Cbl Proteins

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Cbl Proteins

Alexander Tsygankov
Cbl Proteins Book PDF

Author : Alexander Tsygankov
Publisher : Nova Publishers
Page : 220 pages
File Size : 49,7 Mb
Release : 2008
Category : Cbl proteins
ISBN : 1604561688

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Cbl Proteins by Alexander Tsygankov Pdf

Cbl proteins are important ubiquitous regulators of various biological processes ranging from defense against infection to bone formation, and the list of these processes grows continuously. There are three Cbl-family proteins in mammals, which exhibit disparate biological effects. Furthermore, all metazoans appear to have Cbl-like proteins playing important regulatory roles in these organisms ranging from round worms and flies to amphibians and birds. One of the interesting peculiarities of the Cbl-mediated regulation is its dependence on multiple molecular mechanisms, which makes this regulation complex and difficult to comprehend. In spite of the considerable progress in the understanding of the Cbl family and its functions, which was achieved not without some unexpected and dramatic turns, Cbl proteins remain rather enigmatic. This book presents an in-depth analysis of the current state of knowledge on this subject. It discusses structure, functions and mechanisms of action of Cbl proteins, including biological and clinical implications of this knowledge. This important book can serve as a good primer for those who wish to enter the area of Cbl research, as well as a convenient reference for those already working in it.

Global Comparative Analysis of CBL-CIPK Gene Families in Plants

Girdhar K. Pandey,Poonam Kanwar,Amita Pandey
Global Comparative Analysis of CBL CIPK Gene Families in Plants Book PDF

Author : Girdhar K. Pandey,Poonam Kanwar,Amita Pandey
Publisher : Springer
Page : 91 pages
File Size : 40,5 Mb
Release : 2014-08-11
Category : Science
ISBN : 9783319090788

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Global Comparative Analysis of CBL-CIPK Gene Families in Plants by Girdhar K. Pandey,Poonam Kanwar,Amita Pandey Pdf

Calcium plays pivotal role in regulating the physiological as well as developmental processes in plants. Till now, several calcium sensors have been discovered, which regulate the diverse signaling pathways involved in plant growth and development. One of the major calcium sensors CBL (calcineurin B-like) is decoding the calcium signal during various environmental stresses in plants. Calcium mediated signal is transduced downstream by CBL-interacting protein kinases (CIPKs), which generally phosphorylate the target proteins such as transcription factors or transporters/channel leading to a response. Mutant based approach has provided valuable information in the functional analysis of individual members of CBL and CIPK gene family in Arabidopsis. Both CBL and CIPK gene families have previously been identified and characterized in Arabidopsis and rice. Identification and characterization of CBLs and CIPKs in other plant species such as Oryza sativa, Pisum sativum, Cicer arietinum, Zea mays, Populus euphratica, Vitis vinifera, Malus domestica, Gossypium hirsutum, Sorghum bicolor, Brassica napus, Vicia faba, Phaseolus vulgaris, Ammopiptanthus mongolicus and Triticum aestivum are still in juvenile stage. Overall, Global Comparative Analysis of CBL-CIPK Gene Families in Plants is a comprehensive study focused on the diverse role of CBL-CIPK module in different stress signaling and also to identify a newly emerging role of this calcium-signaling module in plant growth and development across different plant species. In addition, beside Arabidopsis, it will provide backbone of knowledge to perform a detail molecular investigation in crop plant species and could possibly enable in designing strategies to tame abiotic stress tolerance and development in important agronomical crop plants. This book will act as handy and informative source in this field for students as well as advanced researchers.

