Vesicle Trafficking In Cancer

Author : Yosef Yarden,Gabi Tarcic
Publisher : Springer Science & Business Media
Page : 402 pages
File Size : 42,6 Mb
Release : 2013-04-02
Category : Medical
ISBN : 9781461465287

Get Book

Vesicle Trafficking in Cancer by Yosef Yarden,Gabi Tarcic Pdf

Endocytosis and vesicular trafficking determine the landscape of the cell’s exterior, namely the density of surface molecules, such as receptors for growth factors and cytokines, adhesion molecules like integrins and cadherins, and a plethora of nutrient carriers. Hence, endocytosis is involved in signal transduction, cell adhesion and migration, as well as metabolism. To exploit these fundamental processes, malignancies subtly and multiply manipulate the endocytosis and the subsequent trafficking of protein cargoes. This is achieved by simultaneously altering the cytoskeleton, vesicle budding, cargo sorting and intracellular degradation. By highlighting the underlying molecular processes and concentrating on specific examples, this book reviews the recent emergence of derailed endocytosis and vesicular trafficking as a landmark of cancer. In-depth understanding of this common feature of tumors might lead the way to drug-induced strategies, able to rectify intracellular trafficking in cancer.

Author : Nava Segev
Publisher : Springer Science & Business Media
Page : 459 pages
File Size : 53,9 Mb
Release : 2010-05-30
Category : Science
ISBN : 9780387938776

Get Book

Trafficking Inside Cells by Nava Segev Pdf

This book covers the past, present and future of the intra-cellular trafficking field, which has made a quantum leap in the last few decades. It details how the field has developed and evolved as well as examines future directions.

Author : Mansoor M. Amiji,Rajagopal Ramesh
Publisher : Academic Press
Page : 0 pages
File Size : 44,5 Mb
Release : 2018-05-11
Category : Medical
ISBN : 0128127740

Get Book

Diagnostic and Therapeutic Applications of Exosomes in Cancer by Mansoor M. Amiji,Rajagopal Ramesh Pdf

Diagnostic and Therapeutic Applications of Exosomes in Cancer evaluates the potential of exosome content manipulation in the development of novel therapeutics. In recent years, exosomes, the small vesicles produced by all cell types, have been identified as contributors to cancer growth and metastasis. However, due to their unique biophysical properties, they are also being tested for use in therapeutic design and delivery, as well as in diagnostics. This book presents a comprehensive analysis on exosomes, with a main emphasis on their biogenesis and signaling, use as biomarkers, and as tools for imaging, drug delivery and the treatment of cancer.

Author : William J. Gradishar,William C. Wood
Publisher : Springer Science & Business Media
Page : 230 pages
File Size : 46,9 Mb
Release : 2000-08-31
Category : Medical
ISBN : 0792378903

Get Book

Advances in Breast Cancer Management, 2nd edition by William J. Gradishar,William C. Wood Pdf

The optimal management of breast cancer patients relies on the expertise of a team of medical specialists including radiologists, surgeons, radiation therapists and medical oncologists. Much of the progress in breast cancer management made over the last several years reflects the translation of observations made in the laboratory to the clinic. Critically evaluating the impact of new treatment approaches relies on a commitment to well-designed clinical trials. In this volume, Advances in Breast Cancer Management, a renowned group of breast cancer experts have been asked to provide their perspective on management issues that directly effect patients on a day-to-day basis. Dr. Melody Cobleigh discusses the consequences of estrogen deprivation and the ways of ameliorating secondary symptoms and the potential long-term morbidity. Drs. Haigh and Guiliano review the sentinel lymph node biopsy technique including results from their extensive experience. Dr. Abram Recht places into perspective the potential benefit of post-mastectomy radiotherapy and reviews recent trials that address this issue. Dr. Dennis Slamon takes from us from the laboratory to the clinic in explaining the development of Herceptin as a paradigm for therapy targeted to specific molecular characteristics of breast cancer tumor cells. Drs. Nieto, Shpall, Crump and Pritchard offer different perspectives on the future of high-dose chemotherapy with stem cell transplantation as a treatment for breast cancer patients. Drs.

Author : Christophe Lamaze,Ian Prior
Publisher : Springer
Page : 329 pages
File Size : 53,8 Mb
Release : 2018-08-10
Category : Science
ISBN : 9783319967042

Get Book

Endocytosis and Signaling by Christophe Lamaze,Ian Prior Pdf

This book focuses on the context dependency of cell signaling by showing how the endosomal system helps to structure and regulate signaling pathways. The location and concentration of signaling nodes regulate their activation cycles and engagement with distinct effector pathways. Whilst many cell signaling pathways are initiated from the cell surface, endocytosis provides an opportunity for modulating signaling networks’ output. In this book, first a series of reviews describe the endocytic and endosomal system and show how these subcellular platforms sort and regulate a wide range of signaling pathway components and phenotypic outputs. The book then reviews the latest scientific insights into how endocytic trafficking and subcellular location modulate a set of major pathways that are essential to normal cellular function and organisms’ development.

Author : William C. Parks,Robert Mecham
Publisher : Springer Science & Business Media
Page : 255 pages
File Size : 52,9 Mb
Release : 2011-04-07
Category : Science
ISBN : 9783642168611

Get Book

Extracellular Matrix Degradation by William C. Parks,Robert Mecham Pdf

Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases, meprins, serine proteases, and elastases. The volume also discusses the domains responsible for specific biochemical characteristics of the proteases and the physical interactions that occur when the protease interacts with substrate. The topics covered in this volume provide an important context for understanding the role that matrix-degrading proteases play in normal tissue remodeling and in diseases such as cancer and lung disease.

