusion-induced injury. The ideas presented advance the understanding of the relationship of reperfusion injury to the beneficial effects of restoring coronary flow to the myocardium after an ischemic insult.

Author : Friedhelm Beyersdorf
Publisher : CRC Press
Page : 250 pages
File Size : 49,5 Mb
Release : 2001
Category : Medical
ISBN : UOM:39015053172139

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Ischemia-Reperfusion Injury in Cardiac Surgery by Friedhelm Beyersdorf Pdf

Cardiac surgery is associated with ischemia and reperfusion injury for most of the operations performed. During the last decades, major improvements have been done in reducing both ischemic and reperfusion injury and therefore improving the quality of the operation. This book summarizes the newest developments in this field. In addition, specific comments are made concerning the surgical application of the fields in all kinds of operation, including routine cases as well as complex procedures. The reader will gain a detailed insight regarding how to protect patients best during routine cardiac procedures (coronary artery revascularization and valve replacement) as well as prolonged, technically demanding operations

Author : David C. Gaze,Aleksandar Kibel
Publisher : BoD – Books on Demand
Page : 356 pages
File Size : 46,6 Mb
Release : 2021-07-28
Category : Medical
ISBN : 9781839681615

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Cardiac Diseases by David C. Gaze,Aleksandar Kibel Pdf

This is the latest book in a series of cardiovascular-related texts from IntechOpen Publishing. The present volume considers general aspects of cardiac disease and is divided into three distinct sections covering cardiac risk, cardiorenal pathology, and novel interventional surgical techniques. The chapters offer insight into the current state of the art with respect to the risks of developing cardiovascular diseases, maintenance of patent vascular access in patients with the cardiorenal syndrome, and a plethora of novel interventional technologies all aimed at salvaging damaged tissue and improving prognosis and reducing mortality. This volume of 18 chapters is intended for general medical and biomedical students at both undergraduate and postgraduate level. It also offers insightful updates on recent advances in the understanding of the pathophysiology of cardiac diseases and the new techniques added to the medical armamentarium to improve the outcomes and prevent mortality and would be of interest to those working in academia and healthcare science.

Author : Derek Hausenloy,Derek Yellon
Publisher : OUP Oxford
Page : 144 pages
File Size : 43,6 Mb
Release : 2009-08-20
Category : Medical
ISBN : 9780191575488

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Cardioprotection by Derek Hausenloy,Derek Yellon Pdf

Coronary heart disease (CHD) is the leading cause of death worldwide with 3.8 million men and 3.4 million women dying each year. Cardioprotection refers to the prevention of CHD and the clinical improvement in patients suffering from cardiovascular problems. This book focuses on the role of cardioprotection in surgery and the use of pharmacological therapies such as ACE-inhibitors, statins and beta-blockers in order to reduce the myocardial injury sustained by the patient and the significant risk of morbidity and mortality. It includes new cardioprotective strategies aimed at improving the clinical outcomes of patients in these settings, as well as current well-established methods for reducing myocardial injury in acute coronary syndrome patients.

Author : Juan Carlos Kaski,Derek J. Hausenloy,Bernard John Gersh,Derek M. Yellon
Publisher : Springer Science & Business Media
Page : 311 pages
File Size : 52,8 Mb
Release : 2012-07-20
Category : Medical
ISBN : 9781849960199

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Management of Myocardial Reperfusion Injury by Juan Carlos Kaski,Derek J. Hausenloy,Bernard John Gersh,Derek M. Yellon Pdf

Much has been written about reperfusion injury in the past decade but unfortunately the information has been generally presented in the form of original specialist papers and little if any integral publication exists on the topic, summarising and analysing the clinical impact of the condition and its management. The pathophysiology and molecular mechanisms of reperfusion injury are complex and, regarding diagnosis, individual diagnostic techniques have been proposed but without a proper assessment of the relative values of these methods. A publication dealing with integral diagnostic strategies would be welcome by the managing physician. Management of the condition is also problematic, as strategies that appear to work in the experimental models do not translate into beneficial interventions in patients. There is a need for these issues to be addressed and discussed in a monographic fashion. Management of Myocardial Reperfusion Injury will tackle these issues in a modern and systematic way and the information will be delivered in a fashion that will be appealing to the reader.

Author : Anonim
Publisher : ScholarlyEditions
Page : 60 pages
File Size : 49,7 Mb
Release : 2012-12-10
Category : Medical
ISBN : 9781464975110

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Myocardial Ischemia: New Insights for the Healthcare Professional: 2012 Edition by Anonim Pdf

Myocardial Ischemia: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Myocardial Ischemia in a concise format. The editors have built Myocardial Ischemia: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Myocardial Ischemia in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Myocardial Ischemia: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Cherry L. Wainwright,James R. Parratt
Publisher : Springer Science & Business Media
Page : 296 pages
File Size : 51,9 Mb
Release : 2013-11-22
Category : Science
ISBN : 9783662222065

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Myocardial Preconditioning by Cherry L. Wainwright,James R. Parratt Pdf

This book is about the unique ability of the heart to protect itself against the serious consequences of an abrupt reduction in blood flow to the myocardium - a phenomenon which is switched on by stress and termed myocardial preconditioning. This volume describes the main features and characteristics of preconditioning, with respect to the time-course of the protective effect of the phenomenon (first and second windows) and the different sequelae of myocardial ischaemia against which it protects, such as myocardial injury, arrhythmias and contractile dysfunction. The proposed mechanisms underlying the fascinating form of cardioprotection are discussed. Among these are the role of endogenous labile mediators, receptor-linked G proteins, ATP-sensitive potassium channels and protein kinase C activation.