Vesicle Trafficking in Cancer

Yosef Yarden,Gabi Tarcic
Vesicle Trafficking in Cancer Book PDF

Author : Yosef Yarden,Gabi Tarcic
Publisher : Springer Science & Business Media
Page : 402 pages
File Size : 53,8 Mb
Release : 2013-04-02
Category : Medical
ISBN : 9781461465287

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Vesicle Trafficking in Cancer by Yosef Yarden,Gabi Tarcic Pdf

Endocytosis and vesicular trafficking determine the landscape of the cell’s exterior, namely the density of surface molecules, such as receptors for growth factors and cytokines, adhesion molecules like integrins and cadherins, and a plethora of nutrient carriers. Hence, endocytosis is involved in signal transduction, cell adhesion and migration, as well as metabolism. To exploit these fundamental processes, malignancies subtly and multiply manipulate the endocytosis and the subsequent trafficking of protein cargoes. This is achieved by simultaneously altering the cytoskeleton, vesicle budding, cargo sorting and intracellular degradation. By highlighting the underlying molecular processes and concentrating on specific examples, this book reviews the recent emergence of derailed endocytosis and vesicular trafficking as a landmark of cancer. In-depth understanding of this common feature of tumors might lead the way to drug-induced strategies, able to rectify intracellular trafficking in cancer.

Ubiquitin and Protein Degradation

Raymond Joseph Deshaies
Ubiquitin and Protein Degradation Book PDF

Author : Raymond Joseph Deshaies
Publisher : Gulf Professional Publishing
Page : 996 pages
File Size : 41,6 Mb
Release : 2005
Category : Enzymatic analysis
ISBN : 0121828042

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Ubiquitin and Protein Degradation by Raymond Joseph Deshaies Pdf

Ubiquitin and Protein Degradation, Part B will cover chemical biology, ubiquitin derivatives and ubiquitin-like proteins, deubiquitinating enzymes, proteomics as well as techniques to monitor protein degradation. The chapters are highly methodological and focus on application of techniques. *Second part of the Ubiquitin and Protein Degration series *Topics include: E1 Enzymes, E2 Enzymes, E3 Enzymes, Proteasomes, and Isopeptidases.

EGFR Signaling Networks in Cancer Therapy

John D. Haley,William John Gullick
EGFR Signaling Networks in Cancer Therapy Book PDF

Author : John D. Haley,William John Gullick
Publisher : Springer Science & Business Media
Page : 393 pages
File Size : 44,5 Mb
Release : 2009-03-01
Category : Medical
ISBN : 9781597453561

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EGFR Signaling Networks in Cancer Therapy by John D. Haley,William John Gullick Pdf

The epidermal gro wth factor (EGF ) receptor and its downstream signal transduction networks have been implicated in the ontology and maintenance of tumor tissues, which has motivated the discovery and development of molecularly targeted anti-EGF receptor therapies. Over decades of study, the EGF receptor structure, its ligand binding domains, the physical biochemistry underlying its intrinsic tyrosine kinase catalytic function and the modular interactions with SH2, PTB, and SH3 domain containing signaling adaptor p- teins required for signal transduction, have been extensively dissected. Not only is the EGF receptor the nexus of many streams of information, but it also forms one part of a calcul- ing device by forming dimers and oligomers with the other three receptors in its family in response to at least eleven ligands (some of which are expressed in multiple forms with overlapping or quite distinct functions). This phenomenon, while recruiting to the inner surface of the cell membrane and activating multiple second messenger proteins, also allows the possibility of cross talk between these systems, permitting a further layer of information to be exchanged. Less well described are the cross re gulation of the EGF receptor and other anti-apoptotic, mitogenic and metabolic signaling systems. The study of these systems has yielded new surprises. One hurdle in these efforts has been that signal transduction pathways have frequently been defined in the generic absence of their tissue-specific or cell-interaction specific context.