Author : Caterina A. M. La Porta,Stefano Zapperi
Publisher : Cambridge University Press
Page : 187 pages
File Size : 47,6 Mb
Release : 2017-04-20
Category : Science
ISBN : 9781107109599

Get Book

The Physics of Cancer by Caterina A. M. La Porta,Stefano Zapperi Pdf

An introduction to the emerging field of cancer physics, integrating cancer biology with approaches from theoretical and applied physics.

Author : Vladimir Lupashin
Publisher : Frontiers Media SA
Page : 312 pages
File Size : 45,7 Mb
Release : 2022-08-25
Category : Science
ISBN : 9782889768042

Get Book

2021: Highlights in Membrane Traffic by Vladimir Lupashin Pdf

Author : Manfred Schwab
Publisher : Springer Science & Business Media
Page : 3307 pages
File Size : 42,9 Mb
Release : 2008-09-23
Category : Medical
ISBN : 9783540368472

Get Book

Encyclopedia of Cancer by Manfred Schwab Pdf

This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.

Author : Ana Gil De Bona,Jose Antonio Reales-Calderon
Publisher : BoD – Books on Demand
Page : 172 pages
File Size : 55,6 Mb
Release : 2020-03-04
Category : Science
ISBN : 9781789239430

Get Book

Extracellular Vesicles and Their Importance in Human Health by Ana Gil De Bona,Jose Antonio Reales-Calderon Pdf

Extracellular vesicle is a wide term that involves many different types of vesicles. Almost all the cell types studied secrete vesicles to the extracellular environment related to cell - cell communication. Extracellular vesicles have been found in different biological fluids, such as blood, milk, saliva, tears, urine, and cerebrospinal fluid. These vesicles transport different molecules, including mRNA, proteins, and lipids, some of them cell type specific that make them ideal biomarkers in both health and disease conditions. However, their contribution to different conditions is not well understood. The aim of this book is to provide an overview of the extracellular vesicles in the human body, how they are internalized, and their participation in several diseases.

Author : Alexander Birbrair
Publisher : Springer Nature
Page : 160 pages
File Size : 42,7 Mb
Release : 2020-02-06
Category : Medical
ISBN : 9783030357276

Get Book

Tumor Microenvironment by Alexander Birbrair Pdf

This volume discusses recent research advances in cancer biology, focusing on the role of the tumor microenvironment. Taken alongside its companion volumes, Tumor Microenvironment: Recent Advances covers the latest research on various aspects of the tumor microenvironment, as well as future directions. Useful for introducing the newer generation of researchers to the history of how scientists studied the tumor microenvironment as well as how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students, as well as researchers seeking an update on research on the tumor microenvironment.

Author : Anonim
Publisher : Academic Press
Page : 224 pages
File Size : 43,9 Mb
Release : 2021-06-30
Category : Science
ISBN : 9780128235454

Get Book

Monitoring Vesicular Trafficking in Cellular Responses to Stress by Anonim Pdf

Monitoring Vesicular Trafficking in Cellular Responses to Stress, Volume 164 in the Methods in Cell Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Cell Biology series Includes the latest information on the topic of Monitoring vesicular trafficking in cellular responses to stress

Author : Anonim
Publisher : Academic Press
Page : 234 pages
File Size : 44,6 Mb
Release : 2021-07-24
Category : Science
ISBN : 9780128244883

Get Book

Monitoring Vesicular Trafficking in Cellular Responses to Stress - Part B by Anonim Pdf

Monitoring Vesicular Trafficking in Cellular Responses to Stress - Part B, Volume 165 in the Methods in Cell Biology series, highlights new advances in the field, with this new release presenting coverage of different topics, including A novel tool for detecting lysosomal membrane permeabilization by high-throughput fluorescence microscopy, Exploring selective autophagy in Drosophila, Assessment of EGFP-Q74 degradation for the measurement of autophagic flux, Multimodal assessment of autophagy in mammalian cells with a novel, LC3-based tandem reporter, Multiplex quantification of autophagic flux by imaging flow cytometry, Monitoring autophagic flux in Caenorhabditis elegans using p62/SQST-1 reporters, High throughput screening for autophagy, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Cell Biology series Updated release includes the latest information on Monitoring vesicular trafficking in cellular responses to stress

Author : Guangpu Li,Nava Segev
Publisher : Bentham Science Publishers
Page : 180 pages
File Size : 43,7 Mb
Release : 2012-05-21
Category : Science
ISBN : 9781608053650

Get Book

Rab GTPases and Membrane Trafficking by Guangpu Li,Nava Segev Pdf

"Ypt/Rab GTPases form the largest branch of the Ras-related small GTPase superfamily and regulate intracellular membrane trafficking in all eukaryotes. Since their discovery over two decades ago, a wealth of information has accumulated about the roles that"

Author : Anonim
Publisher : Academic Press
Page : 256 pages
File Size : 44,8 Mb
Release : 2020-08-26
Category : Science
ISBN : 9780128212820

Get Book

Actin Cytoskeleton in Cancer Progression and Metastasis - Part A by Anonim Pdf

Actin Cytoskeleton in Cancer Progression and Metastasis - Part A, Volume 355 in the International Review of Cell and Molecular Biology series, provides an overview of the roles of the actin cytoskeleton and some of its key structural regulators, including WASp, Paxillin, Myosin, Testin, L-Plastin and profilin, in central processes underlying cancer progression and metastasis, such as changes in cell morphology and gene expression, acquisition of migratory and invasive capabilities, and evasion from the immune response. Provides comprehensive and timely reviews on actin cytoskeleton and its regulators in cancer biology Offers a wide range of perspectives for basic and translational research Discusses opportunities and challenges for translating knowledge of tumor cell actin cytoskeleton into clinical applications