Handbook of Cell Signaling, Three-Volume Set

Ralph A. Bradshaw,Edward A. Dennis
Handbook of Cell Signaling Three Volume Set Book PDF

Author : Ralph A. Bradshaw,Edward A. Dennis
Publisher : Academic Press
Page : 2576 pages
File Size : 40,6 Mb
Release : 2003-12-02
Category : Science
ISBN : 9780080533575

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Handbook of Cell Signaling, Three-Volume Set by Ralph A. Bradshaw,Edward A. Dennis Pdf

The Handbook of Cell Signaling is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The subject matter has been divided into five main parts (each of which is headed by a recognized expert in the field): * Initiation: Extracellular and Membrane Events * Transmission: Effectors and Cytosolic Events * Nuclear Responses: Gene Expression and Translation * Events in Intracellular Compartments * Cell-Cell and Cell-Matrix Interactions Covered in extensive detail, these areas will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. Tabular and well-illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field! * Contains approximately 470 articles * Provides well-organized sections on each essential area in signaling * Includes discussion on everything from ligand/receptor interactions to organ/organism responses * Extremely user-friendly

Physiological and Molecular Characterization of Crop Resistance to Abiotic Stresses

Monica Boscaiu,Ana Fita
Physiological and Molecular Characterization of Crop Resistance to Abiotic Stresses Book PDF

Author : Monica Boscaiu,Ana Fita
Publisher : MDPI
Page : 488 pages
File Size : 52,6 Mb
Release : 2020-12-02
Category : Science
ISBN : 9783039434589

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Physiological and Molecular Characterization of Crop Resistance to Abiotic Stresses by Monica Boscaiu,Ana Fita Pdf

Abiotic stress represents the main constraint for agriculture, affecting plant growth and productivity worldwide. Yield losses in agriculture will be potentiated in the future by global warming, increasing contamination, and reduced availability of fertile land. The challenge for agriculture of the present and future is that of increasing the food supply for a continuously growing human population under environmental conditions that are deteriorating in many areas of the world. Minimizing the effects of diverse types of abiotic stresses represents a matter of general concern. Research on all topics related to abiotic stress tolerance, from understanding the stress response mechanisms of plants to developing cultivars and crops tolerant to stress, is a priority. This Special Issue is focused on the physiological and molecular characterization of crop resistance to abiotic stresses, including novel research, reviews, and opinion articles covering all aspects of the responses and mechanisms of plant tolerance to abiotic. Contributions on physiological, biochemical, and molecular studies of crop responses to abiotic stresses; the description and role of stress-responsive genes; marker-assisted screening of stress-tolerant genotypes; genetic engineering; and other biotechnological approaches to improve crop tolerance were considered.

Protein Kinases—Advances in Research and Application: 2013 Edition

Anonim
Protein Kinases Advances in Research and Application 2013 Edition Book PDF

Author : Anonim
Publisher : ScholarlyEditions
Page : 133 pages
File Size : 54,8 Mb
Release : 2013-06-21
Category : Medical
ISBN : 9781481691802

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Protein Kinases—Advances in Research and Application: 2013 Edition by Anonim Pdf

Protein Kinases—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Protein-Serine-Threonine Kinases. The editors have built Protein Kinases—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Protein-Serine-Threonine Kinases in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Protein Kinases—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Manual of Clinical Hematology

Joseph J. Mazza
Manual of Clinical Hematology Book PDF

Author : Joseph J. Mazza
Publisher : Lippincott Williams & Wilkins
Page : 484 pages
File Size : 48,8 Mb
Release : 2002
Category : Medical
ISBN : 0781729815

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Manual of Clinical Hematology by Joseph J. Mazza Pdf

Completely revised for its Third Edition, this Spiral(R) Manual is a practical quick-reference guide for the diagnosis and treatment of diseases of the blood. Coverage includes leukemias, disorders of lymph nodes, bleeding disorders, anemias, and platelet disorders. The book is organized by disease type, with several chapters broken down into discussions of specific disorders. Concise and easy-to-read descriptions of each disease provide clinical recommendations and essential pathophysiological information. This edition includes a new chapter on allogeneic and autologous bone marrow transplantation procedures for hematologic malignancies. All other chapters have been extensively revised and updated.

Acute Leukemias

Pier Paolo Piccaluga
Acute Leukemias Book PDF

Author : Pier Paolo Piccaluga
Publisher : BoD – Books on Demand
Page : 324 pages
File Size : 53,5 Mb
Release : 2021-03-24
Category : Medical
ISBN : 9781838811686

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Acute Leukemias by Pier Paolo Piccaluga Pdf

Written by expert research teams, this book describes different aspects of both acute myeloid and acute lymphocytic leukemia, specifically their pathobiology, classification/diagnosis, and treatment. Chapters highlight current research as well as the gold standards for diagnosis and treatment of these diseases, examining recent advances in personalized approaches to acute leukemia.

Trends in Stem Cell Proliferation and Cancer Research

Rodrigo R. Resende,Henning Ulrich
Trends in Stem Cell Proliferation and Cancer Research Book PDF

Author : Rodrigo R. Resende,Henning Ulrich
Publisher : Springer Science & Business Media
Page : 661 pages
File Size : 51,9 Mb
Release : 2013-08-13
Category : Medical
ISBN : 9789400762114

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Trends in Stem Cell Proliferation and Cancer Research by Rodrigo R. Resende,Henning Ulrich Pdf

The book will discuss the molecular mechanisms of cancer diseases, stem cell proliferation and transformation into cancer cells beyond the physiological processes that occur in normal stem cell biology. Some of the key oncogenic events in cancer and their signaling pathways that regulate cell division cycle progression will be described considering prospects for using such knowledge in advanced cancer therapy. Each chapter shall provide an invaluable resource for information on the most current advances in the field, with discussion of controversial issues and areas of emerging importance

Protein Kinases—Advances in Research and Application: 2012 Edition

Anonim
Protein Kinases Advances in Research and Application 2012 Edition Book PDF

Author : Anonim
Publisher : ScholarlyEditions
Page : 111 pages
File Size : 44,5 Mb
Release : 2012-12-26
Category : Medical
ISBN : 9781481602938

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Protein Kinases—Advances in Research and Application: 2012 Edition by Anonim Pdf

Protein Kinases—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Protein Kinases. The editors have built Protein Kinases—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Protein Kinases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Protein Kinases—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Plant Macronutrient Use Efficiency

Mohammad Anwar Hossain,Takehiro Kamiya,David Burritt,Lam-Son Phan Tran,Toru Fujiwara
Plant Macronutrient Use Efficiency Book PDF

Author : Mohammad Anwar Hossain,Takehiro Kamiya,David Burritt,Lam-Son Phan Tran,Toru Fujiwara
Publisher : Academic Press
Page : 418 pages
File Size : 48,9 Mb
Release : 2017-07-27
Category : Science
ISBN : 9780128112946

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Plant Macronutrient Use Efficiency by Mohammad Anwar Hossain,Takehiro Kamiya,David Burritt,Lam-Son Phan Tran,Toru Fujiwara Pdf

Plant Macronutrient Use Efficiency presents an up-to-date overview of the latest research on the molecular and genetic basis of macro-nutrient use efficiency (NUE) in plants, and strategies that can be used to improve NUE and nutrient-associated stress tolerance in crop plants. Plant NUE is a measure of how efficiently plants use available nutrients and an understanding of plant NUE has the potential to help improve the use of limited natural resources and to help achieve global food security. This book presents information important for the development of crop plants with improved macro-NUE, a prerequisite to reducing production costs, expanding crop production into noncompetitive marginal lands with low nutrient resources, and for helping to prevent environmental contamination. Plant Macronutrient Use Efficiency provides a comprehensive overview of the complex mechanisms regulating macro-NUE in crop plants, which is required if plant breeders are to develop modern crop varieties that are more resilient to nutrient-associated stress. Identification of genes responsible for macro-NUE and nutrient-related stress tolerance in crop plants will help us to understand the molecular mechanisms associated with the responses of crop plants to nutrient stress. This volume contains both fundamental and advanced information, and critical commentaries useful for those in all fields of plant science research. Provides details of molecular and genetic aspects of NUE in crop plants and model plant systems Presents information on major macronutrients, nutrient sensing and signaling, and the molecular and genomic issues associated with primary and secondary macronutrients Delivers information on how molecular genetic information associated with NUE can be used to develop plant breeding programs Includes contributions from world-leading plant nutrition research groups

The Epigenetics of Autoimmune Diseases

Moncef Zouali
The Epigenetics of Autoimmune Diseases Book PDF

Author : Moncef Zouali
Publisher : John Wiley & Sons
Page : 472 pages
File Size : 55,8 Mb
Release : 2009-04-01
Category : Medical
ISBN : 0470743565

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The Epigenetics of Autoimmune Diseases by Moncef Zouali Pdf

The role of epigenetic mechanisms in autoimmune disease is only now starting to become clear. Understanding these mechanisms, their effect on cellular function and the role of environmental factors is vital to determining how to manage these often debilitating and fatal diseases. Drawing on the research of leading experts, this book provides a valuable insight into this important new area of autoimmunity research and a clear, up-to-date view on the major advances in the field. Specific coverage includes: How highly developed epigenetic mechanisms are involved in several aspects of normal immune regulation, in addition to maintaining immune tolerance to self-determinants. Specific epigenetic aspects of human autoimmune diseases, including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, autoimmune diabetes, thyroid autoimmunity, inflammatory bowel disease and autoimmune hepatitis. How understanding epigenetic mechanisms can lead to therapeutic strategies based on manipulation of this previously unexploited facet of immune regulation. Discussion of the novel approaches that are being investigated to prevent or treat autoimmune diseases. This book is an essential resource for those actively involved in the field. It is also of interest to basic researchers interested in understanding the origin of autoimmunity and clinical specialists interested in gaining in-depth understanding of the pathogenesis of autoimmune diseases and their treatment.

Goldman-Cecil Medicine E-Book

Lee Goldman,Andrew I. Schafer
Goldman Cecil Medicine E Book Book PDF

Author : Lee Goldman,Andrew I. Schafer
Publisher : Elsevier Health Sciences
Page : 4123 pages
File Size : 48,9 Mb
Release : 2015-04-21
Category : Medical
ISBN : 9780323322850

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Goldman-Cecil Medicine E-Book by Lee Goldman,Andrew I. Schafer Pdf

Since 1927, Goldman-Cecil Medicine has been the world’s most influential internal medicine resource. In the ground-breaking 25th edition, your original purchase ensures you will be up-to-date without the need for a subscription. Through the new, more powerful Expert Consult eBook platform, this "living text" provides continuous updates that will integrate the latest research, guidelines, and treatments into each chapter, ensuring that the content is as current as the day this edition was first published. Goldman-Cecil Medicine offers definitive, unbiased guidance on the evaluation and management of every medical condition, presented by a veritable "Who's Who" of modern medicine. A practical, straightforward style; templated organization; evidence-based references; and robust interactive content combine to make this dynamic resource quite simply the fastest and best place to find all of the authoritative, state-of-the-art clinical answers you need. Expert Consult eBook version included with print purchase: Access continuous updates from Editor Lee Goldman, MD, who thoroughly reviews internal medicine and specialty journals, updating online content to reflect the latest guidelines and translating that evidence into treatment. Interactive Q&A section features over 1,500 board-style questions and answers to aid in preparing for certification or recertification exams. Outstanding supplementary tools include figures, tables, videos, heart and lung sounds, treatment and management algorithms, fully integrated references, and thousands of illustrations and full-color photos. Search all of the text, figures, supplementary material, and references from the book on a variety of devices and at no additional cost — Expert Consult access is included with this title! Practical, bulleted, highly templated text with easy-to-use features including flow charts and treatment boxes. New chapters on global health, cancer biology and genetics, and the human microbiome in health and disease keep you on the cutting edge of medicine. Today's most current evidence-based medicine guidelines help you form a definitive diagnosis and create the best treatment plans possible. Focused coverage of the latest developments in biology includes the specifics of current diagnosis, therapy, and medication doses. The reference of choice for every stage of your career! Goldman-Cecil Medicine is an ideal learning tool for residents, physicians, and students as well as a valuable go-to resource for experienced healthcare professionals.